{"id":"https://openalex.org/W7169672734","doi":"https://doi.org/10.1021/acsptsci.6c00044","title":"PhiKan 083 Inhibits MYCN Expression in Liver Cancer Cells Independent of p53 Pathways","display_name":"PhiKan 083 Inhibits MYCN Expression in Liver Cancer Cells Independent of p53 Pathways","publication_year":2026,"publication_date":"2026-07-18","ids":{"openalex":"https://openalex.org/W7169672734","doi":"https://doi.org/10.1021/acsptsci.6c00044","pmid":"https://pubmed.ncbi.nlm.nih.gov/42614793"},"language":"en","primary_location":{"id":"doi:10.1021/acsptsci.6c00044","doi":"https://doi.org/10.1021/acsptsci.6c00044","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsptsci.6c00044","pdf_url":null,"source":{"id":"https://openalex.org/S4210207642","display_name":"ACS Pharmacology & Translational Science","issn_l":"2575-9108","issn":["2575-9108"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Pharmacology &amp; Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13482878/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5141126194","display_name":"Yali Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN","JP"],"is_corresponding":false,"raw_author_name":"Yali Xu","raw_affiliation_strings":["Medical School of Nanjing University , , Gulou, ,","RIKEN Center for Integrative Medical Sciences , , Tsurumi-ku, ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School of Nanjing University , , Gulou, ,","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"RIKEN Center for Integrative Medical Sciences , , Tsurumi-ku, ,","institution_ids":["https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hricha Mishra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hricha Mishra","raw_affiliation_strings":["RIKEN Center for Integrative Medical Sciences , , Tsurumi-ku, ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Integrative Medical Sciences , , Tsurumi-ku, ,","institution_ids":["https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044249619","display_name":"Masataka Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masataka Takahashi","raw_affiliation_strings":["RIKEN Center for Integrative Medical Sciences , , Tsurumi-ku, ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Integrative Medical Sciences , , Tsurumi-ku, ,","institution_ids":["https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108422238","display_name":"Hajime Nishimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Nishimura","raw_affiliation_strings":["RIKEN Center for Integrative Medical Sciences , , Tsurumi-ku, ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Integrative Medical Sciences , , Tsurumi-ku, ,","institution_ids":["https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026241176","display_name":"Yusuke Suenaga","orcid":"https://orcid.org/0000-0001-6902-5386","observed_orcids":["https://orcid.org/0000-0001-6902-5386"]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Suenaga","raw_affiliation_strings":["Chiba Cancer Center Research Institute , , Chuo-ku, ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiba Cancer Center Research Institute , , Chuo-ku, ,","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007524195","display_name":"Wenkui Yu","orcid":"https://orcid.org/0000-0003-4218-0321","observed_orcids":["https://orcid.org/0000-0003-4218-0321"]},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenkui Yu","raw_affiliation_strings":["Medical School of Nanjing University , , Gulou, ,"],"raw_orcid":"https://orcid.org/0000-0003-4218-0321","affiliations":[{"raw_affiliation_string":"Medical School of Nanjing University , , Gulou, ,","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010525558","display_name":"Yoshitaka Hippo","orcid":"https://orcid.org/0000-0002-4975-1812","observed_orcids":["https://orcid.org/0000-0002-4975-1812"]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshitaka Hippo","raw_affiliation_strings":["Chiba Cancer Center Research Institute , , Chuo-ku, ,"],"raw_orcid":"https://orcid.org/0000-0002-4975-1812","affiliations":[{"raw_affiliation_string":"Chiba Cancer Center Research Institute , , Chuo-ku, ,","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018063097","display_name":"Harukazu Suzuki","orcid":"https://orcid.org/0000-0002-8087-0836","observed_orcids":["https://orcid.org/0000-0002-8087-0836"]},"institutions":[{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Harukazu Suzuki","raw_affiliation_strings":["RIKEN Center for Integrative Medical Sciences , , Tsurumi-ku, ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Integrative Medical Sciences , , Tsurumi-ku, ,","institution_ids":["https://openalex.org/I4210150921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002127115","display_name":"Xian\u2010Yang Qin","orcid":"https://orcid.org/0000-0002-0110-6849","observed_orcids":["https://orcid.org/0000-0002-0110-6849"]},"institutions":[{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]},{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Xian-Yang Qin","raw_affiliation_strings":["Gifu University Graduate School of Medicine , , Yanagido, ,","RIKEN Center for Integrative Medical Sciences , , Tsurumi-ku, ,"],"raw_orcid":"https://orcid.org/0000-0002-0110-6849","affiliations":[{"raw_affiliation_string":"Gifu University Graduate School of Medicine , , Yanagido, ,","institution_ids":["https://openalex.org/I42405503"]},{"raw_affiliation_string":"RIKEN Center for Integrative Medical Sciences , , Tsurumi-ku, ,","institution_ids":["https://openalex.org/I4210150921"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002127115"],"corresponding_institution_ids":["https://openalex.org/I4210150921","https://openalex.org/I42405503"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54443516,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"8","first_page":"2225","last_page":"2233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.05350000038743019,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.7459999918937683},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/p53-independent-pathway","display_name":"p53-independent pathway","score":0.7440000176429749},{"id":"https://openalex.org/keywords/myc-transcription-factor","display_name":"MYC transcription factors","score":0.7170000076293945},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.6620000004768372},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7739999890327454},{"id":"https://openalex.org/keywords/zmiz1","display_name":"ZMIZ1","score":0.75},{"id":"https://openalex.org/keywords/atf3","display_name":"ATF3","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fosl2","display_name":"FOSL2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.546999990940094},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8799999952316284}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7315000295639038},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5728999972343445},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.555899977684021},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5333999991416931},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5302000045776367},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.5242000222206116},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4742000102996826},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4359000027179718},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4000999927520752},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.39989998936653137},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3919000029563904},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.38960000872612},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.35749998688697815},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3573000133037567},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3425000011920929},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.33550000190734863},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.3287999927997589},{"id":"https://openalex.org/C2910353367","wikidata":"https://www.wikidata.org/wiki/Q420267","display_name":"Proto-Oncogene Proteins c-myc","level":4,"score":0.32670000195503235},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.31520000100135803},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.3066999912261963},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29510000348091125},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.28189998865127563},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2808000147342682},{"id":"https://openalex.org/C2779314089","wikidata":"https://www.wikidata.org/wiki/Q18026830","display_name":"HCCS","level":3,"score":0.2676999866962433},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.26179999113082886},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26030001044273376},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.25870001316070557},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.257099986076355},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2531999945640564}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1021/acsptsci.6c00044","doi":"https://doi.org/10.1021/acsptsci.6c00044","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsptsci.6c00044","pdf_url":null,"source":{"id":"https://openalex.org/S4210207642","display_name":"ACS Pharmacology & Translational Science","issn_l":"2575-9108","issn":["2575-9108"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Pharmacology &amp; Translational Science","raw_type":"journal-article"},{"id":"pmid:42614793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42614793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS pharmacology & translational science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13482878","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13482878/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Pharmacol Transl Sci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13482878","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13482878/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Pharmacol Transl Sci","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6475690603256226,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4443719294","display_name":"Role of membrane lipid-modulated signal transductions in endotoxin hyperresponse of fatty livers","funder_award_id":"20K07349","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6256722741","display_name":null,"funder_award_id":"JPMJNX25E3","funder_id":"https://openalex.org/F4320334789","funder_display_name":"Japan Science and Technology Agency"},{"id":"https://openalex.org/G6799259135","display_name":"\u304c\u3093\u5e79\u7d30\u80de\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u52d5\u614b\u306e\u8ffd\u8de1\u3092\u57fa\u8ef8\u3068\u3057\u305f\u809d\u304c\u3093\u306e\u75c5\u614b\u89e3\u660e\u3068\u5275\u85ac\u7814\u7a76","funder_award_id":"23fk0210100h0003","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6929734035","display_name":null,"funder_award_id":"JP23ama121053","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G8357636956","display_name":"Molecular pathology and drug discovery of sepsis&#8211;related liver injury by tracing protein crosslinking dynamics","funder_award_id":"24K10088","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8515493181","display_name":null,"funder_award_id":"JP24jm0210092s0104","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1964081206","https://openalex.org/W1971837077","https://openalex.org/W1976873804","https://openalex.org/W1980763900","https://openalex.org/W2002015871","https://openalex.org/W2002889430","https://openalex.org/W2016591815","https://openalex.org/W2028319026","https://openalex.org/W2039933549","https://openalex.org/W2043398720","https://openalex.org/W2072052957","https://openalex.org/W2110947069","https://openalex.org/W2136786699","https://openalex.org/W2752211658","https://openalex.org/W2752942423","https://openalex.org/W2761031851","https://openalex.org/W2801937548","https://openalex.org/W2898903963","https://openalex.org/W2899474289","https://openalex.org/W2998448538","https://openalex.org/W3002831182","https://openalex.org/W3025022288","https://openalex.org/W3030794675","https://openalex.org/W3035959711","https://openalex.org/W3128646645","https://openalex.org/W4210774372","https://openalex.org/W4232620598","https://openalex.org/W4304084233","https://openalex.org/W4387611122","https://openalex.org/W4390698774","https://openalex.org/W4392003982","https://openalex.org/W4399561210","https://openalex.org/W4407588561","https://openalex.org/W4412631925","https://openalex.org/W7125409464","https://openalex.org/W7130402067"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"MYCN":[1,28,49,178],"is":[2,111],"a":[3,12,26,36,42,169,187],"key":[4],"oncogenic":[5,152],"driver":[6],"in":[7,51,108,120,186,199],"hepatocellular":[8],"carcinoma":[9],"(HCC)":[10],"and":[11,58,68,72,81,125,143,155,166,180,196],"therapeutic":[13],"challenge":[14],"due":[15],"to":[16,140],"the":[17,56],"historical":[18],"undruggability":[19],"of":[20,60,70,131,137,194],"MYC":[21],"transcription":[22],"factors":[23],"(TFs).":[24],"Using":[25],"high-throughput":[27],"promoter\u2013luciferase":[29],"reporter,":[30],"we":[31],"identified":[32],"PhiKan":[33],"083":[34],"(PK83),":[35],"small":[37],"molecule":[38],"previously":[39],"recognized":[40],"as":[41,118],"mutant":[43],"p53":[44,104],"activator,":[45],"that":[46,87,175],"dose-dependently":[47],"suppresses":[48,177],"expression":[50,179],"HCC":[52,62,79,147,184],"cells.":[53],"PK83":[54,101,176,195],"impaired":[55],"proliferation":[57],"survival":[59],"MYCN-high":[61,109,183],"cells,":[63],"inducing":[64],"DNA":[65],"damage,":[66],"apoptosis,":[67],"loss":[69],"clonogenic":[71],"spheroid":[73],"growth":[74],"potential,":[75],"while":[76],"sparing":[77],"MYCN-low":[78],"cells":[80,110,185],"normal":[82],"hepatocytes.":[83],"Structure\u2013activity":[84],"analysis":[85,127],"revealed":[86],"polar,":[88],"hydrogen-bond-capable":[89],"substituents":[90],"on":[91,115],"PK83\u2019s":[92],"tricyclic":[93],"scaffold":[94],"are":[95],"critical":[96],"for":[97],"its":[98,106],"activity.":[99],"Although":[100],"broadly":[102],"activates":[103],"signaling,":[105],"cytotoxicity":[107],"not":[112],"strictly":[113],"dependent":[114],"intact":[116],"p53,":[117],"confirmed":[119],"p53-knockout":[121],"systems.":[122],"Transcriptome":[123],"profiling":[124],"pathway":[126],"demonstrated":[128],"robust":[129],"suppression":[130],"MYC/MYCN":[132],"targets":[133],"along":[134],"with":[135,159],"modulation":[136],"pathways":[138],"linked":[139],"stress,":[141],"differentiation,":[142],"metabolism.":[144],"In":[145],"primary":[146],"tumors,":[148],"PK83-downregulated":[149],"TFs,":[150],"including":[151],"TFs":[153,164],"ZMIZ1":[154],"TARBP1,":[156],"positively":[157],"correlated":[158],"MYCN,":[160],"whereas":[161],"upregulated":[162],"stress-responsive":[163],"ATF3":[165],"FOSL2":[167],"showed":[168],"negative":[170],"correlation.":[171],"These":[172],"findings":[173],"suggest":[174],"preferentially":[181],"affects":[182],"p53-independent":[188],"manner,":[189],"warranting":[190],"further":[191],"preclinical":[192],"investigation":[193],"related":[197],"compounds":[198],"MYCN-associated":[200],"cancers.":[201]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-07-19T00:00:00"}
