{"id":"https://openalex.org/W7168570956","doi":"https://doi.org/10.64898/2026.07.13.26357981","title":"Clonal hematopoiesis is enriched in melanoma and associated with genotype-specific differences in tumor growth and survival","display_name":"Clonal hematopoiesis is enriched in melanoma and associated with genotype-specific differences in tumor growth and survival","publication_year":2026,"publication_date":"2026-07-16","ids":{"openalex":"https://openalex.org/W7168570956","doi":"https://doi.org/10.64898/2026.07.13.26357981"},"language":"en","primary_location":{"id":"doi:10.64898/2026.07.13.26357981","doi":"https://doi.org/10.64898/2026.07.13.26357981","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.13.26357981","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/07/16/2026.07.13.26357981.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/07/16/2026.07.13.26357981.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114296899","display_name":"Mason Nicholas Alford-Holloway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mason Alford-Holloway","raw_affiliation_strings":["The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075392372","display_name":"Sarah C. Reed","orcid":"https://orcid.org/0000-0003-2191-6643","observed_orcids":["https://orcid.org/0000-0003-2191-6643"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah C. Reed","raw_affiliation_strings":["Medical Scientist Training Program, Vanderbilt University School of Medicine, Nashville, TN","The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Scientist Training Program, Vanderbilt University School of Medicine, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044078412","display_name":"Yash Pershad","orcid":"https://orcid.org/0000-0002-2282-1403","observed_orcids":["https://orcid.org/0000-0002-2282-1403"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yash Pershad","raw_affiliation_strings":["The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002232110","display_name":"Joseph C. Van Amburg","orcid":"https://orcid.org/0000-0002-1410-6995","observed_orcids":["https://orcid.org/0000-0002-1410-6995"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph C. Van Amburg","raw_affiliation_strings":["The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070074526","display_name":"Chad R. Potts","orcid":"https://orcid.org/0000-0003-2319-2474","observed_orcids":["https://orcid.org/0000-0003-2319-2474"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad Potts","raw_affiliation_strings":["The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051485142","display_name":"Sanjay Ram Mohan","orcid":"https://orcid.org/0000-0002-6715-6697","observed_orcids":["https://orcid.org/0000-0002-6715-6697"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay R. Mohan","raw_affiliation_strings":["The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034074869","display_name":"Leo Y. Luo","orcid":"https://orcid.org/0000-0002-3061-4287","observed_orcids":["https://orcid.org/0000-0002-3061-4287"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leo Y. Luo","raw_affiliation_strings":["The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008012217","display_name":"Paul Brent Ferrell","orcid":"https://orcid.org/0000-0003-1140-9154","observed_orcids":["https://orcid.org/0000-0003-1140-9154"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Brent Ferrell","raw_affiliation_strings":["The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049400849","display_name":"Michael Robert Savona","orcid":"https://orcid.org/0000-0003-3763-5504","observed_orcids":["https://orcid.org/0000-0003-3763-5504"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Savona","raw_affiliation_strings":["The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091723009","display_name":"Ben Ho Park","orcid":"https://orcid.org/0000-0001-8119-2291","observed_orcids":["https://orcid.org/0000-0001-8119-2291"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben Ho Park","raw_affiliation_strings":["The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025067315","display_name":"Douglas Buckner Johnson","orcid":"https://orcid.org/0000-0002-6390-773X","observed_orcids":["https://orcid.org/0000-0002-6390-773X"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas B. Johnson","raw_affiliation_strings":["The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012759454","display_name":"Alexander G. Bick","orcid":"https://orcid.org/0000-0001-5824-9595","observed_orcids":["https://orcid.org/0000-0001-5824-9595"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander G. Bick","raw_affiliation_strings":["Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN","The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061478349","display_name":"Ashwin Kishtagari","orcid":"https://orcid.org/0000-0003-1149-4571","observed_orcids":["https://orcid.org/0000-0003-1149-4571"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ashwin Kishtagari","raw_affiliation_strings":["The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Vanderbilt-Ingram Cancer Center, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061478349"],"corresponding_institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.7896000146865845,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.7896000146865845,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.11720000207424164,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.03229999914765358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonal-hematopoiesis-of-indeterminate-potential","display_name":"clonal hematopoiesis of indeterminate potential","score":0.9890000224113464},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tet2","display_name":"TET2","score":0.8259999752044678},{"id":"https://openalex.org/keywords/dnmt3a","display_name":"DNMT3A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.7369999885559082},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7319999933242798},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9629999995231628},{"id":"https://openalex.org/keywords/clone-size","display_name":"clone size","score":0.6349999904632568},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.800000011920929},{"id":"https://openalex.org/keywords/syngeneic-mouse-model","display_name":"syngeneic mouse model","score":0.7279999852180481},{"id":"https://openalex.org/keywords/melanoma-risk-stratification","display_name":"melanoma risk stratification","score":0.824999988079071},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5910000205039978},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.6399999856948853},{"id":"https://openalex.org/keywords/advanced-melanoma","display_name":"advanced melanoma","score":0.625},{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"somatic hypermutation","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.9120000004768372},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6366999745368958},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5329999923706055},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5274999737739563},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5203999876976013},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.47589999437332153},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4542999863624573},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45419999957084656},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.4424000084400177},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4327000081539154},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.4262999892234802},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.3612000048160553},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3467999994754791},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32850000262260437},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.32749998569488525},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31439998745918274},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3052999973297119},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.30250000953674316},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.2651999890804291},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.2644999921321869},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2635999917984009},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.25459998846054077}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.07.13.26357981","doi":"https://doi.org/10.64898/2026.07.13.26357981","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.13.26357981","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/07/16/2026.07.13.26357981.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.07.13.26357981","doi":"https://doi.org/10.64898/2026.07.13.26357981","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.13.26357981","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/07/16/2026.07.13.26357981.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6921318769454956,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7168570956.pdf","grobid_xml":"https://content.openalex.org/works/W7168570956.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7162578693","https://openalex.org/W4413789192","https://openalex.org/W4393092318","https://openalex.org/W4409690607","https://openalex.org/W4410817662","https://openalex.org/W4399328009","https://openalex.org/W4405072689","https://openalex.org/W4390660487","https://openalex.org/W4417018439","https://openalex.org/W7214311407"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"The":[2],"clinical":[3,55,229,300,353],"significance":[4],"of":[5,8,86,236,260,302,406,412,433],"clonal":[6],"hematopoiesis":[7,259],"indeterminate":[9,261],"potential":[10,242,262,418],"(CHIP)":[11,263],"in":[12,64,74,96,216,224,304,346,388,440],"melanoma":[13,39,49,68,83,103,134,157,172,217,225,245,333,365,413],"remains":[14,316],"incompletely":[15,317],"defined,":[16],"particularly":[17,306],"with":[18,48,107,132,136,149,168,177,184,188,199,208,332,342,363,374,378,425],"respect":[19],"to":[20,42,269,294,419],"CHIP":[21,45,60,127,142,181,213,238,287,303,308,327,337,407],"genotype,":[22,309,315],"clone":[23,143,310,338],"size,":[24,311],"and":[25,36,53,62,89,92,111,120,140,218,228,248,275,292,312,334,352,368],"somatic":[26],"mutations":[27,436],"(e.g":[28],"BRAF":[29,77,80,155,314,389],"mutations).":[30],"We":[31,58],"integrated":[32],"human":[33],"cohort":[34,69,104],"data":[35],"a":[37,65,75,153,241,409],"syngeneic":[38,76,154],"mouse":[40],"model":[41,85],"evaluate":[43],"whether":[44],"is":[46,214,252,264,328,340],"associated":[47,167,183,207,341,362],"risk,":[50],"tumor":[51,72,173,226,313,366,442],"growth,":[52],"differential":[54],"outcomes.":[56,230,250],"Methods":[57],"analyzed":[59],"prevalence":[61],"survival":[63,94,109,113,345,370],"large":[66],"treatment-unselected":[67,133],"(n=2,480),":[70],"evaluated":[71,116],"growth":[73,227,367],"-mutant":[78,390],"(":[79],"mut":[81,156],")":[82],"murine":[84,158,351],"TET2":[87,160,192,355],"-CHIP":[88,193,203],"DNMT3A":[90,164,202,359],"-CHIP,":[91,161,165,356,360],"assessed":[93],"outcomes":[95,277,371],"an":[97,146,265],"immune":[98,290,295],"checkpoint":[99,296],"inhibitor":[100],"(ICI)-treated":[101],"advanced":[102,179,376,426],"(n=361).":[105],"Associations":[106],"progression-free":[108],"(PFS)":[110],"overall":[112,344],"(OS)":[114],"were":[115],"using":[117],"Kaplan-Meier":[118],"analyses":[119,220],"multivariable":[121],"Cox":[122],"proportional":[123],"hazards":[124],"models.":[125],"Results":[126],"was":[128,166,182,204,361],"enriched":[129,215,329],"among":[130,330,372],"patients":[131,176,189,331,373,424],"compared":[135,187],"age/sex-matched":[137],"healthy":[138],"controls,":[139],"larger":[141,336],"size":[144,339],"showed":[145],"age-adjusted":[147,347],"association":[148,198],"inferior":[150,343],"OS.":[151,211],"In":[152,349],"model,":[159],"but":[162,298,357],"not":[163,205,358],"significantly":[169,206],"increased":[170,364],"primary":[171],"growth.":[174],"Among":[175],"ICI-treated":[178,375],"melanoma,":[180,305,377],"worse":[185,369],"OS":[186],"without":[190],"CHIP.":[191],"had":[194],"the":[195,299,417],"strongest":[196],"adverse":[197,276],"survival,":[200],"whereas":[201],"PFS":[209],"or":[210,399],"Conclusions":[212],"exploratory":[219,379],"demonstrate":[221],"genotype-specific":[222,237,410],"differences":[223],"These":[231,401],"findings":[232,402],"support":[233,403],"further":[234,404,429],"investigation":[235,405],"profiling":[239],"as":[240,408],"biomarker":[243,411],"for":[244,423],"risk":[246,383,421],"stratification":[247,422],"immunotherapy":[249],"What":[251,319],"already":[253],"known":[254],"on":[255],"this":[256,320,393],"topic":[257],"Clonal":[258],"age-associated":[266],"condition":[267],"linked":[268],"inflammation,":[270],"cardiovascular":[271],"disease,":[272],"hematologic":[273],"malignancy,":[274],"across":[278],"several":[279],"cancer":[280],"settings.":[281],"Prior":[282],"studies":[283,432],"have":[284],"suggested":[285],"that":[286,326,335,381,415],"may":[288,384],"influence":[289],"function":[291],"response":[293],"inhibitors,":[297],"relevance":[301],"by":[307],"defined.":[318],"study":[321,324,394],"adds":[322],"This":[323],"shows":[325],"analyses.":[348],"complementary":[350],"cohorts,":[354],"evidence":[380],"CHIP-associated":[382],"be":[385],"most":[386],"pronounced":[387],"melanoma.":[391,427],"How":[392],"might":[395],"affect":[396],"research,":[397],"practice":[398],"policy":[400],"biology":[414],"has":[416],"refine":[420],"They":[428],"motivate":[430],"mechanistic":[431],"how":[434],"hematopoietic":[435],"shape":[437],"antitumor":[438],"immunity":[439],"specific":[441],"genomic":[443],"contexts.":[444]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-07-17T00:00:00"}
