{"id":"https://openalex.org/W7169763534","doi":"https://doi.org/10.1371/journal.pcbi.1014879","title":"Evolutionary and dynamic constraints converge on a conserved coupling sector in thermally adapted GH1 \u03b2-glucosidases","display_name":"Evolutionary and dynamic constraints converge on a conserved coupling sector in thermally adapted GH1 \u03b2-glucosidases","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7169763534","doi":"https://doi.org/10.1371/journal.pcbi.1014879","pmid":"https://pubmed.ncbi.nlm.nih.gov/42945199","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13712516"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1014879","doi":"https://doi.org/10.1371/journal.pcbi.1014879","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1014879","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1014879&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1014879&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087189284","display_name":"Liu Zheng","orcid":"https://orcid.org/0000-0003-4344-3664","observed_orcids":["https://orcid.org/0000-0003-4344-3664","https://orcid.org/0009-0001-3867-5156","https://orcid.org/0009-0006-0633-1048","https://orcid.org/0009-0006-3630-0939"]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Ting Zheng","raw_affiliation_strings":["Dali University"],"raw_orcid":"https://orcid.org/0009-0001-3867-5156","affiliations":[{"raw_affiliation_string":"Dali University","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100421587","display_name":"Yi Li","orcid":"https://orcid.org/0000-0002-6407-3845","observed_orcids":["https://orcid.org/0000-0002-6407-3845"]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Li","raw_affiliation_strings":["Dali University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dali University","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159799923","display_name":"Xian He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xian He","raw_affiliation_strings":["Dali University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dali University","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081651779","display_name":"Lian-Tao Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lian-Tao Yang","raw_affiliation_strings":["Dali University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dali University","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110586588","display_name":"De-Rui Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"De-Rui Zhao","raw_affiliation_strings":["Dali University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dali University","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159914209","display_name":"Meng-Ting Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng-Ting Liu","raw_affiliation_strings":["Dali University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dali University","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088523149","display_name":"Peng Sang","orcid":"https://orcid.org/0000-0002-8556-2461","observed_orcids":["https://orcid.org/0000-0002-8556-2461"]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peng Sang","raw_affiliation_strings":["Dali University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dali University","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159940298","display_name":"Li-Quan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li-Quan Yang","raw_affiliation_strings":["Dali University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dali University","institution_ids":["https://openalex.org/I6593398"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088523149","https://openalex.org/A5159940298"],"corresponding_institution_ids":["https://openalex.org/I6593398"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43719029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"10","first_page":"e1014879","last_page":"e1014879"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gh1-beta-glucosidase","display_name":"GH1 \u03b2-glucosidase","score":0.949999988079071},{"id":"https://openalex.org/keywords/molecular-dynamics-trajectories","display_name":"molecular dynamics trajectories","score":0.6899999976158142},{"id":"https://openalex.org/keywords/protein-evolution","display_name":"protein evolution","score":0.5080000162124634},{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"protein dynamics","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.6636999845504761},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4729999899864197},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.45399999618530273},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.4016000032424927},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.400299996137619},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.39399999380111694},{"id":"https://openalex.org/C171578705","wikidata":"https://www.wikidata.org/wiki/Q5418700","display_name":"Evolutionary dynamics","level":3,"score":0.36980000138282776},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.353300005197525},{"id":"https://openalex.org/C71914180","wikidata":"https://www.wikidata.org/wiki/Q1071013","display_name":"Conserved quantity","level":2,"score":0.3476000130176544},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.34200000762939453},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.32280001044273376},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3208000063896179},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.310699999332428},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3095000088214874},{"id":"https://openalex.org/C159149176","wikidata":"https://www.wikidata.org/wiki/Q14489129","display_name":"Evolutionary algorithm","level":2,"score":0.3086000084877014},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C2777303404","wikidata":"https://www.wikidata.org/wiki/Q759757","display_name":"Convergence (economics)","level":2,"score":0.2985999882221222},{"id":"https://openalex.org/C13662910","wikidata":"https://www.wikidata.org/wiki/Q193139","display_name":"Trajectory","level":2,"score":0.2955000102519989},{"id":"https://openalex.org/C77405623","wikidata":"https://www.wikidata.org/wiki/Q598451","display_name":"System dynamics","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.25220000743865967},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2515999972820282}],"mesh":[{"descriptor_ui":"D001617","descriptor_name":"beta-Glucosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001617","descriptor_name":"beta-Glucosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001617","descriptor_name":"beta-Glucosidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044602","descriptor_name":"Cellulases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044602","descriptor_name":"Cellulases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1014879","doi":"https://doi.org/10.1371/journal.pcbi.1014879","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1014879","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1014879&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13712516","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13712516/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13712516/pdf/pcbi.1014879.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmid:42945199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42945199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ff4765fafa7d45fd8730db6e91469afb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ff4765fafa7d45fd8730db6e91469afb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 22, Iss 10, p e1014879 (2026)","raw_type":"article"},{"id":"doi:10.5281/zenodo.21441685","doi":"https://doi.org/10.5281/zenodo.21441685","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21441685","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.21441686","doi":"https://doi.org/10.5281/zenodo.21441686","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21441686","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1014879","doi":"https://doi.org/10.1371/journal.pcbi.1014879","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1014879","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1014879&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1979492684","display_name":null,"funder_award_id":"62366002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325826","display_name":"Dali University","ror":"https://ror.org/02y7rck89"},{"id":"https://openalex.org/F4320334984","display_name":"Applied Basic Research Key Project of Yunnan","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7169763534.pdf","grobid_xml":"https://content.openalex.org/works/W7169763534.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1105693001","https://openalex.org/W1975460133","https://openalex.org/W2001438084","https://openalex.org/W2008545402","https://openalex.org/W2026724593","https://openalex.org/W2029118067","https://openalex.org/W2036919909","https://openalex.org/W2038532826","https://openalex.org/W2048822589","https://openalex.org/W2049888624","https://openalex.org/W2057477511","https://openalex.org/W2067174909","https://openalex.org/W2069813219","https://openalex.org/W2081693079","https://openalex.org/W2085036090","https://openalex.org/W2089621788","https://openalex.org/W2103025737","https://openalex.org/W2105371577","https://openalex.org/W2109154308","https://openalex.org/W2112682805","https://openalex.org/W2114850508","https://openalex.org/W2123681603","https://openalex.org/W2128572087","https://openalex.org/W2145317354","https://openalex.org/W2147988069","https://openalex.org/W2158543301","https://openalex.org/W2168974130","https://openalex.org/W2565045120","https://openalex.org/W2783644078","https://openalex.org/W2785092601","https://openalex.org/W2804822363","https://openalex.org/W2911457160","https://openalex.org/W2987335406","https://openalex.org/W3046878556","https://openalex.org/W3119520097","https://openalex.org/W4220892969","https://openalex.org/W4282922306","https://openalex.org/W4297264228","https://openalex.org/W4390057190","https://openalex.org/W4390520644","https://openalex.org/W4406768511","https://openalex.org/W4413357186"],"related_works":["https://openalex.org/W7122653274","https://openalex.org/W2016097521","https://openalex.org/W3158834189","https://openalex.org/W7160964107","https://openalex.org/W7120627910","https://openalex.org/W2542913097","https://openalex.org/W2976723423","https://openalex.org/W2782811133","https://openalex.org/W6945069574","https://openalex.org/W6888792599"],"abstract_inverted_index":{"How":[0],"protein":[1,47],"sequences":[2],"evolve":[3],"to":[4,24],"maintain":[5],"functional":[6,333],"conformational":[7,205],"dynamics":[8,90,192],"under":[9,299],"thermal":[10,33,117,255,284],"stress":[11],"remains":[12],"an":[13,331],"important":[14],"question":[15],"in":[16,137,242,257,342],"molecular":[17,89],"evolution.":[18],"Thermophilic":[19],"enzymes":[20,121,269],"are":[21],"often":[22],"considered":[23],"achieve":[25],"stability":[26],"primarily":[27],"through":[28],"enhanced":[29],"structural":[30,83,155,233,266,318],"rigidity,":[31],"yet":[32],"adaptation":[34,256,285],"may":[35,275],"also":[36,240],"involve":[37],"the":[38,46,131,149,213,222,225,271,289,328,354],"preservation":[39],"or":[40,291],"reorganization":[41,292],"of":[42,72,101,279,293,356],"correlated":[43,280],"motions":[44],"across":[45,130,199],"scaffold.":[48],"Here,":[49],"we":[50,109],"compared":[51],"three":[52,85,120,223],"glycoside":[53],"hydrolase":[54],"family":[55],"1":[56,87],"\u03b2-glucosidases-BsBgl1A,":[57],"9UPT,":[58],"and":[59,76,95,105,126,139,157,193,211,234,307,353],"LQBG8-that":[60],"share":[61],"a":[62,168,194,231,294,339,346],"conserved":[63,273],"(\u03b2/\u03b1)8":[64],"TIM-barrel":[65],"fold":[66,274],"but":[67],"display":[68],"distinct":[69,111,277],"optimal":[70],"temperatures":[71],"approximately":[73],"45,":[74],"65,":[75],"70":[77],"\u00b0C,":[78],"respectively.":[79],"By":[80],"integrating":[81],"comparative":[82],"analysis,":[84,108],"independent":[86,332],"\u03bcs":[88],"simulations":[91],"at":[92,160,175,182,218],"300,":[93],"325,":[94],"350":[96,161,183,219],"K,":[97],"neural":[98],"relational":[99],"inference":[100],"residue-level":[102],"dynamic":[103,112,235,296,305,358],"coupling,":[104],"family-level":[106],"coevolutionary":[107,308],"identified":[110],"strategies":[113],"associated":[114,287],"with":[115,153,207,270,288,312],"their":[116,123],"phenotypes.":[118],"All":[119],"retained":[122,212],"global":[124],"compactness":[125],"principal":[127],"secondary-structure":[128],"framework":[129,341],"simulated":[132],"temperatures,":[133],"indicating":[134],"that":[135,245,254],"differences":[136],"RMSD":[138],"residue":[140,158,191],"flexibility":[141,206],"did":[142],"not":[143,261,323],"reflect":[144],"large-scale":[145],"unfolding.":[146],"BsBgl1A":[147],"showed":[148],"strongest":[150],"temperature":[151],"sensitivity,":[152],"increased":[154],"deviation":[156],"mobility":[159],"K.":[162,184,220],"Its":[163],"inferred":[164],"interaction":[165],"network":[166,216,329],"exhibited":[167],"non-monotonic":[169],"response,":[170],"characterized":[171],"by":[172,179,264],"pronounced":[173],"overcoupling":[174],"325":[176],"K":[177],"followed":[178],"reduced":[180],"connectivity":[181],"In":[185],"contrast,":[186],"9UPT":[187],"maintained":[188],"relatively":[189],"restrained":[190],"highly":[195],"reproducible":[196],"coupling":[197,210,297,306],"topology":[198],"temperatures.":[200],"LQBG8":[201],"combined":[202],"substantial":[203],"local":[204,349],"persistent":[208],"long-range":[209],"highest":[214],"directed":[215],"density":[217],"Across":[221],"enzymes,":[224],"\u03b2\u03b15-\u03b2\u03b17":[226],"region":[227],"repeatedly":[228],"emerged":[229],"as":[230,330],"shared":[232],"center.":[236],"Coevolutionary":[237],"couplings":[238],"were":[239],"enriched":[241],"TIM-barrel-associated":[243],"regions":[244],"spatially":[246],"converged":[247],"on":[248,316,327],"this":[249,317],"sector.":[250],"These":[251],"findings":[252],"indicate":[253],"GH1":[258],"\u03b2-glucosidases":[259],"is":[260,286,310],"adequately":[262],"explained":[263],"uniform":[265],"rigidification.":[267],"Instead,":[268],"same":[272],"adopt":[276],"organizations":[278],"motion,":[281],"while":[282],"greater":[283],"persistence":[290],"\u03b2\u03b15-\u03b2\u03b17-centered":[295],"pattern":[298],"elevated":[300],"temperature.":[301],"The":[302],"correspondence":[303],"between":[304],"enrichment":[309],"consistent":[311],"long-term":[313],"evolutionary":[314],"constraint":[315],"sector,":[319],"although":[320],"it":[321],"does":[322],"establish":[324],"direct":[325],"selection":[326],"unit.":[334],"Our":[335],"results":[336],"therefore":[337],"provide":[338],"testable":[340],"which":[343],"thermostability":[344],"reflects":[345],"balance":[347],"among":[348],"stabilization,":[350],"regional":[351],"flexibility,":[352],"resilience":[355],"higher-order":[357],"organization.":[359]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2026-07-21T00:00:00"}