{"id":"https://openalex.org/W7169517468","doi":"https://doi.org/10.2169/internalmedicine.7556-26","title":"Successful Treatment with Epcoritamab for Refractory Diffuse Large B-cell Lymphoma in a Dialysis-dependent Patient","display_name":"Successful Treatment with Epcoritamab for Refractory Diffuse Large B-cell Lymphoma in a Dialysis-dependent Patient","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7169517468","doi":"https://doi.org/10.2169/internalmedicine.7556-26","pmid":"https://pubmed.ncbi.nlm.nih.gov/42476779"},"language":"en","primary_location":{"id":"doi:10.2169/internalmedicine.7556-26","doi":"https://doi.org/10.2169/internalmedicine.7556-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7556-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7556-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7556-26/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039534058","display_name":"Yuya Sasaki","orcid":"https://orcid.org/0000-0001-8232-0910","observed_orcids":["https://orcid.org/0000-0001-8232-0910"]},"institutions":[{"id":"https://openalex.org/I4210161548","display_name":"Institute of Science Tokyo Hospital","ror":"https://ror.org/058548196","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161548","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuya Sasaki","raw_affiliation_strings":["Department of Hematology, Institute of Science Tokyo Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Institute of Science Tokyo Hospital, Japan","institution_ids":["https://openalex.org/I4210161548"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Keisuke Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161548","display_name":"Institute of Science Tokyo Hospital","ror":"https://ror.org/058548196","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161548","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Tanaka","raw_affiliation_strings":["Department of Hematology, Institute of Science Tokyo Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Institute of Science Tokyo Hospital, Japan","institution_ids":["https://openalex.org/I4210161548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141087852","display_name":"Hisako Nakamaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161548","display_name":"Institute of Science Tokyo Hospital","ror":"https://ror.org/058548196","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161548","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisako Nakamaki","raw_affiliation_strings":["Department of Hematology, Institute of Science Tokyo Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Institute of Science Tokyo Hospital, Japan","institution_ids":["https://openalex.org/I4210161548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112239394","display_name":"Makiko Ogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161548","display_name":"Institute of Science Tokyo Hospital","ror":"https://ror.org/058548196","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161548","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makiko Ogawa","raw_affiliation_strings":["Department of Hematology, Institute of Science Tokyo Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Institute of Science Tokyo Hospital, Japan","institution_ids":["https://openalex.org/I4210161548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002230786","display_name":"Yoshihiro Umezawa","orcid":"https://orcid.org/0000-0003-1027-1552","observed_orcids":["https://orcid.org/0000-0003-1027-1552"]},"institutions":[{"id":"https://openalex.org/I4210161548","display_name":"Institute of Science Tokyo Hospital","ror":"https://ror.org/058548196","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161548","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Umezawa","raw_affiliation_strings":["Department of Hematology, Institute of Science Tokyo Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Institute of Science Tokyo Hospital, Japan","institution_ids":["https://openalex.org/I4210161548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087127498","display_name":"Masahide Yamamoto","orcid":"https://orcid.org/0000-0002-3142-8806","observed_orcids":["https://orcid.org/0000-0002-3142-8806"]},"institutions":[{"id":"https://openalex.org/I4210161548","display_name":"Institute of Science Tokyo Hospital","ror":"https://ror.org/058548196","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161548","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahide Yamamoto","raw_affiliation_strings":["Department of Hematology, Institute of Science Tokyo Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Institute of Science Tokyo Hospital, Japan","institution_ids":["https://openalex.org/I4210161548"]}]},{"author_position":"last","author":{"id":null,"display_name":"Takehiko Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161548","display_name":"Institute of Science Tokyo Hospital","ror":"https://ror.org/058548196","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161548","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takehiko Mori","raw_affiliation_strings":["Department of Hematology, Institute of Science Tokyo Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Institute of Science Tokyo Hospital, Japan","institution_ids":["https://openalex.org/I4210161548"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210161548"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.5170806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epcoritamab","display_name":"epcoritamab","score":1.0},{"id":"https://openalex.org/keywords/dialysis-dependence","display_name":"dialysis dependence","score":0.8460000157356262},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9580000042915344},{"id":"https://openalex.org/keywords/arteriosclerosis","display_name":"arteriosclerosis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.5580000281333923},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.972000002861023},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6861000061035156},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5690000057220459},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5012000203132629},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.4593000113964081},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.30149999260902405},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.27799999713897705},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27709999680519104},{"id":"https://openalex.org/C3017763353","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Malignant lymphoma","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.2506999969482422}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2169/internalmedicine.7556-26","doi":"https://doi.org/10.2169/internalmedicine.7556-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7556-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7556-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},{"id":"pmid:42476779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42476779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal medicine (Tokyo, Japan)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2169/internalmedicine.7556-26","doi":"https://doi.org/10.2169/internalmedicine.7556-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7556-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7556-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7169517468.pdf","grobid_xml":"https://content.openalex.org/works/W7169517468.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2067242291","https://openalex.org/W2744261860","https://openalex.org/W3001767756","https://openalex.org/W3158420832","https://openalex.org/W4285679342","https://openalex.org/W4311537867","https://openalex.org/W4312115076","https://openalex.org/W4388291706","https://openalex.org/W4393982915","https://openalex.org/W4396666025","https://openalex.org/W4400833490","https://openalex.org/W4402542612","https://openalex.org/W4402827909","https://openalex.org/W4412495436"],"related_works":["https://openalex.org/W7124766215","https://openalex.org/W4416266653","https://openalex.org/W4408967307","https://openalex.org/W7223133731","https://openalex.org/W4406260228","https://openalex.org/W4391598714","https://openalex.org/W4388291706","https://openalex.org/W4410822568","https://openalex.org/W4401877091","https://openalex.org/W4389231285"],"abstract_inverted_index":{"The":[0],"efficacy":[1],"of":[2,33,41,73,76],"epcoritamab":[3],"in":[4,17,93],"refractory":[5,26,97],"diffuse":[6],"large":[7],"B-cell":[8],"lymphoma":[9],"(DLBCL)":[10],"has":[11],"been":[12],"established.":[13],"However,":[14,64],"its":[15],"safety":[16],"dialysis-dependent":[18,94],"patients":[19,95],"is":[20],"unclear.":[21],"A":[22],"53-year-old":[23],"man":[24],"with":[25,89,96],"DLBCL":[27],"who":[28],"had":[29],"received":[30],"a":[31,51,55],"series":[32],"different":[34],"chemotherapies":[35],"became":[36],"dependent":[37],"on":[38],"dialysis":[39],"because":[40,72],"worsening":[42],"preexisting":[43],"chronic":[44],"kidney":[45],"disease.":[46],"Epcoritamab":[47,84],"was":[48,58,66],"initiated":[49],"at":[50],"standard":[52],"dose,":[53],"and":[54],"complete":[56],"response":[57],"achieved":[59],"after":[60,68],"the":[61,69,74],"third":[62],"cycle.":[63],"it":[65],"discontinued":[67],"seventh":[70],"cycle":[71],"development":[75],"lower":[77],"leg":[78],"necrosis":[79],"due":[80],"to":[81],"pre-existing":[82],"arteriosclerosis.":[83],"may":[85],"therefore":[86],"be":[87],"feasible":[88],"careful":[90],"monitoring,":[91],"even":[92],"DLBCL.":[98]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-07-18T00:00:00"}
