{"id":"https://openalex.org/W7169537489","doi":"https://doi.org/10.64898/2026.07.11.737986","title":"Edge controllability is associated with treatment response to repetitive transcranial magnetic stimulation in depression","display_name":"Edge controllability is associated with treatment response to repetitive transcranial magnetic stimulation in depression","publication_year":2026,"publication_date":"2026-07-17","ids":{"openalex":"https://openalex.org/W7169537489","doi":"https://doi.org/10.64898/2026.07.11.737986"},"language":"en","primary_location":{"id":"doi:10.64898/2026.07.11.737986","doi":"https://doi.org/10.64898/2026.07.11.737986","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.11.737986","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/07/17/2026.07.11.737986.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/07/17/2026.07.11.737986.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000415774","display_name":"Subham Dey","orcid":"https://orcid.org/0009-0006-9196-6979","observed_orcids":["https://orcid.org/0009-0006-9196-6979"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Subham Dey","raw_affiliation_strings":["Computational Neurostimulation Research Program; Noninvasive Neuromodulation Unit; Experimental Therapeutics and Pathophysiology Branch; National Institute of Mental Health; Bethesda; MD; USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Neurostimulation Research Program; Noninvasive Neuromodulation Unit; Experimental Therapeutics and Pathophysiology Branch; National Institute of Mental Health; Bethesda; MD; USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000415774"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.08720000088214874,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/network-control-theory","display_name":"network control theory","score":0.7879999876022339},{"id":"https://openalex.org/keywords/repetitive-transcranial-magnetic-stimulation","display_name":"repetitive transcranial magnetic stimulation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/treatment-resistant-depression","display_name":"treatment-resistant depression","score":0.8349999785423279},{"id":"https://openalex.org/keywords/structural-connectome","display_name":"structural connectome","score":0.9390000104904175},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.7630000114440918},{"id":"https://openalex.org/keywords/dorsolateral-prefrontal-cortex","display_name":"dorsolateral prefrontal cortex","score":0.9160000085830688},{"id":"https://openalex.org/keywords/middle-frontal-gyrus","display_name":"middle frontal gyrus","score":0.9430000185966492},{"id":"https://openalex.org/keywords/personalized-neuromodulation","display_name":"personalized neuromodulation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/brain-network-dynamics","display_name":"brain network dynamics","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C48209547","wikidata":"https://www.wikidata.org/wiki/Q1331104","display_name":"Controllability","level":2,"score":0.8240000009536743},{"id":"https://openalex.org/C2778581513","wikidata":"https://www.wikidata.org/wiki/Q263962","display_name":"Transcranial magnetic stimulation","level":3,"score":0.7856000065803528},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.6945000290870667},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6158999800682068},{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.48240000009536743},{"id":"https://openalex.org/C162307627","wikidata":"https://www.wikidata.org/wiki/Q204833","display_name":"Enhanced Data Rates for GSM Evolution","level":2,"score":0.4629000127315521},{"id":"https://openalex.org/C2776443511","wikidata":"https://www.wikidata.org/wiki/Q1724687","display_name":"Neurostimulation","level":3,"score":0.4620000123977661},{"id":"https://openalex.org/C2780508717","wikidata":"https://www.wikidata.org/wiki/Q72788","display_name":"Dorsolateral prefrontal cortex","level":4,"score":0.3984000086784363},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3862000107765198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3727000057697296},{"id":"https://openalex.org/C2781423396","wikidata":"https://www.wikidata.org/wiki/Q1558534","display_name":"Inferior frontal gyrus","level":3,"score":0.35929998755455017},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.35440000891685486},{"id":"https://openalex.org/C2779991468","wikidata":"https://www.wikidata.org/wiki/Q3063753","display_name":"Middle frontal gyrus","level":3,"score":0.35269999504089355},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3407999873161316},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C2985799443","wikidata":"https://www.wikidata.org/wiki/Q4955838","display_name":"Brain stimulation","level":3,"score":0.3046000003814697},{"id":"https://openalex.org/C2775956885","wikidata":"https://www.wikidata.org/wiki/Q3064113","display_name":"Superior frontal gyrus","level":3,"score":0.29980000853538513},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.2955999970436096},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.2703000009059906},{"id":"https://openalex.org/C66324658","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Resting state fMRI","level":2,"score":0.2614000141620636},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.259799987077713},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.2538999915122986},{"id":"https://openalex.org/C41982775","wikidata":"https://www.wikidata.org/wiki/Q7000977","display_name":"Network controllability","level":4,"score":0.25380000472068787}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.07.11.737986","doi":"https://doi.org/10.64898/2026.07.11.737986","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.11.737986","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/07/17/2026.07.11.737986.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.07.11.737986","doi":"https://doi.org/10.64898/2026.07.11.737986","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.11.737986","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/07/17/2026.07.11.737986.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7169537489.pdf","grobid_xml":"https://content.openalex.org/works/W7169537489.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2797937024","https://openalex.org/W2588275135","https://openalex.org/W4210328554","https://openalex.org/W7214560860","https://openalex.org/W3157075945","https://openalex.org/W2682224635","https://openalex.org/W2510918787","https://openalex.org/W4280578089","https://openalex.org/W2912361992","https://openalex.org/W4407934081"],"abstract_inverted_index":{"Abstract":[0],"Repetitive":[1],"transcranial":[2],"magnetic":[3],"stimulation":[4],"(rTMS)":[5],"is":[6,59],"an":[7],"established":[8],"treatment":[9,18,155],"for":[10],"major":[11],"depressive":[12],"disorder":[13],"(MDD),":[14],"yet":[15],"variability":[16],"in":[17,120],"response":[19,156],"remains":[20],"a":[21,28,75],"significant":[22,116],"challenge.":[23],"Network":[24],"control":[25],"theory":[26],"provides":[27],"framework":[29],"to":[30,74,125,154],"quantify":[31],"how":[32],"brain":[33],"networks":[34],"facilitate":[35],"state":[36],"transitions,":[37],"but":[38],"prior":[39,73],"work":[40],"has":[41],"focused":[42],"primarily":[43],"on":[44],"node":[45],"level":[46,151],"metrics.":[47],"Here,":[48],"I":[49],"investigate":[50],"whether":[51],"edge":[52,99,146],"based":[53,100,147],"controllability":[54,101,148],"of":[55,79,108],"the":[56,84,95,126],"structural":[57],"connectome":[58],"associated":[60],"with":[61,67,118],"rTMS":[62,82],"outcomes.":[63],"Twenty":[64],"five":[65,76],"patients":[66],"treatment-resistant":[68],"depression":[69],"underwent":[70],"diffusion":[71],"MRI":[72],"week":[77],"course":[78],"high":[80],"frequency":[81],"targeting":[83],"dorsolateral":[85],"prefrontal":[86],"cortex.":[87],"Structural":[88],"connectomes":[89],"were":[90,103],"constructed":[91],"using":[92],"MRtrix3":[93],"and":[94,98,133,157],"Destrieux":[96],"atlas,":[97],"metrics":[102],"computed":[104],"at":[105],"baseline.":[106],"Controllability":[107],"specific":[109],"middle":[110],"frontal":[111,128],"gyrus":[112,135],"centered":[113],"edges":[114],"showed":[115],"associations":[117],"changes":[119],"HAMD-24":[121],"scores,":[122],"including":[123],"connections":[124],"superior":[127],"gyrus,":[129,132],"hippocampus,":[130],"angular":[131],"orbital":[134],"(r":[136],"=":[137],"-(0.470\u20130.597),":[138],"p":[139],"<":[140],"0.05).":[141],"These":[142],"findings":[143],"suggest":[144],"that":[145],"captures":[149],"circuit":[150],"properties":[152],"relevant":[153],"may":[158],"inform":[159],"personalized":[160],"neuromodulation":[161],"strategies.":[162]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-07-18T00:00:00"}
