{"id":"https://openalex.org/W7169727458","doi":"https://doi.org/10.22299/apst.2026.280999","title":"Injectability and mechanical properties of borneol-based solvent removal-induced in situ matrix for periodontal pocket delivery","display_name":"Injectability and mechanical properties of borneol-based solvent removal-induced in situ matrix for periodontal pocket delivery","publication_year":2026,"publication_date":"2026-07-15","ids":{"openalex":"https://openalex.org/W7169727458","doi":"https://doi.org/10.22299/apst.2026.280999"},"language":"en","primary_location":{"id":"doi:10.22299/apst.2026.280999","doi":"https://doi.org/10.22299/apst.2026.280999","is_oa":true,"landing_page_url":"https://doi.org/10.22299/apst.2026.280999","pdf_url":"https://so01.tci-thaijo.org/index.php/APST/article/download/280999/183655","source":{"id":"https://openalex.org/S2764789172","display_name":"Asia-Pacific Journal of Science and Technology","issn_l":"2539-6293","issn":["2539-6293"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319384","host_organization_name":"Khon Kaen University","host_organization_lineage":["https://openalex.org/P4310319384"],"host_organization_lineage_names":["Khon Kaen University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asia-Pacific Journal of Science and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://so01.tci-thaijo.org/index.php/APST/article/download/280999/183655","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016333482","display_name":"Nutdanai Lertsuphotvanit","orcid":"https://orcid.org/0000-0002-1475-4482","observed_orcids":["https://orcid.org/0000-0002-1475-4482"]},"institutions":[{"id":"https://openalex.org/I129488602","display_name":"Burapha University","ror":"https://ror.org/01ff74m36","country_code":"TH","type":"education","lineage":["https://openalex.org/I129488602"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Nutdanai Lertsuphotvanit","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20131, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20131, Thailand","institution_ids":["https://openalex.org/I129488602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045693825","display_name":"Siraprapa Chansatidkosol","orcid":"https://orcid.org/0009-0008-9465-5716","observed_orcids":["https://orcid.org/0009-0008-9465-5716"]},"institutions":[{"id":"https://openalex.org/I129488602","display_name":"Burapha University","ror":"https://ror.org/01ff74m36","country_code":"TH","type":"education","lineage":["https://openalex.org/I129488602"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Siraprapa Chansatidkosol","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20131, Thailand"],"raw_orcid":"https://orcid.org/0009-0008-9465-5716","affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20131, Thailand","institution_ids":["https://openalex.org/I129488602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029694542","display_name":"Tiraniti Chuenbarn","orcid":"https://orcid.org/0000-0003-4181-4433","observed_orcids":["https://orcid.org/0000-0003-4181-4433"]},"institutions":[{"id":"https://openalex.org/I129488602","display_name":"Burapha University","ror":"https://ror.org/01ff74m36","country_code":"TH","type":"education","lineage":["https://openalex.org/I129488602"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Tiraniti Chuenbarn","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20131, Thailand"],"raw_orcid":"https://orcid.org/0000-0003-4181-4433","affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20131, Thailand","institution_ids":["https://openalex.org/I129488602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070001793","display_name":"Thawatchai Phaechamud","orcid":"https://orcid.org/0000-0003-2270-5303","observed_orcids":["https://orcid.org/0000-0003-2270-5303","https://orcid.org/0000-0002-8851-8386"]},"institutions":[{"id":"https://openalex.org/I86677382","display_name":"Silpakorn University","ror":"https://ror.org/02d0tyt78","country_code":"TH","type":"education","lineage":["https://openalex.org/I86677382"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Thawatchai Phaechamud","raw_affiliation_strings":["Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-8851-8386","affiliations":[{"raw_affiliation_string":"Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand","institution_ids":["https://openalex.org/I86677382"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"04","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.05700000002980232,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/borneol","display_name":"borneol","score":0.9869999885559082},{"id":"https://openalex.org/keywords/injectable-drug-delivery","display_name":"injectable drug delivery","score":0.718999981880188},{"id":"https://openalex.org/keywords/periodontal-pockets","display_name":"periodontal pockets","score":0.9470000267028809},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/injectability","display_name":"injectability","score":0.9160000085830688},{"id":"https://openalex.org/keywords/mechanical-properties","display_name":"mechanical properties","score":0.9490000009536743},{"id":"https://openalex.org/keywords/plastic-deformation","display_name":"plastic deformation","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2777964474","wikidata":"https://www.wikidata.org/wiki/Q412435","display_name":"Borneol","level":4,"score":0.8931999802589417},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.6226999759674072},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5651000142097473},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5123999714851379},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.4934999942779541},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.48100000619888306},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4383000135421753},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.39899998903274536},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3792000114917755},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.3682999908924103},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.34279999136924744},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.33480000495910645},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3197000026702881},{"id":"https://openalex.org/C202271784","wikidata":"https://www.wikidata.org/wiki/Q189218","display_name":"Molar","level":2,"score":0.313400000333786},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.31060001254081726},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2897000014781952},{"id":"https://openalex.org/C58747440","wikidata":"https://www.wikidata.org/wiki/Q1059860","display_name":"Gingival and periodontal pocket","level":3,"score":0.2736000120639801},{"id":"https://openalex.org/C2992452445","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontal disease","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.2630999982357025},{"id":"https://openalex.org/C2777239854","wikidata":"https://www.wikidata.org/wiki/Q902638","display_name":"Excipient","level":2,"score":0.262800008058548},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.26080000400543213},{"id":"https://openalex.org/C2985973956","wikidata":"https://www.wikidata.org/wiki/Q1617745","display_name":"High energy","level":2,"score":0.25200000405311584}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.22299/apst.2026.280999","doi":"https://doi.org/10.22299/apst.2026.280999","is_oa":true,"landing_page_url":"https://doi.org/10.22299/apst.2026.280999","pdf_url":"https://so01.tci-thaijo.org/index.php/APST/article/download/280999/183655","source":{"id":"https://openalex.org/S2764789172","display_name":"Asia-Pacific Journal of Science and Technology","issn_l":"2539-6293","issn":["2539-6293"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319384","host_organization_name":"Khon Kaen University","host_organization_lineage":["https://openalex.org/P4310319384"],"host_organization_lineage_names":["Khon Kaen University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asia-Pacific Journal of Science and Technology","raw_type":"journal-article"},{"id":"pmh:oai:so01.tci-thaijo.org:article/280999","doi":null,"is_oa":true,"landing_page_url":"https://so01.tci-thaijo.org/index.php/APST/article/view/280999","pdf_url":null,"source":{"id":"https://openalex.org/S2764789172","display_name":"Asia-Pacific Journal of Science and Technology","issn_l":"2539-6293","issn":["2539-6293"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319384","host_organization_name":"Khon Kaen University","host_organization_lineage":["https://openalex.org/P4310319384"],"host_organization_lineage_names":["Khon Kaen University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2539-6293","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.22299/apst.2026.280999","doi":"https://doi.org/10.22299/apst.2026.280999","is_oa":true,"landing_page_url":"https://doi.org/10.22299/apst.2026.280999","pdf_url":"https://so01.tci-thaijo.org/index.php/APST/article/download/280999/183655","source":{"id":"https://openalex.org/S2764789172","display_name":"Asia-Pacific Journal of Science and Technology","issn_l":"2539-6293","issn":["2539-6293"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319384","host_organization_name":"Khon Kaen University","host_organization_lineage":["https://openalex.org/P4310319384"],"host_organization_lineage_names":["Khon Kaen University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asia-Pacific Journal of Science and Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322683","display_name":"Burapha University","ror":"https://ror.org/01ff74m36"},{"id":"https://openalex.org/F4320323871","display_name":"Silpakorn University","ror":"https://ror.org/02d0tyt78"},{"id":"https://openalex.org/F4320334344","display_name":"Faculty of Pharmaceutical Sciences, Burapha University","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7169727458.pdf","grobid_xml":"https://content.openalex.org/works/W7169727458.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4213080462","https://openalex.org/W7169594006","https://openalex.org/W4381140700","https://openalex.org/W4415495337","https://openalex.org/W3047524165","https://openalex.org/W4363676834","https://openalex.org/W3153721390","https://openalex.org/W4410960082","https://openalex.org/W3007560083","https://openalex.org/W3042211649"],"abstract_inverted_index":{"Solvent":[0],"removal-induced":[1],"in":[2,47],"situ":[3],"matrices":[4],"(ISMs)":[5],"have":[6],"garnered":[7],"attention":[8],"for":[9,101],"periodontitis":[10],"treatment":[11],"because":[12],"of":[13,40,66,126],"their":[14],"capability":[15],"to":[16,56,153],"localize":[17],"antibiotic":[18],"drug":[19,121],"release":[20],"within":[21],"the":[22,97,154],"periodontal":[23,155],"pocket":[24,156],"over":[25],"an":[26],"extended":[27],"duration,":[28],"effectively":[29],"targeting":[30],"and":[31,63,68,83,90,117,132],"eliminating":[32],"infecting":[33],"microbes.":[34],"In":[35],"this":[36],"study,":[37],"various":[38],"concentrations":[39,89],"borneol\u201410%\u201370%\u2014were":[41],"used":[42],"as":[43,119],"a":[44,50,76,135],"matrix":[45,139],"agent":[46],"ISMs,":[48],"with":[49,75,87,93],"40%":[51],"w/w":[52],"borneol-based":[53],"ISM":[54],"selected":[55],"load":[57],"1%":[58],"vancomycin":[59,69,94],"HCl.":[60,95],"The":[61],"injectability":[62],"mechanical":[64],"properties":[65],"drug-free":[67],"HCl-loaded":[70],"borneol":[71,88,138],"ISMs":[72,103],"were":[73,114],"evaluated":[74],"texture":[77],"analyzer.":[78],"Both":[79],"maximum":[80],"injection":[81,98],"force":[82],"energy":[84,99],"increased":[85],"proportionally":[86],"slightly":[91],"further":[92],"Nevertheless,":[96],"required":[100],"borneol-loaded":[102],"at":[104],"10%\u201350%":[105],"was":[106,140],"low,":[107],"from":[108],"12.22\u201325.00":[109],"mJ.":[110],"Consequently,":[111],"these":[112],"formulations":[113],"considered":[115],"appropriate":[116],"feasible":[118],"injectable":[120],"delivery":[122],"systems,":[123],"providing":[124],"ease":[125],"administration":[127],"while":[128],"promoting":[129],"patient":[130],"comfort":[131],"compliance.":[133],"Additionally,":[134],"more":[136],"compact":[137],"formed":[141],"after":[142],"complete":[143],"solvent":[144],"removal;":[145],"it":[146],"exhibited":[147],"plastic":[148],"deformation,":[149],"enabling":[150],"close":[151],"adaptation":[152],"geometry.":[157]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2026-07-20T00:00:00"}