{"id":"https://openalex.org/W7169779486","doi":"https://doi.org/10.1016/j.kisu.2026.01.003","title":"IgA nephropathy: an overview of the disease, its pathophysiology, and involvement of the gut-kidney axis","display_name":"IgA nephropathy: an overview of the disease, its pathophysiology, and involvement of the gut-kidney axis","publication_year":2026,"publication_date":"2026-07-20","ids":{"openalex":"https://openalex.org/W7169779486","doi":"https://doi.org/10.1016/j.kisu.2026.01.003","pmid":"https://pubmed.ncbi.nlm.nih.gov/42483538","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13387150"},"language":"en","primary_location":{"id":"doi:10.1016/j.kisu.2026.01.003","doi":"https://doi.org/10.1016/j.kisu.2026.01.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.kisu.2026.01.003","pdf_url":null,"source":{"id":"https://openalex.org/S4210177655","display_name":"Kidney International Supplements","issn_l":"2157-1716","issn":["2157-1716","2157-1724"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Supplements","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.kisu.2026.01.003","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026871566","display_name":"Chee Kay Cheung","orcid":"https://orcid.org/0000-0001-8593-7625","observed_orcids":["https://orcid.org/0000-0001-8593-7625"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I2802445252","display_name":"University Hospitals of Leicester NHS Trust","ror":"https://ror.org/02fha3693","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Chee Kay Cheung","raw_affiliation_strings":["John Walls Renal Unit, University Hospitals of Leicester NHS Trust, Leicester, UK","Mayer IgA Nephropathy Laboratories, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK"],"raw_orcid":"https://orcid.org/0000-0001-8593-7625","affiliations":[{"raw_affiliation_string":"John Walls Renal Unit, University Hospitals of Leicester NHS Trust, Leicester, UK","institution_ids":["https://openalex.org/I2802445252"]},{"raw_affiliation_string":"Mayer IgA Nephropathy Laboratories, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020252530","display_name":"Laura H. Mariani","orcid":"https://orcid.org/0000-0002-6055-764X","observed_orcids":["https://orcid.org/0000-0002-6055-764X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura H. Mariani","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5026871566"],"corresponding_institution_ids":["https://openalex.org/I153648349","https://openalex.org/I2802445252"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.9659,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.87283237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"15","issue":"1","first_page":"3","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iga-nephropathy","display_name":"IgA nephropathy","score":1.0},{"id":"https://openalex.org/keywords/primary-glomerular-disease","display_name":"primary glomerular disease","score":0.878000020980835},{"id":"https://openalex.org/keywords/gut-kidney-axis","display_name":"gut-kidney axis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.7009999752044678},{"id":"https://openalex.org/keywords/galactose-deficient-iga1","display_name":"galactose-deficient IgA1","score":0.9259999990463257},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.890999972820282},{"id":"https://openalex.org/keywords/immune-complexes","display_name":"immune complexes","score":0.953000009059906},{"id":"https://openalex.org/keywords/mesangial-deposition","display_name":"mesangial deposition","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mucosal-immunity","display_name":"mucosal immunity","score":0.8450000286102295},{"id":"https://openalex.org/keywords/intestinal-epithelial-barrier","display_name":"intestinal epithelial barrier","score":0.9739999771118164},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/susceptibility-loci","display_name":"genetic susceptibility loci","score":0.718999981880188},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.5680000185966492},{"id":"https://openalex.org/keywords/clinical-characteristics","display_name":"clinical features","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36640000343322754},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28769999742507935},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2646999955177307},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.26249998807907104},{"id":"https://openalex.org/C65682993","wikidata":"https://www.wikidata.org/wiki/Q1056451","display_name":"Reflection (computer programming)","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.2547999918460846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23970000445842743},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22169999778270721}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.kisu.2026.01.003","doi":"https://doi.org/10.1016/j.kisu.2026.01.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.kisu.2026.01.003","pdf_url":null,"source":{"id":"https://openalex.org/S4210177655","display_name":"Kidney International Supplements","issn_l":"2157-1716","issn":["2157-1716","2157-1724"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Supplements","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13387150","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13387150/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13387150/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney Int Suppl (2011)","raw_type":"Text"},{"id":"pmid:42483538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42483538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international supplements","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.kisu.2026.01.003","doi":"https://doi.org/10.1016/j.kisu.2026.01.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.kisu.2026.01.003","pdf_url":null,"source":{"id":"https://openalex.org/S4210177655","display_name":"Kidney International Supplements","issn_l":"2157-1716","issn":["2157-1716","2157-1724"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Supplements","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"},{"id":"https://openalex.org/F4320323675","display_name":"Oxford University Hospitals NHS Foundation Trust","ror":"https://ror.org/03h2bh287"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7169779486.pdf","grobid_xml":"https://content.openalex.org/works/W7169779486.grobid-xml"},"referenced_works_count":124,"referenced_works":["https://openalex.org/W1840824980","https://openalex.org/W1966336362","https://openalex.org/W1971086200","https://openalex.org/W1982189917","https://openalex.org/W1983063314","https://openalex.org/W1991210746","https://openalex.org/W1993084542","https://openalex.org/W2003651638","https://openalex.org/W2009393059","https://openalex.org/W2009836284","https://openalex.org/W2021230907","https://openalex.org/W2032354231","https://openalex.org/W2064214572","https://openalex.org/W2075633094","https://openalex.org/W2096681927","https://openalex.org/W2096977413","https://openalex.org/W2099088033","https://openalex.org/W2100076924","https://openalex.org/W2101794801","https://openalex.org/W2102180002","https://openalex.org/W2108789237","https://openalex.org/W2112139283","https://openalex.org/W2113470371","https://openalex.org/W2120366573","https://openalex.org/W2121260651","https://openalex.org/W2125096231","https://openalex.org/W2126237198","https://openalex.org/W2126623226","https://openalex.org/W2135239485","https://openalex.org/W2138161657","https://openalex.org/W2152853007","https://openalex.org/W2153321574","https://openalex.org/W2162337442","https://openalex.org/W2165054263","https://openalex.org/W2166885924","https://openalex.org/W2168259745","https://openalex.org/W2169743937","https://openalex.org/W2181240763","https://openalex.org/W2223268479","https://openalex.org/W2261243133","https://openalex.org/W2324533035","https://openalex.org/W2409073940","https://openalex.org/W2587736924","https://openalex.org/W2602196428","https://openalex.org/W2738099971","https://openalex.org/W2746382716","https://openalex.org/W2768410307","https://openalex.org/W2768469552","https://openalex.org/W2887265391","https://openalex.org/W2889506661","https://openalex.org/W2899014758","https://openalex.org/W2900796514","https://openalex.org/W2914720116","https://openalex.org/W2929806984","https://openalex.org/W2935962542","https://openalex.org/W2937346600","https://openalex.org/W2939528548","https://openalex.org/W2947030778","https://openalex.org/W3000451715","https://openalex.org/W3043693295","https://openalex.org/W3080629152","https://openalex.org/W3082343232","https://openalex.org/W3092114769","https://openalex.org/W3092938579","https://openalex.org/W3099056408","https://openalex.org/W3101888437","https://openalex.org/W3105603278","https://openalex.org/W3118223742","https://openalex.org/W3132083327","https://openalex.org/W3134400441","https://openalex.org/W3161765141","https://openalex.org/W3169331160","https://openalex.org/W3170580589","https://openalex.org/W3172423688","https://openalex.org/W3173040618","https://openalex.org/W3182600246","https://openalex.org/W3188314326","https://openalex.org/W3189370084","https://openalex.org/W3198294358","https://openalex.org/W3201682475","https://openalex.org/W3203723023","https://openalex.org/W3207451318","https://openalex.org/W3207571249","https://openalex.org/W3207725325","https://openalex.org/W3215284682","https://openalex.org/W4210696710","https://openalex.org/W4210864710","https://openalex.org/W4225145323","https://openalex.org/W4225259158","https://openalex.org/W4247172809","https://openalex.org/W4293055992","https://openalex.org/W4307515255","https://openalex.org/W4309324513","https://openalex.org/W4313362173","https://openalex.org/W4327811820","https://openalex.org/W4353040056","https://openalex.org/W4365457345","https://openalex.org/W4375851994","https://openalex.org/W4378211493","https://openalex.org/W4378906950","https://openalex.org/W4381185249","https://openalex.org/W4385582880","https://openalex.org/W4385803938","https://openalex.org/W4387395510","https://openalex.org/W4389295715","https://openalex.org/W4389295716","https://openalex.org/W4390235752","https://openalex.org/W4392112070","https://openalex.org/W4392173293","https://openalex.org/W4393218473","https://openalex.org/W4393991695","https://openalex.org/W4396560206","https://openalex.org/W4399969691","https://openalex.org/W4400266581","https://openalex.org/W4401895631","https://openalex.org/W4402230187","https://openalex.org/W4403838899","https://openalex.org/W4403892386","https://openalex.org/W4408346815","https://openalex.org/W4414335273","https://openalex.org/W7169755852","https://openalex.org/W7169773706","https://openalex.org/W7169789156","https://openalex.org/W7169799986"],"related_works":["https://openalex.org/W4293055992","https://openalex.org/W6891382421","https://openalex.org/W4410429807","https://openalex.org/W7202075603","https://openalex.org/W4386786959","https://openalex.org/W4416032269","https://openalex.org/W4309609802","https://openalex.org/W2604156122","https://openalex.org/W2096977413","https://openalex.org/W4402230187"],"abstract_inverted_index":{"IgA":[0],"nephropathy":[1],"(IgAN)":[2],"is":[3,55,194],"the":[4,71,77,88,91,114,125,132,149,174,178,208],"most":[5],"common":[6],"primary":[7],"glomerular":[8,175],"disease":[9,127],"worldwide.":[10],"Its":[11],"incidence":[12,21],"and":[13,33,54,118,183,204,207],"prevalence":[14],"vary":[15],"widely,":[16],"with":[17,57],"estimates":[18],"of":[19,40,52,61,68,73,81,93,113,134,145,156,177,191,199],"annual":[20],"ranging":[22],"from":[23],"0.06":[24],"to":[25,45,109,131,195],"10.5":[26],"per":[27,29],"100,000":[28],"year":[30],"in":[31,48,76,90,148,186],"adults":[32],"children.":[34],"IgAN":[35,74,104],"represents":[36],"an":[37,197],"important":[38],"cause":[39],"progressive":[41,184],"kidney":[42,46,187],"disease,":[43],"leading":[44],"failure":[47],"a":[49,58,84,135],"large":[50],"proportion":[51],"patients,":[53],"associated":[56],"wide":[59],"spectrum":[60],"clinical":[62,205],"symptoms,":[63],"which":[64,163],"negatively":[65],"impact":[66],"quality":[67],"life.":[69],"Although":[70],"consequences":[72],"manifest":[75],"kidney,":[78,179],"multiple":[79],"lines":[80],"evidence":[82],"support":[83],"major":[85],"role":[86],"for":[87,103],"gut":[89],"pathogenesis":[92,128],"IgAN,":[94,200],"including":[95],"genome-wide":[96],"association":[97],"studies":[98],"that":[99,105,170],"identify":[100],"risk":[101],"loci":[102],"encode":[106],"genes":[107],"related":[108],"mucosal":[110],"immunity,":[111],"maintenance":[112],"intestinal":[115],"epithelial":[116],"barrier,":[117],"inflammatory":[119],"bowel":[120],"disease.":[121],"Further":[122],"insights":[123],"into":[124],"underlying":[126,210],"have":[129],"led":[130],"development":[133],"multihit":[136],"model":[137],"comprising":[138],"4":[139],"sequential":[140],"\"hits\":":[141],"(i)":[142],"increased":[143],"levels":[144],"galactose-deficient":[146,161],"IgA1":[147],"systemic":[150],"circulation,":[151],"(ii)":[152],"followed":[153],"by":[154],"binding":[155],"specific":[157],"autoantibodies":[158],"directed":[159],"against":[160],"IgA1,":[162],"(iii)":[164],"form":[165],"pathogenic":[166],"IgA-containing":[167],"immune":[168],"complexes":[169],"(iv)":[171],"deposit":[172],"within":[173],"mesangium":[176],"triggering":[180],"inflammation,":[181],"damage,":[182],"decline":[185],"function.":[188],"The":[189],"purpose":[190],"this":[192],"article":[193],"provide":[196],"overview":[198],"examining":[201],"its":[202,211],"epidemiology":[203],"features,":[206],"mechanisms":[209],"pathophysiology.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-07-21T00:00:00"}