{"id":"https://openalex.org/W7168146971","doi":"https://doi.org/10.1021/ehp.6c00205","title":"Unveiling the Link between Neonicotinoid Exposure and Cognitive Impairment in the Elderly: A Multiscale Framework Integrating Epidemiological Evidence with Network Toxicology and Molecular Docking","display_name":"Unveiling the Link between Neonicotinoid Exposure and Cognitive Impairment in the Elderly: A Multiscale Framework Integrating Epidemiological Evidence with Network Toxicology and Molecular Docking","publication_year":2026,"publication_date":"2026-07-13","ids":{"openalex":"https://openalex.org/W7168146971","doi":"https://doi.org/10.1021/ehp.6c00205"},"language":"en","primary_location":{"id":"doi:10.1021/ehp.6c00205","doi":"https://doi.org/10.1021/ehp.6c00205","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ehp.6c00205","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/EHP.6c00205?ref=article_openPDF","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/EHP.6c00205?ref=article_openPDF","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091144692","display_name":"Jinfeng Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinfeng Fu","raw_affiliation_strings":["Research Center for Environment and Health, School of Public Health (Shenzhen)","Shenzhen Campus of Sun Yat-sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Environment and Health, School of Public Health (Shenzhen)","institution_ids":[]},{"raw_affiliation_string":"Shenzhen Campus of Sun Yat-sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112528749","display_name":"Jiaojiao Ma","orcid":"https://orcid.org/0009-0002-2174-6517","observed_orcids":["https://orcid.org/0009-0002-2174-6517","https://orcid.org/0000-0001-9731-3529"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaojiao Ma","raw_affiliation_strings":["Research Center for Environment and Health, School of Public Health (Shenzhen)","Shenzhen Campus of Sun Yat-sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Environment and Health, School of Public Health (Shenzhen)","institution_ids":[]},{"raw_affiliation_string":"Shenzhen Campus of Sun Yat-sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072199025","display_name":"Peiyi Liu","orcid":"https://orcid.org/0000-0003-0686-307X","observed_orcids":["https://orcid.org/0000-0003-0686-307X"]},"institutions":[{"id":"https://openalex.org/I4210104954","display_name":"Shenzhen Center for Disease Control and Prevention","ror":"https://ror.org/01jbc0c43","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peiyi Liu","raw_affiliation_strings":["Shenzhen Center for Disease Control and Prevention","Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology"],"raw_orcid":"https://orcid.org/0000-0003-0686-307X","affiliations":[{"raw_affiliation_string":"Shenzhen Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I4210104954"]},{"raw_affiliation_string":"Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130040047","display_name":"Zuhai Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zuhai Chen","raw_affiliation_strings":["Research Center for Environment and Health, School of Public Health (Shenzhen)","Shenzhen Campus of Sun Yat-sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Environment and Health, School of Public Health (Shenzhen)","institution_ids":[]},{"raw_affiliation_string":"Shenzhen Campus of Sun Yat-sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100301527","display_name":"Zhihui Guo","orcid":"https://orcid.org/0009-0001-5477-2626","observed_orcids":["https://orcid.org/0009-0001-5477-2626"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihui Guo","raw_affiliation_strings":["Research Center for Environment and Health, School of Public Health (Shenzhen)","Shenzhen Campus of Sun Yat-sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Environment and Health, School of Public Health (Shenzhen)","institution_ids":[]},{"raw_affiliation_string":"Shenzhen Campus of Sun Yat-sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062557270","display_name":"Xiaohu Ren","orcid":"https://orcid.org/0000-0003-4181-3887","observed_orcids":["https://orcid.org/0000-0003-4181-3887"]},"institutions":[{"id":"https://openalex.org/I4210104954","display_name":"Shenzhen Center for Disease Control and Prevention","ror":"https://ror.org/01jbc0c43","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohu Ren","raw_affiliation_strings":["Shenzhen Center for Disease Control and Prevention","Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology"],"raw_orcid":"https://orcid.org/0000-0003-4181-3887","affiliations":[{"raw_affiliation_string":"Shenzhen Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I4210104954"]},{"raw_affiliation_string":"Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133401909","display_name":"Yiming Ge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiming Ge","raw_affiliation_strings":["Research Center for Environment and Health, School of Public Health (Shenzhen)","Shenzhen Campus of Sun Yat-sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Environment and Health, School of Public Health (Shenzhen)","institution_ids":[]},{"raw_affiliation_string":"Shenzhen Campus of Sun Yat-sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125183000","display_name":"X W Chen","orcid":"https://orcid.org/0009-0000-9243-0208","observed_orcids":["https://orcid.org/0009-0000-9243-0208","https://orcid.org/0009-0006-2730-4153"]},"institutions":[{"id":"https://openalex.org/I4210104954","display_name":"Shenzhen Center for Disease Control and Prevention","ror":"https://ror.org/01jbc0c43","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Chen","raw_affiliation_strings":["Shenzhen Center for Disease Control and Prevention","Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I4210104954"]},{"raw_affiliation_string":"Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102476620","display_name":"Xinxin Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinxin Tang","raw_affiliation_strings":["Research Center for Environment and Health, School of Public Health (Shenzhen)","Shenzhen Campus of Sun Yat-sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Environment and Health, School of Public Health (Shenzhen)","institution_ids":[]},{"raw_affiliation_string":"Shenzhen Campus of Sun Yat-sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xinjie Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinjie Li","raw_affiliation_strings":["Research Center for Environment and Health, School of Public Health (Shenzhen)","Shenzhen Campus of Sun Yat-sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Environment and Health, School of Public Health (Shenzhen)","institution_ids":[]},{"raw_affiliation_string":"Shenzhen Campus of Sun Yat-sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036761416","display_name":"Haiyan Huang","orcid":"https://orcid.org/0000-0002-9931-9884","observed_orcids":["https://orcid.org/0000-0002-9931-9884","https://orcid.org/0009-0004-5567-1394"]},"institutions":[{"id":"https://openalex.org/I4210104954","display_name":"Shenzhen Center for Disease Control and Prevention","ror":"https://ror.org/01jbc0c43","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyan Huang","raw_affiliation_strings":["Shenzhen Center for Disease Control and Prevention","Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I4210104954"]},{"raw_affiliation_string":"Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100752630","display_name":"Yi Chen","orcid":"https://orcid.org/0000-0002-9904-9511","observed_orcids":["https://orcid.org/0000-0002-9904-9511"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Chen","raw_affiliation_strings":["Research Center for Environment and Health, School of Public Health (Shenzhen)","Shenzhen Campus of Sun Yat-sen University"],"raw_orcid":"https://orcid.org/0000-0002-9904-9511","affiliations":[{"raw_affiliation_string":"Research Center for Environment and Health, School of Public Health (Shenzhen)","institution_ids":[]},{"raw_affiliation_string":"Shenzhen Campus of Sun Yat-sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140559181","display_name":"Jianjun Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104954","display_name":"Shenzhen Center for Disease Control and Prevention","ror":"https://ror.org/01jbc0c43","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104954"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianjun Liu","raw_affiliation_strings":["Shenzhen Center for Disease Control and Prevention","Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I4210104954"]},{"raw_affiliation_string":"Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004627084","display_name":"Shaoyou Lu","orcid":"https://orcid.org/0000-0002-8275-4927","observed_orcids":["https://orcid.org/0000-0002-8275-4927"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shaoyou Lu","raw_affiliation_strings":["Research Center for Environment and Health, School of Public Health (Shenzhen)","Shenzhen Campus of Sun Yat-sen University"],"raw_orcid":"https://orcid.org/0000-0002-8275-4927","affiliations":[{"raw_affiliation_string":"Research Center for Environment and Health, School of Public Health (Shenzhen)","institution_ids":[]},{"raw_affiliation_string":"Shenzhen Campus of Sun Yat-sen University","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004627084","https://openalex.org/A5140559181"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210104954"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":3.6325,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.84124587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11641","display_name":"Insect and Pesticide Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonicotinoids","display_name":"neonicotinoids","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9869999885559082},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9079999923706055},{"id":"https://openalex.org/keywords/imidacloprid","display_name":"imidacloprid","score":0.8259999752044678},{"id":"https://openalex.org/keywords/dinotefuran","display_name":"dinotefuran","score":0.9959999918937683},{"id":"https://openalex.org/keywords/thiacloprid","display_name":"thiacloprid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/urinary-pesticide-metabolites","display_name":"urinary pesticide metabolites","score":0.5989999771118164},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/network-toxicology","display_name":"network toxicology","score":0.9179999828338623},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hsp90aa1","display_name":"HSP90AA1","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.9819999933242798},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.7020000219345093},{"id":"https://openalex.org/keywords/mitochondrial-dna-copy-number","display_name":"mitochondrial DNA copy number","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.5267999768257141},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.4657000005245209},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4343000054359436},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4235999882221222},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4059000015258789},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38530001044273376},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3774999976158142},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35830000042915344},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33379998803138733},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3052000105381012},{"id":"https://openalex.org/C3017497123","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Acute exposure","level":2,"score":0.3050000071525574},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3027999997138977},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2987000048160553},{"id":"https://openalex.org/C2777500947","wikidata":"https://www.wikidata.org/wiki/Q902225","display_name":"Neonicotinoid","level":4,"score":0.2897999882698059},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27730000019073486},{"id":"https://openalex.org/C2778753846","wikidata":"https://www.wikidata.org/wiki/Q6554239","display_name":"Link (geometry)","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.2728999853134155},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.2721000015735626},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.2542000114917755},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.2540000081062317}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/ehp.6c00205","doi":"https://doi.org/10.1021/ehp.6c00205","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ehp.6c00205","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/EHP.6c00205?ref=article_openPDF","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1021/ehp.6c00205","doi":"https://doi.org/10.1021/ehp.6c00205","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ehp.6c00205","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/EHP.6c00205?ref=article_openPDF","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2298865650","display_name":null,"funder_award_id":"SZSM202211010","funder_id":"https://openalex.org/F4320335767","funder_display_name":"Sanming Project of Medicine in Shenzhen"},{"id":"https://openalex.org/G2653449043","display_name":null,"funder_award_id":"42077385","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3313910548","display_name":null,"funder_award_id":"42277424","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4462624886","display_name":null,"funder_award_id":"SZSM202211010","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6751252511","display_name":null,"funder_award_id":"SZXK069","funder_id":"https://openalex.org/F4320335767","funder_display_name":"Sanming Project of Medicine in Shenzhen"},{"id":"https://openalex.org/G7584036699","display_name":null,"funder_award_id":"JCYJ20210324141815040","funder_id":"https://openalex.org/F4320326705","funder_display_name":"Science, Technology and Innovation Commission of Shenzhen Municipality"},{"id":"https://openalex.org/G8077513072","display_name":null,"funder_award_id":"JCYJ20230807110903008","funder_id":"https://openalex.org/F4320326705","funder_display_name":"Science, Technology and Innovation Commission of Shenzhen Municipality"},{"id":"https://openalex.org/G917521466","display_name":null,"funder_award_id":"SZXK069","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326705","display_name":"Science, Technology and Innovation Commission of Shenzhen Municipality","ror":null},{"id":"https://openalex.org/F4320335767","display_name":"Sanming Project of Medicine in Shenzhen","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7168146971.pdf","grobid_xml":"https://content.openalex.org/works/W7168146971.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1929734874","https://openalex.org/W1982731367","https://openalex.org/W2047463911","https://openalex.org/W2067768093","https://openalex.org/W2124395110","https://openalex.org/W2149891144","https://openalex.org/W2151468553","https://openalex.org/W2267681011","https://openalex.org/W2549552700","https://openalex.org/W2752158994","https://openalex.org/W2792342160","https://openalex.org/W2885328366","https://openalex.org/W2886361157","https://openalex.org/W2901162259","https://openalex.org/W2902142233","https://openalex.org/W2911461017","https://openalex.org/W2920862727","https://openalex.org/W2922123106","https://openalex.org/W2937508639","https://openalex.org/W2951884886","https://openalex.org/W2969924804","https://openalex.org/W2971095443","https://openalex.org/W2995643387","https://openalex.org/W3005509885","https://openalex.org/W3011164923","https://openalex.org/W3011380763","https://openalex.org/W3032926029","https://openalex.org/W3045208599","https://openalex.org/W3124833262","https://openalex.org/W3127173956","https://openalex.org/W3154590122","https://openalex.org/W3163958091","https://openalex.org/W3164468287","https://openalex.org/W3189666578","https://openalex.org/W3198830854","https://openalex.org/W3206091338","https://openalex.org/W3206856143","https://openalex.org/W3213349599","https://openalex.org/W3214464446","https://openalex.org/W3217247742","https://openalex.org/W3217686687","https://openalex.org/W4206449588","https://openalex.org/W4210511064","https://openalex.org/W4210996273","https://openalex.org/W4229019098","https://openalex.org/W4283366815","https://openalex.org/W4294368569","https://openalex.org/W4296887696","https://openalex.org/W4315927707","https://openalex.org/W4316927863","https://openalex.org/W4323926543","https://openalex.org/W4353016768","https://openalex.org/W4361218693","https://openalex.org/W4368347895","https://openalex.org/W4377012342","https://openalex.org/W4381662743","https://openalex.org/W4385496821","https://openalex.org/W4385620596","https://openalex.org/W4386619791","https://openalex.org/W4387235331","https://openalex.org/W4387909500","https://openalex.org/W4390907976","https://openalex.org/W4392350114","https://openalex.org/W4392701989","https://openalex.org/W4393201869","https://openalex.org/W4394840123","https://openalex.org/W4401008255","https://openalex.org/W4402858183","https://openalex.org/W4404279371","https://openalex.org/W4404929127","https://openalex.org/W4405571581","https://openalex.org/W4405763772","https://openalex.org/W4407318014","https://openalex.org/W4407767057","https://openalex.org/W4408039530","https://openalex.org/W4408840133","https://openalex.org/W4409218470","https://openalex.org/W4410511259","https://openalex.org/W4410574145","https://openalex.org/W4410951114","https://openalex.org/W4411097830","https://openalex.org/W4411592906","https://openalex.org/W4411730065","https://openalex.org/W4414100406","https://openalex.org/W4414155316","https://openalex.org/W4414407715","https://openalex.org/W4414664451","https://openalex.org/W4414722579","https://openalex.org/W4416088805","https://openalex.org/W4416416216","https://openalex.org/W4416524385","https://openalex.org/W4416955144","https://openalex.org/W4417161510","https://openalex.org/W7123474831"],"related_works":["https://openalex.org/W7170074781","https://openalex.org/W4410264268","https://openalex.org/W4405571581","https://openalex.org/W3185509612","https://openalex.org/W4385289307","https://openalex.org/W3211502936","https://openalex.org/W7220666810","https://openalex.org/W4415230624","https://openalex.org/W4412140316","https://openalex.org/W4406887355"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Neonicotinoids":[7],"(NEOs)":[8],"are":[9,43],"the":[10,40,83,99,123,127,193],"most":[11],"widely":[12],"used":[13],"insecticides":[14],"worldwide":[15],"and":[16,39,56,74,117,134,155,171,203],"have":[17],"been":[18,28,181],"detected":[19],"in":[20,30,35,61,145,160,183,192,200],"various":[21],"biological":[22],"samples.":[23],"While":[24],"NEO":[25,87],"neurotoxicity":[26,147],"has":[27,180],"demonstrated":[29],"animal":[31],"studies,":[32],"epidemiological":[33],"evidence":[34],"humans":[36],"remains":[37],"limited,":[38],"underlying":[41],"mechanisms":[42],"not":[44],"fully":[45],"elucidated.":[46],"In":[47],"this":[48],"study,":[49],"urinary":[50],"concentrations":[51],"of":[52,86,101],"six":[53],"parent":[54],"NEOs":[55,94],"four":[57],"metabolites":[58],"were":[59,79,120],"quantified":[60],"1150":[62],"older":[63],"adults":[64],"from":[65],"Shenzhen,":[66],"China.":[67],"Quantile-based":[68],"g-computation,":[69],"weighted":[70],"quantile":[71],"sum":[72],"regression,":[73],"Bayesian":[75],"kernel":[76],"machine":[77],"regression":[78],"employed":[80],"to":[81,93,126],"assess":[82],"joint":[84],"effects":[85],"mixture":[88],"on":[89],"cognitive":[90,102,184],"impairment.":[91],"Co-exposure":[92],"was":[95,190],"positively":[96],"associated":[97],"with":[98],"risk":[100],"impairment":[103],"(OR":[104],"=":[105,111],"1.65,":[106],"95%":[107],"CI:":[108],"1.05\u20132.60,":[109],"P":[110],"0.03).":[112],"Imidacloprid":[113],"(IMI),":[114],"dinotefuran":[115],"(DIN),":[116],"thiacloprid":[118],"(THD)":[119],"recognized":[121],"as":[122,142],"major":[124],"contributors":[125],"overall":[128],"effect.":[129],"Moreover,":[130],"integrative":[131],"network":[132],"toxicology":[133],"molecular":[135],"docking":[136],"analyses":[137],"identified":[138],"eight":[139],"core":[140],"targets":[141],"potential":[143],"mediators":[144],"NEO-induced":[146],"(HSP90AA1,":[148],"TP53,":[149],"JUN,":[150],"EGFR,":[151],"JAK2,":[152],"STAT3,":[153],"MET,":[154],"PIK3R1),":[156],"suggesting":[157],"coordinated":[158],"disruptions":[159],"neuroactive":[161],"ligand\u2013receptor":[162],"interactions,":[163],"kinase-regulated":[164],"signaling":[165],"pathways,":[166],"inflammatory":[167],"responses,":[168],"apoptosis":[169],"processes,":[170],"synaptic":[172],"function.":[173],"Although":[174],"mitochondrial":[175],"DNA":[176],"copy":[177],"number":[178],"(mtDNA-CN)":[179],"implicated":[182],"aging,":[185],"no":[186],"significant":[187],"mediating":[188],"effect":[189],"observed":[191],"exposure-outcome":[194],"relationship.":[195],"These":[196],"findings":[197],"warrant":[198],"validation":[199],"large-scale":[201],"cohorts":[202],"experimental":[204],"studies.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-07-14T00:00:00"}
