{"id":"https://openalex.org/W7168733162","doi":"https://doi.org/10.1097/aln.0000000000006257","title":"Effect of Fractalkine Signaling on Neuroinflammation and Neuropathic Pain\u2013like Behavior in Mice","display_name":"Effect of Fractalkine Signaling on Neuroinflammation and Neuropathic Pain\u2013like Behavior in Mice","publication_year":2026,"publication_date":"2026-07-16","ids":{"openalex":"https://openalex.org/W7168733162","doi":"https://doi.org/10.1097/aln.0000000000006257","pmid":"https://pubmed.ncbi.nlm.nih.gov/42461101"},"language":"en","primary_location":{"id":"doi:10.1097/aln.0000000000006257","doi":"https://doi.org/10.1097/aln.0000000000006257","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aln.0000000000006257","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102734706","display_name":"Qingyuan Fan","orcid":"https://orcid.org/0000-0003-4749-4418","observed_orcids":["https://orcid.org/0000-0003-4749-4418"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingyuan Fan","raw_affiliation_strings":["Qingyuan Fan, M.D., Ph.D.: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingyuan Fan, M.D., Ph.D.: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141045025","display_name":"Jihye Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jihye Kim","raw_affiliation_strings":["Jihye Kim, Ph.D.: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jihye Kim, Ph.D.: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436650","display_name":"Jie Zhang","orcid":"https://orcid.org/0000-0001-8264-5950","observed_orcids":["https://orcid.org/0000-0001-8264-5950","https://orcid.org/0000-0002-3354-0690","https://orcid.org/0009-0004-5802-3392"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Zhang","raw_affiliation_strings":["Jie Zhang, M.D., Ph.D.: Departments of Pain Management and Neurosciences, Neurological Institute, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jie Zhang, M.D., Ph.D.: Departments of Pain Management and Neurosciences, Neurological Institute, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141008979","display_name":"Quanri Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quanri Zhang","raw_affiliation_strings":["Quanri Zhang, Ph.D.: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quanri Zhang, Ph.D.: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057058278","display_name":"Mihyun Hwang","orcid":"https://orcid.org/0000-0003-2639-0265","observed_orcids":["https://orcid.org/0000-0003-2639-0265"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mi-Hyun Hwang","raw_affiliation_strings":["Mi-Hyun Hwang, Ph.D.: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":"https://orcid.org/0000-0003-2639-0265","affiliations":[{"raw_affiliation_string":"Mi-Hyun Hwang, Ph.D.: Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160017366","display_name":"Jing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["Jing Li, M.D.: Departments of Pain Management and Neurosciences, Neurological Institute, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jing Li, M.D.: Departments of Pain Management and Neurosciences, Neurological Institute, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141008393","display_name":"Fei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fei Li","raw_affiliation_strings":["Fei Li, M.D.: Departments of Pain Management and Neurosciences, Neurological Institute, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fei Li, M.D.: Departments of Pain Management and Neurosciences, Neurological Institute, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140991365","display_name":"Yan Yin","orcid":"https://orcid.org/0000-0003-2450-2542","observed_orcids":["https://orcid.org/0000-0003-2450-2542"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Yin","raw_affiliation_strings":["Yan Yin, M.D.: Departments of Pain Management and Neurosciences, Neurological Institute, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":"https://orcid.org/0000-0003-2450-2542","affiliations":[{"raw_affiliation_string":"Yan Yin, M.D.: Departments of Pain Management and Neurosciences, Neurological Institute, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102027604","display_name":"Yingchun Han","orcid":"https://orcid.org/0000-0003-1937-7871","observed_orcids":["https://orcid.org/0000-0003-1937-7871"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingchun Han","raw_affiliation_strings":["Yingchun Han, M.D., Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yingchun Han, M.D., Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136700216","display_name":"Karan Shah","orcid":"https://orcid.org/0000-0003-1155-0246","observed_orcids":["https://orcid.org/0000-0003-1155-0246"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karan Shah","raw_affiliation_strings":["Karan Shah, M.S.: Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":"https://orcid.org/0000-0003-1155-0246","affiliations":[{"raw_affiliation_string":"Karan Shah, M.S.: Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038360689","display_name":"Riqiang Yan","orcid":"https://orcid.org/0000-0001-7195-7617","observed_orcids":["https://orcid.org/0000-0001-7195-7617"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Riqiang Yan","raw_affiliation_strings":["Riqiang Yan, Ph.D.: Department of Neuroscience, University of Connecticut, Farmington, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Riqiang Yan, Ph.D.: Department of Neuroscience, University of Connecticut, Farmington, Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103131602","display_name":"Jianguo Cheng","orcid":"https://orcid.org/0000-0002-2318-0812","observed_orcids":["https://orcid.org/0000-0002-2318-0812"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianguo Cheng","raw_affiliation_strings":["Jianguo Cheng, M.D., Ph.D.: Departments of Pain Management and Neurosciences, Neurological Institute, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":"https://orcid.org/0000-0002-2318-0812","affiliations":[{"raw_affiliation_string":"Jianguo Cheng, M.D., Ph.D.: Departments of Pain Management and Neurosciences, Neurological Institute, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6917,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.93284269,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cx3cl1","display_name":"fractalkine","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cx3cr1","display_name":"CX3CR1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/chronic-constriction-injury","display_name":"chronic constriction injury","score":0.8379999995231628},{"id":"https://openalex.org/keywords/sciatic-nerve-injury","display_name":"sciatic nerve injury","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tgf-beta-smad2-3-signaling","display_name":"TGF-\u03b2/Smad2/3 signaling","score":0.949999988079071},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/neuroimmune-interactions","display_name":"neuroimmune interactions","score":0.6570000052452087},{"id":"https://openalex.org/keywords/mechanical-allodynia","display_name":"mechanical allodynia","score":0.7929999828338623},{"id":"https://openalex.org/keywords/thermal-hyperalgesia","display_name":"thermal hyperalgesia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8640000224113464}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8855999708175659},{"id":"https://openalex.org/C82321936","wikidata":"https://www.wikidata.org/wiki/Q14907780","display_name":"CX3CL1","level":5,"score":0.7792999744415283},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.770799994468689},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7027000188827515},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6703000068664551},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6541000008583069},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6134999990463257},{"id":"https://openalex.org/C31179232","wikidata":"https://www.wikidata.org/wiki/Q14911549","display_name":"CX3CR1","level":5,"score":0.5738999843597412},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.49480000138282776},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.486299991607666},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4138000011444092},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3970000147819519},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3813000023365021},{"id":"https://openalex.org/C5858377","wikidata":"https://www.wikidata.org/wiki/Q986112","display_name":"CXCL10","level":4,"score":0.3727000057697296},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33899998664855957},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3278000056743622},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32190001010894775},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3109999895095825},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.29910001158714294},{"id":"https://openalex.org/C2779828298","wikidata":"https://www.wikidata.org/wiki/Q4035577","display_name":"CD36","level":3,"score":0.28029999136924744},{"id":"https://openalex.org/C2776588550","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve injury","level":3,"score":0.271699994802475},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.2621000111103058},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2563999891281128}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/aln.0000000000006257","doi":"https://doi.org/10.1097/aln.0000000000006257","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aln.0000000000006257","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:42461101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42461101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W1555940993","https://openalex.org/W1602487811","https://openalex.org/W1652900453","https://openalex.org/W1913122697","https://openalex.org/W1964756626","https://openalex.org/W1984115097","https://openalex.org/W1989833758","https://openalex.org/W1996260034","https://openalex.org/W2000770184","https://openalex.org/W2001743906","https://openalex.org/W2001952628","https://openalex.org/W2003926510","https://openalex.org/W2005804545","https://openalex.org/W2008669330","https://openalex.org/W2008794259","https://openalex.org/W2033283555","https://openalex.org/W2040017947","https://openalex.org/W2041670239","https://openalex.org/W2051515361","https://openalex.org/W2056688527","https://openalex.org/W2066663538","https://openalex.org/W2071306907","https://openalex.org/W2072724964","https://openalex.org/W2075715972","https://openalex.org/W2077196241","https://openalex.org/W2084271278","https://openalex.org/W2085600478","https://openalex.org/W2094660330","https://openalex.org/W2096330567","https://openalex.org/W2098853912","https://openalex.org/W2100641995","https://openalex.org/W2113107925","https://openalex.org/W2117478398","https://openalex.org/W2119368421","https://openalex.org/W2126972955","https://openalex.org/W2134557769","https://openalex.org/W2135247591","https://openalex.org/W2135340760","https://openalex.org/W2145384905","https://openalex.org/W2145738273","https://openalex.org/W2155756882","https://openalex.org/W2159443316","https://openalex.org/W2161057248","https://openalex.org/W2161768939","https://openalex.org/W2164655074","https://openalex.org/W2196308323","https://openalex.org/W2203955786","https://openalex.org/W2344400190","https://openalex.org/W2468871454","https://openalex.org/W2535664532","https://openalex.org/W2749719837","https://openalex.org/W2770429776","https://openalex.org/W2786438865","https://openalex.org/W2786697307","https://openalex.org/W2795978601","https://openalex.org/W2896958428","https://openalex.org/W2921692604","https://openalex.org/W2922530701","https://openalex.org/W2950336920","https://openalex.org/W2951726419","https://openalex.org/W2989415830","https://openalex.org/W2989711540","https://openalex.org/W2995210504","https://openalex.org/W2999832851","https://openalex.org/W3014550437","https://openalex.org/W3018792857","https://openalex.org/W3024344030","https://openalex.org/W3132348208","https://openalex.org/W3137886092","https://openalex.org/W3160287454","https://openalex.org/W3183462396","https://openalex.org/W3197976728","https://openalex.org/W3214400783","https://openalex.org/W4211063028","https://openalex.org/W4211119836","https://openalex.org/W4293900457","https://openalex.org/W4297180989","https://openalex.org/W4307231822","https://openalex.org/W4360985066"],"related_works":["https://openalex.org/W3183462396","https://openalex.org/W2006680088","https://openalex.org/W3031238268","https://openalex.org/W2001743906","https://openalex.org/W2052193782","https://openalex.org/W1602487811","https://openalex.org/W1973251099","https://openalex.org/W2164655074","https://openalex.org/W4399210054","https://openalex.org/W3204410038"],"abstract_inverted_index":{"BACKGROUND:":[0],"Neuropathic":[1,82],"pain":[2],"is":[3,22],"the":[4,17,26,37,49,64,70,74,90,159,179,222,259,264,269,274],"most":[5],"prevalent":[6],"and":[7,19,45,73,105,115,122,130,138,141,152,167,170,175,213,227,241,252,268],"incapacitating":[8],"form":[9],"of":[10,28,39,51,60,66,158,165,172,181,188,198],"chronic":[11,93],"pain.":[12,53],"Understanding":[13],"its":[14,182],"pathogenesis":[15,50,65],"at":[16],"cellular":[18],"molecular":[20,129],"levels":[21],"crucial":[23],"to":[24,108,163],"guide":[25],"development":[27],"new":[29],"therapeutics.":[30],"A":[31],"major":[32],"controversy":[33],"has":[34],"been":[35],"on":[36],"roles":[38],"Fractalkine":[40],"(CX3CL1)":[41],"signaling":[42,62,112,154,237,249],"between":[43,250],"neurons":[44],"immune":[46,253],"cells":[47,254],"in":[48,63,87,101,178,190,200],"neuropathic":[52,67,243],"This":[54],"study":[55],"investigated":[56],"two":[57,256],"distinct":[58,110,257],"pathways":[59],"CX3CL1":[61,111,118,153,199,218,236,248,265,275],"pain,":[68],"namely":[69],"CX3CR1-dependent":[71,260],"pathway":[72,261,271],"transforming":[75],"growth":[76],"factor":[77],"\u03b2":[78],"(TGF-\u03b2)/Smad2/3-dependent":[79],"pathway.":[80],"METHODS:":[81],"pain-like":[83,244],"behavior":[84],"was":[85],"induced":[86],"mice":[88,107,192,202],"using":[89,128],"sciatic":[91,160],"nerve":[92,161],"constriction":[94],"injury":[95,151],"(CCI)":[96],"model.":[97],"Experiments":[98],"were":[99,126],"performed":[100],"wild-type,":[102],"CX3CR1":[103,189],"knockout,":[104],"CX3CL1-transgenic":[106],"examine":[109],"pathways.":[113],"Microglia":[114],"macrophage":[116],"activation,":[117,212],"processing,":[119],"TGF-\u03b2/Smad2/3":[120,205],"signaling,":[121,206],"inflammatory":[123],"cytokine":[124],"expression":[125,147,180],"assessed":[127],"immunohistochemical":[131],"techniques.":[132],"Behavioral":[133],"assays":[134],"quantified":[135],"mechanical":[136],"allodynia":[137],"thermal":[139],"hyperalgesia,":[140],"transcriptomic":[142],"analyses":[143],"evaluated":[144],"neuroimmune":[145,228],"gene":[146],"changes":[148],"after":[149],"CCI":[150,157],"manipulations.":[155],"RESULTS:":[156],"led":[162],"activation":[164],"microglia":[166,211],"macrophages,":[168],"cleavage":[169],"consumption":[171],"full-length":[173],"CX3CL1,":[174],"a":[176],"decrease":[177],"downstream":[183],"TGF-\u03b2":[184],"family":[185],"proteins.":[186],"Deletion":[187],"CX3CR1-knockout":[191],"exacerbated":[193],"CCI-induced":[194,215,223],"neuroinflammation.":[195],"Conversely,":[196],"overexpression":[197,219],"CX3CL1-Tg":[201],"significantly":[203],"enhanced":[204],"reduced":[207],"proinflammatory":[208],"cytokines,":[209],"inhibited":[210],"alleviated":[214],"hyperalgesia.":[216],"Moreover,":[217],"effectively":[220,238],"reversed":[221],"differentially":[224],"expressed":[225],"genes":[226],"responses.":[229],"CONCLUSIONS:":[230],"These":[231],"findings":[232],"demonstrate":[233],"that":[234],"enhancing":[235],"mitigates":[239],"neuroinflammation":[240],"alleviates":[242],"behavior,":[245],"likely":[246],"through":[247,263,273],"neuronal":[251],"via":[255],"pathways:":[258],"mediated":[262,272],"N":[266],"terminus":[267],"TGF-\u03b2-dependent":[270],"C":[276],"terminus.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-07-17T00:00:00"}
