{"id":"https://openalex.org/W7170033967","doi":"https://doi.org/10.1186/s13148-026-02174-1","title":"New perspective on epigenetic modification and immunotherapy in endometrial cancer","display_name":"New perspective on epigenetic modification and immunotherapy in endometrial cancer","publication_year":2026,"publication_date":"2026-07-22","ids":{"openalex":"https://openalex.org/W7170033967","doi":"https://doi.org/10.1186/s13148-026-02174-1"},"language":"en","primary_location":{"id":"doi:10.1186/s13148-026-02174-1","doi":"https://doi.org/10.1186/s13148-026-02174-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-026-02174-1","pdf_url":null,"source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13148-026-02174-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5143455881","display_name":"Haoqian Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144384","display_name":"Third Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/039nw9e11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144384"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoqian Zhang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","National Clinical Research Center for Obstetrics and Gynecology, Henan Branch, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","Zhengzhou Key Laboratory of Cervical Disease, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210144384"]},{"raw_affiliation_string":"National Clinical Research Center for Obstetrics and Gynecology, Henan Branch, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210144384"]},{"raw_affiliation_string":"Zhengzhou Key Laboratory of Cervical Disease, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210144384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125494787","display_name":"Dandan Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144384","display_name":"Third Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/039nw9e11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144384"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dandan Shen","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","National Clinical Research Center for Obstetrics and Gynecology, Henan Branch, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","Zhengzhou Key Laboratory of Cervical Disease, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210144384"]},{"raw_affiliation_string":"National Clinical Research Center for Obstetrics and Gynecology, Henan Branch, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210144384"]},{"raw_affiliation_string":"Zhengzhou Key Laboratory of Cervical Disease, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210144384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072651667","display_name":"\u6797\u5357\u5c71","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nanshan Lin","raw_affiliation_strings":["The Second Clinical Medical School of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical Medical School of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141288983","display_name":"L Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144384","display_name":"Third Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/039nw9e11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144384"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Yang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","National Clinical Research Center for Obstetrics and Gynecology, Henan Branch, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","Zhengzhou Key Laboratory of Cervical Disease, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210144384"]},{"raw_affiliation_string":"National Clinical Research Center for Obstetrics and Gynecology, Henan Branch, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210144384"]},{"raw_affiliation_string":"Zhengzhou Key Laboratory of Cervical Disease, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210144384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062987117","display_name":"Chenchen Ren","orcid":"https://orcid.org/0000-0003-3308-2447","observed_orcids":["https://orcid.org/0000-0003-3308-2447","https://orcid.org/0000-0002-3606-583X"]},"institutions":[{"id":"https://openalex.org/I4210144384","display_name":"Third Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/039nw9e11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144384"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chenchen Ren","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","National Clinical Research Center for Obstetrics and Gynecology, Henan Branch, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","Zhengzhou Key Laboratory of Cervical Disease, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210144384"]},{"raw_affiliation_string":"National Clinical Research Center for Obstetrics and Gynecology, Henan Branch, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210144384"]},{"raw_affiliation_string":"Zhengzhou Key Laboratory of Cervical Disease, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I4210144384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062987117"],"corresponding_institution_ids":["https://openalex.org/I4210144384"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49834652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9319999814033508},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.9559999704360962},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pole-mutation","display_name":"POLE mutation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/mismatch-repair-deficiency","display_name":"mismatch repair deficiency","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dnmt-inhibitors","display_name":"DNMT inhibitors","score":0.7749999761581421},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lsd1-inhibitors","display_name":"LSD1 inhibitors","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/prmt-inhibitors","display_name":"PRMT inhibitors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bet-proteins","display_name":"BET proteins","score":0.8650000095367432},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.8999999761581421},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9160000085830688},{"id":"https://openalex.org/keywords/dostarlimab","display_name":"dostarlimab","score":0.9139999747276306},{"id":"https://openalex.org/keywords/durvalumab","display_name":"durvalumab","score":0.9670000076293945},{"id":"https://openalex.org/keywords/lenvatinib","display_name":"lenvatinib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.9059000015258789},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6905999779701233},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6687999963760376},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6237999796867371},{"id":"https://openalex.org/C2780737395","wikidata":"https://www.wikidata.org/wiki/Q18353741","display_name":"Epigenetic therapy","level":5,"score":0.5239999890327454},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4961000084877014},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.492000013589859},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.4830999970436096},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47540000081062317},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.459199994802475},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.4293000102043152},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4259999990463257},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.4205999970436096},{"id":"https://openalex.org/C114691636","wikidata":"https://www.wikidata.org/wiki/Q5031434","display_name":"Cancer epigenetics","level":5,"score":0.4027000069618225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39739999175071716},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.362199991941452},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35569998621940613},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.3529999852180481},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.3328000009059906},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29249998927116394},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.28459998965263367},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.26980000734329224},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.267300009727478},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.25440001487731934}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s13148-026-02174-1","doi":"https://doi.org/10.1186/s13148-026-02174-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-026-02174-1","pdf_url":null,"source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s13148-026-02174-1","doi":"https://doi.org/10.1186/s13148-026-02174-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-026-02174-1","pdf_url":null,"source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8267794847488403}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8509478802","display_name":null,"funder_award_id":"82303741","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Endometrial":[0],"carcinoma":[1],"(EC)":[2],"is":[3],"a":[4,167],"heterogeneous":[5],"gynecological":[6],"malignancy.":[7],"Epigenetic":[8],"dysregulation":[9],"promotes":[10],"the":[11,52,84],"initiation,":[12],"progression,":[13],"immune":[14,148],"evasion,":[15],"and":[16,28,35,43,67,78,102,129,144,160],"therapeutic":[17],"resistance":[18],"of":[19],"EC.":[20,176],"Aberrant":[21],"DNA":[22,62],"methylation,":[23,25],"histone":[24,26],"acetylation,":[27],"chromatin":[29],"remodeling":[30],"affect":[31],"key":[32],"EC-associated":[33],"pathways":[34],"help":[36],"shape":[37],"distinct":[38],"molecular":[39],"subtypes,":[40],"including":[41,91,118],"POLE-mutated":[42],"mismatch":[44],"repair-deficient":[45],"tumours.":[46],"In":[47,111],"this":[48,164],"review,":[49],"we":[50,113],"summarize":[51],"major":[53],"epigenetic":[54,69,116,154],"alterations":[55],"implicated":[56],"in":[57,89,106],"EC,":[58,90],"with":[59,156],"emphasis":[60],"on":[61,171],"methylation":[63],"regulators,":[64],"histone-modifying":[65],"enzymes,":[66],"emerging":[68],"targets":[70],"such":[71,97],"as":[72,98],"DNMTs,":[73],"HDACs,":[74],"LSD1,":[75],"EZH2,":[76],"PRMTs,":[77],"BET":[79],"proteins.":[80],"We":[81],"further":[82],"highlight":[83],"rapidly":[85],"evolving":[86],"immunotherapy":[87,158],"landscape":[88],"clinically":[92,168],"established":[93],"or":[94,108],"practice-changing":[95],"regimens":[96],"pembrolizumab-,":[99],"dostarlimab-,":[100],"durvalumab-,":[101],"lenvatinib-based":[103],"strategies,":[104,163],"particularly":[105],"advanced":[107],"recurrent":[109],"disease.":[110],"parallel,":[112],"discuss":[114],"investigational":[115],"therapies,":[117],"DNMT":[119],"inhibitors,":[120,122,124,128],"HDAC":[121],"LSD1":[123],"EZH2-targeted":[125],"agents,":[126],"PRMT":[127],"BRD4-directed":[130],"approaches,":[131],"which":[132],"are":[133],"being":[134],"explored":[135],"to":[136,147],"restore":[137],"tumour":[138,142],"suppressor":[139],"pathways,":[140],"enhance":[141],"immunogenicity,":[143],"improve":[145],"sensitivity":[146],"checkpoint":[149],"blockade.":[150],"By":[151],"integrating":[152],"EC-specific":[153],"mechanisms":[155],"current":[157],"advances":[159],"ongoing":[161],"combination":[162],"review":[165],"provides":[166],"oriented":[169],"perspective":[170],"biomarker-guided":[172],"precision":[173],"treatment":[174],"for":[175]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-07-23T00:00:00"}
