{"id":"https://openalex.org/W7168369390","doi":"https://doi.org/10.1111/acel.70621","title":"Liver\u2010 and Immune\u2010Enriched Molecular Signatures Associated With Mortality in Older Adults","display_name":"Liver\u2010 and Immune\u2010Enriched Molecular Signatures Associated With Mortality in Older Adults","publication_year":2026,"publication_date":"2026-07-01","ids":{"openalex":"https://openalex.org/W7168369390","doi":"https://doi.org/10.1111/acel.70621","pmid":"https://pubmed.ncbi.nlm.nih.gov/42455656","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13372077"},"language":"en","primary_location":{"id":"doi:10.1111/acel.70621","doi":"https://doi.org/10.1111/acel.70621","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.70621","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1111/acel.70621","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081993283","display_name":"Yi\u2010Long Huang","orcid":"https://orcid.org/0000-0002-0980-4828","observed_orcids":["https://orcid.org/0000-0002-0980-4828"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi\u2010Long Huang","raw_affiliation_strings":["Center for Healthy Longevity and Aging Sciences National Yang Ming Chiao Tung University  Taipei Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Healthy Longevity and Aging Sciences National Yang Ming Chiao Tung University  Taipei Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050680539","display_name":"Wei\u2010Ju Lee","orcid":"https://orcid.org/0000-0003-4326-333X","observed_orcids":["https://orcid.org/0000-0003-4326-333X"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei\u2010Ju Lee","raw_affiliation_strings":["Center for Healthy Longevity and Aging Sciences National Yang Ming Chiao Tung University  Taipei Taiwan","Department of Family Medicine Taipei Veterans General Hospital Yuanshan Branch  Yilan Taiwan","Department of Geriatric Medicine, School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-4326-333X","affiliations":[{"raw_affiliation_string":"Center for Healthy Longevity and Aging Sciences National Yang Ming Chiao Tung University  Taipei Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Department of Family Medicine Taipei Veterans General Hospital Yuanshan Branch  Yilan Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Department of Geriatric Medicine, School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140954767","display_name":"Pei\u2010Lin Lee","orcid":"https://orcid.org/0000-0002-3041-8710","observed_orcids":["https://orcid.org/0000-0002-3041-8710"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pei\u2010Lin Lee","raw_affiliation_strings":["Center for Healthy Longevity and Aging Sciences National Yang Ming Chiao Tung University  Taipei Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-3041-8710","affiliations":[{"raw_affiliation_string":"Center for Healthy Longevity and Aging Sciences National Yang Ming Chiao Tung University  Taipei Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101633462","display_name":"Li\u2010Ning Peng","orcid":"https://orcid.org/0000-0003-1308-9553","observed_orcids":["https://orcid.org/0000-0003-1308-9553"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Li\u2010Ning Peng","raw_affiliation_strings":["Center for Geriatrics and Gerontology Taipei Veterans General Hospital  Taipei Taiwan","Center for Healthy Longevity and Aging Sciences National Yang Ming Chiao Tung University  Taipei Taiwan","Department of Geriatric Medicine, School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Geriatrics and Gerontology Taipei Veterans General Hospital  Taipei Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Center for Healthy Longevity and Aging Sciences National Yang Ming Chiao Tung University  Taipei Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Department of Geriatric Medicine, School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038285208","display_name":"Fei\u2010Yuan Hsiao","orcid":"https://orcid.org/0000-0003-1660-9120","observed_orcids":["https://orcid.org/0000-0003-1660-9120"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Fei\u2010Yuan Hsiao","raw_affiliation_strings":["Graduate Institute of Clinical Pharmacy, College of Medicine National Taiwan University  Taipei Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Clinical Pharmacy, College of Medicine National Taiwan University  Taipei Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086359211","display_name":"Liang\u2010Kung Chen","orcid":"https://orcid.org/0000-0002-2387-8508","observed_orcids":["https://orcid.org/0000-0002-2387-8508"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Liang\u2010Kung Chen","raw_affiliation_strings":["Center for Geriatrics and Gerontology Taipei Veterans General Hospital  Taipei Taiwan","Center for Healthy Longevity and Aging Sciences National Yang Ming Chiao Tung University  Taipei Taiwan","Taipei Municipal Gan\u2010Dau Hospital (Managed by Taipei Veterans General Hospital)  Taipei Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-2387-8508","affiliations":[{"raw_affiliation_string":"Center for Geriatrics and Gerontology Taipei Veterans General Hospital  Taipei Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Center for Healthy Longevity and Aging Sciences National Yang Ming Chiao Tung University  Taipei Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Taipei Municipal Gan\u2010Dau Hospital (Managed by Taipei Veterans General Hospital)  Taipei Taiwan","institution_ids":["https://openalex.org/I2803004286"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5086359211"],"corresponding_institution_ids":["https://openalex.org/I148366613","https://openalex.org/I2803004286"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42016807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"7","first_page":"e70621","last_page":"e70621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.45190000534057617,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.45190000534057617,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.12349999696016312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.08950000256299973,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.9729999899864197},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7319999933242798},{"id":"https://openalex.org/keywords/biological-aging","display_name":"biological aging","score":0.8809999823570251},{"id":"https://openalex.org/keywords/plasma-proteomics","display_name":"plasma proteomics","score":0.8190000057220459},{"id":"https://openalex.org/keywords/plasma-metabolomics","display_name":"plasma metabolomics","score":0.984000027179718},{"id":"https://openalex.org/keywords/mortality-risk-score","display_name":"mortality risk score","score":0.6959999799728394},{"id":"https://openalex.org/keywords/immune-related-proteins","display_name":"immune-related proteins","score":0.9359999895095825},{"id":"https://openalex.org/keywords/coagulation-cascade","display_name":"coagulation cascade","score":0.8299999833106995},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9470000267028809},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.8880000114440918},{"id":"https://openalex.org/keywords/bile-acid-metabolism","display_name":"bile acid metabolism","score":1.0},{"id":"https://openalex.org/keywords/multi-omics-profiling","display_name":"multi-omics profiling","score":0.656000018119812},{"id":"https://openalex.org/keywords/biological-age-assessment","display_name":"biological age assessment","score":0.5989999771118164},{"id":"https://openalex.org/keywords/age-related-physiological-decline","display_name":"age-related physiological decline","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6265000104904175},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5393000245094299},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5178999900817871},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4715999960899353},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4683000147342682},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.4431999921798706},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.44279998540878296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3968999981880188},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.384799987077713},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3831000030040741},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35670000314712524},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.3449000120162964},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33640000224113464},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.3294000029563904},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3172999918460846},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.3167000114917755},{"id":"https://openalex.org/C2777984932","wikidata":"https://www.wikidata.org/wiki/Q7336293","display_name":"Risk of mortality","level":2,"score":0.31540000438690186},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.30559998750686646},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.29510000348091125},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.2946999967098236},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.29170000553131104},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.28780001401901245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2874000072479248},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.2827000021934509},{"id":"https://openalex.org/C2991747559","wikidata":"https://www.wikidata.org/wiki/Q4915075","display_name":"Biological age","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2720000147819519},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.2700999975204468},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26109999418258667}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/acel.70621","doi":"https://doi.org/10.1111/acel.70621","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.70621","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13372077","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13372077/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13372077/pdf/ACEL-25-e70621.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"Text"},{"id":"pmid:42455656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42455656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/acel.70621","doi":"https://doi.org/10.1111/acel.70621","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.70621","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1033988673","display_name":null,"funder_award_id":"AS-CFII-111-209","funder_id":"https://openalex.org/F4320321041","funder_display_name":"Academia Sinica"},{"id":"https://openalex.org/G8250725717","display_name":null,"funder_award_id":"AS-CFII-111","funder_id":"https://openalex.org/F4320321041","funder_display_name":"Academia Sinica"}],"funders":[{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"},{"id":"https://openalex.org/F4320321528","display_name":"Shanghai Educational Development Foundation","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320331164","display_name":"National Science and Technology Council","ror":"https://ror.org/00wnb9798"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7168369390.pdf","grobid_xml":"https://content.openalex.org/works/W7168369390.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W2023535895","https://openalex.org/W2025944550","https://openalex.org/W2080974824","https://openalex.org/W2091119704","https://openalex.org/W2121091193","https://openalex.org/W2157886160","https://openalex.org/W2159914115","https://openalex.org/W2173367702","https://openalex.org/W2318079341","https://openalex.org/W2815133411","https://openalex.org/W2912654909","https://openalex.org/W2949100461","https://openalex.org/W3021249782","https://openalex.org/W4200586973","https://openalex.org/W4205358347","https://openalex.org/W4210448201","https://openalex.org/W4281615507","https://openalex.org/W4313531093","https://openalex.org/W4386334003","https://openalex.org/W4404197535","https://openalex.org/W4409533117","https://openalex.org/W4411301962","https://openalex.org/W4414970377"],"related_works":["https://openalex.org/W7134901660","https://openalex.org/W7214586891","https://openalex.org/W4417145832","https://openalex.org/W4403906275","https://openalex.org/W7220840784","https://openalex.org/W4404330114","https://openalex.org/W4415949085","https://openalex.org/W3101689851","https://openalex.org/W4401427258","https://openalex.org/W7164416166"],"abstract_inverted_index":{"Quantifying":[0],"biological":[1,89,225],"aging":[2,241],"requires":[3],"biomarkers":[4],"that":[5],"capture":[6],"multisystem":[7],"physiological":[8,43],"decline":[9],"beyond":[10],"chronological":[11],"age.":[12],"We":[13,91],"aimed":[14],"to":[15,33,81,131],"compare":[16],"the":[17,57,147,175,179,213],"prognostic":[18],"performance":[19],"of":[20,67,151,215],"plasma":[21,46,216],"proteomics,":[22],"metabolomics,":[23],"and":[24,32,41,48,86,104,121,168,185,200,211,231,242],"conventional":[25],"clinical":[26,169],"risk":[27,40,135,170,207],"factors":[28,171],"for":[29,64,224],"all-cause":[30,97],"mortality,":[31],"characterize":[34],"molecular":[35,84,202],"pathways":[36,233],"associated":[37,95,204],"with":[38,96,192,205],"mortality":[39,98,134,156,193,206],"age-related":[42,243],"decline.":[44,245],"Untargeted":[45],"proteomics":[47],"metabolomics":[49],"were":[50,79,138],"profiled":[51],"in":[52,141,174,208],"848":[53],"community-dwelling":[54],"adults":[55,210],"from":[56,146],"I-Lan":[58],"Longitudinal":[59,148],"Aging":[60,149],"Study":[61,150],"(ILAS),":[62],"followed":[63],"a":[65,220],"mean":[66],"8.5":[68],"years,":[69],"during":[70],"which":[71,137],"92":[72],"deaths":[73],"occurred.":[74],"Cox":[75],"proportional":[76],"hazards":[77],"models":[78,165],"applied":[80],"identify":[82,198],"mortality-associated":[83],"features":[85],"their":[87],"enriched":[88],"pathways.":[90],"identified":[92,229],"79":[93],"proteins":[94],"(FDR":[99],"<":[100],"0.1),":[101],"predominantly":[102],"liver-derived":[103],"immune-related.":[105],"Pathway":[106],"analysis":[107],"revealed":[108],"coordinated":[109],"dysregulation":[110],"across":[111],"coagulation":[112],"cascades,":[113],"complement":[114],"activation,":[115],"oxidative":[116],"stress":[117],"responses,":[118],"glucose":[119],"metabolism,":[120],"bile":[122],"acid":[123],"metabolism.":[124],"Elastic":[125],"net":[126],"regression":[127],"was":[128],"subsequently":[129],"used":[130],"construct":[132],"omics-based":[133],"scores,":[136],"further":[139],"evaluated":[140],"an":[142],"independent":[143],"validation":[144,181],"cohort":[145],"Taipei":[152],"(LAST).":[153],"A":[154],"20-protein":[155],"score":[157],"achieved":[158],"strong":[159],"discrimination":[160],"(C-index":[161,166,172],"0.81),":[162],"outperforming":[163],"metabolite-based":[164],"0.77)":[167],"0.73)":[173],"discovery":[176],"cohort.":[177],"In":[178],"external":[180],"cohort,":[182],"both":[183],"proteomic-":[184],"metabolomic-derived":[186],"scores":[187],"showed":[188],"directionally":[189],"consistent":[190],"associations":[191],"risk.":[194],"Together,":[195],"these":[196],"findings":[197],"liver-":[199],"immune-enriched":[201],"signatures":[203],"older":[209],"support":[212],"utility":[214],"multi-omics":[217],"profiling":[218],"as":[219],"scalable":[221],"precision":[222],"tool":[223],"age":[226],"assessment.":[227],"The":[228],"proteomic":[230],"metabolomic":[232],"may":[234],"help":[235],"inform":[236],"future":[237],"interventions":[238],"targeting":[239],"systemic":[240],"functional":[244]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-07-16T00:00:00"}