{"id":"https://openalex.org/W7168210671","doi":"https://doi.org/10.1016/j.ijantimicag.2026.107925","title":"Outcomes for persons with triple-class resistant HIV and a history of virologic failure","display_name":"Outcomes for persons with triple-class resistant HIV and a history of virologic failure","publication_year":2026,"publication_date":"2026-07-13","ids":{"openalex":"https://openalex.org/W7168210671","doi":"https://doi.org/10.1016/j.ijantimicag.2026.107925","pmid":"https://pubmed.ncbi.nlm.nih.gov/42442619","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13594993"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijantimicag.2026.107925","doi":"https://doi.org/10.1016/j.ijantimicag.2026.107925","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijantimicag.2026.107925","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0924857926002128/pdf","source":{"id":"https://openalex.org/S5248501","display_name":"International Journal of Antimicrobial Agents","issn_l":"0924-8579","issn":["0924-8579","1872-7913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Antimicrobial Agents","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0924857926002128/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079562113","display_name":"Suzanne Marie Ingle","orcid":"https://orcid.org/0000-0003-3057-6636","observed_orcids":["https://orcid.org/0000-0003-3057-6636"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Suzanne M. Ingle","raw_affiliation_strings":["Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Electronic address: s.ingle@bristol.ac.uk"],"raw_orcid":"https://orcid.org/0000-0003-3057-6636","affiliations":[{"raw_affiliation_string":"Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Electronic address: s.ingle@bristol.ac.uk","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067996191","display_name":"Fabrice Bonnet","orcid":"https://orcid.org/0000-0001-5927-4178","observed_orcids":["https://orcid.org/0000-0001-5927-4178","https://orcid.org/0000-0001-9255-8228"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210106115","display_name":"Bordeaux Population Health","ror":"https://ror.org/00xzzba89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]},{"id":"https://openalex.org/I4210111110","display_name":"H\u00f4pital Saint-Andr\u00e9","ror":"https://ror.org/021959v84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210111110"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabrice Bonnet","raw_affiliation_strings":["CHU de Bordeaux, H\u00f4pital Saint Andr\u00e9, Service de M\u00e9decine Interne et Maladies Infectieuses, Bordeaux, France; Bordeaux Population Health Research Center INSERM U1219, Universit\u00e9 de Bordeaux - ISPED, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU de Bordeaux, H\u00f4pital Saint Andr\u00e9, Service de M\u00e9decine Interne et Maladies Infectieuses, Bordeaux, France; Bordeaux Population Health Research Center INSERM U1219, Universit\u00e9 de Bordeaux - ISPED, Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210106115","https://openalex.org/I4210111110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001041075","display_name":"Linda Wittkop","orcid":"https://orcid.org/0000-0003-2403-0960","observed_orcids":["https://orcid.org/0000-0003-2403-0960"]},"institutions":[{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210106115","display_name":"Bordeaux Population Health","ror":"https://ror.org/00xzzba89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]},{"id":"https://openalex.org/I4405259406","display_name":"SISTM: Statistics In System biology and Translational Medicine","ror":"https://ror.org/026t7px13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1326498283","https://openalex.org/I4210131512","https://openalex.org/I4405259406"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Linda Wittkop","raw_affiliation_strings":["Bordeaux Population Health Research Center INSERM U1219, Universit\u00e9 de Bordeaux - ISPED, Bordeaux, France; INRIA SISTM, Talence, France; CHU de Bordeaux, Service d'information m\u00e9dicale, INSERM, Bordeaux, France"],"raw_orcid":"https://orcid.org/0000-0003-2403-0960","affiliations":[{"raw_affiliation_string":"Bordeaux Population Health Research Center INSERM U1219, Universit\u00e9 de Bordeaux - ISPED, Bordeaux, France; INRIA SISTM, Talence, France; CHU de Bordeaux, Service d'information m\u00e9dicale, INSERM, Bordeaux, France","institution_ids":["https://openalex.org/I1326498283","https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210106115","https://openalex.org/I4405259406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059371192","display_name":"Alexandra Calmy","orcid":"https://orcid.org/0000-0002-1137-6826","observed_orcids":["https://orcid.org/0000-0002-1137-6826"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alexandra Calmy","raw_affiliation_strings":["HIV Unit, Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Unit, Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006038114","display_name":"Ram\u00f3n Teira","orcid":"https://orcid.org/0000-0002-0172-564X","observed_orcids":["https://orcid.org/0000-0002-0172-564X"]},"institutions":[{"id":"https://openalex.org/I4210103576","display_name":"Hospital Sierrallana","ror":"https://ror.org/01b2c5015","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210103576"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ramon Teira","raw_affiliation_strings":["Service of Internal Medicine, Hospital Universitario de Sierrallana, Torrelavega, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Internal Medicine, Hospital Universitario de Sierrallana, Torrelavega, Spain","institution_ids":["https://openalex.org/I4210103576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049087432","display_name":"Peter F. Rebeiro","orcid":"https://orcid.org/0000-0003-1951-9104","observed_orcids":["https://orcid.org/0000-0003-1951-9104"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter F. Rebeiro","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA"],"raw_orcid":"https://orcid.org/0000-0003-1951-9104","affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108093663","display_name":"Heidi M. Crane","orcid":"https://orcid.org/0000-0002-3308-7005","observed_orcids":["https://orcid.org/0000-0002-3308-7005"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heidi M. Crane","raw_affiliation_strings":["Center for AIDS Research, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for AIDS Research, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023418842","display_name":"Christoph Stephan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Stephan","raw_affiliation_strings":["Department of Internal Medicine, University Hospital Frankfurt, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Frankfurt, Frankfurt, Germany","institution_ids":["https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107482619","display_name":"Marc van der Valk","orcid":"https://orcid.org/0000-0002-8290-6425","observed_orcids":["https://orcid.org/0000-0002-8290-6425"]},"institutions":[{"id":"https://openalex.org/I4210120830","display_name":"Stichting HIV Monitoring","ror":"https://ror.org/02w6k4f12","country_code":"NL","type":"other","lineage":["https://openalex.org/I4210120830"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4405253132","display_name":"Amsterdam institute for Immunology and Infectious Diseases","ror":"https://ror.org/00bcn1057","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405253132"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marc van der Valk","raw_affiliation_strings":["Amsterdam Institute for Immunology & Infectious Diseases and Stichting HIV Monitoring, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-8290-6425","affiliations":[{"raw_affiliation_string":"Amsterdam Institute for Immunology & Infectious Diseases and Stichting HIV Monitoring, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I4210120830","https://openalex.org/I4210151833","https://openalex.org/I4405253132","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107868535","display_name":"Christoph Boesecke","orcid":"https://orcid.org/0000-0003-0686-6537","observed_orcids":["https://orcid.org/0000-0003-0686-6537"]},"institutions":[{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Boesecke","raw_affiliation_strings":["Department of Medicine I, Bonn University Hospital, Bonn, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0686-6537","affiliations":[{"raw_affiliation_string":"Department of Medicine I, Bonn University Hospital, Bonn, Germany","institution_ids":["https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068835724","display_name":"Giota Touloumi","orcid":"https://orcid.org/0000-0002-5951-0844","observed_orcids":["https://orcid.org/0000-0002-5951-0844"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Giota Touloumi","raw_affiliation_strings":["Department of Hygiene, Epidemiology & Medical Statistics, Medical School, National & Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0002-5951-0844","affiliations":[{"raw_affiliation_string":"Department of Hygiene, Epidemiology & Medical Statistics, Medical School, National & Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042984783","display_name":"M. John Gill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. John Gill","raw_affiliation_strings":["Department of Medicine, University of Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046356585","display_name":"Katharina Grabmeier\u2010Pfistershammer","orcid":"https://orcid.org/0000-0003-0665-5414","observed_orcids":["https://orcid.org/0000-0003-0665-5414"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Katharina Grabmeier-Pfistershammer","raw_affiliation_strings":["Medical University of Innsbruck, Innsbruck, Austria"],"raw_orcid":"https://orcid.org/0000-0003-0665-5414","affiliations":[{"raw_affiliation_string":"Medical University of Innsbruck, Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051397076","display_name":"Federico Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210113665","display_name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada","ror":"https://ror.org/026yy9j15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210113665"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4405268343","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Infecciosas","ror":"https://ror.org/00nd8zg79","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4405268343"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Federico Garcia","raw_affiliation_strings":["Servicio de Microbiolog\u00eda Cl\u00ednica, Hospital Universitario Cl\u00ednico San Cecilio, Instituto de Investigacion Biosanitaria IBS-Granada, CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Granada, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Microbiolog\u00eda Cl\u00ednica, Hospital Universitario Cl\u00ednico San Cecilio, Instituto de Investigacion Biosanitaria IBS-Granada, CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Granada, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210113665","https://openalex.org/I4210115082","https://openalex.org/I4405268343"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069733218","display_name":"Francesca Ceccherini\u2010Silberstein","orcid":"https://orcid.org/0000-0002-6024-5101","observed_orcids":["https://orcid.org/0000-0002-6024-5101"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Ceccherini-Silberstein","raw_affiliation_strings":["Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021580400","display_name":"Greer Burkholder","orcid":"https://orcid.org/0000-0001-7185-3025","observed_orcids":["https://orcid.org/0000-0001-7185-3025"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greer Burkholder","raw_affiliation_strings":["University of Alabama, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013017179","display_name":"Adam Trickey","orcid":"https://orcid.org/0000-0003-3462-2898","observed_orcids":["https://orcid.org/0000-0003-3462-2898"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adam Trickey","raw_affiliation_strings":["Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK"],"raw_orcid":"https://orcid.org/0000-0003-3462-2898","affiliations":[{"raw_affiliation_string":"Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015955757","display_name":"Jonathan A C Sterne","orcid":"https://orcid.org/0000-0001-8496-6053","observed_orcids":["https://orcid.org/0000-0001-8496-6053","https://orcid.org/0000-0002-5127-4728","https://orcid.org/0000-0003-1619-8456"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan A.C. Sterne","raw_affiliation_strings":["Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063582365","display_name":"Mojgan Hessamfar","orcid":"https://orcid.org/0000-0001-6475-1768","observed_orcids":["https://orcid.org/0000-0001-6475-1768"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210106115","display_name":"Bordeaux Population Health","ror":"https://ror.org/00xzzba89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]},{"id":"https://openalex.org/I4210111110","display_name":"H\u00f4pital Saint-Andr\u00e9","ror":"https://ror.org/021959v84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210111110"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mojgan Hessamfar","raw_affiliation_strings":["CHU de Bordeaux, H\u00f4pital Saint Andr\u00e9, Service de M\u00e9decine Interne et Maladies Infectieuses, Bordeaux, France; Bordeaux Population Health Research Center INSERM U1219, Universit\u00e9 de Bordeaux - ISPED, Bordeaux, France"],"raw_orcid":"https://orcid.org/0000-0001-6475-1768","affiliations":[{"raw_affiliation_string":"CHU de Bordeaux, H\u00f4pital Saint Andr\u00e9, Service de M\u00e9decine Interne et Maladies Infectieuses, Bordeaux, France; Bordeaux Population Health Research Center INSERM U1219, Universit\u00e9 de Bordeaux - ISPED, Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210106115","https://openalex.org/I4210111110"]}]}],"institutions":[],"countries_distinct_count":11,"institutions_distinct_count":27,"corresponding_author_ids":["https://openalex.org/A5079562113"],"corresponding_institution_ids":["https://openalex.org/I36234482"],"apc_list":{"value":3280,"currency":"USD","value_usd":3280},"apc_paid":{"value":3280,"currency":"USD","value_usd":3280},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.48563152,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":"11","first_page":"107925","last_page":"107925"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virologic-failure","display_name":"virological failure","score":0.7870000004768372},{"id":"https://openalex.org/keywords/raltegravir","display_name":"raltegravir","score":0.9169999957084656},{"id":"https://openalex.org/keywords/etravirine","display_name":"etravirine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/darunavir-ritonavir","display_name":"darunavir/ritonavir","score":0.9940000176429749},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.6909999847412109},{"id":"https://openalex.org/keywords/viral-suppression","display_name":"viral suppression","score":0.9319999814033508},{"id":"https://openalex.org/keywords/treatment-switching","display_name":"treatment switching","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8334000110626221},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.692300021648407},{"id":"https://openalex.org/C2776452011","wikidata":"https://www.wikidata.org/wiki/Q311463","display_name":"Sida","level":4,"score":0.47369998693466187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3781999945640564},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.34299999475479126},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3190000057220459},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.31679999828338623},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.31299999356269836},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.2930999994277954},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2782000005245209},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.26330000162124634},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.257099986076355},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2540999948978424}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1016/j.ijantimicag.2026.107925","doi":"https://doi.org/10.1016/j.ijantimicag.2026.107925","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijantimicag.2026.107925","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0924857926002128/pdf","source":{"id":"https://openalex.org/S5248501","display_name":"International Journal of Antimicrobial Agents","issn_l":"0924-8579","issn":["0924-8579","1872-7913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Antimicrobial Agents","raw_type":"journal-article"},{"id":"pmid:42442619","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42442619","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of antimicrobial agents","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13594993","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42442619/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Antimicrob Agents","raw_type":"Text"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire/e0ea46c1-7bd3-4729-a4ee-b6f382d2c84f","doi":null,"is_oa":true,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/e0ea46c1-7bd3-4729-a4ee-b6f382d2c84f","pdf_url":null,"source":{"id":"https://openalex.org/S7407055359","display_name":"Explore Bristol Research","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ingle, S M, Bonnet, F, Wittkop, L, Calmy, A, Teira, R, Rebeiro, P, Crane, H M, Stephan, C, van der Valk, M, Boesecke, C, Touloumi, G, Gill, M J, Grabmeier-Pfisterhammer, K, Garcia, F, Ceccherini-Silberstein, F, Burkholder, G A, Trickey, A J W, Sterne, J A C, Hessamfar, M 2026, 'Outcomes for persons with triple-class resistant HIV and a history of virologic failure', International Journal of Antimicrobial Agents, vol. 67, no. 11, 107925. https://doi.org/10.1016/j.ijantimicag.2026.107925","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/e0ea46c1-7bd3-4729-a4ee-b6f382d2c84f","doi":null,"is_oa":true,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/e0ea46c1-7bd3-4729-a4ee-b6f382d2c84f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ingle, S M, Bonnet, F, Wittkop, L, Calmy, A, Teira, R, Rebeiro, P, Crane, H M, Stephan, C, van der Valk, M, Boesecke, C, Touloumi, G, Gill, M J, Grabmeier-Pfisterhammer, K, Garcia, F, Ceccherini-Silberstein, F, Burkholder, G A, Trickey, A J W, Sterne, J A C, Hessamfar, M 2026, 'Outcomes for persons with triple-class resistant HIV and a history of virologic failure', International Journal of Antimicrobial Agents, vol. 67, no. 11, 107925. https://doi.org/10.1016/j.ijantimicag.2026.107925","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:aou:unige:196147","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:196147","pdf_url":"https://access.archive-ouverte.unige.ch/access/metadata/d7476577-c07d-47e9-a46e-d8a1a6f54d36/download","source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International journal of antimicrobial agents, vol. 67, no. 11 (2026) 107925","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-05737404v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05737404","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Antimicrobial Agents, 2026, 67 (11), pp.107925. ⟨10.1016/j.ijantimicag.2026.107925⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.ijantimicag.2026.107925","doi":"https://doi.org/10.1016/j.ijantimicag.2026.107925","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijantimicag.2026.107925","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0924857926002128/pdf","source":{"id":"https://openalex.org/S5248501","display_name":"International Journal of Antimicrobial Agents","issn_l":"0924-8579","issn":["0924-8579","1872-7913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Antimicrobial Agents","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G156834405","display_name":"Investigating the effect of climate extremes and global warming on HIV outcomes in sub-Saharan Africa","funder_award_id":"222770/Z/21/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2260452393","display_name":"1/3 Collaborative Research in HIV/AIDS, Alcohol, and Related Comorbidities (COMpAAAS) Tripartite: ART-CC, KP, and VA","funder_award_id":"U01AA026209","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G2659292052","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0611-10168","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G4098140815","display_name":null,"funder_award_id":"R01-AI181733","funder_id":"https://openalex.org/F4320309123","funder_display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5991616004","display_name":"Investigating the effect of climate extremes and global warming on HIV outcomes in sub-Saharan Africa","funder_award_id":"222770","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G9000860504","display_name":"A secure analytics platform to study the prognosis of people with HIV in the USA, Canada and Europe and comparative effectiveness of treatment regimens: the Antiretroviral Therapy Cohort Collaboration","funder_award_id":"R01AI181733","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309123","display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7168210671.pdf","grobid_xml":"https://content.openalex.org/works/W7168210671.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1592438403","https://openalex.org/W1996564823","https://openalex.org/W2038981426","https://openalex.org/W2085405111","https://openalex.org/W2124248661","https://openalex.org/W2156933277","https://openalex.org/W3092824650","https://openalex.org/W4213428638","https://openalex.org/W4295350608","https://openalex.org/W4310781134","https://openalex.org/W4386700358","https://openalex.org/W4391166148","https://openalex.org/W4399503853","https://openalex.org/W4405081234"],"related_works":["https://openalex.org/W3021327870","https://openalex.org/W4310781134","https://openalex.org/W4200084393","https://openalex.org/W7212054657","https://openalex.org/W4396229336","https://openalex.org/W7163695605","https://openalex.org/W4403785736","https://openalex.org/W4387393269","https://openalex.org/W2118571087","https://openalex.org/W4406946578"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"outcomes":[3,207],"of":[4,39,56,112,119,142,169,187,190,206,252,261,271],"heavily":[5],"treatment":[6],"experienced":[7],"people":[8],"with":[9],"HIV":[10,44],"(PWH)":[11],"who":[12],"received":[13,85],"the":[14,31,234,269],"antiretroviral":[15],"therapy":[16],"salvage":[17],"regimen":[18,218],"containing":[19],"raltegravir,":[20],"etravirine,":[21],"and":[22,41,70,80,89,96,127,152,211,227],"darunavir/ritonavir":[23],"(known":[24],"as":[25],"TRIO).":[26],"METHODS:":[27],"Data":[28],"were":[29,49,150,172,193],"from":[30],"ART":[32],"Cohort":[33],"Collaboration,":[34],"which":[35],"is":[36],"a":[37,54,133,184,259,266],"collaboration":[38],"European":[40],"North":[42],"American":[43],"cohort":[45],"studies.":[46],"Adult":[47],"PWH":[48,255],"eligible":[50,147],"if":[51],"they":[52],"had":[53],"history":[55,260],"virologic":[57,91,113,129],"failure":[58,92],"while":[59],"receiving":[60],"nonnucleoside":[61,81],"reverse-transcriptase":[62,82],"inhibitors;":[63],"three":[64,76,214,244],"or":[65,77,215,245],"more":[66,216,246],"primary":[67],"protease":[68],"inhibitor":[69,74,83],"nucleoside":[71],"reverse":[72],"transcriptase":[73],"mutations;":[75,84],"fewer":[78],"darunavir":[79],"TRIO":[86,94,101,107,210,223,230,239,257],"between":[87],"2007":[88],"2018;":[90],"at":[93,106,196],"start;":[95],"did":[97],"not":[98],"receive":[99],"any":[100],"drugs":[102],"previously.":[103],"Follow-up":[104],"began":[105],"start.":[108],"We":[109,131],"examined":[110],"rates":[111],"suppression":[114],"on":[115,175,229],"TRIO,":[116],"AIDS/death,":[117],"receipt":[118],"drug-reducing":[120,185,267],"regimens":[121],"post-TRIO":[122],"in":[123],"those":[124],"virologically":[125,173,194,253],"suppressed,":[126],"subsequent":[128],"response.":[130],"used":[132],"competing":[134],"risks":[135],"framework":[136],"to":[137,183,242,265],"estimate":[138],"5-y":[139,203],"cumulative":[140,204],"incidence":[141,205],"outcomes.":[143],"RESULTS:":[144],"Among":[145],"126":[146],"PWH,":[148],"24%":[149],"female,":[151],"median":[153],"age":[154],"was":[155,162,208,240],"46":[156],"y":[157,164],"(IQR:":[158,165],"41-50).":[159],"Median":[160],"follow-up":[161],"7.9":[163],"5.1-9.3).":[166],"A":[167],"total":[168],"94":[170],"(74.6%)":[171],"suppressed":[174,195,254],"TRIO.":[176],"Of":[177],"these,":[178],"26":[179,191],"(28%)":[180],"subsequently":[181],"switched":[182,264],"regimen,":[186,248,268],"whom":[188,272],"19":[189],"(73.1%)":[192],"their":[197],"next":[198],"viral":[199],"load":[200],"measure.":[201],"The":[202],"stop":[209,222],"start":[212],"another":[213,243],"drug":[217,247],"(39.1%);":[219],"simplify":[220],"(16.0%);":[221],"without":[224],"switching":[225],"(8.8%);":[226],"death":[228],"(7.2%).":[231],"CONCLUSIONS:":[232],"Although":[233],"most":[235],"common":[236],"outcome":[237],"after":[238],"switch":[241],"almost":[249],"one":[250],"third":[251],"under":[256],"(with":[258],"multidrug":[262],"resistance)":[263],"majority":[270],"maintained":[273],"suppression.":[274]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-07-14T00:00:00"}