{"id":"https://openalex.org/W7168903975","doi":"https://doi.org/10.1186/s12866-026-05403-y","title":"Extended lag phases and variable antibiotic tolerance in \u03b2-lactam-induced small colony variants of Enterococcus faecalis","display_name":"Extended lag phases and variable antibiotic tolerance in \u03b2-lactam-induced small colony variants of Enterococcus faecalis","publication_year":2026,"publication_date":"2026-07-17","ids":{"openalex":"https://openalex.org/W7168903975","doi":"https://doi.org/10.1186/s12866-026-05403-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/42464162"},"language":"en","primary_location":{"id":"doi:10.1186/s12866-026-05403-y","doi":"https://doi.org/10.1186/s12866-026-05403-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12866-026-05403-y","pdf_url":null,"source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12866-026-05403-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073084209","display_name":"Lara Thieme","orcid":"https://orcid.org/0000-0002-5850-0417","observed_orcids":["https://orcid.org/0000-0002-5850-0417"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lara Thieme","raw_affiliation_strings":["Dynamics42 GmbH, Jena, 07745, Germany","Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany","Leibniz Center for Photonics in Infection Research, Jena, 07743, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dynamics42 GmbH, Jena, 07745, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany","institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I76198965"]},{"raw_affiliation_string":"Leibniz Center for Photonics in Infection Research, Jena, 07743, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032310670","display_name":"Kamran Ahmad Mirza","orcid":"https://orcid.org/0009-0008-1943-768X","observed_orcids":["https://orcid.org/0009-0008-1943-768X"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kamran A. Mirza","raw_affiliation_strings":["Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany","Leibniz Center for Photonics in Infection Research, Jena, 07743, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany","institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I76198965"]},{"raw_affiliation_string":"Leibniz Center for Photonics in Infection Research, Jena, 07743, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110464398","display_name":"Mehri Azimi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mehri Azimi","raw_affiliation_strings":["Department Cellular and Molecular Medicine, Department of Medicine, University of Ottawa, Ottawa, ON, K1N 9A9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Cellular and Molecular Medicine, Department of Medicine, University of Ottawa, Ottawa, ON, K1N 9A9, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120432078","display_name":"Nicole Enslinger","orcid":"https://orcid.org/0009-0003-5094-9409","observed_orcids":["https://orcid.org/0009-0003-5094-9409"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicole Enslinger","raw_affiliation_strings":["Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany","institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084893467","display_name":"Mara Lohde","orcid":"https://orcid.org/0009-0009-1718-7231","observed_orcids":["https://orcid.org/0009-0009-1718-7231"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mara Lohde","raw_affiliation_strings":["Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany","institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058844738","display_name":"Mateusz Jundzill","orcid":"https://orcid.org/0009-0000-7264-9165","observed_orcids":["https://orcid.org/0009-0000-7264-9165"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mateusz Jundzill","raw_affiliation_strings":["Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany","Leibniz Center for Photonics in Infection Research, Jena, 07743, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany","institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I76198965"]},{"raw_affiliation_string":"Leibniz Center for Photonics in Infection Research, Jena, 07743, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006329781","display_name":"Christian Brandt","orcid":"https://orcid.org/0000-0002-7199-3957","observed_orcids":["https://orcid.org/0000-0002-7199-3957"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I4210140556","display_name":"InfectoGnostics Research Campus Jena","ror":"https://ror.org/03wysya92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210140556"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Brandt","raw_affiliation_strings":["InfectoGnostics Research Campus, Jena, 07743, Germany","Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"InfectoGnostics Research Campus, Jena, 07743, Germany","institution_ids":["https://openalex.org/I4210140556"]},{"raw_affiliation_string":"Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany","institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065659547","display_name":"Mathias Wilhelm Pletz","orcid":"https://orcid.org/0000-0001-8157-2753","observed_orcids":["https://orcid.org/0000-0001-8157-2753"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias W. Pletz","raw_affiliation_strings":["Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany","Leibniz Center for Photonics in Infection Research, Jena, 07743, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany","institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I76198965"]},{"raw_affiliation_string":"Leibniz Center for Photonics in Infection Research, Jena, 07743, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087795864","display_name":"Oliwia Makarewicz","orcid":"https://orcid.org/0000-0002-4404-1862","observed_orcids":["https://orcid.org/0000-0002-4404-1862"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliwia Makarewicz","raw_affiliation_strings":["Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany. Oliwia.makarewicz@med.uni-jena.de","Leibniz Center for Photonics in Infection Research, Jena, 07743, Germany. Oliwia.makarewicz@med.uni-jena.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, Jena, 07747, Germany. Oliwia.makarewicz@med.uni-jena.de","institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I76198965"]},{"raw_affiliation_string":"Leibniz Center for Photonics in Infection Research, Jena, 07743, Germany. Oliwia.makarewicz@med.uni-jena.de","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55134453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.5175999999046326,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.5175999999046326,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.2667999863624573,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.11180000007152557,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-colony-variants","display_name":"small colony variants","score":0.9739999771118164},{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":1.0},{"id":"https://openalex.org/keywords/beta-lactam-antibiotics","display_name":"beta-lactam antibiotics","score":0.9039999842643738},{"id":"https://openalex.org/keywords/antibiotic-tolerance","display_name":"antibiotic tolerance","score":0.9160000085830688},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.6650000214576721},{"id":"https://openalex.org/keywords/lag-phase","display_name":"lag phase","score":0.781000018119812},{"id":"https://openalex.org/keywords/growth-kinetics","display_name":"growth kinetics","score":0.8240000009536743},{"id":"https://openalex.org/keywords/minimum-bactericidal-concentration","display_name":"minimum bactericidal concentration","score":0.9190000295639038},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.949999988079071},{"id":"https://openalex.org/keywords/penicillin-g","display_name":"penicillin G","score":0.8460000157356262},{"id":"https://openalex.org/keywords/ceftriaxone","display_name":"ceftriaxone","score":1.0},{"id":"https://openalex.org/keywords/combination-antibiotic-therapy","display_name":"combination antibiotic therapy","score":0.656000018119812},{"id":"https://openalex.org/keywords/galleria-mellonella-infection-model","display_name":"Galleria mellonella infection model","score":0.8619999885559082},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.8650000095367432},{"id":"https://openalex.org/keywords/persistent-infection","display_name":"persistent infection","score":0.6679999828338623},{"id":"https://openalex.org/keywords/phenotypic-adaptation","display_name":"phenotypic adaptation","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9050999879837036},{"id":"https://openalex.org/C2779895986","wikidata":"https://www.wikidata.org/wiki/Q140014","display_name":"Enterococcus faecalis","level":4,"score":0.779699981212616},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5891000032424927},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5102999806404114},{"id":"https://openalex.org/C2780585763","wikidata":"https://www.wikidata.org/wiki/Q517258","display_name":"Enterococcus","level":3,"score":0.4968000054359436},{"id":"https://openalex.org/C136622501","wikidata":"https://www.wikidata.org/wiki/Q6934671","display_name":"Multidrug tolerance","level":4,"score":0.48249998688697815},{"id":"https://openalex.org/C75778745","wikidata":"https://www.wikidata.org/wiki/Q342626","display_name":"Lag","level":2,"score":0.42879998683929443},{"id":"https://openalex.org/C190612196","wikidata":"https://www.wikidata.org/wiki/Q180502","display_name":"Parasitology","level":2,"score":0.3747999966144562},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.35589998960494995},{"id":"https://openalex.org/C2993377847","wikidata":"https://www.wikidata.org/wiki/Q1771903","display_name":"Lag time","level":2,"score":0.3221000134944916},{"id":"https://openalex.org/C126116589","wikidata":"https://www.wikidata.org/wiki/Q7175","display_name":"Mycology","level":2,"score":0.3208000063896179},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.31630000472068787},{"id":"https://openalex.org/C2778663903","wikidata":"https://www.wikidata.org/wiki/Q140018","display_name":"Streptococcaceae","level":3,"score":0.3073999881744385},{"id":"https://openalex.org/C2777677444","wikidata":"https://www.wikidata.org/wiki/Q140010","display_name":"Enterococcus faecium","level":3,"score":0.27559998631477356},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.2508000135421753}],"mesh":[{"descriptor_ui":"D000097902","descriptor_name":"beta Lactam Antibiotics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097902","descriptor_name":"beta Lactam Antibiotics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097902","descriptor_name":"beta Lactam Antibiotics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097902","descriptor_name":"beta Lactam Antibiotics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002443","descriptor_name":"Ceftriaxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002443","descriptor_name":"Ceftriaxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002443","descriptor_name":"Ceftriaxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002443","descriptor_name":"Ceftriaxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009036","descriptor_name":"Moths","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D009036","descriptor_name":"Moths","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D009036","descriptor_name":"Moths","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D009036","descriptor_name":"Moths","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016908","descriptor_name":"Gram-Positive Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016908","descriptor_name":"Gram-Positive Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016908","descriptor_name":"Gram-Positive Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016908","descriptor_name":"Gram-Positive Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12866-026-05403-y","doi":"https://doi.org/10.1186/s12866-026-05403-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12866-026-05403-y","pdf_url":null,"source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},{"id":"pmid:42464162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42464162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:aff54c8971944b888d4ed20ebe4e5dac","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/aff54c8971944b888d4ed20ebe4e5dac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Microbiology, Vol 26, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13377840","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13377840/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Microbiol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12866-026-05403-y","doi":"https://doi.org/10.1186/s12866-026-05403-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12866-026-05403-y","pdf_url":null,"source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.5435308218002319}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324588","display_name":"Universit\u00e4tsklinikum Jena","ror":"https://ror.org/035rzkx15"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1980580626","https://openalex.org/W2016691753","https://openalex.org/W2051780892","https://openalex.org/W2093728268","https://openalex.org/W2096404632","https://openalex.org/W2134454646","https://openalex.org/W2155626221","https://openalex.org/W2339518458","https://openalex.org/W2341166238","https://openalex.org/W2562944419","https://openalex.org/W2762696494","https://openalex.org/W2788228074","https://openalex.org/W2789843538","https://openalex.org/W2793298145","https://openalex.org/W2893372179","https://openalex.org/W2898044297","https://openalex.org/W2977818680","https://openalex.org/W3080710666","https://openalex.org/W3087564697","https://openalex.org/W3089641580","https://openalex.org/W3206501079","https://openalex.org/W3206816321","https://openalex.org/W4205177984","https://openalex.org/W4211125726","https://openalex.org/W4313458759","https://openalex.org/W4321373705","https://openalex.org/W4362557431","https://openalex.org/W4379376495","https://openalex.org/W4399682661","https://openalex.org/W4400132918","https://openalex.org/W4400461722","https://openalex.org/W4403671413","https://openalex.org/W4415294133"],"related_works":[],"abstract_inverted_index":{"Small":[0],"colony":[1,35],"variants":[2,148],"(SCVs)":[3],"of":[4,220,226],"Enterococcus":[5],"faecalis":[6,197],"are":[7],"associated":[8,132],"with":[9,133,144],"persistent":[10],"infections":[11],"and":[12,20,46,49,60,65,81,103,201,231],"have":[13],"been":[14],"linked":[15],"to":[16,32],"altered":[17],"antibiotic":[18,54],"susceptibility":[19,55,109],"tolerance.":[21],"Here,":[22],"we":[23],"investigated":[24],"SCVs":[25,38,76,138,176,194],"emerging":[26],"under":[27,43],"\u03b2-lactam":[28],"exposure":[29,92],"in":[30,41,186,195],"comparison":[31],"corresponding":[33],"normal":[34],"phenotypes":[36],"(NCPs).":[37],"were":[39,68,86,129],"generated":[40],"vitro":[42],"benzylpenicillin,":[44],"ceftriaxone,":[45,163],"combination":[47],"therapy":[48],"characterized":[50],"by":[51],"growth":[52,79,209],"kinetics,":[53],"(MIC),":[56],"killing":[57,122,151],"dynamics":[58,67,123,210],"(MDK),":[59],"bactericidal":[61,165],"activity":[62,166],"(MBC).":[63],"Virulence":[64],"infection":[66,179],"further":[69,157],"assessed":[70],"using":[71],"the":[72,172,224],"Galleria":[73],"mellonella":[74,174],"model.":[75],"displayed":[77],"reduced":[78,108,187],"rates":[80],"prolonged":[82,140],"lag":[83],"phases,":[84],"which":[85],"partially":[87],"reversible":[88,202],"upon":[89],"subcultivation.":[90],"\u03b2-Lactam":[91],"induced":[93],"substantial":[94],"MIC":[95,216],"increases":[96],"across":[97,169],"multiple":[98],"lineages,":[99],"including":[100],"both":[101],"SCV":[102,134,221],"NCP":[104],"variants,":[105],"indicating":[106],"that":[107,128,193],"represents":[110],"a":[111,117,199],"general":[112],"adaptive":[113,203],"response":[114],"rather":[115,211],"than":[116,212],"phenotype-specific":[118],"trait.":[119],"In":[120,171],"contrast,":[121],"revealed":[124],"heterogeneous":[125,200],"tolerance":[126,206],"profiles":[127],"not":[130,183],"consistently":[131],"formation.":[135],"While":[136],"selected":[137],"exhibited":[139],"MDK":[141],"values":[142,156],"consistent":[143],"increased":[145],"tolerance,":[146,230],"other":[147],"showed":[149,177],"rapid":[150],"despite":[152],"elevated":[153],"MICs.":[154],"MBC":[155],"supported":[158],"this":[159],"dissociation,":[160],"particularly":[161],"for":[162],"where":[164],"remained":[167],"limited":[168],"variants.":[170],"G.":[173],"model,":[175],"delayed":[178],"onset":[180],"but":[181],"did":[182],"uniformly":[184],"result":[185],"virulence.":[188],"Together,":[189],"these":[190],"findings":[191],"indicate":[192],"E.":[196],"represent":[198],"state.":[204],"Antibiotic":[205],"depends":[207],"on":[208],"phenotype":[213],"alone,":[214],"while":[215],"shifts":[217],"occur":[218],"independently":[219],"formation,":[222],"highlighting":[223],"importance":[225],"distinguishing":[227],"between":[228],"resistance,":[229],"phenotypic":[232],"adaptation.":[233]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-07-17T00:00:00"}
