{"id":"https://openalex.org/W7168284389","doi":"https://doi.org/10.3389/fimmu.2026.1937764","title":"A predictive multiphysics framework for optimizing focused ultrasound-assisted immune checkpoint blockade","display_name":"A predictive multiphysics framework for optimizing focused ultrasound-assisted immune checkpoint blockade","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7168284389","doi":"https://doi.org/10.3389/fimmu.2026.1937764","pmid":"https://pubmed.ncbi.nlm.nih.gov/42909101","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13683793"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1937764","doi":"https://doi.org/10.3389/fimmu.2026.1937764","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1937764","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1937764/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1937764/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094256824","display_name":"Marina Koutsi","orcid":"https://orcid.org/0009-0007-6833-6028","observed_orcids":["https://orcid.org/0009-0007-6833-6028"]},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Marina Koutsi","raw_affiliation_strings":["Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus","institution_ids":["https://openalex.org/I34771391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040343131","display_name":"Fotios Mpekris","orcid":"https://orcid.org/0000-0002-7125-4062","observed_orcids":["https://orcid.org/0000-0002-7125-4062"]},"institutions":[{"id":"https://openalex.org/I55905543","display_name":"Cyprus Institute of Neurology and Genetics","ror":"https://ror.org/01ggsp920","country_code":"CY","type":"nonprofit","lineage":["https://openalex.org/I55905543"]}],"countries":["CY"],"is_corresponding":true,"raw_author_name":"Fotios Mpekris","raw_affiliation_strings":["Cancer Genetics, Therapeutics and Ultrastructural Pathology Department, The Cyprus Institute of Neurology and Genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genetics, Therapeutics and Ultrastructural Pathology Department, The Cyprus Institute of Neurology and Genetics","institution_ids":["https://openalex.org/I55905543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057504407","display_name":"Triantafyllos Stylianopoulos","orcid":"https://orcid.org/0000-0002-3093-1696","observed_orcids":["https://orcid.org/0000-0002-3093-1696"]},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":true,"raw_author_name":"Triantafyllos Stylianopoulos","raw_affiliation_strings":["Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus","institution_ids":["https://openalex.org/I34771391"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040343131","https://openalex.org/A5057504407"],"corresponding_institution_ids":["https://openalex.org/I34771391","https://openalex.org/I55905543"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36722014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1937764","last_page":"1937764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/focused-ultrasound","display_name":"focused ultrasound","score":0.9959999918937683},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8980000019073486},{"id":"https://openalex.org/keywords/antibody-delivery","display_name":"antibody delivery","score":0.6209999918937683},{"id":"https://openalex.org/keywords/anti-pd-1-antibody","display_name":"anti-PD-1","score":0.7540000081062317},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.7440000176429749},{"id":"https://openalex.org/keywords/tumor-perfusion","display_name":"tumor perfusion","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C46435376","wikidata":"https://www.wikidata.org/wiki/Q1829750","display_name":"Multiphysics","level":3,"score":0.939300000667572},{"id":"https://openalex.org/C2780365114","wikidata":"https://www.wikidata.org/wiki/Q169478","display_name":"MATLAB","level":2,"score":0.5841000080108643},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5770999789237976},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.42160001397132874},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.36309999227523804},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.32409998774528503},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.28790000081062317},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.2734000086784363},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2728999853134155},{"id":"https://openalex.org/C135628077","wikidata":"https://www.wikidata.org/wiki/Q220184","display_name":"Finite element method","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.2574999928474426},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.2533000111579895}],"mesh":[{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000095763","descriptor_name":"Immunoinformatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3389/fimmu.2026.1937764","doi":"https://doi.org/10.3389/fimmu.2026.1937764","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1937764","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1937764/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:42909101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42909101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13683793","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13683793/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:929b9e55a30543f6b4daa321e59c0278","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/929b9e55a30543f6b4daa321e59c0278","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"},{"id":"doi:10.5281/zenodo.21355648","doi":"https://doi.org/10.5281/zenodo.21355648","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21355648","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Model"},{"id":"doi:10.5281/zenodo.21355649","doi":"https://doi.org/10.5281/zenodo.21355649","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21355649","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Model"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1937764","doi":"https://doi.org/10.3389/fimmu.2026.1937764","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1937764","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1937764/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7858056067","display_name":null,"funder_award_id":"101141357","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7168284389.pdf","grobid_xml":"https://content.openalex.org/works/W7168284389.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W218692517","https://openalex.org/W795306870","https://openalex.org/W1515901388","https://openalex.org/W1964128680","https://openalex.org/W1968583232","https://openalex.org/W1972308765","https://openalex.org/W1980271045","https://openalex.org/W1990564747","https://openalex.org/W1992560794","https://openalex.org/W1998266575","https://openalex.org/W2006833192","https://openalex.org/W2013496530","https://openalex.org/W2014282546","https://openalex.org/W2022540958","https://openalex.org/W2025521327","https://openalex.org/W2043097112","https://openalex.org/W2045190338","https://openalex.org/W2047356443","https://openalex.org/W2066724170","https://openalex.org/W2076672259","https://openalex.org/W2083085047","https://openalex.org/W2104300873","https://openalex.org/W2115481097","https://openalex.org/W2116162163","https://openalex.org/W2141766828","https://openalex.org/W2155464214","https://openalex.org/W2158303916","https://openalex.org/W2158642531","https://openalex.org/W2164194411","https://openalex.org/W2169169493","https://openalex.org/W2171157655","https://openalex.org/W2172055586","https://openalex.org/W2536034592","https://openalex.org/W2571012263","https://openalex.org/W2586781596","https://openalex.org/W2606343471","https://openalex.org/W2615301036","https://openalex.org/W2793869682","https://openalex.org/W2795166918","https://openalex.org/W2797542438","https://openalex.org/W2884203840","https://openalex.org/W2889014367","https://openalex.org/W2889167864","https://openalex.org/W2909932177","https://openalex.org/W2911810632","https://openalex.org/W2912521584","https://openalex.org/W2913497263","https://openalex.org/W2918971228","https://openalex.org/W2943781197","https://openalex.org/W2974011264","https://openalex.org/W2980837762","https://openalex.org/W2982130750","https://openalex.org/W2984395743","https://openalex.org/W3003714437","https://openalex.org/W3004769637","https://openalex.org/W3006101499","https://openalex.org/W3023611224","https://openalex.org/W3028823371","https://openalex.org/W3035540747","https://openalex.org/W3087169700","https://openalex.org/W3093174348","https://openalex.org/W3118385724","https://openalex.org/W3118874590","https://openalex.org/W3121602482","https://openalex.org/W3151427897","https://openalex.org/W3164258354","https://openalex.org/W3170714444","https://openalex.org/W3187303418","https://openalex.org/W3187668469","https://openalex.org/W3203685240","https://openalex.org/W4206695861","https://openalex.org/W4220783622","https://openalex.org/W4229040635","https://openalex.org/W4283277900","https://openalex.org/W4286433606","https://openalex.org/W4289745375","https://openalex.org/W4293102128","https://openalex.org/W4300717227","https://openalex.org/W4311707412","https://openalex.org/W4317207492","https://openalex.org/W4320167832","https://openalex.org/W4320913146","https://openalex.org/W4321447691","https://openalex.org/W4362521833","https://openalex.org/W4380576955","https://openalex.org/W4382679534","https://openalex.org/W4389977941","https://openalex.org/W4391311235","https://openalex.org/W4391757110","https://openalex.org/W4392111810","https://openalex.org/W4392716676","https://openalex.org/W4393087783","https://openalex.org/W4393994458","https://openalex.org/W4399203598","https://openalex.org/W4399387719","https://openalex.org/W4400110180","https://openalex.org/W4400124789","https://openalex.org/W4400300083","https://openalex.org/W4401667917","https://openalex.org/W4402086995","https://openalex.org/W4404192992","https://openalex.org/W4404763202","https://openalex.org/W4404839359","https://openalex.org/W4408538408","https://openalex.org/W4410092862","https://openalex.org/W4410859602","https://openalex.org/W4411571125","https://openalex.org/W4414431703","https://openalex.org/W4415879486","https://openalex.org/W4416121272","https://openalex.org/W4416773194","https://openalex.org/W7143828985","https://openalex.org/W7164420328"],"related_works":["https://openalex.org/W4392918992","https://openalex.org/W4367052126","https://openalex.org/W2103672376","https://openalex.org/W3083249075","https://openalex.org/W3093174348","https://openalex.org/W4415213080","https://openalex.org/W3082405911","https://openalex.org/W3082193258","https://openalex.org/W3095699881","https://openalex.org/W3136681383"],"abstract_inverted_index":{"The":[0],"efficacy":[1],"of":[2,49,59,91,137,187,221],"immune":[3,29,64,92,100,122,151,175,210,230],"checkpoint":[4,93,176,211],"blockers":[5,94],"in":[6,102,111],"solid":[7,103],"tumors":[8],"remains":[9,70],"limited":[10],"by":[11,18],"the":[12,19,46,60,85,89,166,185,196,222],"physical":[13],"and":[14,26,63,95,98,121,131,142,154,170,178,206,232],"biological":[15],"barriers":[16],"posed":[17],"tumor":[20,42,86,119,129,155,179,223],"microenvironment,":[21,87],"which":[22],"restrict":[23],"antibody":[24,149,171,188,226],"transport":[25,62],"suppress":[27],"anti-tumor":[28,229],"responses.":[30],"Focused":[31],"ultrasound":[32,83,159,183],"has":[33],"emerged":[34],"as":[35,134],"a":[36,56,75,201],"promising":[37],"strategy":[38],"to":[39,79],"transiently":[40],"enhance":[41],"perfusion,":[43],"thereby":[44],"improving":[45],"intratumoral":[47],"delivery":[48,90],"immunotherapeutic":[50],"agents.":[51],"Despite":[52],"encouraging":[53],"experimental":[54,113],"findings,":[55],"quantitative":[57],"understanding":[58],"coupled":[61],"mechanisms":[65],"underlying":[66],"focused":[67,82,158,182,208,218],"ultrasound-enhanced":[68],"immunotherapy":[69],"incomplete.":[71],"Here,":[72],"we":[73],"developed":[74],"multiphysics":[76],"computational":[77,198],"model":[78],"investigate":[80],"how":[81,217],"modulates":[84],"enhances":[88,225],"influences":[96],"innate":[97],"adaptive":[99],"responses":[101,231],"tumors.":[104],"Model":[105],"predictions":[106],"were":[107],"validated":[108],"against":[109],"published":[110],"vivo":[112],"data,":[114],"demonstrating":[115],"good":[116],"agreement":[117],"with":[118,181,191],"growth":[120],"response":[123],"measurements.":[124],"Parametric":[125],"analysis":[126],"identified":[127],"both":[128],"microenvironment":[130,224],"therapy-related":[132],"parameters":[133],"key":[135],"determinants":[136],"treatment":[138],"efficacy.":[139],"Stromal":[140],"normalization":[141],"increased":[143],"vessel":[144],"wall":[145],"pore":[146],"radius":[147],"enhanced":[148,174],"delivery,":[150],"cell":[152],"accumulation":[153],"control,":[156],"while":[157],"further":[160],"amplified":[161],"these":[162],"effects.":[163],"Moreover,":[164],"increasing":[165],"anti-PD-1/PD-1":[167],"binding":[168],"affinity":[169],"administration":[172],"dose":[173],"inhibition":[177],"suppression,":[180],"broadening":[184],"range":[186],"characteristics":[189],"associated":[190],"favorable":[192],"therapeutic":[193,234],"outcomes.":[194],"Overall,":[195],"proposed":[197],"framework":[199],"provides":[200],"predictive":[202],"platform":[203],"for":[204],"investigating":[205],"optimizing":[207],"ultrasound-assisted":[209],"blockade,":[212],"offering":[213],"mechanistic":[214],"insight":[215],"into":[216],"ultrasound-induced":[219],"modulation":[220],"transport,":[227],"promotes":[228],"improves":[233],"response.":[235]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-07-15T00:00:00"}
