{"id":"https://openalex.org/W7168239157","doi":"https://doi.org/10.1093/neuonc/noag155","title":"Focused ultrasound-mediated blood-brain barrier opening reshapes plasma extracellular vesicle size distribution without elevating concentration in glioblastoma patients","display_name":"Focused ultrasound-mediated blood-brain barrier opening reshapes plasma extracellular vesicle size distribution without elevating concentration in glioblastoma patients","publication_year":2026,"publication_date":"2026-07-13","ids":{"openalex":"https://openalex.org/W7168239157","doi":"https://doi.org/10.1093/neuonc/noag155","pmid":"https://pubmed.ncbi.nlm.nih.gov/42446136","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13731854"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noag155","doi":"https://doi.org/10.1093/neuonc/noag155","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noag155","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/neuonc/noag155","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003179253","display_name":"Massimiliano Del Bene","orcid":"https://orcid.org/0000-0002-6672-9721","observed_orcids":["https://orcid.org/0000-0002-6672-9721"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]},{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimiliano Del Bene","raw_affiliation_strings":["Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS , Milan,","Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta , Milan,","Department of Pharmacological and Biomolecular Sciences, University of Milan , Milan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS , Milan,","institution_ids":["https://openalex.org/I6141010"]},{"raw_affiliation_string":"Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta , Milan,","institution_ids":["https://openalex.org/I4210164485"]},{"raw_affiliation_string":"Department of Pharmacological and Biomolecular Sciences, University of Milan , Milan,","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020750771","display_name":"Daniela Osti","orcid":"https://orcid.org/0000-0001-7794-3400","observed_orcids":["https://orcid.org/0000-0001-7794-3400"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Osti","raw_affiliation_strings":["Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS , Milan,"],"raw_orcid":"https://orcid.org/0000-0001-7794-3400","affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS , Milan,","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003184469","display_name":"Marta Bonada","orcid":"https://orcid.org/0009-0002-7263-5219","observed_orcids":["https://orcid.org/0009-0002-7263-5219"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Bonada","raw_affiliation_strings":["Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta , Milan,"],"raw_orcid":"https://orcid.org/0009-0002-7263-5219","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta , Milan,","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013103346","display_name":"Riccardo Pascuzzo","orcid":"https://orcid.org/0000-0001-6555-1784","observed_orcids":["https://orcid.org/0000-0001-6555-1784"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccardo Pascuzzo","raw_affiliation_strings":["Data Science Center, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,","Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,"],"raw_orcid":"https://orcid.org/0000-0001-6555-1784","affiliations":[{"raw_affiliation_string":"Data Science Center, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,","institution_ids":["https://openalex.org/I4210164485"]},{"raw_affiliation_string":"Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115999525","display_name":"Annica Piccardi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annica Piccardi","raw_affiliation_strings":["Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta , Milan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta , Milan,","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065348965","display_name":"Giovanni Carone","orcid":"https://orcid.org/0000-0002-5854-5711","observed_orcids":["https://orcid.org/0000-0002-5854-5711"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Carone","raw_affiliation_strings":["Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta , Milan,"],"raw_orcid":"https://orcid.org/0000-0002-5854-5711","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta , Milan,","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140738834","display_name":"Lisa Meanti","orcid":"https://orcid.org/0009-0009-7844-5353","observed_orcids":["https://orcid.org/0009-0009-7844-5353"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lisa Meanti","raw_affiliation_strings":["Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta , Milan,"],"raw_orcid":"https://orcid.org/0009-0009-7844-5353","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta , Milan,","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029578370","display_name":"Mario Stanziano","orcid":"https://orcid.org/0000-0002-5843-0965","observed_orcids":["https://orcid.org/0000-0002-5843-0965"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Stanziano","raw_affiliation_strings":["Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,"],"raw_orcid":"https://orcid.org/0000-0002-5843-0965","affiliations":[{"raw_affiliation_string":"Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053795910","display_name":"Valentina Caldiera","orcid":"https://orcid.org/0000-0003-3105-3343","observed_orcids":["https://orcid.org/0000-0003-3105-3343"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Caldiera","raw_affiliation_strings":["Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,"],"raw_orcid":"https://orcid.org/0000-0003-3105-3343","affiliations":[{"raw_affiliation_string":"Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010972683","display_name":"Carla Carozzi","orcid":"https://orcid.org/0000-0001-6677-1172","observed_orcids":["https://orcid.org/0000-0001-6677-1172"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carla Carozzi","raw_affiliation_strings":["Neurointensive Care Unit, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,"],"raw_orcid":"https://orcid.org/0000-0001-6677-1172","affiliations":[{"raw_affiliation_string":"Neurointensive Care Unit, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008395527","display_name":"Antonio Silvani","orcid":"https://orcid.org/0000-0002-4791-1042","observed_orcids":["https://orcid.org/0000-0002-4791-1042"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Silvani","raw_affiliation_strings":["Department of Neuro-oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuro-oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034482720","display_name":"Elisa F M Ciceri","orcid":"https://orcid.org/0000-0002-6716-2923","observed_orcids":["https://orcid.org/0000-0002-6716-2923"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisa Francesca Maria Ciceri","raw_affiliation_strings":["Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,"],"raw_orcid":"https://orcid.org/0000-0002-6716-2923","affiliations":[{"raw_affiliation_string":"Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034991162","display_name":"Marina Grisoli","orcid":"https://orcid.org/0000-0002-7663-446X","observed_orcids":["https://orcid.org/0000-0002-7663-446X"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marina Grisoli","raw_affiliation_strings":["Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan,","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108062851","display_name":"Giuliana Pelicci","orcid":"https://orcid.org/0000-0003-0986-8255","observed_orcids":["https://orcid.org/0000-0003-0986-8255"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]},{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuliana Pelicci","raw_affiliation_strings":["Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS , Milan,","Department of Translational Medicine, University of Piemonte Orientale , Novara,"],"raw_orcid":"https://orcid.org/0000-0003-0986-8255","affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS , Milan,","institution_ids":["https://openalex.org/I6141010"]},{"raw_affiliation_string":"Department of Translational Medicine, University of Piemonte Orientale , Novara,","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025887435","display_name":"Francesco DiMeco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT","US"],"is_corresponding":true,"raw_author_name":"Francesco DiMeco","raw_affiliation_strings":["Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta , Milan,","Department of Neurosurgery, Johns Hopkins Medical School , Baltimore, Maryland,","Department of Oncology and Hematology-Oncology, University of Milan , Milan,"],"raw_orcid":"https://orcid.org/0000-0002-6672-9721","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta , Milan,","institution_ids":["https://openalex.org/I4210164485"]},{"raw_affiliation_string":"Department of Neurosurgery, Johns Hopkins Medical School , Baltimore, Maryland,","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Oncology and Hematology-Oncology, University of Milan , Milan,","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5025887435"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I189158943","https://openalex.org/I2799853436","https://openalex.org/I4210164485"],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":{"value":5132,"currency":"USD","value_usd":5132},"fwci":2.9546,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.92301661,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"28","issue":"11","first_page":"2637","last_page":"2649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.10499999672174454,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/focused-ultrasound","display_name":"focused ultrasound","score":0.9440000057220459},{"id":"https://openalex.org/keywords/blood-brain-barrier-opening","display_name":"blood-brain barrier opening","score":0.9959999918937683},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.8989999890327454},{"id":"https://openalex.org/keywords/vesicle-size-distribution","display_name":"vesicle size distribution","score":0.796999990940094},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mr-guided-ultrasound","display_name":"MR-guided ultrasound","score":0.6480000019073486},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7742999792098999},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.708299994468689},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.6388999819755554},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.607200026512146},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5799999833106995},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.47540000081062317},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.46880000829696655},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.40529999136924744},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.3935000002384186},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3919000029563904},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.3824000060558319},{"id":"https://openalex.org/C2988731192","wikidata":"https://www.wikidata.org/wiki/Q7410159","display_name":"Blood sampling","level":2,"score":0.365200012922287},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.3440000116825104},{"id":"https://openalex.org/C104628117","wikidata":"https://www.wikidata.org/wiki/Q3964828","display_name":"Sonication","level":2,"score":0.33059999346733093},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.3269999921321869},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.32089999318122864},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.3208000063896179},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3163999915122986},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.31299999356269836},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.30809998512268066},{"id":"https://openalex.org/C48126324","wikidata":"https://www.wikidata.org/wiki/Q5276136","display_name":"Digital polymerase chain reaction","level":4,"score":0.2955999970436096},{"id":"https://openalex.org/C6899612","wikidata":"https://www.wikidata.org/wiki/Q852911","display_name":"Resistive touchscreen","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.28999999165534973},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.2854999899864197},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27559998631477356},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.26249998807907104},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.26109999418258667},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.25929999351501465},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.2554999887943268},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.2549999952316284}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000073890","descriptor_name":"Liquid Biopsy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/neuonc/noag155","doi":"https://doi.org/10.1093/neuonc/noag155","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noag155","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmid:42446136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42446136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13731854","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13731854/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noag155","doi":"https://doi.org/10.1093/neuonc/noag155","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noag155","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1951724000","https://openalex.org/W1987604193","https://openalex.org/W2056416291","https://openalex.org/W2057946028","https://openalex.org/W2140156946","https://openalex.org/W2337184316","https://openalex.org/W2519325617","https://openalex.org/W2524760208","https://openalex.org/W2548698908","https://openalex.org/W2761639206","https://openalex.org/W2767039541","https://openalex.org/W2788032521","https://openalex.org/W2807573412","https://openalex.org/W2894662202","https://openalex.org/W2899918208","https://openalex.org/W2957938627","https://openalex.org/W2972005444","https://openalex.org/W2982601398","https://openalex.org/W2989077840","https://openalex.org/W2991205899","https://openalex.org/W2996422462","https://openalex.org/W3014809880","https://openalex.org/W3021349954","https://openalex.org/W3028954187","https://openalex.org/W3040036203","https://openalex.org/W3049236781","https://openalex.org/W3081946550","https://openalex.org/W3093174348","https://openalex.org/W3096646947","https://openalex.org/W3134763185","https://openalex.org/W3174246647","https://openalex.org/W3201963003","https://openalex.org/W3202057530","https://openalex.org/W4287447441","https://openalex.org/W4308174390","https://openalex.org/W4317915794","https://openalex.org/W4366978370","https://openalex.org/W4385360590","https://openalex.org/W4386799303","https://openalex.org/W4387041624","https://openalex.org/W4389489847","https://openalex.org/W4391649568","https://openalex.org/W4392205579","https://openalex.org/W4395012414","https://openalex.org/W4400914740","https://openalex.org/W4409342261","https://openalex.org/W4410417239","https://openalex.org/W4410468178","https://openalex.org/W4412004339","https://openalex.org/W4413311290","https://openalex.org/W4416589103","https://openalex.org/W4417359741"],"related_works":["https://openalex.org/W7148792207","https://openalex.org/W4405626715","https://openalex.org/W4410889508","https://openalex.org/W4410820588","https://openalex.org/W7204213091","https://openalex.org/W3134763185","https://openalex.org/W4400288033","https://openalex.org/W3028954187","https://openalex.org/W4400288458","https://openalex.org/W3108824621"],"abstract_inverted_index":{"BACKGROUND:":[0],"Focused":[1],"ultrasound-mediated":[2],"blood-brain":[3],"barrier":[4],"opening":[5],"(FUS-BBBO)":[6],"is":[7],"hypothesized":[8],"to":[9,26,47,227,232,258],"enhance":[10,213],"liquid":[11],"biopsy":[12],"by":[13,85,90,137],"facilitating":[14],"the":[15,21,28,49,140,144,186,214,221,234],"release":[16],"of":[17,30,52,132,139,143,150,216],"tumor":[18],"material":[19],"into":[20],"circulation.":[22],"This":[23],"study":[24],"aimed":[25],"evaluate":[27],"impact":[29],"MR-guided":[31,63],"FUS-BBBO":[32,64],"on":[33],"plasma":[34],"extracellular":[35],"vesicle":[36,152],"(EV)":[37],"concentrations":[38,155],"and":[39,76,88,98,105,120,156,175],"size":[40,126,145],"distributions,":[41],"alongside":[42],"cell-free":[43],"DNA":[44],"(cfDNA)":[45],"profiles,":[46],"determine":[48],"clinical":[50,189,251],"efficacy":[51],"this":[53,223],"approach":[54],"in":[55,66,246],"glioblastoma":[56],"(GB)":[57],"patients.":[58],"METHODS:":[59],"We":[60],"performed":[61],"14":[62],"procedures":[65],"patients":[67],"with":[68,70,117,162,253],"GB":[69],"blood":[71],"sampling":[72],"1":[73,77],"h":[74,78],"before":[75],"after":[79,115],"sonication.":[80],"Plasma":[81],"EVs":[82,200],"were":[83,101],"isolated":[84],"size-exclusion":[86],"chromatography":[87],"quantified":[89],"tunable":[91],"resistive":[92],"pulse":[93],"sensing":[94],"technology.":[95],"cfDNA":[96,154],"concentration":[97,110],"fragment":[99],"profiles":[100],"assessed":[102],"using":[103],"fluorometric":[104],"electrophoretic":[106],"methods.":[107],"RESULTS:":[108],"EV":[109,125],"showed":[111,158],"no":[112,169],"consistent":[113,196],"change":[114],"FUS-BBBO,":[116],"marked":[118],"inter-patient":[119],"inter-procedure":[121],"heterogeneity.":[122],"In":[123],"contrast,":[124],"displayed":[127],"a":[128,159,202],"reproducible":[129],"diameter":[130],"reduction":[131],"\u223c8-10":[133],"nm,":[134],"driven":[135],"predominantly":[136],"contraction":[138],"upper":[141],"tail":[142],"distribution,":[146],"indicating":[147],"selective":[148,203],"modulation":[149,204],"larger":[151],"subpopulations.":[153],"fragmentation":[157],"heterogeneous":[160],"pattern,":[161],"occasional":[163],"patient-specific":[164],"increases.":[165],"Exploratory":[166],"analyses":[167],"revealed":[168],"significant":[170],"associations":[171],"between":[172],"biomarker":[173,193],"changes":[174],"procedural":[176],"parameters":[177],"except":[178],"for":[179],"treated":[180],"volume.":[181],"CONCLUSIONS:":[182],"Our":[183],"findings":[184],"challenge":[185],"assumption":[187],"that":[188,218],"BBBO":[190,211],"uniformly":[191],"increases":[192],"abundance.":[194],"The":[195],"shift":[197],"toward":[198],"smaller":[199],"suggests":[201],"rather":[205],"than":[206],"an":[207],"increased":[208],"release.":[209],"While":[210],"may":[212,224],"detectability":[215],"analytes":[217],"poorly":[219],"cross":[220],"BBB,":[222],"not":[225],"apply":[226],"EVs,":[228],"which":[229],"are":[230,256],"able":[231],"traverse":[233],"BBB":[235],"under":[236],"physiological":[237],"conditions,":[238],"further":[239],"supporting":[240],"their":[241],"value":[242],"as":[243],"liquid-biopsy":[244],"substrates":[245],"neuro-oncology.":[247],"Future":[248],"studies":[249],"integrating":[250],"data":[252],"mechanistic":[254],"models":[255],"necessary":[257],"refine":[259],"FUS-enhanced":[260],"diagnostic":[261],"strategies.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-07-15T00:00:00"}