{"id":"https://openalex.org/W7169587383","doi":"https://doi.org/10.66223/pediatria.2026.2.001","title":"Diagnosis and risk stratification of acute lymphoblastic leukemia: what\u2019s new?","display_name":"Diagnosis and risk stratification of acute lymphoblastic leukemia: what\u2019s new?","publication_year":2026,"publication_date":"2026-06-15","ids":{"openalex":"https://openalex.org/W7169587383","doi":"https://doi.org/10.66223/pediatria.2026.2.001"},"language":"en","primary_location":{"id":"doi:10.66223/pediatria.2026.2.001","doi":"https://doi.org/10.66223/pediatria.2026.2.001","is_oa":false,"landing_page_url":"https://doi.org/10.66223/pediatria.2026.2.001","pdf_url":null,"source":{"id":"https://openalex.org/S4393915331","display_name":"Pediatri\u00e2","issn_l":"0479-7876","issn":["0479-7876"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatria","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054892440","display_name":"Hasan A. Burnusuzov","orcid":"https://orcid.org/0000-0002-3316-9916","observed_orcids":["https://orcid.org/0000-0002-3316-9916"]},"institutions":[{"id":"https://openalex.org/I2801117330","display_name":"Medical University Plovdiv","ror":"https://ror.org/02kzxd152","country_code":"BG","type":"education","lineage":["https://openalex.org/I2801117330"]}],"countries":["BG"],"is_corresponding":true,"raw_author_name":"H. Burnusuzov","raw_affiliation_strings":["Department of Pediatrics, Medical University - Plovdiv"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Medical University - Plovdiv","institution_ids":["https://openalex.org/I2801117330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054892440"],"corresponding_institution_ids":["https://openalex.org/I2801117330"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"L\u0425VI","issue":"2/2026","first_page":"3","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8330000042915344},{"id":"https://openalex.org/keywords/2022-who-classification","display_name":"WHO 2022 classification","score":0.8809999823570251},{"id":"https://openalex.org/keywords/multiparameter-flow-cytometry","display_name":"multiparameter flow cytometry","score":0.906000018119812},{"id":"https://openalex.org/keywords/early-t-cell-precursor-acute-lymphoblastic-leukemia","display_name":"early T-cell precursor acute lymphoblastic leukemia","score":0.8140000104904175},{"id":"https://openalex.org/keywords/ph-like-all","display_name":"Ph-like ALL","score":0.718999981880188},{"id":"https://openalex.org/keywords/gene-rearrangement","display_name":"gene rearrangement","score":0.7879999876022339},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.46299999952316284},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.9679999947547913},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.7091000080108643},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6359000205993652},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.5878000259399414},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43810001015663147},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.38580000400543213},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3797999918460846},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3702000081539154},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35659998655319214},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.3357999920845032},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.3215000033378601},{"id":"https://openalex.org/C4661277","wikidata":"https://www.wikidata.org/wiki/Q1054157","display_name":"Cog","level":2,"score":0.31040000915527344},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3086000084877014},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.30550000071525574},{"id":"https://openalex.org/C179786068","wikidata":"https://www.wikidata.org/wiki/Q16257937","display_name":"Molecular diagnostics","level":2,"score":0.30410000681877136},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3009999990463257},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.30079999566078186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28060001134872437},{"id":"https://openalex.org/C13460635","wikidata":"https://www.wikidata.org/wiki/Q85753676","display_name":"Classification scheme","level":2,"score":0.27720001339912415},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.2705000042915344},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.26660001277923584},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.26109999418258667}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.66223/pediatria.2026.2.001","doi":"https://doi.org/10.66223/pediatria.2026.2.001","is_oa":false,"landing_page_url":"https://doi.org/10.66223/pediatria.2026.2.001","pdf_url":null,"source":{"id":"https://openalex.org/S4393915331","display_name":"Pediatri\u00e2","issn_l":"0479-7876","issn":["0479-7876"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatria","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2130308619","https://openalex.org/W2079911103","https://openalex.org/W4415173376","https://openalex.org/W4313454313","https://openalex.org/W2143832057","https://openalex.org/W1997131528","https://openalex.org/W2154862290","https://openalex.org/W4407410660","https://openalex.org/W4391379781","https://openalex.org/W2009208222"],"abstract_inverted_index":{"The":[0,48,191],"diagnosis":[1],"and":[2,28,43,67,86,97,111,179,208],"risk":[3],"stratification":[4],"of":[5,18,22,40,154,161,168,193,204],"acute":[6],"lymphoblastic":[7],"leukemia":[8],"(ALL)":[9],"has":[10,137],"undergone":[11],"a":[12,90,122,152],"fundamental":[13],"evolution":[14],"with":[15,78,128,201],"the":[16,19,23,29,38,76,141,166,202],"introduction":[17],"5th":[20],"edition":[21],"WHO":[24],"classification":[25],"(WHO":[26],"2022)":[27],"International":[30],"Consensus":[31],"Classifier":[32],"(ICC":[33],"2022).":[34],"These":[35],"systems":[36,175],"require":[37],"integration":[39],"morphological,":[41],"immunophenotypic":[42],"precise":[44],"molecular":[45,170],"genetic":[46,112],"data.":[47],"modern":[49],"diagnostic":[50],"process":[51],"is":[52,100,116,195],"moving":[53],"from":[54],"quantitative":[55],"morphological":[56],"assessment":[57],"to":[58,118,163,188],"multiparameter":[59,148],"flow":[60,149],"cytometry":[61,150],"(MFC)":[62],"for":[63,125],"cell":[64],"lineage":[65],"determination":[66],"specific":[68,87],"phenotypes":[69],"such":[70],"as":[71,121,140,177],"ETP-ALL.":[72],"ICC":[73],"2022":[74],"expands":[75],"taxonomy":[77],"nine":[79],"new":[80],"categories":[81],"based":[82],"on":[83],"gene":[84],"rearrangements":[85],"mutations,":[88],"including":[89],"detailed":[91],"distinction":[92],"between":[93],"Ph-positive":[94],"subtypes":[95],"(ALL-L":[96],"ALL-M).":[98],"Prognosis":[99],"assessed":[101],"by":[102],"combining":[103],"static":[104],"clinical":[105],"factors":[106],"(age,":[107],"WBC,":[108],"extramedullary":[109],"involvement)":[110],"aberrations.":[113],"Particular":[114],"attention":[115],"paid":[117],"Ph-like":[119],"ALL":[120],"powerful":[123],"predictor":[124],"targeted":[126],"therapy":[127,174],"TKIs":[129],"or":[130],"JAK":[131],"inhibitors.":[132],"Measurable":[133],"residual":[134],"disease":[135],"(MRD)":[136],"been":[138],"established":[139],"most":[142],"significant":[143],"dynamic":[144],"prognostic":[145],"marker.":[146],"While":[147],"achieves":[151],"sensitivity":[153],"10-5,":[155],"next-generation":[156],"sequencing":[157],"(NGS)":[158],"allows":[159],"detection":[160],"up":[162],"10-6,":[164],"defining":[165],"concept":[167],"\u201cdeep":[169],"remission\u201d.":[171],"Integrated":[172],"risk-adapted":[173],"(such":[176],"COG":[178],"BFM)":[180],"use":[181],"MRD":[182],"status":[183],"at":[184],"key":[185],"time":[186],"points":[187],"refine":[189],"treatment.":[190],"future":[192],"diagnostics":[194],"directed":[196],"towards":[197],"standardizing":[198],"ultrasensitive":[199],"methods":[200],"aim":[203],"optimizing":[205],"therapeutic":[206],"response":[207],"preventing":[209],"relapse.":[210]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-07-18T00:00:00"}
