{"id":"https://openalex.org/W7167836632","doi":"https://doi.org/10.15698/cst2026.07.318","title":"Polyamine-mediated inhibition of ferroptosis contributes to geroprotection","display_name":"Polyamine-mediated inhibition of ferroptosis contributes to geroprotection","publication_year":2026,"publication_date":"2026-07-03","ids":{"openalex":"https://openalex.org/W7167836632","doi":"https://doi.org/10.15698/cst2026.07.318","pmid":"https://pubmed.ncbi.nlm.nih.gov/42444672","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13358466"},"language":"en","primary_location":{"id":"doi:10.15698/cst2026.07.318","doi":"https://doi.org/10.15698/cst2026.07.318","is_oa":true,"landing_page_url":"https://doi.org/10.15698/cst2026.07.318","pdf_url":"http://www.cell-stress.com/wp-content/uploads/2026a-madeo-cell-stress.pdf","source":{"id":"https://openalex.org/S4210196648","display_name":"Cell Stress","issn_l":"2523-0204","issn":["2523-0204"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317901","host_organization_name":"Shared Science Publishers OG","host_organization_lineage":["https://openalex.org/P4310317901"],"host_organization_lineage_names":["Shared Science Publishers OG"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stress","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell-stress.com/wp-content/uploads/2026a-madeo-cell-stress.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078054009","display_name":"Frank Madeo","orcid":"https://orcid.org/0000-0002-5070-1329","observed_orcids":["https://orcid.org/0000-0002-5070-1329"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]},{"id":"https://openalex.org/I4210108044","display_name":"Nawi Graz","ror":"https://ror.org/01mm16571","country_code":"AT","type":"education","lineage":["https://openalex.org/I4210108044"]},{"id":"https://openalex.org/I4210117258","display_name":"BioTechMed-Graz","ror":"https://ror.org/02jfbm483","country_code":"AT","type":"facility","lineage":["https://openalex.org/I4210117258"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Frank Madeo","raw_affiliation_strings":["BioHealth Graz, Graz 8010, Austria","BioTechMed Graz, Graz 8010, Austria","Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz 8010, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioHealth Graz, Graz 8010, Austria","institution_ids":["https://openalex.org/I4210117258"]},{"raw_affiliation_string":"BioTechMed Graz, Graz 8010, Austria","institution_ids":["https://openalex.org/I4210117258"]},{"raw_affiliation_string":"Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz 8010, Austria","institution_ids":["https://openalex.org/I15766117","https://openalex.org/I4210108044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030912064","display_name":"Didac Carmona\u2010Guti\u00e9rrez","orcid":"https://orcid.org/0000-0001-7548-7771","observed_orcids":["https://orcid.org/0000-0001-7548-7771"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]},{"id":"https://openalex.org/I4210108044","display_name":"Nawi Graz","ror":"https://ror.org/01mm16571","country_code":"AT","type":"education","lineage":["https://openalex.org/I4210108044"]},{"id":"https://openalex.org/I4210117258","display_name":"BioTechMed-Graz","ror":"https://ror.org/02jfbm483","country_code":"AT","type":"facility","lineage":["https://openalex.org/I4210117258"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Didac Carmona-Gutierrez","raw_affiliation_strings":["BioHealth Graz, Graz 8010, Austria","Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz 8010, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioHealth Graz, Graz 8010, Austria","institution_ids":["https://openalex.org/I4210117258"]},{"raw_affiliation_string":"Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz 8010, Austria","institution_ids":["https://openalex.org/I15766117","https://openalex.org/I4210108044"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075296559","display_name":"Guido Kroemer","orcid":"https://orcid.org/0000-0002-9334-4405","observed_orcids":["https://orcid.org/0000-0002-9334-4405"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102325","display_name":"H\u00f4pital Europ\u00e9en Georges-Pompidou","ror":"https://ror.org/016vx5156","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102325","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4405255799","display_name":"Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse","ror":"https://ror.org/03ef0j886","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405255799"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Guido Kroemer","raw_affiliation_strings":["Institut du Cancer Paris CARPEM, Department of Biology, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, Paris, France","Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Inserm U1138, Centre de Recherche des Cordeliers, Equipe labellis\u00e9e par la Ligue contre le cancer, Paris, France","Universit\u00e9 Paris-Saclay, INSERM US23/CNRS UAR 3655, Metabolomics and Cell Biology Platforms, UMS AMMICa, Institut Gustave Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut du Cancer Paris CARPEM, Department of Biology, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102325"]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Inserm U1138, Centre de Recherche des Cordeliers, Equipe labellis\u00e9e par la Ligue contre le cancer, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, INSERM US23/CNRS UAR 3655, Metabolomics and Cell Biology Platforms, UMS AMMICa, Institut Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405255799"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5075296559","https://openalex.org/A5078054009"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I15766117","https://openalex.org/I204730241","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I39804081","https://openalex.org/I4210092322","https://openalex.org/I4210097159","https://openalex.org/I4210102325","https://openalex.org/I4210108044","https://openalex.org/I4210117258","https://openalex.org/I4405255799"],"apc_list":{"value":1190,"currency":"EUR","value_usd":1283},"apc_paid":{"value":1190,"currency":"EUR","value_usd":1283},"fwci":2.0521,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.88818273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"10","issue":"1","first_page":"49","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.4796999990940094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.4796999990940094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.2816999852657318,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.19419999420642853,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyamines","display_name":"polyamines","score":0.796999990940094},{"id":"https://openalex.org/keywords/spermine","display_name":"spermine","score":0.7670000195503235},{"id":"https://openalex.org/keywords/spermidine","display_name":"spermidine","score":1.0},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/healthspan","display_name":"healthspan","score":0.6050000190734863},{"id":"https://openalex.org/keywords/iron-chelation","display_name":"iron chelation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8790000081062317},{"id":"https://openalex.org/keywords/ferritinophagy","display_name":"ferritinophagy","score":0.8679999709129333},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/acrolein","display_name":"acrolein","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8939999938011169},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.5950000286102295},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C2777497464","wikidata":"https://www.wikidata.org/wiki/Q418834","display_name":"Spermidine","level":3,"score":0.9070000052452087},{"id":"https://openalex.org/C2776109719","wikidata":"https://www.wikidata.org/wiki/Q424597","display_name":"Spermine","level":3,"score":0.9042999744415283},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7461000084877014},{"id":"https://openalex.org/C2780115381","wikidata":"https://www.wikidata.org/wiki/Q421959","display_name":"Polyamine","level":2,"score":0.7056000232696533},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.6410999894142151},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5740000009536743},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5293999910354614},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5167999863624573},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.453000009059906},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.3797999918460846},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.3750999867916107},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3619000017642975},{"id":"https://openalex.org/C121289238","wikidata":"https://www.wikidata.org/wiki/Q931579","display_name":"Ornithine decarboxylase","level":3,"score":0.34310001134872437},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.335999995470047},{"id":"https://openalex.org/C2777167505","wikidata":"https://www.wikidata.org/wiki/Q410190","display_name":"Putrescine","level":3,"score":0.3174999952316284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3075999915599823},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.30239999294281006},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.29739999771118164},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2874000072479248},{"id":"https://openalex.org/C2778001298","wikidata":"https://www.wikidata.org/wiki/Q1036906","display_name":"Histone acetyltransferase","level":4,"score":0.25589999556541443}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.15698/cst2026.07.318","doi":"https://doi.org/10.15698/cst2026.07.318","is_oa":true,"landing_page_url":"https://doi.org/10.15698/cst2026.07.318","pdf_url":"http://www.cell-stress.com/wp-content/uploads/2026a-madeo-cell-stress.pdf","source":{"id":"https://openalex.org/S4210196648","display_name":"Cell Stress","issn_l":"2523-0204","issn":["2523-0204"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317901","host_organization_name":"Shared Science Publishers OG","host_organization_lineage":["https://openalex.org/P4310317901"],"host_organization_lineage_names":["Shared Science Publishers OG"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stress","raw_type":"journal-article"},{"id":"pmid:42444672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42444672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell stress","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13358466","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13358466/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stress","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-05702661v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05702661","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Stress, 2026, 10 (1), pp.49-52. ⟨10.15698/cst2026.07.318⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:560d55bffe4b4804bbdbba68fd1471e3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/560d55bffe4b4804bbdbba68fd1471e3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Stress, Vol 10, Pp 49-52 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.15698/cst2026.07.318","doi":"https://doi.org/10.15698/cst2026.07.318","is_oa":true,"landing_page_url":"https://doi.org/10.15698/cst2026.07.318","pdf_url":"http://www.cell-stress.com/wp-content/uploads/2026a-madeo-cell-stress.pdf","source":{"id":"https://openalex.org/S4210196648","display_name":"Cell Stress","issn_l":"2523-0204","issn":["2523-0204"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317901","host_organization_name":"Shared Science Publishers OG","host_organization_lineage":["https://openalex.org/P4310317901"],"host_organization_lineage_names":["Shared Science Publishers OG"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stress","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1044593785","display_name":null,"funder_award_id":"P29262","funder_id":"https://openalex.org/F4320325582","funder_display_name":"Karl-Franzens-Universit\u00e4t Graz"},{"id":"https://openalex.org/G1348591106","display_name":null,"funder_award_id":"ANR-23-CE44-0030","funder_id":"https://openalex.org/F4320316862","funder_display_name":"Equipex"},{"id":"https://openalex.org/G1397743473","display_name":null,"funder_award_id":"101095604","funder_id":"https://openalex.org/F4320315890","funder_display_name":"Seerave Foundation"},{"id":"https://openalex.org/G1540355574","display_name":null,"funder_award_id":"ANR-22-CE14-0066","funder_id":"https://openalex.org/F4320316862","funder_display_name":"Equipex"},{"id":"https://openalex.org/G1716190585","display_name":null,"funder_award_id":"101052444","funder_id":"https://openalex.org/F4320322893","funder_display_name":"Institut Universitaire de France"},{"id":"https://openalex.org/G1743485262","display_name":null,"funder_award_id":"Cancer_18006","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G1846858737","display_name":null,"funder_award_id":"101095604","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G1941370527","display_name":null,"funder_award_id":"ANR-23-R4HC-0006 Ener-LIGHT","funder_id":"https://openalex.org/F4320316862","funder_display_name":"Equipex"},{"id":"https://openalex.org/G1963894250","display_name":null,"funder_award_id":"ANR-18- IDEX-0001","funder_id":"https://openalex.org/F4320331438","funder_display_name":"Universit\u00e9 de Paris"},{"id":"https://openalex.org/G2109069054","display_name":null,"funder_award_id":"21-ESRE-0028","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G2161503289","display_name":null,"funder_award_id":"ERC-2021-ADG","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G2179318311","display_name":null,"funder_award_id":"ANR-23-R4HC-0006 En-er-LIGHT","funder_id":"https://openalex.org/F4320315890","funder_display_name":"Seerave Foundation"},{"id":"https://openalex.org/G2203660494","display_name":null,"funder_award_id":"825410","funder_id":"https://openalex.org/F4320322893","funder_display_name":"Institut Universitaire de France"},{"id":"https://openalex.org/G2260018823","display_name":"Lung cancer prevention and interception","funder_award_id":"ANR-23-RHUS-0010","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2264961340","display_name":"Biomarkers affecting the transition from cardiovascular disease to lung cancer: towards stratified interception.","funder_award_id":"101095604","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2351262490","display_name":null,"funder_award_id":"101052444","funder_id":"https://openalex.org/F4320315890","funder_display_name":"Seerave Foundation"},{"id":"https://openalex.org/G2374589210","display_name":null,"funder_award_id":"F3012","funder_id":"https://openalex.org/F4320325582","funder_display_name":"Karl-Franzens-Universit\u00e4t Graz"},{"id":"https://openalex.org/G2469459663","display_name":null,"funder_award_id":"ANR-21-RHUS-0017","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G2564658597","display_name":null,"funder_award_id":"P31727","funder_id":"https://openalex.org/F4320325582","funder_display_name":"Karl-Franzens-Universit\u00e4t Graz"},{"id":"https://openalex.org/G2633149742","display_name":"Gut OncoMicrobiome Signatures (GOMS) associated with cancer incidence, prognosis and prediction of treatment response.","funder_award_id":"825410","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2699422577","display_name":null,"funder_award_id":"101095604","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G2714391379","display_name":null,"funder_award_id":"ANR-21-RHUS-0017","funder_id":"https://openalex.org/F4320315890","funder_display_name":"Seerave Foundation"},{"id":"https://openalex.org/G2992841218","display_name":null,"funder_award_id":"21-ESRE-0028","funder_id":"https://openalex.org/F4320322893","funder_display_name":"Institut Universitaire de France"},{"id":"https://openalex.org/G2998623936","display_name":null,"funder_award_id":"P37278","funder_id":"https://openalex.org/F4320325582","funder_display_name":"Karl-Franzens-Universit\u00e4t Graz"},{"id":"https://openalex.org/G3231222199","display_name":null,"funder_award_id":"#ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G3280152251","display_name":"Mitochondrial copper targeting to modulate inflammatory macrophages","funder_award_id":"ANR-23-CE44-0030","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3489513111","display_name":null,"funder_award_id":"ANR-23-RHUS-0010","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G3536394303","display_name":null,"funder_award_id":"ANR-23-R4HC-0006 En-er-LIGHT","funder_id":"https://openalex.org/F4320322893","funder_display_name":"Institut Universitaire de France"},{"id":"https://openalex.org/G3649057135","display_name":"Pro-autophagic polyphenols and polyamines for longevity","funder_award_id":"P 27893","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G3745988485","display_name":null,"funder_award_id":"ANR-23-R4HC-0006 Ener-LIGHT","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G3772543176","display_name":null,"funder_award_id":"825410","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G4007257112","display_name":null,"funder_award_id":"ERC-2021-ADG","funder_id":"https://openalex.org/F4320322893","funder_display_name":"Institut Universitaire de France"},{"id":"https://openalex.org/G420978141","display_name":null,"funder_award_id":"ANR-23-R4HC-0006 En-er-LIGHT","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G4364925233","display_name":null,"funder_award_id":"ERC-2021-ADG","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G4378222322","display_name":null,"funder_award_id":"P27893","funder_id":"https://openalex.org/F4320325582","funder_display_name":"Karl-Franzens-Universit\u00e4t Graz"},{"id":"https://openalex.org/G4707887143","display_name":null,"funder_award_id":"18-IDEX-0001","funder_id":"https://openalex.org/F4320331438","funder_display_name":"Universit\u00e9 de Paris"},{"id":"https://openalex.org/G4744413284","display_name":null,"funder_award_id":"ANR-23-R4HC-0006 En-er-LIGHT","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G4880911435","display_name":null,"funder_award_id":"825410","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G4900465205","display_name":null,"funder_award_id":"825410","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G4968846622","display_name":null,"funder_award_id":"ERC-2021-ADG","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G4990482369","display_name":null,"funder_award_id":"ANR-21-RHUS-0017","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G5334831218","display_name":null,"funder_award_id":"ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G540687550","display_name":null,"funder_award_id":"ANR-23-RHUS-0010","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G5409723808","display_name":"Microbiota-centered interventions to solve antibiotics-induced primary resistance to immune checkpoint inhibitors","funder_award_id":"ANR-21-RHUS-0017","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5468290041","display_name":null,"funder_award_id":"101052444","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G5495091266","display_name":null,"funder_award_id":"DOC-50","funder_id":"https://openalex.org/F4320325582","funder_display_name":"Karl-Franzens-Universit\u00e4t Graz"},{"id":"https://openalex.org/G571454778","display_name":"Energizing the failing heart","funder_award_id":"ANR-23-R4HC-0006","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5767140378","display_name":null,"funder_award_id":"ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320315890","funder_display_name":"Seerave Foundation"},{"id":"https://openalex.org/G5790172013","display_name":null,"funder_award_id":"ERC-2021-ADG","funder_id":"https://openalex.org/F4320315890","funder_display_name":"Seerave Foundation"},{"id":"https://openalex.org/G5953624409","display_name":null,"funder_award_id":"21-ESRE-0028","funder_id":"https://openalex.org/F4320315890","funder_display_name":"Seerave Foundation"},{"id":"https://openalex.org/G6186480481","display_name":"Causal epigenetic changes during aging and caloric restriction","funder_award_id":"P29203","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G6277830544","display_name":"Potentiation of antimycotics with human-tolerable flavonoids","funder_award_id":"P37278","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G6300988664","display_name":null,"funder_award_id":"101052444","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G6610179393","display_name":null,"funder_award_id":"101095604","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G668953012","display_name":null,"funder_award_id":"101095604","funder_id":"https://openalex.org/F4320322893","funder_display_name":"Institut Universitaire de France"},{"id":"https://openalex.org/G6718544961","display_name":null,"funder_award_id":"ANR-23-RHUS-0010","funder_id":"https://openalex.org/F4320315890","funder_display_name":"Seerave Foundation"},{"id":"https://openalex.org/G69196502","display_name":null,"funder_award_id":"21-ESRE-0028","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G7041469554","display_name":null,"funder_award_id":"ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320322893","funder_display_name":"Institut Universitaire de France"},{"id":"https://openalex.org/G7080048889","display_name":null,"funder_award_id":"ANR-23","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G722373514","display_name":null,"funder_award_id":"P29203","funder_id":"https://openalex.org/F4320325582","funder_display_name":"Karl-Franzens-Universit\u00e4t Graz"},{"id":"https://openalex.org/G7309355080","display_name":null,"funder_award_id":"ANR-23-RHUS-0010","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G7319818416","display_name":null,"funder_award_id":"101052444","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G7562053067","display_name":null,"funder_award_id":"ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320328577","funder_display_name":"Minist\u00e8re des Solidarit\u00e9s et de la Sant\u00e9"},{"id":"https://openalex.org/G7662726268","display_name":null,"funder_award_id":"825410","funder_id":"https://openalex.org/F4320315890","funder_display_name":"Seerave Foundation"},{"id":"https://openalex.org/G7828449318","display_name":"Metabolic and Cardiovascular Disease","funder_award_id":"W 1226","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G7914284967","display_name":null,"funder_award_id":"F3012","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G816800923","display_name":null,"funder_award_id":"ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320322363","funder_display_name":"Ligue Contre le Cancer"},{"id":"https://openalex.org/G8316913482","display_name":null,"funder_award_id":"21-ESRE-0028","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G8386792218","display_name":null,"funder_award_id":"ANR-23-RHUS-0010 LUCA-pi","funder_id":"https://openalex.org/F4320316862","funder_display_name":"Equipex"},{"id":"https://openalex.org/G8471630636","display_name":null,"funder_award_id":"ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G8538166538","display_name":"Universit\u00e9 de Paris","funder_award_id":"ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8809306651","display_name":null,"funder_award_id":"ANR-23-RHUS-0010","funder_id":"https://openalex.org/F4320322893","funder_display_name":"Institut Universitaire de France"},{"id":"https://openalex.org/G8815602807","display_name":"The RUSH (retention using selective hooks) system: a chemical-genetic system for the in vivo manipulation of intercellular communication","funder_award_id":"ANR-22-CE14-0066","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8904710281","display_name":null,"funder_award_id":"W1226","funder_id":"https://openalex.org/F4320325582","funder_display_name":"Karl-Franzens-Universit\u00e4t Graz"},{"id":"https://openalex.org/G8991455713","display_name":null,"funder_award_id":"ANR-21-RHUS-0017","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G915670629","display_name":null,"funder_award_id":"ANR-21-RHUS-0017","funder_id":"https://openalex.org/F4320322893","funder_display_name":"Institut Universitaire de France"},{"id":"https://openalex.org/G920874889","display_name":"Metabolic control of aging and disease","funder_award_id":"COE 14","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"}],"funders":[{"id":"https://openalex.org/F4320315890","display_name":"Seerave Foundation","ror":"https://ror.org/01p3x3413"},{"id":"https://openalex.org/F4320316862","display_name":"Equipex","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"},{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"},{"id":"https://openalex.org/F4320322893","display_name":"Institut Universitaire de France","ror":"https://ror.org/055khg266"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"},{"id":"https://openalex.org/F4320325582","display_name":"Karl-Franzens-Universit\u00e4t Graz","ror":"https://ror.org/01faaaf77"},{"id":"https://openalex.org/F4320325668","display_name":"Direction G\u00e9n\u00e9rale de l\u2019offre de Soins","ror":null},{"id":"https://openalex.org/F4320328577","display_name":"Minist\u00e8re des Solidarit\u00e9s et de la Sant\u00e9","ror":null},{"id":"https://openalex.org/F4320331438","display_name":"Universit\u00e9 de Paris","ror":"https://ror.org/05f82e368"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7167836632.pdf","grobid_xml":"https://content.openalex.org/works/W7167836632.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1996152690","https://openalex.org/W1997183854","https://openalex.org/W2025994995","https://openalex.org/W2045611938","https://openalex.org/W2059107485","https://openalex.org/W2097821680","https://openalex.org/W2224270925","https://openalex.org/W2518357275","https://openalex.org/W2554740475","https://openalex.org/W2784734859","https://openalex.org/W2810175432","https://openalex.org/W2895969593","https://openalex.org/W2921575300","https://openalex.org/W3012507702","https://openalex.org/W3092966039","https://openalex.org/W3123922203","https://openalex.org/W3155861482","https://openalex.org/W3190631166","https://openalex.org/W4210471125","https://openalex.org/W4312181028","https://openalex.org/W4319063470","https://openalex.org/W4391168739","https://openalex.org/W4392294768","https://openalex.org/W4392757422","https://openalex.org/W4401428136","https://openalex.org/W4409533117","https://openalex.org/W4410496918","https://openalex.org/W7117715914","https://openalex.org/W7126264354","https://openalex.org/W7163323865"],"related_works":["https://openalex.org/W7163323865","https://openalex.org/W4411949905","https://openalex.org/W7215702390","https://openalex.org/W2045611938","https://openalex.org/W4407924724","https://openalex.org/W1751251000","https://openalex.org/W4328136180","https://openalex.org/W7165568076","https://openalex.org/W7161947024","https://openalex.org/W4309657549"],"abstract_inverted_index":{"Abstract":[0],"Geroprotection":[1],"aims":[2],"at":[3],"extending":[4],"healthspan":[5],"by":[6,113],"delaying":[7],"age-associated":[8],"pathologies.":[9],"Polyamines":[10],"including":[11,131],"spermine":[12,33,103,155],"and":[13,56,77,89,97,150,159,172,181],"spermidine":[14,51],"are":[15],"interconvertible":[16],"metabolites":[17],"whose":[18],"longevity-promoting":[19],"effects":[20],"have":[21],"traditionally":[22],"been":[23],"attributed":[24],"to":[25,64,73,177],"autophagy":[26,171],"induction.":[27],"In":[28,80],"addition,":[29],"recent":[30],"evidence":[31,130],"identifies":[32],"as":[34],"an":[35],"endogenous":[36],"Fe":[37,107,139],"2+":[38,108,140],"chelator":[39],"that":[40,102,154],"suppresses":[41],"ferroptosis,":[42],"thereby":[43],"complementing":[44],"the":[45],"autophagy-inducing":[46],"activity":[47,55],"of":[48,60,92,129],"spermidine.":[49],"Indeed,":[50],"inhibits":[52],"EP300":[53],"acetyltransferase":[54],"supports":[57],"hypusination-dependent":[58],"activation":[59],"TFEB,":[61],"both":[62,91],"leading":[63],"autophagy.":[65],"However,":[66],"enhanced":[67],"autophagic":[68],"flux":[69],"may":[70],"increase":[71],"susceptibility":[72],"ferroptosis":[74,174],"through":[75],"ferritinophagy":[76],"lipid":[78,95,136],"remodeling.":[79],"parallel,":[81],"polyamine":[82,116],"catabolism":[83],"generates":[84],"H":[85],"2":[86,88],"O":[87],"acrolein,":[90],"which":[93,169],"facilitate":[94],"peroxidation":[96,137],"ferroptotic":[98,124],"demise.":[99],"The":[100],"discovery":[101],"directly":[104],"chelates":[105],"redox-active":[106],"closes":[109],"a":[110,165],"conceptual":[111],"gap":[112],"explaining":[114],"how":[115],"supplementation":[117],"can":[118],"promote":[119],"longevity":[120],"while":[121],"avoiding":[122],"excessive":[123],"cell":[125],"loss.":[126],"Multiple":[127],"lines":[128],"metabolomics,":[132],"isotope":[133],"tracing,":[134],"cell-free":[135],"systems,":[138],"-binding":[141],"biophysics,":[142],"mass":[143],"spectrometry,":[144],"Raman":[145],"spectroscopy,":[146],"nuclear":[147],"magnetic":[148],"resonance":[149],"disease":[151],"models":[152],"demonstrate":[153],"limits":[156],"labile":[157],"iron":[158],"ferroptosis.":[160],"Together,":[161],"these":[162],"findings":[163],"support":[164],"unified":[166],"model":[167],"in":[168],"spermidine-driven":[170],"spermine-mediated":[173],"inhibition":[175],"cooperate":[176],"preserve":[178],"tissue":[179],"homeostasis":[180],"healthspan.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-07-10T00:00:00"}