{"id":"https://openalex.org/W7167908026","doi":"https://doi.org/10.1016/j.xjon.2026.101957","title":"Substance use disorder\u2013associated tricuspid endocarditis: Staged surgery from valvectomy to replacement","display_name":"Substance use disorder\u2013associated tricuspid endocarditis: Staged surgery from valvectomy to replacement","publication_year":2026,"publication_date":"2026-07-10","ids":{"openalex":"https://openalex.org/W7167908026","doi":"https://doi.org/10.1016/j.xjon.2026.101957","pmid":"https://pubmed.ncbi.nlm.nih.gov/42948116","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13711186"},"language":"en","primary_location":{"id":"doi:10.1016/j.xjon.2026.101957","doi":"https://doi.org/10.1016/j.xjon.2026.101957","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjon.2026.101957","pdf_url":"https://www.jtcvsopen.org/article/S2666-2736(26)00380-3/pdf","source":{"id":"https://openalex.org/S4210197350","display_name":"JTCVS Open","issn_l":"2666-2736","issn":["2666-2736"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jtcvsopen.org/article/S2666-2736(26)00380-3/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039037998","display_name":"Joshua G. Crane","orcid":"https://orcid.org/0009-0007-2553-2133","observed_orcids":["https://orcid.org/0009-0007-2553-2133"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua G. Crane","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":"https://orcid.org/0009-0007-2553-2133","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037295798","display_name":"Toyokazu Endo","orcid":"https://orcid.org/0000-0002-0772-236X","observed_orcids":["https://orcid.org/0000-0002-0772-236X"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toyokazu Endo","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012694099","display_name":"Jaimin R. Trivedi","orcid":"https://orcid.org/0000-0001-7152-1338","observed_orcids":["https://orcid.org/0000-0001-7152-1338"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaimin R. Trivedi","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034405832","display_name":"Brian L. Ganzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian L. Ganzel","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140445859","display_name":"Sharini Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharini Shah","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091640576","display_name":"Siddharth Pahwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siddharth V. Pahwa","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111657778","display_name":"Mark S. Slaughter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark S. Slaughter","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081482232","display_name":"Michele Gallo","orcid":"https://orcid.org/0000-0002-1392-4558","observed_orcids":["https://orcid.org/0000-0002-1392-4558"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michele Gallo","raw_affiliation_strings":["Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081482232"],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":{"value":2431,"currency":"USD","value_usd":2431},"apc_paid":{"value":2431,"currency":"USD","value_usd":2431},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.5026102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":null,"first_page":"101957","last_page":"101957"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12598","display_name":"Cardiac Structural Anomalies and Repair","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tricuspid-valve-infective-endocarditis","display_name":"tricuspid valve infective endocarditis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/substance-use-disorders","display_name":"substance use disorders","score":0.9269999861717224},{"id":"https://openalex.org/keywords/injection-drug-use","display_name":"intravenous drug use","score":0.9700000286102295},{"id":"https://openalex.org/keywords/drug-abstinence","display_name":"drug abstinence","score":0.8820000290870667},{"id":"https://openalex.org/keywords/survival-outcomes","display_name":"survival outcomes","score":0.6600000262260437},{"id":"https://openalex.org/keywords/postoperative-mortality","display_name":"postoperative mortality","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7694000005722046},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6284999847412109},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.3154999911785126},{"id":"https://openalex.org/C2779946567","wikidata":"https://www.wikidata.org/wiki/Q1344255","display_name":"Tricuspid valve","level":2,"score":0.3025999963283539},{"id":"https://openalex.org/C2991912374","wikidata":"https://www.wikidata.org/wiki/Q400711","display_name":"Substance use","level":2,"score":0.24089999496936798},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.23899999260902405},{"id":"https://openalex.org/C2780026749","wikidata":"https://www.wikidata.org/wiki/Q7912830","display_name":"Valve replacement","level":3,"score":0.21459999680519104},{"id":"https://openalex.org/C2908559789","wikidata":"https://www.wikidata.org/wiki/Q1780241","display_name":"Tricuspid Valve Insufficiency","level":3,"score":0.2013999968767166},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.19280000030994415},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.1923000067472458}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.xjon.2026.101957","doi":"https://doi.org/10.1016/j.xjon.2026.101957","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjon.2026.101957","pdf_url":"https://www.jtcvsopen.org/article/S2666-2736(26)00380-3/pdf","source":{"id":"https://openalex.org/S4210197350","display_name":"JTCVS Open","issn_l":"2666-2736","issn":["2666-2736"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13711186","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13711186/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13711186/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS Open","raw_type":"Text"},{"id":"pmid:42948116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42948116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS open","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:41fcffbdc7144ea0b4d7d688e6e3e5d3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/41fcffbdc7144ea0b4d7d688e6e3e5d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JTCVS Open, Vol 33, Iss , Pp 101957- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.xjon.2026.101957","doi":"https://doi.org/10.1016/j.xjon.2026.101957","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xjon.2026.101957","pdf_url":"https://www.jtcvsopen.org/article/S2666-2736(26)00380-3/pdf","source":{"id":"https://openalex.org/S4210197350","display_name":"JTCVS Open","issn_l":"2666-2736","issn":["2666-2736"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTCVS Open","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7167908026.pdf","grobid_xml":"https://content.openalex.org/works/W7167908026.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2898078060","https://openalex.org/W2890703227","https://openalex.org/W2281489918","https://openalex.org/W7160336620","https://openalex.org/W2017970981","https://openalex.org/W2010243365","https://openalex.org/W2029727834","https://openalex.org/W4206354245","https://openalex.org/W2988989327","https://openalex.org/W4407898509"],"abstract_inverted_index":{"Objectives:":[0],"Optimal":[1],"surgical":[2,118,133],"treatment":[3,134,249],"of":[4,15,154,202,227,277],"infective":[5,7],"tricuspid":[6,31,52,105],"endocarditis":[8,25],"(TVIE)":[9],"is":[10,245,280],"controversial":[11],"in":[12,141,210,225,250,270],"the":[13,43,145,211,236],"setting":[14],"active":[16],"substance":[17],"use.":[18],"This":[19],"study":[20,276],"evaluated":[21],"patients":[22,131],"who":[23,71,90],"had":[24],"that":[26,190],"was":[27,39,65,139,169,204,215,223,238],"not":[28,76,115,184],"amenable":[29,77],"to":[30,41,68,78],"valve":[32,53,106,254],"repair.":[33],"In":[34,128,188],"these":[35],"patients,":[36,146],"a":[37,50,151,271],"valvectomy":[38,73,92,138,244],"performed":[40],"remove":[42],"diseased":[44],"tissue.":[45],"Patients":[46,89,109],"were":[47,101,125,148,158,195],"then":[48],"offered":[49],"subsequent":[51],"replacement":[54,107,255],"after":[55,80,221,235,256],"proper":[56],"follow-up":[57],"and":[58,84,123,166,172,180,207,232,240],"drug":[59,96,112,218],"abstinence.":[60],"Methods:":[61],"A":[62],"single-center":[63],"database":[64],"queried":[66],"(2015-2025)":[67],"identify":[69],"adults":[70],"underwent":[72,91,132],"for":[74,98,103,135,264],"TVIE":[75],"repair":[79],"failed":[81],"medical":[82],"therapy":[83],"persistent":[85,111],"positive":[86],"blood":[87],"cultures.":[88],"with":[93,110,150],"documented":[94],"intravenous":[95,262],"abstinence":[97,259],"6":[99,205,265],"months":[100,266],"considered":[102],"staged":[104],"(sTVR).":[108],"use":[113,219],"did":[114,183],"receive":[116,185],"further":[117],"treatment.":[119],"Baseline":[120],"characteristics,":[121],"outcomes,":[122],"survival":[124,168],"evaluated.":[126],"Results:":[127],"total,":[129],"153":[130],"TVIE.":[136],"Tricuspid":[137,243,253],"required":[140],"51":[142],"patients.":[143,228,252],"Of":[144],"66%":[147],"female,":[149],"median":[152,199,208],"age":[153],"30":[155],"years.":[156],"There":[157],"2":[159],"operative":[160,197],"mortalities":[161],"(3.9%).":[162],"The":[163],"1-,":[164],"5-,":[165],"8-year":[167],"91%,":[170],"62%,":[171],"51%,":[173],"respectively;":[174],"26":[175],"(51%)":[176],"received":[177,191],"an":[178,192,246,258],"sTVR":[179,186,222,237],"25":[181],"(49%)":[182],"(non-sTVR).":[187],"those":[189],"sTVR,":[193],"there":[194],"0":[196],"mortalities,":[198],"postoperative":[200],"length":[201],"stay":[203],"days,":[206],"hours":[209],"intensive":[212],"care":[213],"unit":[214],"30.":[216],"Intravenous":[217],"relapse":[220],"present":[224],"57.7%":[226],"Survival":[229],"at":[230],"1":[231],"5":[233],"years":[234],"100%":[239],"60%.":[241],"Conclusions:":[242],"acceptable":[247,268],"initial":[248],"high-risk":[251],"completing":[257],"program":[260],"from":[261],"drugs":[263],"has":[267],"outcomes":[269,279],"complex":[272],"patient":[273],"population.":[274],"Further":[275],"long-term":[278],"warranted.":[281]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-07-11T00:00:00"}