{"id":"https://openalex.org/W7169503115","doi":"https://doi.org/10.1016/j.vas.2026.100772","title":"Lipid remodeling in swine spermatozoa: Innovative model for the analysis of oxysterols during capacitation","display_name":"Lipid remodeling in swine spermatozoa: Innovative model for the analysis of oxysterols during capacitation","publication_year":2026,"publication_date":"2026-07-17","ids":{"openalex":"https://openalex.org/W7169503115","doi":"https://doi.org/10.1016/j.vas.2026.100772","pmid":"https://pubmed.ncbi.nlm.nih.gov/42502770"},"language":"en","primary_location":{"id":"doi:10.1016/j.vas.2026.100772","doi":"https://doi.org/10.1016/j.vas.2026.100772","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vas.2026.100772","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2451943X26002024/pdf","source":{"id":"https://openalex.org/S2898580889","display_name":"Veterinary and Animal Science","issn_l":"2451-943X","issn":["2451-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary and Animal Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2451943X26002024/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106970962","display_name":"Carlo Di Carlo","orcid":"https://orcid.org/0009-0009-4268-2111","observed_orcids":["https://orcid.org/0009-0009-4268-2111"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlo Di Carlo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-4268-2111","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141101911","display_name":"Eugelio Fabiola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabiola Eugelio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042370444","display_name":"Rams\u00e9s Belda-P\u00e9rez","orcid":"https://orcid.org/0000-0002-0959-5050","observed_orcids":["https://orcid.org/0000-0002-0959-5050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramses Belda-Perez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089997340","display_name":"Costanza Cimini","orcid":"https://orcid.org/0000-0001-8472-461X","observed_orcids":["https://orcid.org/0000-0001-8472-461X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Costanza Cimini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141057824","display_name":"Fanti Federico","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Federico Fanti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050062307","display_name":"Valbonetti Luca","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luca Valbonetti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010485840","display_name":"Bernab\u00f2 Nicola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124326101","display_name":"University of Teramo","ror":"https://ror.org/01yetye73","country_code":"IT","type":"education","lineage":["https://openalex.org/I124326101"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Bernab\u00f2","raw_affiliation_strings":["Department of Biosciences and Technology for Food, Agriculture and Environment , University of Teramo , Via Renato Balzarini , 1 , 64100 Teramo , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences and Technology for Food, Agriculture and Environment , University of Teramo , Via Renato Balzarini , 1 , 64100 Teramo , Italy","institution_ids":["https://openalex.org/I124326101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049747676","display_name":"Compagnone Dario","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dario Compagnone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108756973","display_name":"Barboni Barbara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Barboni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2780,"currency":"USD","value_usd":2780},"apc_paid":{"value":2780,"currency":"USD","value_usd":2780},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.56008573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":null,"first_page":"100772","last_page":"100772"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sperm-capacitation","display_name":"sperm capacitation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/oxysterols","display_name":"oxysterols","score":0.9900000095367432},{"id":"https://openalex.org/keywords/7-ketocholesterol","display_name":"7-ketocholesterol","score":0.8899999856948853},{"id":"https://openalex.org/keywords/7beta-hydroxycholesterol","display_name":"7\u03b2-hydroxycholesterol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/7alpha-hydroxycholesterol","display_name":"7\u03b1-hydroxycholesterol","score":1.0},{"id":"https://openalex.org/keywords/oviduct-epithelial-cells","display_name":"oviductal epithelial cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9670000076293945},{"id":"https://openalex.org/keywords/lipid-remodeling","display_name":"lipid remodeling","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C2780301668","wikidata":"https://www.wikidata.org/wiki/Q1728362","display_name":"Capacitation","level":3,"score":0.9919000267982483},{"id":"https://openalex.org/C2778111914","wikidata":"https://www.wikidata.org/wiki/Q7116159","display_name":"Oxysterol","level":3,"score":0.917900025844574},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5199999809265137},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.5162000060081482},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4814999997615814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4593999981880188},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.36809998750686646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3366999924182892},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.33649998903274536},{"id":"https://openalex.org/C88972607","wikidata":"https://www.wikidata.org/wiki/Q2666904","display_name":"Human fertilization","level":2,"score":0.3336000144481659},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.29010000824928284},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2842000126838684},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.28360000252723694},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2773999869823456},{"id":"https://openalex.org/C79266657","wikidata":"https://www.wikidata.org/wiki/Q424178","display_name":"Lipid raft","level":3,"score":0.2628999948501587},{"id":"https://openalex.org/C512716672","wikidata":"https://www.wikidata.org/wiki/Q200117","display_name":"In vitro fertilisation","level":3,"score":0.2599000036716461},{"id":"https://openalex.org/C2778520758","wikidata":"https://www.wikidata.org/wiki/Q3443277","display_name":"Flushing","level":2,"score":0.259799987077713},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.25049999356269836}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.vas.2026.100772","doi":"https://doi.org/10.1016/j.vas.2026.100772","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vas.2026.100772","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2451943X26002024/pdf","source":{"id":"https://openalex.org/S2898580889","display_name":"Veterinary and Animal Science","issn_l":"2451-943X","issn":["2451-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary and Animal Science","raw_type":"journal-article"},{"id":"pmid:42502770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42502770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary and animal science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13400372","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13400372/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vet Anim Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.vas.2026.100772","doi":"https://doi.org/10.1016/j.vas.2026.100772","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vas.2026.100772","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2451943X26002024/pdf","source":{"id":"https://openalex.org/S2898580889","display_name":"Veterinary and Animal Science","issn_l":"2451-943X","issn":["2451-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary and Animal Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G190230254","display_name":null,"funder_award_id":"C43C22000380007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2083104366","display_name":null,"funder_award_id":"337 ECS00000041","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7169503115.pdf","grobid_xml":"https://content.openalex.org/works/W7169503115.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W908481357","https://openalex.org/W1870184698","https://openalex.org/W1987032312","https://openalex.org/W2008946411","https://openalex.org/W2011301426","https://openalex.org/W2011669085","https://openalex.org/W2013411735","https://openalex.org/W2022991915","https://openalex.org/W2024412789","https://openalex.org/W2060148494","https://openalex.org/W2063706408","https://openalex.org/W2109279728","https://openalex.org/W2110585531","https://openalex.org/W2120622581","https://openalex.org/W2135528705","https://openalex.org/W2141232122","https://openalex.org/W2142804096","https://openalex.org/W2155991068","https://openalex.org/W2167859595","https://openalex.org/W2175091752","https://openalex.org/W2322694394","https://openalex.org/W2342249984","https://openalex.org/W2436042621","https://openalex.org/W2552782005","https://openalex.org/W2586115249","https://openalex.org/W2736315156","https://openalex.org/W2741777229","https://openalex.org/W2947231102","https://openalex.org/W2953040197","https://openalex.org/W2995961938","https://openalex.org/W2999203292","https://openalex.org/W3003257820","https://openalex.org/W3033117154","https://openalex.org/W3035965352","https://openalex.org/W3040708562","https://openalex.org/W3044688921","https://openalex.org/W3128261063","https://openalex.org/W3209176260","https://openalex.org/W4210535426","https://openalex.org/W4229038140","https://openalex.org/W4322770869","https://openalex.org/W4388455622","https://openalex.org/W4413979552"],"related_works":[],"abstract_inverted_index":{"Capacitation":[0],"is":[1],"a":[2,96,179,207],"vital":[3],"process":[4],"that":[5],"prepares":[6],"spermatozoa":[7,128],"for":[8,189,209],"successful":[9],"fertilization":[10],"by":[11,197],"inducing":[12],"significant":[13],"biochemical":[14,200],"and":[15,47,57,86,107,129,132,153,163,191,199,218],"biophysical":[16],"changes":[17,59],"in":[18,60,64,126,170,184,216],"the":[19,24,55,145,148,158,211],"plasma":[20],"membrane.":[21],"Among":[22],"these,":[23],"role":[25,181],"of":[26,31,67,182,213],"oxysterols":[27,79,183],"-":[28,33],"oxygenated":[29],"derivatives":[30],"cholesterol":[32],"has":[34],"garnered":[35],"increasing":[36],"attention":[37],"due":[38],"to":[39,53,92,101,173],"their":[40,195],"influence":[41],"on":[42],"membrane":[43,186],"dynamics,":[44,187],"signaling":[45],"pathways,":[46],"capacitation-related":[48],"modifications.":[49],"This":[50,204],"study":[51,205],"aimed":[52],"evaluate":[54],"temporal":[56],"treatment-dependent":[58],"oxysterol":[61,124,146,214],"concentrations":[62,125],"during":[63,135,202],"vitro":[65],"capacitation":[66,174],"swine":[68,102],"spermatozoa.":[69],"Using":[70],"ultra-high-performance":[71],"liquid":[72],"chromatography-tandem":[73],"mass":[74],"spectrometry":[75],"(UHPLC-MS/MS),":[76],"three":[77,93,115],"key":[78],"were":[80,90],"quantified:":[81],"7\u03b2-hydroxycholesterol":[82],"(7\u03b2-OHC),":[83],"7\u03b1-hydroxycholesterol":[84],"(7\u03b1-OHC),":[85],"7-ketocholesterol":[87],"(7-KC).":[88],"Spermatozoa":[89],"subjected":[91],"experimental":[94],"conditions:":[95],"control":[97],"group":[98],"(Ctrl),":[99],"exposure":[100],"oviductal":[103],"epithelial":[104],"cells":[105],"(SOEC),":[106],"SOEC":[108,159],"pre-treated":[109],"with":[110],"progesterone":[111],"(SOEC":[112],"P4),":[113],"at":[114],"time":[116,154],"points":[117],"(t0,":[118],"t2h,":[119],"t4h).":[120],"Findings":[121],"reveal":[122],"baseline":[123],"non-capacitated":[127],"demonstrate":[130],"condition-":[131],"time-dependent":[133],"dynamics":[134,215],"capacitation.":[136,203],"Notably,":[137],"Principal":[138],"Component":[139],"Analysis":[140],"(PCA)":[141],"highlighted":[142],"7-KC":[143],"as":[144,167],"showing":[147],"largest":[149],"variation":[150],"across":[151],"conditions":[152],"points,":[155],"particularly":[156],"under":[157],"P4":[160],"condition.":[161],"7\u03b2-":[162],"7\u03b1-OHC":[164],"showed":[165],"stability":[166],"possibly":[168],"involved":[169],"distinct":[171],"contributions":[172],"processes.":[175],"These":[176],"results":[177],"suggest":[178],"potential":[180],"sperm":[185],"especially":[188],"7-KC,":[190],"offer":[192],"insights":[193],"into":[194],"modulation":[196],"physiological":[198],"cues":[201],"provides":[206],"foundation":[208],"understanding":[210],"implications":[212],"fertility":[217],"reproductive":[219],"biology.":[220]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-07-18T00:00:00"}