{"id":"https://openalex.org/W7169727886","doi":"https://doi.org/10.38053/acmj.1873004","title":"Evaluation of etodolac and thiocolchicoside on cutaneous wound healing: an experimental rat study","display_name":"Evaluation of etodolac and thiocolchicoside on cutaneous wound healing: an experimental rat study","publication_year":2026,"publication_date":"2026-07-16","ids":{"openalex":"https://openalex.org/W7169727886","doi":"https://doi.org/10.38053/acmj.1873004"},"language":"en","primary_location":{"id":"doi:10.38053/acmj.1873004","doi":"https://doi.org/10.38053/acmj.1873004","is_oa":true,"landing_page_url":"https://doi.org/10.38053/acmj.1873004","pdf_url":null,"source":{"id":"https://openalex.org/S4210215369","display_name":"Anatolian Current Medical Journal","issn_l":"2718-0115","issn":["2718-0115"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anatolian Current Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.38053/acmj.1873004","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041883934","display_name":"Yunus Emre Bulum","orcid":"https://orcid.org/0000-0001-5568-8170","observed_orcids":["https://orcid.org/0000-0001-5568-8170"]},"institutions":[{"id":"https://openalex.org/I57913696","display_name":"Istanbul Medeniyet University","ror":"https://ror.org/05j1qpr59","country_code":"TR","type":"education","lineage":["https://openalex.org/I57913696"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Yunus Emre Bulum","raw_affiliation_strings":["\u0130STANBUL MEDEN\u0130YET \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130"],"raw_orcid":"https://orcid.org/0000-0001-5568-8170","affiliations":[{"raw_affiliation_string":"\u0130STANBUL MEDEN\u0130YET \u00dcN\u0130VERS\u0130TES\u0130, TIP FAK\u00dcLTES\u0130","institution_ids":["https://openalex.org/I57913696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050869136","display_name":"S\u00f6nmez Sa\u011flam","orcid":"https://orcid.org/0000-0003-2651-8003","observed_orcids":["https://orcid.org/0000-0003-2651-8003"]},"institutions":[{"id":"https://openalex.org/I54001450","display_name":"D\u00fczce \u00dcniversitesi","ror":"https://ror.org/04175wc52","country_code":"TR","type":"education","lineage":["https://openalex.org/I54001450"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"S\u00f6nmez Sa\u011flam","raw_affiliation_strings":["D\u00dcZCE \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0003-2651-8003","affiliations":[{"raw_affiliation_string":"D\u00dcZCE \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I54001450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074243987","display_name":"M\u00fccahid Osman Y\u00fccel","orcid":"https://orcid.org/0000-0002-9405-2367","observed_orcids":["https://orcid.org/0000-0002-9405-2367"]},"institutions":[{"id":"https://openalex.org/I54001450","display_name":"D\u00fczce \u00dcniversitesi","ror":"https://ror.org/04175wc52","country_code":"TR","type":"education","lineage":["https://openalex.org/I54001450"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"M\u00fccahid Osman Y\u00fccel","raw_affiliation_strings":["D\u00dcZCE \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0002-9405-2367","affiliations":[{"raw_affiliation_string":"D\u00dcZCE \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I54001450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094305123","display_name":"Ra\u015fit Emin Dalaslan","orcid":"https://orcid.org/0000-0001-5068-8024","observed_orcids":["https://orcid.org/0000-0001-5068-8024"]},"institutions":[{"id":"https://openalex.org/I54001450","display_name":"D\u00fczce \u00dcniversitesi","ror":"https://ror.org/04175wc52","country_code":"TR","type":"education","lineage":["https://openalex.org/I54001450"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ra\u015fit Emin Dalaslan","raw_affiliation_strings":["D\u00dcZCE \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0001-5068-8024","affiliations":[{"raw_affiliation_string":"D\u00dcZCE \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I54001450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024095564","display_name":"Mehmet Ar\u0131can","orcid":"https://orcid.org/0000-0002-0649-2339","observed_orcids":["https://orcid.org/0000-0002-0649-2339"]},"institutions":[{"id":"https://openalex.org/I54001450","display_name":"D\u00fczce \u00dcniversitesi","ror":"https://ror.org/04175wc52","country_code":"TR","type":"education","lineage":["https://openalex.org/I54001450"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Ar\u0131can","raw_affiliation_strings":["D\u00dcZCE \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0002-0649-2339","affiliations":[{"raw_affiliation_string":"D\u00dcZCE \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I54001450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029667927","display_name":"Zekeriya Okan Karaduman","orcid":"https://orcid.org/0000-0002-6719-3666","observed_orcids":["https://orcid.org/0000-0002-6719-3666"]},"institutions":[{"id":"https://openalex.org/I54001450","display_name":"D\u00fczce \u00dcniversitesi","ror":"https://ror.org/04175wc52","country_code":"TR","type":"education","lineage":["https://openalex.org/I54001450"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zekeriya Okan Karaduman","raw_affiliation_strings":["D\u00dcZCE \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0002-6719-3666","affiliations":[{"raw_affiliation_string":"D\u00dcZCE \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I54001450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090979914","display_name":"Ay\u015fe Nur Toks\u00f6z Y\u0131ld\u0131r\u0131m","orcid":"https://orcid.org/0000-0003-1708-0003","observed_orcids":["https://orcid.org/0000-0003-1708-0003"]},"institutions":[{"id":"https://openalex.org/I57913696","display_name":"Istanbul Medeniyet University","ror":"https://ror.org/05j1qpr59","country_code":"TR","type":"education","lineage":["https://openalex.org/I57913696"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ay\u015fe Nur Toks\u00f6z Y\u0131ld\u0131r\u0131m","raw_affiliation_strings":["\u0130STANBUL MEDEN\u0130YET \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0003-1708-0003","affiliations":[{"raw_affiliation_string":"\u0130STANBUL MEDEN\u0130YET \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I57913696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041883934"],"corresponding_institution_ids":["https://openalex.org/I57913696"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"4","first_page":"631","last_page":"637"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etodolac","display_name":"etodolac","score":1.0},{"id":"https://openalex.org/keywords/thiocolchicoside","display_name":"thiocolchicoside","score":1.0},{"id":"https://openalex.org/keywords/cutaneous-wound-healing","display_name":"skin wound healing","score":0.9810000061988831},{"id":"https://openalex.org/keywords/full-thickness-excisional-wounds","display_name":"full-thickness excisional wounds","score":0.9269999861717224},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.6620000004768372},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6190000176429749},{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9369999766349792},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8884999752044678},{"id":"https://openalex.org/C2777807940","wikidata":"https://www.wikidata.org/wiki/Q2465218","display_name":"Etodolac","level":2,"score":0.784600019454956},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7208999991416931},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.6438999772071838},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5271000266075134},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4291999936103821},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3684999942779541},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3199000060558319},{"id":"https://openalex.org/C3019114686","wikidata":"https://www.wikidata.org/wiki/Q3089676","display_name":"Rat model","level":2,"score":0.31459999084472656},{"id":"https://openalex.org/C2992926266","wikidata":"https://www.wikidata.org/wiki/Q609370","display_name":"Adult male","level":2,"score":0.2802000045776367},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2572000026702881}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.38053/acmj.1873004","doi":"https://doi.org/10.38053/acmj.1873004","is_oa":true,"landing_page_url":"https://doi.org/10.38053/acmj.1873004","pdf_url":null,"source":{"id":"https://openalex.org/S4210215369","display_name":"Anatolian Current Medical Journal","issn_l":"2718-0115","issn":["2718-0115"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anatolian Current Medical Journal","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/1873004","doi":null,"is_oa":true,"landing_page_url":"https://izlik.org/JA26FN69FH","pdf_url":"https://dergipark.org.tr/en/download/article-file/5647549","source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Anatolian Current Medical Journal, Vol. 8 No. 4","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.38053/acmj.1873004","doi":"https://doi.org/10.38053/acmj.1873004","is_oa":true,"landing_page_url":"https://doi.org/10.38053/acmj.1873004","pdf_url":null,"source":{"id":"https://openalex.org/S4210215369","display_name":"Anatolian Current Medical Journal","issn_l":"2718-0115","issn":["2718-0115"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anatolian Current Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7169727886.pdf","grobid_xml":"https://content.openalex.org/works/W7169727886.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1509156154","https://openalex.org/W1968922109","https://openalex.org/W2092260863","https://openalex.org/W2112323960","https://openalex.org/W2127903487","https://openalex.org/W2353982544","https://openalex.org/W2889037211","https://openalex.org/W2893949635","https://openalex.org/W3000636545","https://openalex.org/W3013379147","https://openalex.org/W3041720930","https://openalex.org/W3047104964","https://openalex.org/W4281816153","https://openalex.org/W4290467451","https://openalex.org/W4301398373","https://openalex.org/W4310718213","https://openalex.org/W4390548083","https://openalex.org/W4400726400","https://openalex.org/W4401360459","https://openalex.org/W4403605629","https://openalex.org/W4404188989","https://openalex.org/W4404792624","https://openalex.org/W4408613256","https://openalex.org/W4411153880","https://openalex.org/W4413259839","https://openalex.org/W4414809878","https://openalex.org/W4416093225","https://openalex.org/W4416231057","https://openalex.org/W4416596674"],"related_works":["https://openalex.org/W4411510774","https://openalex.org/W3191968960","https://openalex.org/W2968703686","https://openalex.org/W7147068236","https://openalex.org/W2103686928","https://openalex.org/W4402027205","https://openalex.org/W2189151509","https://openalex.org/W4365134840","https://openalex.org/W3012720606","https://openalex.org/W2279676662"],"abstract_inverted_index":{"Aims:":[0],"This":[1,35],"experimental":[2,37],"study":[3,38],"aimed":[4],"to":[5],"evaluate":[6],"the":[7],"effects":[8],"of":[9,103],"etodolac":[10],"and":[11,32,65,96,100,105,133,141],"thiocolchicoside,":[12,62],"administered":[13,80],"alone":[14],"or":[15],"in":[16,22,47,123],"combination,":[17],"on":[18,89,109,129,137],"cutaneous":[19],"wound":[20,27,45,72,113,124],"healing":[21],"a":[23,42],"rat":[24],"full-thickness":[25,43],"excisional":[26,44],"model":[28,46],"using":[29,41],"macroscopic,":[30],"histopathological,":[31],"immunohistochemical":[33,101],"parameters.Methods:":[34],"controlled":[36],"was":[39,73],"conducted":[40],"24":[48],"male":[49],"Wistar":[50],"albino":[51],"rats.":[52],"Animals":[53],"were":[54,79,87,107,115,127],"randomized":[55],"into":[56],"four":[57],"groups":[58,118],"(n=6":[59],"each):":[60],"etodolac,":[61],"combination":[63],"(etodolac+thiocolchicoside),":[64],"control.":[66],"A":[67],"standardized":[68],"2-cm":[69],"dorsal":[70],"skin":[71],"created":[74],"under":[75],"general":[76],"anesthesia.":[77],"Treatments":[78],"orally":[81],"for":[82],"14":[83,142],"days.":[84],"Wound":[85],"areas":[86,114],"measured":[88],"postoperative":[90],"days":[91,138],"0,":[92],"3,":[93],"7,":[94,139],"10,":[95,140],"14.":[97],"Histopathological":[98],"evaluation":[99],"analysis":[102],"CD31":[104],"TGF-\u03b21":[106],"performed":[108],"day":[110,130],"14.Results:":[111],"Baseline":[112],"comparable":[116],"among":[117],"(p=0.912).":[119],"Significant":[120],"intergroup":[121],"differences":[122],"area":[125],"reduction":[126],"observed":[128],"3":[131],"(p=0.041)":[132],"became":[134],"more":[135],"pronounced":[136],"(all":[143],"p":[144]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-07-20T00:00:00"}