{"id":"https://openalex.org/W7169867950","doi":"https://doi.org/10.1016/j.molmet.2026.102426","title":"Sex-specific differences of amlexanox in a mouse model for atherosclerosis and MASLD","display_name":"Sex-specific differences of amlexanox in a mouse model for atherosclerosis and MASLD","publication_year":2026,"publication_date":"2026-07-21","ids":{"openalex":"https://openalex.org/W7169867950","doi":"https://doi.org/10.1016/j.molmet.2026.102426","pmid":"https://pubmed.ncbi.nlm.nih.gov/42480839","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13453042"},"language":"en","primary_location":{"id":"doi:10.1016/j.molmet.2026.102426","doi":"https://doi.org/10.1016/j.molmet.2026.102426","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmet.2026.102426","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2212877826001109/pdf","source":{"id":"https://openalex.org/S2764545133","display_name":"Molecular Metabolism","issn_l":"2212-8778","issn":["2212-8778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2212877826001109/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040581854","display_name":"Eleonora Mungo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eleonora Mungo","raw_affiliation_strings":["Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113421784","display_name":"Michelle Ha\u00df","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michelle Ha\u00df","raw_affiliation_strings":["Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043844111","display_name":"Denis Benning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Denis Benning","raw_affiliation_strings":["Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086646466","display_name":"Tobias Schmid","orcid":"https://orcid.org/0000-0002-1952-5259","observed_orcids":["https://orcid.org/0000-0002-1952-5259"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Schmid","raw_affiliation_strings":["Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093275702","display_name":"Silvia Kuntschar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Silvia Kuntschar","raw_affiliation_strings":["Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029122887","display_name":"Sofie Patrizia Meyer","orcid":"https://orcid.org/0000-0002-7992-1448","observed_orcids":["https://orcid.org/0000-0002-7992-1448"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sofie P. Meyer","raw_affiliation_strings":["Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry I, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008549279","display_name":"Lisa Hahnefeld","orcid":"https://orcid.org/0000-0002-0382-5695","observed_orcids":["https://orcid.org/0000-0002-0382-5695"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210107844","display_name":"Fraunhofer Institute for Translational Medicine and Pharmacology","ror":"https://ror.org/01s1h3j07","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210107844","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lisa Hahnefeld","raw_affiliation_strings":["Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Sandh\u00f6fer Allee 1, Frankfurt am Main, 60528, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Sandh\u00f6fer Allee 1, Frankfurt am Main, 60528, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210107844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076151801","display_name":"Erika Dorochow","orcid":"https://orcid.org/0000-0002-0383-3273","observed_orcids":["https://orcid.org/0000-0002-0383-3273"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Erika Dorochow","raw_affiliation_strings":["Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021683292","display_name":"Urs Christen","orcid":"https://orcid.org/0000-0003-4165-7976","observed_orcids":["https://orcid.org/0000-0003-4165-7976"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Urs Christen","raw_affiliation_strings":["Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of General Pharmacology and Toxicology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of General Pharmacology and Toxicology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085217351","display_name":"Edith Hintermann","orcid":"https://orcid.org/0000-0002-0943-8098","observed_orcids":["https://orcid.org/0000-0002-0943-8098"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Edith Hintermann","raw_affiliation_strings":["Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of General Pharmacology and Toxicology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of General Pharmacology and Toxicology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069217472","display_name":"Rebekka Medert","orcid":"https://orcid.org/0000-0001-7571-3732","observed_orcids":["https://orcid.org/0000-0001-7571-3732"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rebekka Medert","raw_affiliation_strings":["Institute of Pharmacology, Ruprechts-Karl University Heidelberg, Im Neuenheimer Feld 366, Heidelberg, 69120, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, Ruprechts-Karl University Heidelberg, Im Neuenheimer Feld 366, Heidelberg, 69120, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075862457","display_name":"Marc Freichel","orcid":"https://orcid.org/0000-0003-1387-2636","observed_orcids":["https://orcid.org/0000-0003-1387-2636"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marc Freichel","raw_affiliation_strings":["Institute of Pharmacology, Ruprechts-Karl University Heidelberg, Im Neuenheimer Feld 366, Heidelberg, 69120, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, Ruprechts-Karl University Heidelberg, Im Neuenheimer Feld 366, Heidelberg, 69120, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078612562","display_name":"Gerd Gei\u00dflinger","orcid":"https://orcid.org/0000-0003-0552-7488","observed_orcids":["https://orcid.org/0000-0003-0552-7488"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210107844","display_name":"Fraunhofer Institute for Translational Medicine and Pharmacology","ror":"https://ror.org/01s1h3j07","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210107844","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerd Geisslinger","raw_affiliation_strings":["Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Sandh\u00f6fer Allee 1, Frankfurt am Main, 60528, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Sandh\u00f6fer Allee 1, Frankfurt am Main, 60528, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210107844"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006482373","display_name":"Ellen Niederberger","orcid":"https://orcid.org/0000-0002-3909-5751","observed_orcids":["https://orcid.org/0000-0002-3909-5751"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210107844","display_name":"Fraunhofer Institute for Translational Medicine and Pharmacology","ror":"https://ror.org/01s1h3j07","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210107844","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ellen Niederberger","raw_affiliation_strings":["Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Sandh\u00f6fer Allee 1, Frankfurt am Main, 60528, Germany. Electronic address: e.niederberger@em.uni-frankfurt.de"],"raw_orcid":"https://orcid.org/0000-0002-3909-5751","affiliations":[{"raw_affiliation_string":"Goethe-University Frankfurt, Faculty of Medicine, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Sandh\u00f6fer Allee 1, Frankfurt am Main, 60528, Germany. Electronic address: e.niederberger@em.uni-frankfurt.de","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210107844"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006482373"],"corresponding_institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210107844"],"apc_list":{"value":4270,"currency":"USD","value_usd":4270},"apc_paid":{"value":4270,"currency":"USD","value_usd":4270},"fwci":2.4543,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.81752278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"111","issue":null,"first_page":"102426","last_page":"102426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.1387999951839447,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.04259999841451645,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amlexanox","display_name":"amlexanox","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8519999980926514},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8550000190734863},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8019999861717224},{"id":"https://openalex.org/keywords/serum-lipid-metabolism","display_name":"serum lipid metabolism","score":0.6980000138282776},{"id":"https://openalex.org/keywords/bile-acid-metabolism","display_name":"bile acid metabolism","score":0.8830000162124634},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.9409999847412109},{"id":"https://openalex.org/keywords/atherosclerotic-plaque-composition","display_name":"atherosclerotic plaque composition","score":0.8090000152587891},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.6604999899864197},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.6276000142097473},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5376999974250793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5295000076293945},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4799000024795532},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.44690001010894775},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4357999861240387},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4250999987125397},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4083000123500824},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.392300009727478},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.38440001010894775},{"id":"https://openalex.org/C2778110834","wikidata":"https://www.wikidata.org/wiki/Q419724","display_name":"Fenofibrate","level":2,"score":0.37929999828338623},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.37880000472068787},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.3601999878883362},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.34599998593330383},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.3418999910354614},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3260999917984009},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.32120001316070557},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3181999921798706},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.31119999289512634},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.310699999332428},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3050999939441681},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.30070000886917114},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.2881999909877777},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.275299996137619},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.27230000495910645},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.26170000433921814},{"id":"https://openalex.org/C144464004","wikidata":"https://www.wikidata.org/wiki/Q3077338","display_name":"Lipid A","level":3,"score":0.2599000036716461},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2578999996185303},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2558000087738037},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.25369998812675476},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2524000108242035},{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.25130000710487366}],"mesh":[{"descriptor_ui":"D000071449","descriptor_name":"Proprotein Convertase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071449","descriptor_name":"Proprotein Convertase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000631","descriptor_name":"Aminopyridines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000631","descriptor_name":"Aminopyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.molmet.2026.102426","doi":"https://doi.org/10.1016/j.molmet.2026.102426","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmet.2026.102426","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2212877826001109/pdf","source":{"id":"https://openalex.org/S2764545133","display_name":"Molecular Metabolism","issn_l":"2212-8778","issn":["2212-8778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Metabolism","raw_type":"journal-article"},{"id":"pmid:42480839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42480839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13453042","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13453042/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Metab","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e44f988deec64d29adc089927ebb4440","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e44f988deec64d29adc089927ebb4440","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Metabolism, Vol 111, Iss , Pp 102426- (2026)","raw_type":"article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/522216","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/522216","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"doi:10.24406/publica-9927","doi":"https://doi.org/10.24406/publica-9927","is_oa":true,"landing_page_url":"https://doi.org/10.24406/publica-9927","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.1016/j.molmet.2026.102426","doi":"https://doi.org/10.1016/j.molmet.2026.102426","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmet.2026.102426","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2212877826001109/pdf","source":{"id":"https://openalex.org/S2764545133","display_name":"Molecular Metabolism","issn_l":"2212-8778","issn":["2212-8778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321773","display_name":"Fraunhofer-Gesellschaft","ror":"https://ror.org/05hkkdn48"},{"id":"https://openalex.org/F4320321961","display_name":"Hessisches Ministerium f\u00fcr Wissenschaft und Kunst","ror":"https://ror.org/00zd5gr55"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7169867950.pdf","grobid_xml":"https://content.openalex.org/works/W7169867950.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1885256726","https://openalex.org/W1977859620","https://openalex.org/W1990819179","https://openalex.org/W2016661258","https://openalex.org/W2033863085","https://openalex.org/W2042725827","https://openalex.org/W2045612646","https://openalex.org/W2079332279","https://openalex.org/W2086410640","https://openalex.org/W2110528304","https://openalex.org/W2130410032","https://openalex.org/W2138202978","https://openalex.org/W2148927360","https://openalex.org/W2151102178","https://openalex.org/W2159922234","https://openalex.org/W2170539205","https://openalex.org/W2619938137","https://openalex.org/W2734574592","https://openalex.org/W2742240523","https://openalex.org/W2767309773","https://openalex.org/W2904381205","https://openalex.org/W2907987213","https://openalex.org/W2942695470","https://openalex.org/W2944368913","https://openalex.org/W2981265650","https://openalex.org/W2982553009","https://openalex.org/W2984343428","https://openalex.org/W3020512321","https://openalex.org/W3180307605","https://openalex.org/W3184419739","https://openalex.org/W3217210153","https://openalex.org/W4211191293","https://openalex.org/W4220667323","https://openalex.org/W4224052225","https://openalex.org/W4283804489","https://openalex.org/W4289518254","https://openalex.org/W4293222079","https://openalex.org/W4297348603","https://openalex.org/W4310088498","https://openalex.org/W4321019953","https://openalex.org/W4362473527","https://openalex.org/W4378212465","https://openalex.org/W4386189889","https://openalex.org/W4388023974","https://openalex.org/W4389255308","https://openalex.org/W4400869996","https://openalex.org/W4401184193","https://openalex.org/W4403195696","https://openalex.org/W4407058261","https://openalex.org/W7117715860"],"related_works":["https://openalex.org/W4403195696","https://openalex.org/W2982553009","https://openalex.org/W4289518254","https://openalex.org/W3087932587","https://openalex.org/W7201835999","https://openalex.org/W1966259797","https://openalex.org/W2743274282","https://openalex.org/W2985195462","https://openalex.org/W3083439167","https://openalex.org/W4414453807"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Inhibitor-\u03baB":[1],"kinase":[2,9],"epsilon":[3],"(IKK\u03b5)":[4],"is":[5],"a":[6],"non-canonical":[7],"I\u03baB":[8],"involved":[10],"in":[11,133,146,150,167,171,206,213,234,250],"NF-\u03baB":[12],"signaling":[13],"and":[14,29,51,65,87,95,110,152,155,163,173,180,236,239],"type":[15,81],"I":[16],"interferon":[17],"responses.":[18],"We":[19],"recently":[20],"demonstrated":[21],"sex-dependent":[22,148],"effects":[23,61],"of":[24,74,160,203,230],"IKK\u03b5":[25,76,101,195],"deletion":[26],"on":[27,62],"atherosclerosis":[28,205],"metabolic":[30,52,179,235],"dysfunction-associated":[31],"steatotic":[32],"liver":[33,172],"disease":[34],"(MASLD),":[35],"with":[36,83,99,197],"male":[37,128,214],"knockout":[38],"mice":[39,47,82,129,137,219],"showing":[40],"protection":[41],"against":[42],"both":[43,251],"diseases,":[44],"while":[45],"female":[46,136,218],"exhibited":[48,130],"exacerbated":[49],"inflammatory":[50,63,181],"disturbances.":[53],"These":[54,142,225],"divergent":[55],"outcomes":[56,143],"were":[57,144],"linked":[58],"to":[59,243],"differential":[60],"pathways":[64],"lipid":[66,108,140,154,223],"metabolism.":[67],"METHODS:":[68],"To":[69],"evaluate":[70,244],"the":[71,100,121,228,241],"therapeutic":[72,194,245],"potential":[73],"pharmacological":[75],"inhibition,":[77],"we":[78],"treated":[79],"wild":[80],"established":[84],"atherosclerotic":[85],"plaques":[86],"hepatic":[88,153,222],"steatosis":[89],"-":[90,98],"induced":[91],"by":[92],"PCSK9":[93],"gain-of-function":[94],"Paigen":[96],"diet":[97],"inhibitor":[102],"amlexanox.":[103],"RESULTS:":[104],"Amlexanox":[105],"modulated":[106],"serum":[107,151],"levels":[109],"altered":[111],"plaque":[112,118],"composition":[113],"but":[114,209],"did":[115],"not":[116,200],"halt":[117],"progression.":[119],"In":[120,216],"liver,":[122],"treatment":[123],"produced":[124],"marked":[125],"sex-specific":[126,232],"effects:":[127],"substantial":[131],"improvement":[132],"steatosis,":[134],"whereas":[135],"showed":[138],"worsened":[139],"accumulation.":[141],"reflected":[145],"pronounced":[147],"differences":[149],"metabolite":[156],"profiles,":[157],"indicating":[158],"regulation":[159],"fatty":[161],"acid":[162],"bile-acid":[164],"metabolism":[165],"predominantly":[166],"males.":[168],"Protein":[169],"analyses":[170,233],"adipose":[174],"tissue":[175],"further":[176],"supported":[177],"opposing":[178],"responses":[182],"between":[183],"sexes":[184],"after":[185],"amlexanox":[186,198,249],"treatment.":[187],"CONCLUSIONS:":[188],"Collectively,":[189],"our":[190],"findings":[191],"indicate":[192],"that":[193],"inhibition":[196],"does":[199],"prevent":[201],"progression":[202],"advanced":[204],"this":[207],"model":[208],"effectively":[210],"ameliorates":[211],"MASLD":[212],"mice.":[215],"contrast,":[217],"experience":[220],"aggravated":[221],"deposition.":[224],"results":[226],"underscore":[227],"importance":[229],"incorporating":[231],"cardiovascular":[237],"research":[238],"highlight":[240],"need":[242],"strategies":[246],"such":[247],"as":[248],"sexes.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-07-22T00:00:00"}