{"id":"https://openalex.org/W7168238296","doi":"https://doi.org/10.15343/0104-7809.202650e18732025i","title":"Senotherapy: scientific advances and clinical potential of senolytic therapies","display_name":"Senotherapy: scientific advances and clinical potential of senolytic therapies","publication_year":2026,"publication_date":"2026-07-14","ids":{"openalex":"https://openalex.org/W7168238296","doi":"https://doi.org/10.15343/0104-7809.202650e18732025i"},"language":"en","primary_location":{"id":"doi:10.15343/0104-7809.202650e18732025i","doi":"https://doi.org/10.15343/0104-7809.202650e18732025i","is_oa":true,"landing_page_url":"https://doi.org/10.15343/0104-7809.202650e18732025i","pdf_url":"https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/download/2066/2068","source":{"id":"https://openalex.org/S4210177534","display_name":"O Mundo da Sa\u00fade","issn_l":"0104-7809","issn":["0104-7809","1980-3990"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"O Mundo da Sa\u00fade","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/download/2066/2068","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5140749135","display_name":"Adriele Afonso Miranda","orcid":"https://orcid.org/0009-0004-8845-5663","observed_orcids":["https://orcid.org/0009-0004-8845-5663"]},"institutions":[{"id":"https://openalex.org/I162185876","display_name":"Universidade da Amaz\u00f4nia","ror":"https://ror.org/003vxvw45","country_code":"BR","type":"education","lineage":["https://openalex.org/I162185876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriele Afonso Miranda","raw_affiliation_strings":["Universidade da Amaz\u00f4nia \u2013 UNAMA. Bel\u00e9m/PA, Brasil"],"raw_orcid":"https://orcid.org/0009-0004-8845-5663","affiliations":[{"raw_affiliation_string":"Universidade da Amaz\u00f4nia \u2013 UNAMA. Bel\u00e9m/PA, Brasil","institution_ids":["https://openalex.org/I162185876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140744718","display_name":"Amanda Camile Mancio Leal","orcid":"https://orcid.org/0009-0005-3118-0598","observed_orcids":["https://orcid.org/0009-0005-3118-0598"]},"institutions":[{"id":"https://openalex.org/I162185876","display_name":"Universidade da Amaz\u00f4nia","ror":"https://ror.org/003vxvw45","country_code":"BR","type":"education","lineage":["https://openalex.org/I162185876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Amanda Camile Mancio Leal","raw_affiliation_strings":["Universidade da Amaz\u00f4nia \u2013 UNAMA. Bel\u00e9m/PA, Brasil"],"raw_orcid":"https://orcid.org/0009-0005-3118-0598","affiliations":[{"raw_affiliation_string":"Universidade da Amaz\u00f4nia \u2013 UNAMA. Bel\u00e9m/PA, Brasil","institution_ids":["https://openalex.org/I162185876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140658204","display_name":"Anderson Wallace Galv\u00e3o Fontes","orcid":"https://orcid.org/0009-0005-2222-3031","observed_orcids":["https://orcid.org/0009-0005-2222-3031"]},"institutions":[{"id":"https://openalex.org/I162185876","display_name":"Universidade da Amaz\u00f4nia","ror":"https://ror.org/003vxvw45","country_code":"BR","type":"education","lineage":["https://openalex.org/I162185876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Anderson Wallace Galv\u00e3o Fontes","raw_affiliation_strings":["Universidade da Amaz\u00f4nia \u2013 UNAMA. Bel\u00e9m/PA, Brasil"],"raw_orcid":"https://orcid.org/0009-0005-2222-3031","affiliations":[{"raw_affiliation_string":"Universidade da Amaz\u00f4nia \u2013 UNAMA. Bel\u00e9m/PA, Brasil","institution_ids":["https://openalex.org/I162185876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102635684","display_name":"Eliel Amorim Barros","orcid":"https://orcid.org/0009-0007-4829-983X","observed_orcids":["https://orcid.org/0009-0007-4829-983X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eliel Amorim Barros","raw_affiliation_strings":["Hospital Adventista de Bel\u00e9m \u2013 HAB. Bel\u00e9m/PA, Brasil"],"raw_orcid":"https://orcid.org/0009-0007-4829-983X","affiliations":[{"raw_affiliation_string":"Hospital Adventista de Bel\u00e9m \u2013 HAB. Bel\u00e9m/PA, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140599823","display_name":"Joseane Rodrigues Da Silva","orcid":"https://orcid.org/0000-0002-0426-9467","observed_orcids":["https://orcid.org/0000-0002-0426-9467"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Joseane Rodrigues Da Silva","raw_affiliation_strings":["N\u00facleo de Medicina Tropical, Universidade Federal do Par\u00e1 \u2013 UFPA. Bel\u00e9m/PA, Brasil"],"raw_orcid":"https://orcid.org/0000-0002-0426-9467","affiliations":[{"raw_affiliation_string":"N\u00facleo de Medicina Tropical, Universidade Federal do Par\u00e1 \u2013 UFPA. Bel\u00e9m/PA, Brasil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038350607","display_name":"Auriekson Noronha Queiroz","orcid":"https://orcid.org/0000-0002-1139-1268","observed_orcids":["https://orcid.org/0000-0002-1139-1268"]},"institutions":[{"id":"https://openalex.org/I162185876","display_name":"Universidade da Amaz\u00f4nia","ror":"https://ror.org/003vxvw45","country_code":"BR","type":"education","lineage":["https://openalex.org/I162185876"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Auriekson Noronha Queiroz","raw_affiliation_strings":["Universidade da Amaz\u00f4nia \u2013 UNAMA. Bel\u00e9m/PA, Brasil"],"raw_orcid":"https://orcid.org/0000-0002-1139-1268","affiliations":[{"raw_affiliation_string":"Universidade da Amaz\u00f4nia \u2013 UNAMA. Bel\u00e9m/PA, Brasil","institution_ids":["https://openalex.org/I162185876"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.47816667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"50","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/senotherapy","display_name":"senotherapy","score":0.9779999852180481},{"id":"https://openalex.org/keywords/senolytic-therapy","display_name":"senolytic therapy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/senescent-cells","display_name":"senescent cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8989999890327454},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.7850000262260437},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9919999837875366},{"id":"https://openalex.org/keywords/fisetin","display_name":"fisetin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/navitoclax","display_name":"navitoclax","score":0.9959999918937683},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.8659999966621399},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9020000100135803},{"id":"https://openalex.org/keywords/stem-cell-preservation","display_name":"stem cell preservation","score":0.800000011920929},{"id":"https://openalex.org/keywords/anti-apoptotic-pathways","display_name":"anti-apoptotic pathways","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6848999857902527},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.6103000044822693},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.48429998755455017},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.43709999322891235},{"id":"https://openalex.org/C2994543053","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical testing","level":2,"score":0.4296000003814697},{"id":"https://openalex.org/C2993043200","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical research","level":2,"score":0.42500001192092896},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.32710000872612},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.3206000030040741},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3127000033855438},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3057999908924103},{"id":"https://openalex.org/C3019692148","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Therapeutic modalities","level":2,"score":0.2924000024795532},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.28790000081062317},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.28790000081062317},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.28299999237060547},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.27000001072883606},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2574000060558319},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2547999918460846},{"id":"https://openalex.org/C520753416","wikidata":"https://www.wikidata.org/wiki/Q38344","display_name":"Animal testing","level":2,"score":0.25130000710487366},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.15343/0104-7809.202650e18732025i","doi":"https://doi.org/10.15343/0104-7809.202650e18732025i","is_oa":true,"landing_page_url":"https://doi.org/10.15343/0104-7809.202650e18732025i","pdf_url":"https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/download/2066/2068","source":{"id":"https://openalex.org/S4210177534","display_name":"O Mundo da Sa\u00fade","issn_l":"0104-7809","issn":["0104-7809","1980-3990"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"O Mundo da Sa\u00fade","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.15343/0104-7809.202650e18732025i","doi":"https://doi.org/10.15343/0104-7809.202650e18732025i","is_oa":true,"landing_page_url":"https://doi.org/10.15343/0104-7809.202650e18732025i","pdf_url":"https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/download/2066/2068","source":{"id":"https://openalex.org/S4210177534","display_name":"O Mundo da Sa\u00fade","issn_l":"0104-7809","issn":["0104-7809","1980-3990"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"O Mundo da Sa\u00fade","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7168238296.pdf","grobid_xml":"https://content.openalex.org/works/W7168238296.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W205310263","https://openalex.org/W1994682895","https://openalex.org/W2113373290","https://openalex.org/W2739438570","https://openalex.org/W2788548733","https://openalex.org/W2801266108","https://openalex.org/W2860743873","https://openalex.org/W2906721882","https://openalex.org/W2915779410","https://openalex.org/W2928157366","https://openalex.org/W2947927825","https://openalex.org/W2974643180","https://openalex.org/W3042236956","https://openalex.org/W3118615836","https://openalex.org/W3126596299","https://openalex.org/W3146830857","https://openalex.org/W3160798261","https://openalex.org/W4221032046","https://openalex.org/W4290988933","https://openalex.org/W4292488030","https://openalex.org/W4379599076","https://openalex.org/W4387033531","https://openalex.org/W4388626094","https://openalex.org/W4389334381","https://openalex.org/W4390603880","https://openalex.org/W4390654508","https://openalex.org/W4391578931","https://openalex.org/W4394755169","https://openalex.org/W4395070946","https://openalex.org/W4402420918","https://openalex.org/W4403703585","https://openalex.org/W4404876611","https://openalex.org/W4405917546","https://openalex.org/W4407794196","https://openalex.org/W7168259769"],"related_works":["https://openalex.org/W7215175408","https://openalex.org/W7168259769","https://openalex.org/W7131415024","https://openalex.org/W7220465808","https://openalex.org/W3094092646","https://openalex.org/W4414421754","https://openalex.org/W3042236956","https://openalex.org/W4389224920","https://openalex.org/W4402151218","https://openalex.org/W4385620612"],"abstract_inverted_index":{"Senotherapy":[0],"represents":[1,232],"an":[2],"emerging":[3],"therapeutic":[4,225],"approach":[5],"to":[6,15,22,53,104,252],"combat":[7],"deleterious":[8],"senescent":[9,221],"cells,":[10],"whose":[11],"pro-inflammatory":[12],"accumulation":[13],"contributes":[14],"various":[16],"aging-associated":[17],"pathologies.":[18],"This":[19],"study":[20],"aimed":[21],"analyze":[23],"and":[24,38,64,77,111,153,162,166,179,182,203,206,223,248],"systematize":[25],"recent":[26],"scientific":[27,131],"advances":[28,242],"in":[29,105,108,116,133,171,183,214,243,250,259],"senotherapy,":[30],"with":[31,91,127],"emphasis":[32],"on":[33],"senolytic":[34,137],"therapies,":[35],"their":[36],"innovations,":[37],"clinical":[39,118,238],"potential.":[40],"An":[41],"integrative":[42],"literature":[43],"review":[44],"was":[45],"conducted":[46],"covering":[47],"the":[48,73,99,141,149,154,160,207,220],"period":[49],"from":[50,84],"January":[51],"2019":[52],"June":[54],"2025,":[55],"carried":[56],"out":[57],"across":[58,201],"four":[59],"databases:":[60],"SciELO,":[61],"PubMed,":[62],"ScienceDirect,":[63],"Web":[65],"of":[66,87,94,98,130,143,173,199,209],"Science,":[67],"following":[68],"PRISMA":[69],"2020":[70],"guidelines":[71],"for":[72,218],"identification,":[74],"screening,":[75],"eligibility,":[76],"inclusion":[78],"stages.":[79],"Fifteen":[80],"articles":[81],"were":[82,102],"selected":[83],"a":[85,92,123,128,233],"total":[86],"113":[88],"identified":[89],"publications,":[90],"predominance":[93],"preclinical":[95,169,254],"evidence":[96,122],"(13":[97],"15":[100],"studies":[101,217],"restricted":[103],"vitro":[106],"or":[107],"vivo":[109],"designs)":[110],"only":[112],"two":[113],"compounds":[114],"referenced":[115],"preliminary":[117],"trials.":[119],"The":[120],"results":[121],"rapidly":[124],"expanding":[125],"field,":[126],"peak":[129],"productivity":[132],"2024,":[134],"revealing":[135],"that":[136,230],"therapies":[138],"predominantly":[139],"target":[140],"modulation":[142],"anti-apoptotic":[144],"pathways":[145],"\u2013":[146],"such":[147,158],"as":[148,159],"Bcl-2":[150],"protein":[151],"family":[152],"PI3K/AKT/mTOR":[155],"pathway.":[156],"Agents":[157],"dasatinib":[161],"quercetin":[163],"combination,":[164],"fisetin,":[165],"navitoclax":[167],"demonstrated":[168],"efficacy":[170],"models":[172],"neurodegenerative":[174],"diseases,":[175],"metabolic":[176],"disorders,":[177],"musculoskeletal":[178],"cardiovascular":[180],"conditions,":[181],"stem":[184],"cell":[185],"preservation.":[186],"However,":[187],"significant":[188],"challenges":[189],"persist,":[190],"including":[191],"on-target":[192],"toxicity":[193],"(e.g.,":[194],"navitoclax-induced":[195],"thrombocytopenia),":[196],"contextual":[197],"heterogeneity":[198],"response":[200],"tissues":[202],"age":[204],"groups,":[205],"absence":[208],"fully":[210],"validated":[211],"non-invasive":[212],"biomarkers":[213],"all":[215],"analyzed":[216],"quantifying":[219],"burden":[222],"monitoring":[224],"efficacy.":[226],"It":[227],"is":[228],"concluded":[229],"senotherapy":[231],"promising":[234],"frontier,":[235],"but":[236],"its":[237],"consolidation":[239],"requires":[240],"articulated":[241],"safety,":[244],"specificity,":[245],"patient":[246],"stratification,":[247],"standardization,":[249],"order":[251],"translate":[253],"potential":[255],"into":[256],"effective":[257],"applications":[258],"aging":[260],"medicine.":[261]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-07-15T00:00:00"}