{"id":"https://openalex.org/W7169727096","doi":"https://doi.org/10.3390/foods15142539","title":"From Biofortification to HT-29 Growth Inhibition: Selenium-Enriched Sunflower Sprouts Modulate Apoptosis- and Cell Cycle-Related Markers","display_name":"From Biofortification to HT-29 Growth Inhibition: Selenium-Enriched Sunflower Sprouts Modulate Apoptosis- and Cell Cycle-Related Markers","publication_year":2026,"publication_date":"2026-07-17","ids":{"openalex":"https://openalex.org/W7169727096","doi":"https://doi.org/10.3390/foods15142539","pmid":"https://pubmed.ncbi.nlm.nih.gov/42511285","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13408742"},"language":"en","primary_location":{"id":"doi:10.3390/foods15142539","doi":"https://doi.org/10.3390/foods15142539","is_oa":true,"landing_page_url":"https://doi.org/10.3390/foods15142539","pdf_url":null,"source":{"id":"https://openalex.org/S2737939966","display_name":"Foods","issn_l":"2304-8158","issn":["2304-8158"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foods","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/foods15142539","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086246834","display_name":"Piyanete Chantiratikul","orcid":"https://orcid.org/0000-0003-4033-8703","observed_orcids":["https://orcid.org/0000-0003-4033-8703"]},"institutions":[{"id":"https://openalex.org/I123096312","display_name":"Mahasarakham University","ror":"https://ror.org/0453j3c58","country_code":"TH","type":"education","lineage":["https://openalex.org/I123096312"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Piyanete Chantiratikul","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand"],"raw_orcid":"https://orcid.org/0000-0003-4033-8703","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand","institution_ids":["https://openalex.org/I123096312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074570510","display_name":"Anut Chantiratikul","orcid":"https://orcid.org/0000-0002-8313-5802","observed_orcids":["https://orcid.org/0000-0002-8313-5802"]},"institutions":[{"id":"https://openalex.org/I123096312","display_name":"Mahasarakham University","ror":"https://ror.org/0453j3c58","country_code":"TH","type":"education","lineage":["https://openalex.org/I123096312"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Anut Chantiratikul","raw_affiliation_strings":["Department of Agricultural Technology, Faculty of Technology, Mahasarakham University, Kantharawichai District, Maha Sarakham 44150, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-8313-5802","affiliations":[{"raw_affiliation_string":"Department of Agricultural Technology, Faculty of Technology, Mahasarakham University, Kantharawichai District, Maha Sarakham 44150, Thailand","institution_ids":["https://openalex.org/I123096312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141152755","display_name":"Yada Laotongsan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123096312","display_name":"Mahasarakham University","ror":"https://ror.org/0453j3c58","country_code":"TH","type":"education","lineage":["https://openalex.org/I123096312"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Yada Laotongsan","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand","institution_ids":["https://openalex.org/I123096312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141153311","display_name":"Gondanai Lasungneon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123096312","display_name":"Mahasarakham University","ror":"https://ror.org/0453j3c58","country_code":"TH","type":"education","lineage":["https://openalex.org/I123096312"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Gondanai Lasungneon","raw_affiliation_strings":["Natural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand","institution_ids":["https://openalex.org/I123096312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027162534","display_name":"Worachot Saengha","orcid":"https://orcid.org/0000-0002-5975-0864","observed_orcids":["https://orcid.org/0000-0002-5975-0864"]},"institutions":[{"id":"https://openalex.org/I123096312","display_name":"Mahasarakham University","ror":"https://ror.org/0453j3c58","country_code":"TH","type":"education","lineage":["https://openalex.org/I123096312"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Worachot Saengha","raw_affiliation_strings":["Natural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand","institution_ids":["https://openalex.org/I123096312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070287749","display_name":"Thipphiya Karirat","orcid":"https://orcid.org/0000-0002-9715-027X","observed_orcids":["https://orcid.org/0000-0002-9715-027X"]},"institutions":[{"id":"https://openalex.org/I123096312","display_name":"Mahasarakham University","ror":"https://ror.org/0453j3c58","country_code":"TH","type":"education","lineage":["https://openalex.org/I123096312"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Thipphiya Karirat","raw_affiliation_strings":["Natural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand","institution_ids":["https://openalex.org/I123096312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116500794","display_name":"Piyathida Promjamorn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123096312","display_name":"Mahasarakham University","ror":"https://ror.org/0453j3c58","country_code":"TH","type":"education","lineage":["https://openalex.org/I123096312"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Piyathida Promjamorn","raw_affiliation_strings":["Natural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand","institution_ids":["https://openalex.org/I123096312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020542437","display_name":"Nyuk Ling","orcid":"https://orcid.org/0000-0002-1301-4730","observed_orcids":["https://orcid.org/0000-0002-1301-4730"]},"institutions":[{"id":"https://openalex.org/I157696592","display_name":"Universiti Malaysia Terengganu","ror":"https://ror.org/02474f074","country_code":"MY","type":"education","lineage":["https://openalex.org/I157696592"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Nyuk Ling Ma","raw_affiliation_strings":["BIOSES Research Interest Group, Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, Kuala Nerus 21030, Terengganu, Malaysia"],"raw_orcid":"https://orcid.org/0000-0002-1301-4730","affiliations":[{"raw_affiliation_string":"BIOSES Research Interest Group, Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, Kuala Nerus 21030, Terengganu, Malaysia","institution_ids":["https://openalex.org/I157696592"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071548667","display_name":"Vijitra Luang\u2010In","orcid":"https://orcid.org/0000-0002-5009-5058","observed_orcids":["https://orcid.org/0000-0002-5009-5058"]},"institutions":[{"id":"https://openalex.org/I123096312","display_name":"Mahasarakham University","ror":"https://ror.org/0453j3c58","country_code":"TH","type":"education","lineage":["https://openalex.org/I123096312"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Vijitra Luang-In","raw_affiliation_strings":["Natural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-5009-5058","affiliations":[{"raw_affiliation_string":"Natural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai District, Maha Sarakham 44150, Thailand","institution_ids":["https://openalex.org/I123096312"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071548667"],"corresponding_institution_ids":["https://openalex.org/I123096312"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":3.3014,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.84333905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"15","issue":"14","first_page":"2539","last_page":"2539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selenium-biofortification","display_name":"selenium biofortification","score":0.9580000042915344},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/colorectal-adenocarcinoma","display_name":"colorectal adenocarcinoma","score":0.9390000104904175},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.765999972820282},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.921999990940094},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.5569999814033508},{"id":"https://openalex.org/keywords/purine-metabolites","display_name":"purine metabolites","score":0.7310000061988831},{"id":"https://openalex.org/keywords/lysophosphatidylcholine","display_name":"lysophosphatidylcholine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/quinic-acid-derivatives","display_name":"quinic acid derivatives","score":0.8700000047683716},{"id":"https://openalex.org/keywords/functional-food-ingredients","display_name":"functional food ingredients","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2779197568","wikidata":"https://www.wikidata.org/wiki/Q423986","display_name":"Sunflower","level":2,"score":0.5965999960899353},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.5746999979019165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5705000162124634},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.525600016117096},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.42910000681877136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.428600013256073},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.3707999885082245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3596999943256378},{"id":"https://openalex.org/C2776576667","wikidata":"https://www.wikidata.org/wiki/Q864310","display_name":"Biofortification","level":3,"score":0.35830000042915344},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.35109999775886536},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3398999869823456},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3303000032901764},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3228999972343445},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.3127000033855438},{"id":"https://openalex.org/C553756173","wikidata":"https://www.wikidata.org/wiki/Q876","display_name":"Selenium","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2928999960422516},{"id":"https://openalex.org/C2780132029","wikidata":"https://www.wikidata.org/wiki/Q752276","display_name":"Functional food","level":2,"score":0.2831999957561493},{"id":"https://openalex.org/C207778908","wikidata":"https://www.wikidata.org/wiki/Q190022","display_name":"Auxin","level":3,"score":0.27320000529289246},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.27250000834465027},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.266400009393692},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2660999894142151},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2624000012874603},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2623000144958496},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2574000060558319},{"id":"https://openalex.org/C2776971262","wikidata":"https://www.wikidata.org/wiki/Q5597007","display_name":"Grape seed extract","level":3,"score":0.25360000133514404}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/foods15142539","doi":"https://doi.org/10.3390/foods15142539","is_oa":true,"landing_page_url":"https://doi.org/10.3390/foods15142539","pdf_url":null,"source":{"id":"https://openalex.org/S2737939966","display_name":"Foods","issn_l":"2304-8158","issn":["2304-8158"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foods","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13408742","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13408742/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13408742/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foods","raw_type":"Text"},{"id":"pmid:42511285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42511285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foods (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:301a8ea26d004d53bc42e962a5bd38ed","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/301a8ea26d004d53bc42e962a5bd38ed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Foods, Vol 15, Iss 14, p 2539 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/foods15142539","doi":"https://doi.org/10.3390/foods15142539","is_oa":true,"landing_page_url":"https://doi.org/10.3390/foods15142539","pdf_url":null,"source":{"id":"https://openalex.org/S2737939966","display_name":"Foods","issn_l":"2304-8158","issn":["2304-8158"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foods","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.9208999872207642,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324290","display_name":"Mahasarakham University","ror":"https://ror.org/0453j3c58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7169727096.pdf","grobid_xml":"https://content.openalex.org/works/W7169727096.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W2083727483","https://openalex.org/W2541737002","https://openalex.org/W2623405658","https://openalex.org/W2740507770","https://openalex.org/W2976380466","https://openalex.org/W3003385877","https://openalex.org/W3003697872","https://openalex.org/W3013475891","https://openalex.org/W3047445240","https://openalex.org/W3047899669","https://openalex.org/W3091697385","https://openalex.org/W3120085192","https://openalex.org/W3127206605","https://openalex.org/W3164225852","https://openalex.org/W3192019106","https://openalex.org/W3208936304","https://openalex.org/W4200400468","https://openalex.org/W4205828286","https://openalex.org/W4210476086","https://openalex.org/W4214726605","https://openalex.org/W4224256726","https://openalex.org/W4287831692","https://openalex.org/W4292181728","https://openalex.org/W4292714984","https://openalex.org/W4293771231","https://openalex.org/W4297994924","https://openalex.org/W4308382417","https://openalex.org/W4309692619","https://openalex.org/W4319297976","https://openalex.org/W4321599892","https://openalex.org/W4382795604","https://openalex.org/W4384008014","https://openalex.org/W4385621478","https://openalex.org/W4387140482","https://openalex.org/W4387331488","https://openalex.org/W4389936034","https://openalex.org/W4389941394","https://openalex.org/W4392125812","https://openalex.org/W4399364538","https://openalex.org/W4400772799","https://openalex.org/W4400792447","https://openalex.org/W4402715547","https://openalex.org/W4406016323","https://openalex.org/W4407167908","https://openalex.org/W4407322422","https://openalex.org/W4407945078"],"related_works":["https://openalex.org/W2999573396","https://openalex.org/W2022298189","https://openalex.org/W2905086446","https://openalex.org/W1753703163","https://openalex.org/W1983241176","https://openalex.org/W2103880066","https://openalex.org/W2592869246","https://openalex.org/W7161967929","https://openalex.org/W4224314710","https://openalex.org/W2035698941"],"abstract_inverted_index":{"Selenium":[0],"biofortification":[1],"of":[2,16,24,116,196,220],"edible":[3],"sprouts":[4,137,223],"is":[5],"a":[6,225],"promising":[7],"strategy":[8],"to":[9,93,106],"enhance":[10],"the":[11,22,86,133,191],"cancer":[12],"cell":[13,60,162,208],"growth-inhibitory":[14],"potential":[15],"plant-based":[17],"foods.":[18],"This":[19],"study":[20],"investigated":[21],"effects":[23],"selenium":[25],"(Se)-enriched":[26],"sunflower":[27,197,222],"sprout":[28,198],"extracts":[29],"on":[30],"human":[31],"colorectal":[32],"adenocarcinoma":[33],"HT-29":[34,201],"cells":[35,202],"in":[36,169,179,192,200,217],"comparison":[37],"with":[38,158],"non-enriched":[39],"sprouts.":[40],"Cytotoxicity":[41],"was":[42],"evaluated":[43],"by":[44,49,55,64,69],"MTT":[45],"assay,":[46,52,57],"clonogenic":[47],"survival":[48],"colony":[50,117],"formation":[51,118],"wound":[53,125],"closure":[54,126],"wound-healing":[56],"apoptosis-":[58,206],"and":[59,66,98,124,141,148,150,153,161,175,184,203,207,216],"cycle-related":[61,209],"gene":[62],"expression":[63,68],"qRT-PCR,":[65],"protein":[67,155],"Western":[70],"blotting.":[71],"Metabolite":[72],"profiles":[73],"were":[74],"characterized":[75],"using":[76],"LC-MS/MS-based":[77],"untargeted":[78],"metabolomics.":[79],"Se":[80,188],"enrichment":[81,189],"markedly":[82],"enhanced":[83,190],"cytotoxicity,":[84],"reducing":[85],"IC50":[87],"from":[88,101],"413.80":[89],"\u00b1":[90,95,103,108,121,129],"6.00":[91,96],"(control)":[92,105],"152.90":[94],"\u00b5g/mL":[97],"increasing":[99],"Emax":[100],"59.29":[102],"0.11%":[104],"75.70":[107],"0.49%.":[109],"The":[110],"Se-enriched":[111,136,221],"extract":[112,199],"showed":[113],"greater":[114],"inhibition":[115],"(IC50":[119,127],"53.72":[120],"1.12":[122],"\u00b5g/mL)":[123],"76.07":[128],"0.06":[130],"\u00b5g/mL).":[131],"At":[132],"molecular":[134],"level,":[135],"upregulated":[138],"Bax,":[139],"caspase-3":[140],"p21,":[142],"downregulated":[143],"Bcl-2,":[144],"CDK4,":[145],"NF-\u03baB":[146],"p65":[147],"MMP-9,":[149],"increased":[151],"Bax":[152],"p21":[154],"levels,":[156],"linked":[157],"apoptosis-related":[159],"signaling":[160],"cycle":[163],"modulation.":[164],"Metabolomics":[165],"revealed":[166],"significant":[167],"increases":[168],"purine-related":[170],"metabolites,":[171],"lysophosphatidylcholine":[172],"(LPC)":[173],"18:3,":[174],"choline,":[176],"alongside":[177],"decreases":[178],"several":[180],"quinic":[181],"acid":[182],"derivatives":[183],"related":[185],"phenolic":[186],"metabolites.":[187],"vitro":[193],"antiproliferative":[194],"activity":[195],"may":[204],"modulate":[205],"markers.":[210],"These":[211],"findings":[212],"support":[213],"further":[214],"mechanistic":[215],"vivo":[218],"investigations":[219],"as":[224],"candidate":[226],"functional":[227],"food":[228],"ingredient.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-07-20T00:00:00"}