{"id":"https://openalex.org/W7167683347","doi":"https://doi.org/10.64898/2026.07.02.736041","title":"Cell-type-specific coupling of single-unit spikes to cortical ripples conserved across macaque and human V1","display_name":"Cell-type-specific coupling of single-unit spikes to cortical ripples conserved across macaque and human V1","publication_year":2026,"publication_date":"2026-07-07","ids":{"openalex":"https://openalex.org/W7167683347","doi":"https://doi.org/10.64898/2026.07.02.736041"},"language":"en","primary_location":{"id":"doi:10.64898/2026.07.02.736041","doi":"https://doi.org/10.64898/2026.07.02.736041","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.02.736041","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.07.02.736041","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012995196","display_name":"Katar\u00edna Studeni\u010dov\u00e1","orcid":"https://orcid.org/0009-0007-6619-4222","observed_orcids":["https://orcid.org/0009-0007-6619-4222"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Katar\u00edna Studeni\u010dov\u00e1","raw_affiliation_strings":["Faculty of Mathematics and Physics, Charles University, Prague, The Czech Republic"],"raw_orcid":"https://orcid.org/0009-0007-6619-4222","affiliations":[{"raw_affiliation_string":"Faculty of Mathematics and Physics, Charles University, Prague, The Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046133297","display_name":"Aitor Morales-Gregorio","orcid":"https://orcid.org/0000-0002-2403-928X","observed_orcids":["https://orcid.org/0000-0002-2403-928X"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Aitor Morales-Gregorio","raw_affiliation_strings":["Faculty of Mathematics and Physics, Charles University, Prague, The Czech Republic"],"raw_orcid":"https://orcid.org/0000-0002-2403-928X","affiliations":[{"raw_affiliation_string":"Faculty of Mathematics and Physics, Charles University, Prague, The Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074545959","display_name":"Antonio Lozano","orcid":"https://orcid.org/0000-0003-4508-1484","observed_orcids":["https://orcid.org/0000-0003-4508-1484"]},"institutions":[{"id":"https://openalex.org/I1295801184","display_name":"Netherlands Institute for Neuroscience","ror":"https://ror.org/05csn2x06","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1295801184","https://openalex.org/I1322597698"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Antonio Lozano","raw_affiliation_strings":["Netherlands Institute for Neuroscience, Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-4508-1484","affiliations":[{"raw_affiliation_string":"Netherlands Institute for Neuroscience, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I1295801184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065945849","display_name":"Xing Chen","orcid":"https://orcid.org/0000-0002-3589-1750","observed_orcids":["https://orcid.org/0000-0002-3589-1750"]},"institutions":[{"id":"https://openalex.org/I1295801184","display_name":"Netherlands Institute for Neuroscience","ror":"https://ror.org/05csn2x06","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1295801184","https://openalex.org/I1322597698"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Xing Chen","raw_affiliation_strings":["Department of Ophthalmology, University of Pittsburgh, Pittsburgh, USA","Netherlands Institute for Neuroscience, Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-3589-1750","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Pittsburgh, Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Netherlands Institute for Neuroscience, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I1295801184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019433569","display_name":"Cristina Soto\u2010S\u00e1nchez","orcid":"https://orcid.org/0000-0003-4447-5967","observed_orcids":["https://orcid.org/0000-0003-4447-5967","https://orcid.org/0000-0001-5002-5976"]},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Soto-S\u00e1nchez","raw_affiliation_strings":["Bioengineering Institute, University Miguel Hernandez, Elche, Spain"],"raw_orcid":"https://orcid.org/0000-0003-4447-5967","affiliations":[{"raw_affiliation_string":"Bioengineering Institute, University Miguel Hernandez, Elche, Spain","institution_ids":["https://openalex.org/I111262870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037134228","display_name":"Eduardo Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-7052-6011","observed_orcids":["https://orcid.org/0000-0002-7052-6011"]},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduardo Fernandez","raw_affiliation_strings":["Bioengineering Institute, University Miguel Hernandez, Elche, Spain"],"raw_orcid":"https://orcid.org/0000-0002-7052-6011","affiliations":[{"raw_affiliation_string":"Bioengineering Institute, University Miguel Hernandez, Elche, Spain","institution_ids":["https://openalex.org/I111262870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055456794","display_name":"Paolo Papale","orcid":"https://orcid.org/0000-0002-6249-841X","observed_orcids":["https://orcid.org/0000-0002-6249-841X"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]},{"id":"https://openalex.org/I1295801184","display_name":"Netherlands Institute for Neuroscience","ror":"https://ror.org/05csn2x06","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1295801184","https://openalex.org/I1322597698"]}],"countries":["IT","NL"],"is_corresponding":false,"raw_author_name":"Paolo Papale","raw_affiliation_strings":["Department of Medicine and Surgery, Neuroscience Unit, University of Parma, Parma, Italy","Netherlands Institute for Neuroscience, Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-6249-841X","affiliations":[{"raw_affiliation_string":"Department of Medicine and Surgery, Neuroscience Unit, University of Parma, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Netherlands Institute for Neuroscience, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I1295801184"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085904958","display_name":"Karol\u00edna Korvasov\u00e1","orcid":"https://orcid.org/0000-0002-6369-7808","observed_orcids":["https://orcid.org/0000-0002-6369-7808"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Karol\u00edna Korvasov\u00e1","raw_affiliation_strings":["Faculty of Mathematics and Physics, Charles University, Prague, The Czech Republic"],"raw_orcid":"https://orcid.org/0000-0002-6369-7808","affiliations":[{"raw_affiliation_string":"Faculty of Mathematics and Physics, Charles University, Prague, The Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5085904958"],"corresponding_institution_ids":["https://openalex.org/I21250087"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-visual-cortex","display_name":"primary visual cortex","score":0.9459999799728394},{"id":"https://openalex.org/keywords/macaque","display_name":"macaque","score":0.6510000228881836},{"id":"https://openalex.org/keywords/human-visual-cortex","display_name":"human visual cortex","score":0.734000027179718},{"id":"https://openalex.org/keywords/deep-layer-neurons","display_name":"deep-layer neurons","score":0.5879999995231628},{"id":"https://openalex.org/keywords/phase-locking","display_name":"phase locking","score":0.7960000038146973},{"id":"https://openalex.org/keywords/interspecies-conservation","display_name":"interspecies conservation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/neural-oscillations","display_name":"neural oscillations","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C2778950215","wikidata":"https://www.wikidata.org/wiki/Q177601","display_name":"Macaque","level":2,"score":0.8080000281333923},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7218000292778015},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.48809999227523804},{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.44940000772476196},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.43869999051094055},{"id":"https://openalex.org/C2780196419","wikidata":"https://www.wikidata.org/wiki/Q1762173","display_name":"Nerve net","level":2,"score":0.43720000982284546},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.42899999022483826},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.4228000044822693},{"id":"https://openalex.org/C2908832724","wikidata":"https://www.wikidata.org/wiki/Q7187600","display_name":"Photic Stimulation","level":4,"score":0.3837999999523163},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3723999857902527},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.3684000074863434},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35850000381469727},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C2779599953","wikidata":"https://www.wikidata.org/wiki/Q1776117","display_name":"Ripple","level":3,"score":0.3046000003814697},{"id":"https://openalex.org/C2989183493","wikidata":"https://www.wikidata.org/wiki/Q2040587","display_name":"Phase locking","level":3,"score":0.2784000039100647},{"id":"https://openalex.org/C119088629","wikidata":"https://www.wikidata.org/wiki/Q558363","display_name":"Visual system","level":3,"score":0.2768999934196472},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C2779175743","wikidata":"https://www.wikidata.org/wiki/Q156606","display_name":"Rhesus macaque","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.26030001044273376},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2565999925136566},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.2535000145435333},{"id":"https://openalex.org/C191178318","wikidata":"https://www.wikidata.org/wiki/Q2256906","display_name":"Thresholding","level":3,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.07.02.736041","doi":"https://doi.org/10.64898/2026.07.02.736041","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.02.736041","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.07.02.736041","doi":"https://doi.org/10.64898/2026.07.02.736041","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.02.736041","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2137940296","display_name":null,"funder_award_id":"PRIMUS/24/MED/007","funder_id":"https://openalex.org/F4320309755","funder_display_name":"Univerzita Karlova v Praze"},{"id":"https://openalex.org/G2903847244","display_name":null,"funder_award_id":"GAUK 224226","funder_id":"https://openalex.org/F4320309755","funder_display_name":"Univerzita Karlova v Praze"}],"funders":[{"id":"https://openalex.org/F4320309755","display_name":"Univerzita Karlova v Praze","ror":"https://ror.org/024d6js02"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1582051163","https://openalex.org/W1975837017","https://openalex.org/W1976211348","https://openalex.org/W2000256732","https://openalex.org/W2002062751","https://openalex.org/W2036216984","https://openalex.org/W2045373812","https://openalex.org/W2047124134","https://openalex.org/W2087861759","https://openalex.org/W2088663330","https://openalex.org/W2089395591","https://openalex.org/W2096519870","https://openalex.org/W2097924980","https://openalex.org/W2099512174","https://openalex.org/W2115569429","https://openalex.org/W2118669438","https://openalex.org/W2131301953","https://openalex.org/W2139787850","https://openalex.org/W2139935979","https://openalex.org/W2162013747","https://openalex.org/W2178044595","https://openalex.org/W2229256208","https://openalex.org/W2405066192","https://openalex.org/W2475837820","https://openalex.org/W2520859978","https://openalex.org/W2765562806","https://openalex.org/W2883680372","https://openalex.org/W2980938713","https://openalex.org/W3048917371","https://openalex.org/W3104213443","https://openalex.org/W3122868809","https://openalex.org/W3206812283","https://openalex.org/W3212597472","https://openalex.org/W4210754920","https://openalex.org/W4220843196","https://openalex.org/W4293585853","https://openalex.org/W4318024729","https://openalex.org/W4386545107","https://openalex.org/W4386828252","https://openalex.org/W4387967806","https://openalex.org/W4390400341","https://openalex.org/W4390765553","https://openalex.org/W4390975871","https://openalex.org/W4393338879","https://openalex.org/W4394577481","https://openalex.org/W4396885941","https://openalex.org/W4400009614","https://openalex.org/W4406327061","https://openalex.org/W4411375848","https://openalex.org/W7130313132"],"related_works":["https://openalex.org/W2027152713","https://openalex.org/W2405066192","https://openalex.org/W2420307379","https://openalex.org/W4293585853","https://openalex.org/W3212597472","https://openalex.org/W4321504262","https://openalex.org/W4399741612","https://openalex.org/W4390400341","https://openalex.org/W4284893323","https://openalex.org/W2898988061"],"abstract_inverted_index":{"Abstract":[0,148],"Cortical":[1],"ripples":[2,40,136],"are":[3,26],"brief":[4],"high-frequency":[5],"(80\u2013150":[6],"Hz)":[7],"oscillatory":[8],"bursts":[9],"in":[10,34,41,74,99,125],"the":[11],"extracellular":[12],"potential,":[13],"associated":[14],"with":[15,47,109],"memory":[16],"and":[17,29,51,64,79,123,145],"attention.":[18],"So":[19],"far,":[20],"it":[21],"is":[22,117],"unclear":[23],"whether":[24],"they":[25],"brain-state":[27],"specific":[28],"which":[30],"neuron":[31],"types":[32],"participate":[33],"their":[35,66],"generation.":[36],"We":[37],"report":[38],"cortical":[39,135],"macaque":[42],"V1":[43,126],"at":[44],"rest,":[45],"present":[46],"both":[48],"eyes":[49],"open":[50],"closed.":[52],"Using":[53],"massively":[54],"parallel":[55],"Utah":[56],"array":[57],"recordings,":[58],"we":[59],"identify":[60],"six":[61],"single-unit":[62],"classes":[63,72],"describe":[65],"relation":[67],"to":[68],"ripple-band":[69,81],"oscillations.":[70],"The":[71,113],"differ":[73],"firing-rate":[75],"modulation,":[76],"phase-locking":[77],"strength,":[78],"preferred":[80],"phase.":[82],"One":[83],"class":[84],"of":[85,127],"putative":[86],"deep-layer":[87],"neurons":[88],"exhibits":[89],"non-sinusoidal":[90],"phase":[91],"locking,":[92],"explained":[93],"by":[94],"a":[95,100,128,139],"simple":[96],"thresholding":[97],"mechanism":[98],"computational":[101],"model.":[102],"During":[103],"ripples,":[104],"most":[105],"units":[106],"fire":[107],"irregularly":[108],"transient":[110],"regular":[111],"bursts.":[112],"ripple-associated":[114],"spiking":[115],"organisation":[116],"largely":[118],"preserved":[119],"during":[120],"natural-image":[121],"viewing":[122],"confirmed":[124],"blind":[129],"human.":[130],"Together,":[131],"these":[132],"findings":[133],"suggest":[134],"arise":[137],"from":[138],"shared":[140],"circuit":[141],"conserved":[142],"across":[143],"species":[144],"conditions.":[146],"Graphical":[147]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-07-09T00:00:00"}