{"id":"https://openalex.org/W7168564408","doi":"https://doi.org/10.1161/atvbaha.126.323867","title":"Aortic Stenosis Hyalectan Remodeling Revealed by Proteomics and Glycoproteomics","display_name":"Aortic Stenosis Hyalectan Remodeling Revealed by Proteomics and Glycoproteomics","publication_year":2026,"publication_date":"2026-07-16","ids":{"openalex":"https://openalex.org/W7168564408","doi":"https://doi.org/10.1161/atvbaha.126.323867","pmid":"https://pubmed.ncbi.nlm.nih.gov/42460473"},"language":"en","primary_location":{"id":"doi:10.1161/atvbaha.126.323867","doi":"https://doi.org/10.1161/atvbaha.126.323867","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvbaha.126.323867","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13506200/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066928738","display_name":"Siqi Yin","orcid":"https://orcid.org/0000-0002-1360-6840","observed_orcids":["https://orcid.org/0000-0002-1360-6840"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Siqi Yin","raw_affiliation_strings":["National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025625690","display_name":"Ursula Mayr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ursula Mayr","raw_affiliation_strings":["National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073434822","display_name":"Javier Barallobre\u2010Barreiro","orcid":"https://orcid.org/0000-0001-6236-2304","observed_orcids":["https://orcid.org/0000-0001-6236-2304"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Javier Barallobre-Barreiro","raw_affiliation_strings":["National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)"],"raw_orcid":"https://orcid.org/0000-0001-6236-2304","affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050582468","display_name":"Elisa Duregotti","orcid":"https://orcid.org/0000-0003-1409-4063","observed_orcids":["https://orcid.org/0000-0003-1409-4063"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elisa Duregotti","raw_affiliation_strings":["National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082758671","display_name":"Anna Kate Barton","orcid":"https://orcid.org/0000-0002-7953-3015","observed_orcids":["https://orcid.org/0000-0002-7953-3015"]},"institutions":[{"id":"https://openalex.org/I4210087520","display_name":"British Heart Foundation Centre for Cardiovascular Science","ror":"https://ror.org/002g4nt27","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087520","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna K. Barton","raw_affiliation_strings":["British Heart Foundation Centre for Cardiovascular Science, College of Medicine and Veterinary Medicine, University of Edinburgh, United Kingdom (A.K.B., R.B., M.R.D.)"],"raw_orcid":"https://orcid.org/0000-0002-7953-3015","affiliations":[{"raw_affiliation_string":"British Heart Foundation Centre for Cardiovascular Science, College of Medicine and Veterinary Medicine, University of Edinburgh, United Kingdom (A.K.B., R.B., M.R.D.)","institution_ids":["https://openalex.org/I4210087520","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004308174","display_name":"Rong Bing","orcid":"https://orcid.org/0000-0002-8305-4906","observed_orcids":["https://orcid.org/0000-0002-8305-4906"]},"institutions":[{"id":"https://openalex.org/I4210087520","display_name":"British Heart Foundation Centre for Cardiovascular Science","ror":"https://ror.org/002g4nt27","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087520","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rong Bing","raw_affiliation_strings":["British Heart Foundation Centre for Cardiovascular Science, College of Medicine and Veterinary Medicine, University of Edinburgh, United Kingdom (A.K.B., R.B., M.R.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Heart Foundation Centre for Cardiovascular Science, College of Medicine and Veterinary Medicine, University of Edinburgh, United Kingdom (A.K.B., R.B., M.R.D.)","institution_ids":["https://openalex.org/I4210087520","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041067727","display_name":"Dyana Markose","orcid":"https://orcid.org/0000-0002-4739-8509","observed_orcids":["https://orcid.org/0000-0002-4739-8509"]},"institutions":[{"id":"https://openalex.org/I4210151647","display_name":"Centre for Inflammation Research","ror":"https://ror.org/05wcr1b38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210151647","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dyana Markose","raw_affiliation_strings":["Centre for Inflammation Research, Institute for Regeneration and Repair, College of Medicine and Veterinary Medicine, University of Edinburgh, United Kingdom (D.M., N.C.H.)"],"raw_orcid":"https://orcid.org/0000-0002-4739-8509","affiliations":[{"raw_affiliation_string":"Centre for Inflammation Research, Institute for Regeneration and Repair, College of Medicine and Veterinary Medicine, University of Edinburgh, United Kingdom (D.M., N.C.H.)","institution_ids":["https://openalex.org/I4210151647","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061059098","display_name":"Xiaoke Yin","orcid":"https://orcid.org/0000-0002-5172-0935","observed_orcids":["https://orcid.org/0000-0002-5172-0935"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Xiaoke Yin","raw_affiliation_strings":["National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)"],"raw_orcid":"https://orcid.org/0000-0002-5172-0935","affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082674887","display_name":"Padmini Sarathchandra","orcid":"https://orcid.org/0000-0001-9331-3046","observed_orcids":["https://orcid.org/0000-0001-9331-3046"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Padmini Sarathchandra","raw_affiliation_strings":["National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)"],"raw_orcid":"https://orcid.org/0000-0001-9331-3046","affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032711837","display_name":"Bhawana Singh","orcid":"https://orcid.org/0000-0002-5834-8320","observed_orcids":["https://orcid.org/0000-0002-5834-8320"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bhawana Singh","raw_affiliation_strings":["National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)"],"raw_orcid":"https://orcid.org/0000-0002-5834-8320","affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102950242","display_name":"Wen\u2010Yu Lin","orcid":"https://orcid.org/0000-0002-4979-2921","observed_orcids":["https://orcid.org/0000-0002-4979-2921"]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-Yu Lin","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (W.-Y.L.)"],"raw_orcid":"https://orcid.org/0000-0002-4979-2921","affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (W.-Y.L.)","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026597514","display_name":"Marika Fava","orcid":"https://orcid.org/0000-0002-3839-8988","observed_orcids":["https://orcid.org/0000-0002-3839-8988"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I32003884","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I32003884"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marika Fava","raw_affiliation_strings":["School of Cardiovascular and Metabolic Medicine &amp; Sciences, Faculty of Life Sciences &amp; Medicine, King\u2019s College London, British Heart Foundation Centre, London, United Kingdom (M.F., F.B., A.M.S., K.T.)"],"raw_orcid":"https://orcid.org/0000-0002-3839-8988","affiliations":[{"raw_affiliation_string":"School of Cardiovascular and Metabolic Medicine &amp; Sciences, Faculty of Life Sciences &amp; Medicine, King\u2019s College London, British Heart Foundation Centre, London, United Kingdom (M.F., F.B., A.M.S., K.T.)","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I32003884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029587581","display_name":"Lukas Emanuel Schmidt","orcid":"https://orcid.org/0000-0001-7565-1455","observed_orcids":["https://orcid.org/0000-0001-7565-1455"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Lukas E. Schmidt","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Austria (L.E.S., C.H., M.M.)"],"raw_orcid":"https://orcid.org/0000-0001-7565-1455","affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Austria (L.E.S., C.H., M.M.)","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087531300","display_name":"Ferheen Baig","orcid":"https://orcid.org/0009-0001-8038-4109","observed_orcids":["https://orcid.org/0009-0001-8038-4109"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I32003884","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I32003884"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ferheen Baig","raw_affiliation_strings":["School of Cardiovascular and Metabolic Medicine &amp; Sciences, Faculty of Life Sciences &amp; Medicine, King\u2019s College London, British Heart Foundation Centre, London, United Kingdom (M.F., F.B., A.M.S., K.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Cardiovascular and Metabolic Medicine &amp; Sciences, Faculty of Life Sciences &amp; Medicine, King\u2019s College London, British Heart Foundation Centre, London, United Kingdom (M.F., F.B., A.M.S., K.T.)","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I32003884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081626253","display_name":"Ajay M. Shah","orcid":"https://orcid.org/0000-0002-6547-0631","observed_orcids":["https://orcid.org/0000-0002-6547-0631","https://orcid.org/0000-0002-2825-3419"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I32003884","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I32003884"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ajay M. Shah","raw_affiliation_strings":["School of Cardiovascular and Metabolic Medicine &amp; Sciences, Faculty of Life Sciences &amp; Medicine, King\u2019s College London, British Heart Foundation Centre, London, United Kingdom (M.F., F.B., A.M.S., K.T.)"],"raw_orcid":"https://orcid.org/0000-0002-6547-0631","affiliations":[{"raw_affiliation_string":"School of Cardiovascular and Metabolic Medicine &amp; Sciences, Faculty of Life Sciences &amp; Medicine, King\u2019s College London, British Heart Foundation Centre, London, United Kingdom (M.F., F.B., A.M.S., K.T.)","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I32003884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101999780","display_name":"Konstantinos Theofilatos","orcid":"https://orcid.org/0000-0001-6799-0553","observed_orcids":["https://orcid.org/0000-0001-6799-0553"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I32003884","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I32003884"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Konstantinos Theofilatos","raw_affiliation_strings":["School of Cardiovascular and Metabolic Medicine &amp; Sciences, Faculty of Life Sciences &amp; Medicine, King\u2019s College London, British Heart Foundation Centre, London, United Kingdom (M.F., F.B., A.M.S., K.T.)"],"raw_orcid":"https://orcid.org/0000-0001-6799-0553","affiliations":[{"raw_affiliation_string":"School of Cardiovascular and Metabolic Medicine &amp; Sciences, Faculty of Life Sciences &amp; Medicine, King\u2019s College London, British Heart Foundation Centre, London, United Kingdom (M.F., F.B., A.M.S., K.T.)","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I32003884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111557618","display_name":"Najma Latif","orcid":"https://orcid.org/0000-0002-5622-2150","observed_orcids":["https://orcid.org/0000-0002-5622-2150"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Najma Latif","raw_affiliation_strings":["National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)"],"raw_orcid":"https://orcid.org/0000-0002-5622-2150","affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003272933","display_name":"Christian Hengstenberg","orcid":"https://orcid.org/0000-0002-8284-2994","observed_orcids":["https://orcid.org/0000-0002-8284-2994"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christian Hengstenberg","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Austria (L.E.S., C.H., M.M.)"],"raw_orcid":"https://orcid.org/0000-0002-8284-2994","affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Austria (L.E.S., C.H., M.M.)","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111830280","display_name":"Tam\u00e1s Radovits","orcid":"https://orcid.org/0009-0009-4090-776X","observed_orcids":["https://orcid.org/0009-0009-4090-776X"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Tam\u00e1s Radovits","raw_affiliation_strings":["Heart and Vascular Center, Department of Cardiology, Semmelweis University, Budapest, Hungary (T.R., B.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart and Vascular Center, Department of Cardiology, Semmelweis University, Budapest, Hungary (T.R., B.M.)","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086692319","display_name":"B\u00e9la P\u00e9ter Merkely","orcid":"https://orcid.org/0000-0001-6514-0723","observed_orcids":["https://orcid.org/0000-0001-6514-0723"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"B\u00e9la Merkely","raw_affiliation_strings":["Heart and Vascular Center, Department of Cardiology, Semmelweis University, Budapest, Hungary (T.R., B.M.)"],"raw_orcid":"https://orcid.org/0000-0001-6514-0723","affiliations":[{"raw_affiliation_string":"Heart and Vascular Center, Department of Cardiology, Semmelweis University, Budapest, Hungary (T.R., B.M.)","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091451403","display_name":"Neil Cowan Henderson","orcid":"https://orcid.org/0000-0002-2273-4094","observed_orcids":["https://orcid.org/0000-0002-2273-4094"]},"institutions":[{"id":"https://openalex.org/I4210151647","display_name":"Centre for Inflammation Research","ror":"https://ror.org/05wcr1b38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210151647","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neil C. Henderson","raw_affiliation_strings":["Centre for Inflammation Research, Institute for Regeneration and Repair, College of Medicine and Veterinary Medicine, University of Edinburgh, United Kingdom (D.M., N.C.H.)"],"raw_orcid":"https://orcid.org/0000-0002-2273-4094","affiliations":[{"raw_affiliation_string":"Centre for Inflammation Research, Institute for Regeneration and Repair, College of Medicine and Veterinary Medicine, University of Edinburgh, United Kingdom (D.M., N.C.H.)","institution_ids":["https://openalex.org/I4210151647","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065833063","display_name":"Marc Richard Dweck","orcid":"https://orcid.org/0000-0001-9847-5917","observed_orcids":["https://orcid.org/0000-0001-9847-5917"]},"institutions":[{"id":"https://openalex.org/I4210087520","display_name":"British Heart Foundation Centre for Cardiovascular Science","ror":"https://ror.org/002g4nt27","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087520","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marc R. Dweck","raw_affiliation_strings":["British Heart Foundation Centre for Cardiovascular Science, College of Medicine and Veterinary Medicine, University of Edinburgh, United Kingdom (A.K.B., R.B., M.R.D.)"],"raw_orcid":"https://orcid.org/0000-0001-9847-5917","affiliations":[{"raw_affiliation_string":"British Heart Foundation Centre for Cardiovascular Science, College of Medicine and Veterinary Medicine, University of Edinburgh, United Kingdom (A.K.B., R.B., M.R.D.)","institution_ids":["https://openalex.org/I4210087520","https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012684500","display_name":"Manuel Mayr","orcid":"https://orcid.org/0000-0002-0597-829X","observed_orcids":["https://orcid.org/0000-0002-0597-829X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","GB"],"is_corresponding":false,"raw_author_name":"Manuel Mayr","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Austria (L.E.S., C.H., M.M.)","National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)"],"raw_orcid":"https://orcid.org/0000-0002-0597-829X","affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Austria (L.E.S., C.H., M.M.)","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (S.Y., U.M., J.B.-B., E.D., X.Y., P.S., B.S., N.L., M.M.)","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.59032993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"9","first_page":"e323867","last_page":"e323867"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcific-aortic-valve-disease","display_name":"calcific aortic valve disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/aortic-stenosis","display_name":"aortic stenosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.9700000286102295},{"id":"https://openalex.org/keywords/adamts5","display_name":"ADAMTS5","score":0.7860000133514404},{"id":"https://openalex.org/keywords/versican","display_name":"versican","score":0.9750000238418579},{"id":"https://openalex.org/keywords/aggrecan","display_name":"aggrecan","score":1.0},{"id":"https://openalex.org/keywords/pentraxin-3","display_name":"pentraxin 3","score":0.972000002861023},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9010000228881836},{"id":"https://openalex.org/keywords/valvular-interstitial-cells","display_name":"valvular interstitial cells","score":0.8759999871253967},{"id":"https://openalex.org/keywords/osteoblast-like-cells","display_name":"osteoblast-like cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/aortic-valve-gradient","display_name":"aortic valve gradient","score":0.6700000166893005},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C159470946","wikidata":"https://www.wikidata.org/wiki/Q14888030","display_name":"Versican","level":4,"score":0.9624999761581421},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7105000019073486},{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.590499997138977},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5680000185966492},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5016999840736389},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.49900001287460327},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.46970000863075256},{"id":"https://openalex.org/C2779457992","wikidata":"https://www.wikidata.org/wiki/Q18028707","display_name":"Lumican","level":5,"score":0.4618000090122223},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.4212000072002411},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.40630000829696655},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40389999747276306},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4018999934196472},{"id":"https://openalex.org/C2781414266","wikidata":"https://www.wikidata.org/wiki/Q531019","display_name":"Aortic valve stenosis","level":3,"score":0.3650999963283539},{"id":"https://openalex.org/C2778916964","wikidata":"https://www.wikidata.org/wiki/Q14905499","display_name":"Biglycan","level":5,"score":0.3619999885559082},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.36000001430511475},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.3472000062465668},{"id":"https://openalex.org/C2776229121","wikidata":"https://www.wikidata.org/wiki/Q215620","display_name":"Heart valve","level":2,"score":0.31709998846054077},{"id":"https://openalex.org/C2777323849","wikidata":"https://www.wikidata.org/wiki/Q616003","display_name":"Aortic aneurysm","level":3,"score":0.31450000405311584},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3012000024318695},{"id":"https://openalex.org/C2781355080","wikidata":"https://www.wikidata.org/wiki/Q860167","display_name":"Bicuspid aortic valve","level":3,"score":0.2953000068664551},{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.2939000129699707},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.29089999198913574},{"id":"https://openalex.org/C2781460891","wikidata":"https://www.wikidata.org/wiki/Q422360","display_name":"Osteonectin","level":5,"score":0.28600001335144043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2856999933719635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27900001406669617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2768999934196472},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.2736999988555908},{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25699999928474426},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.2556000053882599}],"mesh":[{"descriptor_ui":"D000071116","descriptor_name":"ADAMTS5 Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D000071116","descriptor_name":"ADAMTS5 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071116","descriptor_name":"ADAMTS5 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000074085","descriptor_name":"Mice, Knockout, ApoE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000683","descriptor_name":"Serum Amyloid P-Component","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053674","descriptor_name":"Aggrecans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053675","descriptor_name":"Versicans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/atvbaha.126.323867","doi":"https://doi.org/10.1161/atvbaha.126.323867","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvbaha.126.323867","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},{"id":"pmid:42460473","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42460473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, thrombosis, and vascular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13506200","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13506200/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arterioscler Thromb Vasc Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13506200","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13506200/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arterioscler Thromb Vasc Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1779949457","https://openalex.org/W1844301679","https://openalex.org/W1964541789","https://openalex.org/W1971540719","https://openalex.org/W1983618726","https://openalex.org/W2010897349","https://openalex.org/W2027412679","https://openalex.org/W2030989962","https://openalex.org/W2039182800","https://openalex.org/W2040205330","https://openalex.org/W2057568088","https://openalex.org/W2060798250","https://openalex.org/W2069392482","https://openalex.org/W2073749468","https://openalex.org/W2096132697","https://openalex.org/W2126364995","https://openalex.org/W2148596250","https://openalex.org/W2150058785","https://openalex.org/W2158217645","https://openalex.org/W2176734656","https://openalex.org/W2261882824","https://openalex.org/W2326187533","https://openalex.org/W2395253867","https://openalex.org/W2405874976","https://openalex.org/W2571353526","https://openalex.org/W2618161716","https://openalex.org/W2754477979","https://openalex.org/W2762363211","https://openalex.org/W2795030131","https://openalex.org/W2803980412","https://openalex.org/W2892074258","https://openalex.org/W2926429704","https://openalex.org/W2962865476","https://openalex.org/W2966429506","https://openalex.org/W2972824451","https://openalex.org/W3033195625","https://openalex.org/W3044807317","https://openalex.org/W3122546528","https://openalex.org/W3132661792","https://openalex.org/W3206080769","https://openalex.org/W3216128438","https://openalex.org/W4226457922","https://openalex.org/W4296185277","https://openalex.org/W4306155798","https://openalex.org/W4309306080","https://openalex.org/W4362522958","https://openalex.org/W4383710497","https://openalex.org/W4386272631","https://openalex.org/W4411540231","https://openalex.org/W4417492474"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Calcific":[1],"aortic":[2,33,75,188,291,321],"valve":[3,230,264],"(AV)":[4],"disease":[5],"(CAVD)":[6],"is":[7,275],"recognized":[8],"as":[9,171],"an":[10],"active":[11],"pathological":[12],"process":[13],"involving":[14],"extracellular":[15,21,71],"matrix":[16,22,72],"remodeling.":[17],"This":[18,285],"study":[19,286],"investigates":[20],"remodeling":[23,73,289],"through":[24],"proteomic":[25],"analysis":[26,196],"and":[27,37,50,62,110,150,159,169,191,210,222,248,262],"a":[28,100,276,280],"novel":[29],"mouse":[30,101],"model":[31,102],"of":[32,70,92,173,197,216,272,278],"stenosis.":[34,322],"METHODS:":[35],"Proteomic":[36,109,195],"glycoproteomic":[38,111],"analyses":[39,112],"were":[40],"conducted":[41],"on":[42,74],"AV":[43,143,307],"leaflets":[44],"from":[45,199,296],"heart":[46],"transplant":[47],"donors":[48],"(n=29)":[49],"patients":[51],"with":[52,86,106,119,140,186,236,304],"CAVD":[53,56,117,302],"(n=17).":[54],"Each":[55],"sample":[57],"was":[58,129,184,244,255],"subdivided":[59],"into":[60],"noncalcified":[61,125],"calcified":[63,132,251],"regions.":[64,133],"To":[65],"investigate":[66],"the":[67,89],"functional":[68],"impact":[69],"stenosis,":[76],"we":[77],"crossed":[78],"apolipoprotein":[79],"E-deficient":[80],"mice":[81,87,205],"(":[82,94],"ApoE":[83],"\u2212/\u2212":[84],")":[85,97],"lacking":[88],"catalytic":[90],"domain":[91],"ADAMTS5":[93,253],"Adamts5":[95,176,200,311],"\u0394cat":[96,177,201,312],"to":[98,166,228,246,257,298],"generate":[99],"combining":[103],"hyalectan":[104,114,137,182,318],"accumulation":[105,115,183,261],"hypercholesterolemia.":[107],"RESULTS:":[108],"revealed":[113,206],"in":[116,124,131,136,142,223,239,250,300,306],"compared":[118],"control":[120],"valves.":[121],"Versican":[122],"predominated":[123],"regions,":[126],"while":[127,233],"aggrecan":[128,160,234,299],"enriched":[130],"The":[134],"shift":[135,295],"composition":[138],"correlated":[139],"changes":[141,305],"pressure":[144,308],"gradient,":[145],"elevated":[146,207],"osteoblast-like":[147,240],"cell":[148,266],"markers,":[149],"inflammatory":[151],"proteins,":[152],"most":[153],"notably":[154],"pentraxin":[155,211],"3.":[156],"Both":[157],"versican":[158,227,260,297],"are":[161],"characterized":[162],"by":[163,269],"their":[164],"ability":[165],"bind":[167],"hyaluronan":[168,247,282,288],"serve":[170],"substrates":[172],"ADAMTS5.":[174],"In":[175,310],"/ApoE":[178,202,313],"\u2212":[179,203,314],"/\u2212":[180,204,315],"mice,":[181,316],"associated":[185],"narrowed":[187],"cusp":[189],"separation":[190],"increased":[192,270],"post-AV":[193],"velocity.":[194],"AVs":[198],"versican,":[208],"aggrecan,":[209],"3,":[212],"recapitulating":[213],"key":[214],"features":[215],"human":[217,301],"CAVD.":[218],"Single-cell":[219],"RNA":[220],"sequencing":[221],"vitro":[224],"experiments":[225],"linked":[226],"activated":[229],"interstitial":[231,265],"cells,":[232],"colocalized":[235],"calcification":[237],"markers":[238],"cells.":[241],"Pentraxin":[242],"3":[243],"bound":[245],"accumulated":[249],"AVs.":[252],"deficiency":[254],"sufficient":[256],"cause":[258],"intact":[259],"promote":[263],"activation,":[267],"accompanied":[268],"expression":[271],"osteopontin.":[273],"Osteopontin":[274],"ligand":[277],"CD44,":[279],"principle":[281],"receptor.":[283],"CONCLUSIONS:":[284],"highlights":[287],"during":[290],"stenosis":[292],"pathogenesis.":[293],"A":[294],"correlates":[303],"gradient.":[309],"impaired":[317],"catabolism":[319],"promotes":[320]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-07-17T00:00:00"}
