{"id":"https://openalex.org/W7169759667","doi":"https://doi.org/10.1016/j.jdcr.2026.07.019","title":"Giant cutaneous squamous cell carcinoma in situ with progression to lymph node metastasis","display_name":"Giant cutaneous squamous cell carcinoma in situ with progression to lymph node metastasis","publication_year":2026,"publication_date":"2026-07-20","ids":{"openalex":"https://openalex.org/W7169759667","doi":"https://doi.org/10.1016/j.jdcr.2026.07.019","pmid":"https://pubmed.ncbi.nlm.nih.gov/42990711","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13735157"},"language":"en","primary_location":{"id":"doi:10.1016/j.jdcr.2026.07.019","doi":"https://doi.org/10.1016/j.jdcr.2026.07.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jdcr.2026.07.019","pdf_url":"https://www.jaadcasereports.org/article/S2352-5126(26)00439-X/pdf","source":{"id":"https://openalex.org/S2764486142","display_name":"JAAD Case Reports","issn_l":"2352-5126","issn":["2352-5126"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAAD Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jaadcasereports.org/article/S2352-5126(26)00439-X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5141180413","display_name":"Jennifer Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Rodriguez","raw_affiliation_strings":["Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141186369","display_name":"Sa Rang Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sa Rang Kim","raw_affiliation_strings":["Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011482853","display_name":"Jeff R. Gehlhausen","orcid":"https://orcid.org/0000-0002-7659-1105","observed_orcids":["https://orcid.org/0000-0002-7659-1105"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey R. Gehlhausen","raw_affiliation_strings":["Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070727750","display_name":"Sean R. Christensen","orcid":"https://orcid.org/0000-0003-2711-0026","observed_orcids":["https://orcid.org/0000-0003-2711-0026"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sean R. Christensen","raw_affiliation_strings":["Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":"https://orcid.org/0000-0003-2711-0026","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070727750"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":750,"currency":"USD","value_usd":750},"apc_paid":{"value":750,"currency":"USD","value_usd":750},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50420723,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":null,"first_page":"174","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11868","display_name":"Cancer and Skin Lesions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bowen-s-disease","display_name":"Bowen's disease","score":0.9039999842643738},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/progression-to-invasive-carcinoma","display_name":"progression to invasive carcinoma","score":0.7260000109672546},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.5540000200271606},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.917900025844574},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.5776000022888184},{"id":"https://openalex.org/C2992571226","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node metastasis","level":4,"score":0.53329998254776},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5264000296592712},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.49309998750686646},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.4268999993801117},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38960000872612},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.3749000132083893},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3686000108718872},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3483999967575073},{"id":"https://openalex.org/C3019926457","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Distant metastasis","level":4,"score":0.32010000944137573},{"id":"https://openalex.org/C2994460389","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Epidermoid carcinoma","level":3,"score":0.31790000200271606},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.289900004863739},{"id":"https://openalex.org/C2778804307","wikidata":"https://www.wikidata.org/wiki/Q809758","display_name":"Basal cell carcinoma","level":3,"score":0.2856999933719635},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.2854999899864197},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27320000529289246},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.2515999972820282}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jdcr.2026.07.019","doi":"https://doi.org/10.1016/j.jdcr.2026.07.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jdcr.2026.07.019","pdf_url":"https://www.jaadcasereports.org/article/S2352-5126(26)00439-X/pdf","source":{"id":"https://openalex.org/S2764486142","display_name":"JAAD Case Reports","issn_l":"2352-5126","issn":["2352-5126"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAAD Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13735157","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735157/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735157/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAAD Case Rep","raw_type":"Text"},{"id":"pmid:42990711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42990711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAAD case reports","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1016/j.jdcr.2026.07.019","doi":"https://doi.org/10.1016/j.jdcr.2026.07.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jdcr.2026.07.019","pdf_url":"https://www.jaadcasereports.org/article/S2352-5126(26)00439-X/pdf","source":{"id":"https://openalex.org/S2764486142","display_name":"JAAD Case Reports","issn_l":"2352-5126","issn":["2352-5126"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAAD Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7169759667.pdf","grobid_xml":"https://content.openalex.org/works/W7169759667.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1841145309","https://openalex.org/W1985727791","https://openalex.org/W2153074608","https://openalex.org/W2194096842","https://openalex.org/W2606620611","https://openalex.org/W2919910901","https://openalex.org/W2925126612","https://openalex.org/W2987672090","https://openalex.org/W2987703378","https://openalex.org/W4296518717"],"related_works":["https://openalex.org/W7167466559","https://openalex.org/W2404341199","https://openalex.org/W2728099946","https://openalex.org/W71125670","https://openalex.org/W7167915648","https://openalex.org/W3167560382","https://openalex.org/W2895604270","https://openalex.org/W2899221534","https://openalex.org/W1988843123","https://openalex.org/W1536051768"],"abstract_inverted_index":{"Cutaneous":[0],"squamous":[1],"cell":[2],"carcinoma":[3],"in":[4,52],"situ":[5],"(SCCIS),":[6],"defined":[7,41],"by":[8],"full-thickness":[9],"keratinocyte":[10],"atypia":[11],"confined":[12],"to":[13,27,46,49],"the":[14],"epidermis":[15],"without":[16],"dermal":[17],"invasion,":[18],"typically":[19],"exhibits":[20],"indolent":[21],"behavior":[22],"but":[23],"may":[24,44,63],"rarely":[25],"progress":[26],"invasive":[28],"carcinoma,":[29],"particularly":[30],"when":[31],"inadequately":[32],"treated":[33],"or":[34,69],"long-standing.1":[35],"Giant":[36],"SCCIS":[37,59],"is":[38],"a":[39],"loosely":[40],"term":[42],"that":[43],"refer":[45],"lesions":[47,57],"\u22655":[48],"10":[50],"cm":[51],"diameter.2,3":[53],"These":[54],"very":[55],"large":[56],"of":[58,67],"are":[60],"rare":[61],"and":[62],"exhibit":[64],"increased":[65],"rates":[66],"invasion":[68],"metastasis,":[70],"though":[71],"prognosis":[72],"remains":[73],"poorly":[74],"defined.":[75]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-07-21T00:00:00"}