{"id":"https://openalex.org/W7169777902","doi":"https://doi.org/10.1186/s12943-026-02732-4","title":"Evidence of endothelial anergy and T-cell exclusion in microsatellite stable colorectal liver metastases revealed through human hemi-liver perfusion and spatial transcriptomics","display_name":"Evidence of endothelial anergy and T-cell exclusion in microsatellite stable colorectal liver metastases revealed through human hemi-liver perfusion and spatial transcriptomics","publication_year":2026,"publication_date":"2026-07-20","ids":{"openalex":"https://openalex.org/W7169777902","doi":"https://doi.org/10.1186/s12943-026-02732-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/42477793","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13673828"},"language":"en","primary_location":{"id":"doi:10.1186/s12943-026-02732-4","doi":"https://doi.org/10.1186/s12943-026-02732-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-026-02732-4","pdf_url":null,"source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12943-026-02732-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076745657","display_name":"Peter Kok-Ting Wan","orcid":"https://orcid.org/0000-0003-0414-5453","observed_orcids":["https://orcid.org/0000-0003-0414-5453"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Peter Kok-Ting Wan","raw_affiliation_strings":["Department of Oncology, University of Oxford, Oxford, UK. peter.wan@oncology.ox.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Oxford, Oxford, UK. peter.wan@oncology.ox.ac.uk","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132921320","display_name":"Ranchu Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ranchu Cheng","raw_affiliation_strings":["Department of Oncology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141199272","display_name":"David Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Johnson","raw_affiliation_strings":["Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040633107","display_name":"Carl Lee","orcid":"https://orcid.org/0000-0002-6776-2793","observed_orcids":["https://orcid.org/0000-0002-6776-2793"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4405264228","display_name":"Kennedy Institute of Rheumatology","ror":"https://ror.org/01ahsqc77","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149","https://openalex.org/I4405264228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carl Lee","raw_affiliation_strings":["Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4405264228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103851145","display_name":"Shihong Wu","orcid":"https://orcid.org/0009-0006-7952-7965","observed_orcids":["https://orcid.org/0009-0006-7952-7965","https://orcid.org/0000-0002-8684-8330"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shihong Wu","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068166031","display_name":"Areeb Mian","orcid":"https://orcid.org/0000-0002-4035-4052","observed_orcids":["https://orcid.org/0000-0002-4035-4052"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Areeb Mian","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085420959","display_name":"Ahmet Hazini","orcid":"https://orcid.org/0000-0002-8552-2005","observed_orcids":["https://orcid.org/0000-0002-8552-2005"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ahmet Hazini","raw_affiliation_strings":["Department of Oncology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113175974","display_name":"Sorayya Moradi","orcid":"https://orcid.org/0009-0005-8098-5210","observed_orcids":["https://orcid.org/0009-0005-8098-5210"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sorayya Moradi","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068251680","display_name":"Kate Friesen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kate Friesen","raw_affiliation_strings":["Department of Oncology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017808466","display_name":"Flurin Caviezel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Flurin Caviezel","raw_affiliation_strings":["Department of Oncology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057300171","display_name":"Syed Hussain Abbas","orcid":"https://orcid.org/0000-0002-9434-2970","observed_orcids":["https://orcid.org/0000-0002-9434-2970"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Syed Hussain Abbas","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001775125","display_name":"Brannon Nicholls","orcid":"https://orcid.org/0009-0004-9498-2267","observed_orcids":["https://orcid.org/0009-0004-9498-2267"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brannon Nicholls","raw_affiliation_strings":["Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084777192","display_name":"Hatem Sadik","orcid":"https://orcid.org/0000-0003-3323-0278","observed_orcids":["https://orcid.org/0000-0003-3323-0278"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hatem Sadik","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020843226","display_name":"Adil Siraj Lakha","orcid":"https://orcid.org/0000-0002-9525-127X","observed_orcids":["https://orcid.org/0000-0002-9525-127X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adil Lakha","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058316303","display_name":"Keaton Ian Jones","orcid":"https://orcid.org/0000-0002-4765-2167","observed_orcids":["https://orcid.org/0000-0002-4765-2167"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Keaton Jones","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001875218","display_name":"Girishkumar Kaitholil Kumaran","orcid":"https://orcid.org/0000-0003-3000-7978","observed_orcids":["https://orcid.org/0000-0003-3000-7978"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Girishkumar Kumaran","raw_affiliation_strings":["Nuffield Department of Medicine, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132671327","display_name":"Matthew J. Bottomley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew J. Bottomley","raw_affiliation_strings":["Nuffield Department of Medicine, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103971091","display_name":"R. E. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rob Jones","raw_affiliation_strings":["Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126607349","display_name":"Mark Coles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4405264228","display_name":"Kennedy Institute of Rheumatology","ror":"https://ror.org/01ahsqc77","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149","https://openalex.org/I4405264228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Coles","raw_affiliation_strings":["Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4405264228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032852377","display_name":"Rachael J. M. Bashford-Rogers","orcid":"https://orcid.org/0000-0002-6838-0711","observed_orcids":["https://orcid.org/0000-0002-6838-0711"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rachael Bashford-Rogers","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042082739","display_name":"Constantin C. Coussios","orcid":"https://orcid.org/0000-0001-8792-7818","observed_orcids":["https://orcid.org/0000-0001-8792-7818"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Constantin Coussios","raw_affiliation_strings":["Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129203867","display_name":"Len Seymour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Len Seymour","raw_affiliation_strings":["Department of Oncology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113802126","display_name":"Robert Carlisle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert Carlisle","raw_affiliation_strings":["Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129092424","display_name":"Kerry Fisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kerry Fisher","raw_affiliation_strings":["Department of Oncology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014763229","display_name":"Alex Nicolas Gordon-Weeks","orcid":"https://orcid.org/0000-0003-2997-4194","observed_orcids":["https://orcid.org/0000-0003-2997-4194"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alex Gordon-Weeks","raw_affiliation_strings":["Department of Oncology, University of Oxford, Oxford, UK. alex.gordon-weeks@nds.ox.ac.uk","Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. alex.gordon-weeks@nds.ox.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Oxford, Oxford, UK. alex.gordon-weeks@nds.ox.ac.uk","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. alex.gordon-weeks@nds.ox.ac.uk","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014763229","https://openalex.org/A5076745657"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":{"value":5090,"currency":"USD","value_usd":5090},"fwci":2.5575,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.83345809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"25","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-liver-metastases","display_name":"colorectal liver metastases","score":0.9610000252723694},{"id":"https://openalex.org/keywords/t-cell-exclusion","display_name":"T-cell exclusion","score":0.8389999866485596},{"id":"https://openalex.org/keywords/t-cell-extravasation","display_name":"T cell extravasation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.6980000138282776},{"id":"https://openalex.org/keywords/normothermic-machine-perfusion","display_name":"normothermic machine perfusion","score":0.7260000109672546},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cd4-t-cell-exhaustion","display_name":"CD4+ T cell exhaustion","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hypoxic-niche","display_name":"hypoxic niche","score":0.5899999737739563},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6420000195503235},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.5720000267028809},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7851999998092651},{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.6777999997138977},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6414999961853027},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5539000034332275},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.508899986743927},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4950000047683716},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47679999470710754},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4018999934196472},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.3986000120639801},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.390500009059906},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.37209999561309814},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.34459999203681946},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3379000127315521},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3021000027656555},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2994999885559082},{"id":"https://openalex.org/C2779974255","wikidata":"https://www.wikidata.org/wiki/Q1479893","display_name":"Leukocyte extravasation","level":3,"score":0.288100004196167},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.2847000062465668},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.27559998631477356},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.2721000015735626},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.2524000108242035}],"mesh":[{"descriptor_ui":"D000099285","descriptor_name":"Spatial Transcriptomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017635","descriptor_name":"Clonal Anergy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12943-026-02732-4","doi":"https://doi.org/10.1186/s12943-026-02732-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-026-02732-4","pdf_url":null,"source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},{"id":"doi:10.64898/2025.12.09.693114","doi":"https://doi.org/10.64898/2025.12.09.693114","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2025.12.09.693114","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13673828","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13673828/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13673828/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cancer","raw_type":"Text"},{"id":"pmid:42477793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42477793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:14017129c54b4e0bb912eca1e271a3c3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/14017129c54b4e0bb912eca1e271a3c3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer, Vol 25, Iss 1 (2026)","raw_type":"article"},{"id":"doi:10.6084/m9.figshare.c.8777144","doi":"https://doi.org/10.6084/m9.figshare.c.8777144","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.8777144","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Collection"},{"id":"doi:10.6084/m9.figshare.c.8777144.v1","doi":"https://doi.org/10.6084/m9.figshare.c.8777144.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.8777144.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Collection"}],"best_oa_location":{"id":"doi:10.1186/s12943-026-02732-4","doi":"https://doi.org/10.1186/s12943-026-02732-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-026-02732-4","pdf_url":null,"source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G241512071","display_name":null,"funder_award_id":"DRCPGM-Jun25/100008","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7169777902.pdf","grobid_xml":"https://content.openalex.org/works/W7169777902.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W5139590","https://openalex.org/W1986222655","https://openalex.org/W2020406481","https://openalex.org/W2101234009","https://openalex.org/W2107665951","https://openalex.org/W2109092551","https://openalex.org/W2110065044","https://openalex.org/W2114290117","https://openalex.org/W2119160928","https://openalex.org/W2169281690","https://openalex.org/W2533236332","https://openalex.org/W2533419167","https://openalex.org/W2624831627","https://openalex.org/W2786672974","https://openalex.org/W2791965482","https://openalex.org/W2797665619","https://openalex.org/W2800392236","https://openalex.org/W2808837841","https://openalex.org/W2898120081","https://openalex.org/W2902652978","https://openalex.org/W2911964244","https://openalex.org/W2938645074","https://openalex.org/W2949177718","https://openalex.org/W2951222857","https://openalex.org/W2984472267","https://openalex.org/W3003257820","https://openalex.org/W3024659015","https://openalex.org/W3026606390","https://openalex.org/W3029242248","https://openalex.org/W3047081808","https://openalex.org/W3111521801","https://openalex.org/W3112328834","https://openalex.org/W3129369221","https://openalex.org/W3133261845","https://openalex.org/W3184268904","https://openalex.org/W3193609746","https://openalex.org/W3197639828","https://openalex.org/W3198201872","https://openalex.org/W3199007722","https://openalex.org/W3203622089","https://openalex.org/W3206775306","https://openalex.org/W3214596602","https://openalex.org/W3215932031","https://openalex.org/W4200375058","https://openalex.org/W4200468913","https://openalex.org/W4210297691","https://openalex.org/W4214620261","https://openalex.org/W4221120384","https://openalex.org/W4283325018","https://openalex.org/W4288065939","https://openalex.org/W4289792154","https://openalex.org/W4292064516","https://openalex.org/W4302362633","https://openalex.org/W4306178456","https://openalex.org/W4307357496","https://openalex.org/W4317787046","https://openalex.org/W4322719806","https://openalex.org/W4362676625","https://openalex.org/W4378648463","https://openalex.org/W4380986217","https://openalex.org/W4385444202","https://openalex.org/W4385986833","https://openalex.org/W4386067114","https://openalex.org/W4386275867","https://openalex.org/W4389207477","https://openalex.org/W4389326973","https://openalex.org/W4392348423","https://openalex.org/W4394010927","https://openalex.org/W4395071408","https://openalex.org/W4395113153","https://openalex.org/W4396781858","https://openalex.org/W4396895004","https://openalex.org/W4399318772","https://openalex.org/W4401505664","https://openalex.org/W4401967826","https://openalex.org/W4402604581","https://openalex.org/W4403908995","https://openalex.org/W4405150968","https://openalex.org/W4406272768","https://openalex.org/W4407010611","https://openalex.org/W4408201414","https://openalex.org/W4409039434","https://openalex.org/W4409045398","https://openalex.org/W4409244165","https://openalex.org/W4410193214","https://openalex.org/W4410230213","https://openalex.org/W4412025186","https://openalex.org/W4412745982","https://openalex.org/W4413756160","https://openalex.org/W4414781815","https://openalex.org/W4415381421"],"related_works":["https://openalex.org/W7148761739","https://openalex.org/W4417253897","https://openalex.org/W7222491758","https://openalex.org/W7222691032","https://openalex.org/W3003071007","https://openalex.org/W4415381421","https://openalex.org/W7156939526","https://openalex.org/W7148644344","https://openalex.org/W4395014359","https://openalex.org/W4413328166"],"abstract_inverted_index":{"BACKGROUND:":[0],"Colorectal":[1],"liver":[2,53,88,100,188],"metastasis":[3],"(CRLM)":[4],"is":[5,256],"the":[6,19,40,51,87,93,126,186,264],"terminal":[7],"stage":[8],"of":[9,45,67,72,95,174,266],"colorectal":[10],"cancer":[11],"and":[12,35,42,50,98,109,160,205,225,238,247,262],"remains":[13],"largely":[14],"resistant":[15],"to":[16,85,116,131,154,162,258],"immunotherapeutics,":[17],"yet":[18,191],"underlying":[20],"immune":[21],"escape":[22],"mechanisms":[23],"remain":[24],"poorly":[25],"understood.":[26],"Through":[27],"novel":[28,267],"observational":[29],"methods":[30],"focused":[31],"on":[32,230],"human":[33,82],"living":[34],"fixed":[36],"tissue,":[37],"we":[38,57,90],"profiled":[39],"spatial":[41],"molecular":[43],"features":[44],"microsatellite":[46],"stable":[47],"(MSS)":[48],"CRLM":[49,97,169,197,234],"surrounding":[52],"microenvironment.":[54],"METHODS:":[55],"First,":[56],"re-purposed":[58],"normothermic":[59],"hepatic":[60],"machine":[61],"perfusion":[62],"as":[63],"a":[64,117,139,148,155],"preclinical":[65],"model":[66],"MSS":[68,96,134,233],"CRLM,":[69],"enabling":[70],"delivery":[71],"labelled":[73],"T-cells":[74,122,182,195],"through":[75],"physiological":[76],"vascular":[77],"routes":[78],"into":[79,133],"living,":[80],"tumour-bearing":[81],"livers.":[83],"Second,":[84],"dissect":[86],"microenvironment,":[89],"spatially":[91],"map":[92],"transcriptomes":[94],"adjacent":[99],"at":[101],"single-cell":[102],"resolution":[103],"across":[104,145,223],"~":[105],"1.9":[106],"million":[107],"cells,":[108],"perform":[110],"multiplexed":[111],"immunofluorescence":[112],"applying":[113],"a19-marker":[114],"panel":[115],"validation":[118],"cohort.":[119],"RESULTS:":[120],"Whilst":[121],"readily":[123],"extravasated":[124],"within":[125,168,196,210],"peri-tumoural":[127,158,187,224,244],"liver,":[128,153],"they":[129],"failed":[130],"extravasate":[132,184],"CRLM.":[135],"Spatial":[136],"analyses":[137],"revealed":[138],"progressive":[140],"shift":[141],"in":[142,151,185],"endothelial":[143,166,242],"phenotypes":[144,216],"regions:":[146],"from":[147],"non-inflamed":[149],"state":[150],"normal":[152],"highly":[156],"inflamed,":[157],"endothelium,":[159],"finally":[161],"an":[163,248],"anergic,":[164],"angiogenic":[165],"population":[167],"characterised":[170],"by":[171],"reduced":[172,206],"expression":[173,204],"adhesion":[175],"molecules":[176],"required":[177],"for":[178],"T-cell":[179,236,245,250],"extravasation.":[180],"CD4":[181,194,215],"that":[183],"are":[189,217],"TCR-reactive":[190],"exhausted,":[192],"whereas":[193],"show":[198],"stress":[199,251],"responses,":[200],"impaired":[201],"cytokine":[202],"gene":[203],"TCR":[207],"reactivity,":[208],"residing":[209],"hypoxic":[211],"niches.":[212],"These":[213],"divergent":[214],"associated":[218],"with":[219],"distinct":[220],"fibroblast-myeloid":[221],"niches":[222],"tumour":[226],"regions.":[227],"CONCLUSION:":[228],"Based":[229],"these":[231,260],"observations,":[232],"impair":[235],"extravasation":[237],"simultaneously":[239],"drive":[240],"intra-tumoural":[241,249],"anergy,":[243],"exhaustion":[246],"response.":[252],"Further":[253],"mechanistic":[254],"work":[255],"needed":[257],"validate":[259],"findings":[261],"guide":[263],"development":[265],"immunotherapeutics.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-07-21T00:00:00"}
