{"id":"https://openalex.org/W7170041977","doi":"https://doi.org/10.33545/26646781.2026.v8.i5b.703","title":"Development and validation of a chemiluminescent immunoassay platform for rapid detection of lymphocytic choriomeningitis virus antibodies","display_name":"Development and validation of a chemiluminescent immunoassay platform for rapid detection of lymphocytic choriomeningitis virus antibodies","publication_year":2026,"publication_date":"2026-05-01","ids":{"openalex":"https://openalex.org/W7170041977","doi":"https://doi.org/10.33545/26646781.2026.v8.i5b.703"},"language":"en","primary_location":{"id":"doi:10.33545/26646781.2026.v8.i5b.703","doi":"https://doi.org/10.33545/26646781.2026.v8.i5b.703","is_oa":true,"landing_page_url":"https://doi.org/10.33545/26646781.2026.v8.i5b.703","pdf_url":"https://www.chemistryjournals.net/archives/2026/vol8issue5/PartB/8-7-19-141.pdf","source":{"id":"https://openalex.org/S4387285453","display_name":"International Journal of Advanced Chemistry Research","issn_l":"2664-6781","issn":["2664-6781","2664-679X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advanced Chemistry Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.chemistryjournals.net/archives/2026/vol8issue5/PartB/8-7-19-141.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5140913458","display_name":"Antoine Dubois-Laurent","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Antoine Dubois-Laurent","raw_affiliation_strings":["Department of Analytical Biochemistry , Lyon Institute of Diagnostic Sciences , Lyon , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Biochemistry , Lyon Institute of Diagnostic Sciences , Lyon , France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5140913458"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38742367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"5","first_page":"111","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.7221999764442444,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.7221999764442444,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":0.10100000351667404,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.0502999983727932,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphocytic-choriomeningitis-virus","display_name":"lymphocytic choriomeningitis virus","score":1.0},{"id":"https://openalex.org/keywords/chemiluminescence-immunoassay","display_name":"chemiluminescence immunoassay","score":0.9959999918937683},{"id":"https://openalex.org/keywords/igg-and-igm-antibodies","display_name":"IgM and IgG antibodies","score":0.9039999842643738},{"id":"https://openalex.org/keywords/baculovirus-expression-system","display_name":"baculovirus expression system","score":0.921999990940094},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.7670000195503235},{"id":"https://openalex.org/keywords/rapid-turnaround-testing","display_name":"rapid turnaround testing","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C2780190958","wikidata":"https://www.wikidata.org/wiki/Q1878776","display_name":"Lymphocytic choriomeningitis","level":4,"score":0.9431999921798706},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6585999727249146},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.5738999843597412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5353000164031982},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5281999707221985},{"id":"https://openalex.org/C145802702","wikidata":"https://www.wikidata.org/wiki/Q2931725","display_name":"Chemiluminescence","level":2,"score":0.5127000212669373},{"id":"https://openalex.org/C184112429","wikidata":"https://www.wikidata.org/wiki/Q476174","display_name":"Serial dilution","level":3,"score":0.5062000155448914},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.46209999918937683},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.41280001401901245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3961000144481659},{"id":"https://openalex.org/C2994453816","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Chemiluminescent immunoassay","level":4,"score":0.34150001406669617},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.32589998841285706},{"id":"https://openalex.org/C60325843","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Nucleoprotein","level":3,"score":0.3077999949455261},{"id":"https://openalex.org/C2779574689","wikidata":"https://www.wikidata.org/wiki/Q2368907","display_name":"Arenavirus","level":5,"score":0.29649999737739563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2782000005245209},{"id":"https://openalex.org/C2983449737","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Clinical diagnosis","level":2,"score":0.27799999713897705},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.2750999927520752},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.25600001215934753},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.25600001215934753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.33545/26646781.2026.v8.i5b.703","doi":"https://doi.org/10.33545/26646781.2026.v8.i5b.703","is_oa":true,"landing_page_url":"https://doi.org/10.33545/26646781.2026.v8.i5b.703","pdf_url":"https://www.chemistryjournals.net/archives/2026/vol8issue5/PartB/8-7-19-141.pdf","source":{"id":"https://openalex.org/S4387285453","display_name":"International Journal of Advanced Chemistry Research","issn_l":"2664-6781","issn":["2664-6781","2664-679X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advanced Chemistry Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.33545/26646781.2026.v8.i5b.703","doi":"https://doi.org/10.33545/26646781.2026.v8.i5b.703","is_oa":true,"landing_page_url":"https://doi.org/10.33545/26646781.2026.v8.i5b.703","pdf_url":"https://www.chemistryjournals.net/archives/2026/vol8issue5/PartB/8-7-19-141.pdf","source":{"id":"https://openalex.org/S4387285453","display_name":"International Journal of Advanced Chemistry Research","issn_l":"2664-6781","issn":["2664-6781","2664-679X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Advanced Chemistry Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7170041977.pdf","grobid_xml":"https://content.openalex.org/works/W7170041977.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2418691974","https://openalex.org/W2284639837","https://openalex.org/W1981318710","https://openalex.org/W260781824","https://openalex.org/W2009580027","https://openalex.org/W7117149310","https://openalex.org/W7152520022","https://openalex.org/W2078648155","https://openalex.org/W102041549","https://openalex.org/W2053633049"],"abstract_inverted_index":{"A":[0],"practical":[1],"example":[2],"of":[3,52,63,100,104,113,139,161],"the":[4,16,45,60,82,136],"diagnostic":[5,176],"inadequacy":[6],"surrounding":[7],"lymphocytic":[8],"choriomeningitis":[9],"virus":[10],"(LCMV)":[11],"detection":[12,62],"is":[13],"illustrated":[14],"by":[15,37],"2005":[17],"organ":[18],"transplant":[19],"cluster":[20],"in":[21,77,174,190],"which":[22],"four":[23],"recipients":[24],"developed":[25,167],"fatal":[26],"LCMV":[27,74,156,175],"infection":[28,34,157],"from":[29,152],"a":[30,53,78,110,171],"single":[31],"donor":[32],"whose":[33],"went":[35],"undetected":[36],"conventional":[38,121],"screening":[39],"methodologies.":[40],"The":[41,69,123,166],"present":[42],"research":[43],"describes":[44],"development,":[46],"analytical":[47,137],"validation,":[48],"and":[49,66,102,143,184],"clinical":[50,191],"evaluation":[51,147],"novel":[54],"chemiluminescent":[55,89],"immunoassay":[56],"(CLIA)":[57],"platform":[58,71,169],"for":[59,106,120,186],"rapid":[61],"LCMV-specific":[64],"IgG":[65,107],"IgM":[67],"antibodies.":[68],"CLIA":[70,168],"employed":[72],"recombinant":[73],"nucleoprotein":[75],"expressed":[76],"baculovirus":[79],"system":[80],"as":[81],"capture":[83],"antigen,":[84],"conjugated":[85],"to":[86,117,132],"acridinium":[87],"ester":[88],"labels.":[90],"Analytical":[91],"validation":[92],"using":[93,148],"240":[94],"characterized":[95],"serum":[96,129],"panels":[97],"demonstrated":[98],"sensitivity":[99],"96.8%":[101],"specificity":[103],"98.4%":[105],"detection,":[108],"with":[109,154,163],"turnaround":[111,182],"time":[112],"45":[114],"minutes":[115,119],"compared":[116],"180":[118,149],"ELISA.":[122],"assay":[124],"maintained":[125],"reliable":[126],"performance":[127],"across":[128],"dilutions":[130],"up":[131],"1:256,":[133],"significantly":[134],"exceeding":[135],"range":[138],"standard":[140],"ELISA":[141],"(1:128)":[142],"IFA":[144],"(1:64).":[145],"Clinical":[146],"prospective":[150],"samples":[151],"patients":[153],"suspected":[155],"yielded":[158],"concordance":[159],"rates":[160],"94.2%":[162],"RT-PCR-confirmed":[164],"diagnoses.":[165],"represents":[170],"significant":[172],"advancement":[173],"capability,":[177],"offering":[178],"enhanced":[179],"sensitivity,":[180],"reduced":[181],"time,":[183],"potential":[185],"automated":[187],"high-throughput":[188],"implementation":[189],"laboratories.":[192]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-07-23T00:00:00"}