{"id":"https://openalex.org/W7167642652","doi":"https://doi.org/10.64898/2026.07.06.736680","title":"Dosimetric Characterization and Workflow Optimization of the FLASH-SARRP for Reliable Preclinical Radiobiological Studies","display_name":"Dosimetric Characterization and Workflow Optimization of the FLASH-SARRP for Reliable Preclinical Radiobiological Studies","publication_year":2026,"publication_date":"2026-07-07","ids":{"openalex":"https://openalex.org/W7167642652","doi":"https://doi.org/10.64898/2026.07.06.736680","pmid":"https://pubmed.ncbi.nlm.nih.gov/42465350","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13370466"},"language":"en","primary_location":{"id":"doi:10.64898/2026.07.06.736680","doi":"https://doi.org/10.64898/2026.07.06.736680","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.06.736680","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/07/07/2026.07.06.736680.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/07/07/2026.07.06.736680.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121124783","display_name":"Mich\u00e8le Knol","orcid":"https://orcid.org/0009-0005-9688-6110","observed_orcids":["https://orcid.org/0009-0005-9688-6110"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mich\u00e8le Knol","raw_affiliation_strings":["LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0009-0005-9688-6110","affiliations":[{"raw_affiliation_string":"LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067862269","display_name":"Patrik Gon\u00e7alves Jorge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Patrik Gon\u00e7alves Jorge","raw_affiliation_strings":["LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064865725","display_name":"L. L. Kunz","orcid":"https://orcid.org/0009-0008-6526-6025","observed_orcids":["https://orcid.org/0009-0008-6526-6025"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Louis V. Kunz","raw_affiliation_strings":["LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0009-0008-6526-6025","affiliations":[{"raw_affiliation_string":"LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016249120","display_name":"Pierre Korysko","orcid":"https://orcid.org/0000-0002-7878-2298","observed_orcids":["https://orcid.org/0000-0002-7878-2298"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pierre Korysko","raw_affiliation_strings":["University of Oxford, Oxford, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-7878-2298","affiliations":[{"raw_affiliation_string":"University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032457090","display_name":"Beno\u00eet Petit","orcid":"https://orcid.org/0009-0003-9397-4583","observed_orcids":["https://orcid.org/0009-0003-9397-4583"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Beno\u00eet Petit","raw_affiliation_strings":["LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0009-0003-9397-4583","affiliations":[{"raw_affiliation_string":"LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062471004","display_name":"Andr\u00e9\u2010Dante Durham","orcid":"https://orcid.org/0000-0002-5875-0301","observed_orcids":["https://orcid.org/0000-0002-5875-0301"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Durham","raw_affiliation_strings":["LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-5875-0301","affiliations":[{"raw_affiliation_string":"LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006971681","display_name":"Marie\u2010Catherine Vozenin","orcid":"https://orcid.org/0000-0002-2109-8073","observed_orcids":["https://orcid.org/0000-0002-2109-8073"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Vozenin Marie-Catherine","raw_affiliation_strings":["LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-2109-8073","affiliations":[{"raw_affiliation_string":"LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034074916","display_name":"Pelagia Pauletta Tsoutsou","orcid":"https://orcid.org/0000-0002-6490-9278","observed_orcids":["https://orcid.org/0000-0002-6490-9278"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Pelagia Tsoutsou","raw_affiliation_strings":["LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6490-9278","affiliations":[{"raw_affiliation_string":"LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049449255","display_name":"Nikolaos Koutsouvelis","orcid":"https://orcid.org/0000-0002-9343-8540","observed_orcids":["https://orcid.org/0000-0002-9343-8540"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nikolaos Koutsouvelis","raw_affiliation_strings":["LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-9343-8540","affiliations":[{"raw_affiliation_string":"LiRR - Laboratory of innovation in Radiobiology applied to Radiotherapy/ Faculty of Medicine/ University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Radiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052020078","display_name":"Julie Lascaud","orcid":"https://orcid.org/0000-0002-7649-6909","observed_orcids":["https://orcid.org/0000-0002-7649-6909"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julie Lascaud","raw_affiliation_strings":["Department of Medical Physics, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen (LMU), Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7649-6909","affiliations":[{"raw_affiliation_string":"Department of Medical Physics, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen (LMU), Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034074916"],"corresponding_institution_ids":["https://openalex.org/I114457229","https://openalex.org/I4210106256"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flash-radiotherapy","display_name":"FLASH radiotherapy","score":0.7089999914169312},{"id":"https://openalex.org/keywords/ultra-high-dose-rate-irradiation","display_name":"ultra-high dose rate irradiation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/dosimetric-characterization","display_name":"dosimetric characterization","score":0.8740000128746033},{"id":"https://openalex.org/keywords/gafchromic-film","display_name":"Gafchromic film","score":0.8389999866485596},{"id":"https://openalex.org/keywords/plastic-scintillating-fibers","display_name":"plastic scintillating fibers","score":0.8650000095367432},{"id":"https://openalex.org/keywords/inter-session-variability","display_name":"inter-session variability","score":0.6140000224113464},{"id":"https://openalex.org/keywords/dose-reproducibility","display_name":"dose reproducibility","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C106436119","wikidata":"https://www.wikidata.org/wiki/Q836575","display_name":"Quality assurance","level":3,"score":0.7231000065803528},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.6899999976158142},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.5730999708175659},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.5336999893188477},{"id":"https://openalex.org/C2777526259","wikidata":"https://www.wikidata.org/wiki/Q221836","display_name":"Flash (photography)","level":2,"score":0.5239999890327454},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4408999979496002},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.40849998593330383},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3562999963760376},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.3034999966621399},{"id":"https://openalex.org/C63007395","wikidata":"https://www.wikidata.org/wiki/Q2122891","display_name":"Dose profile","level":3,"score":0.2973000109195709},{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C66882249","wikidata":"https://www.wikidata.org/wiki/Q169336","display_name":"Homogeneous","level":2,"score":0.28679999709129333},{"id":"https://openalex.org/C200601418","wikidata":"https://www.wikidata.org/wiki/Q2193887","display_name":"Reliability engineering","level":1,"score":0.27379998564720154},{"id":"https://openalex.org/C118530786","wikidata":"https://www.wikidata.org/wiki/Q1134732","display_name":"Instrumentation (computer programming)","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2669999897480011},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.26080000400543213},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.260699987411499},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.251800000667572},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.2513999938964844}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.07.06.736680","doi":"https://doi.org/10.64898/2026.07.06.736680","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.06.736680","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/07/07/2026.07.06.736680.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42465350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42465350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13370466","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13370466/pdf/nihpp-2026.07.06.736680v1.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.07.06.736680","doi":"https://doi.org/10.64898/2026.07.06.736680","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.06.736680","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/07/07/2026.07.06.736680.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1285822440","display_name":"Exploring thermoacoustics and biomechanical effects of FLASH radiotherapy on biological tissues.","funder_award_id":"232564","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G8118694249","display_name":null,"funder_award_id":"R01CA254892-1","funder_id":"https://openalex.org/F4320338403","funder_display_name":"Common Fund"},{"id":"https://openalex.org/G9000911869","display_name":"Improving pediatric brain tumor treatments using FLASH radiotherapy","funder_award_id":"R01CA254892","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338403","display_name":"Common Fund","ror":"https://ror.org/001d55x84"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7167642652.pdf","grobid_xml":"https://content.openalex.org/works/W7167642652.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2016410229","https://openalex.org/W2038739812","https://openalex.org/W2938183253","https://openalex.org/W3145502856","https://openalex.org/W7132815792"],"related_works":["https://openalex.org/W4410198315","https://openalex.org/W2948429016","https://openalex.org/W4402945442","https://openalex.org/W7165615087","https://openalex.org/W4313442271","https://openalex.org/W4399326766","https://openalex.org/W4402906450","https://openalex.org/W2968632796","https://openalex.org/W4286213221","https://openalex.org/W4400035440"],"abstract_inverted_index":{"Abstract":[0],"Objective":[1],"The":[2,91,283],"reliable":[3,295],"use":[4],"of":[5,30,95,116,160,166,185,202,210,225,242,251],"preclinical":[6,51,255,296],"small-animal":[7,26,177],"irradiators":[8],"requires":[9],"dosimetric":[10,57],"characterization":[11],"and":[12,40,66,100,125,135,289],"quality":[13],"assurance":[14],"(QA)":[15],"protocols.":[16],"This":[17,246],"study":[18],"aimed":[19],"to":[20,38,77,86,150,234],"characterize":[21],"the":[22,96,114,117,132,136,140,148,190,200,203,216,226,231,238,243,249,263],"FLASH-SARRP,":[23],"a":[24,42,67,120,129,171,206,259,291],"dual-tube":[25],"X-ray":[27,98,162,192,265],"irradiator":[28],"capable":[29],"ultra-high":[31],"dose-rate":[32,197,271],"(UHDR)":[33],"delivery,":[34],"as":[35,37,258],"well":[36],"establish":[39],"validate":[41],"practical":[43,292],"QA":[44,121,228,285],"workflow":[45,122,229],"that":[46,273],"improves":[47,287],"dose":[48,64,280],"reproducibility":[49,288],"for":[50,62,71,152,176,254,294],"FLASH":[52,256],"experiments.":[53],"Approach":[54],"A":[55],"combined":[56],"approach":[58,293],"using":[59,108],"Gafchromic":[60,133],"films":[61],"spatial":[63],"assessment":[65],"plastic":[68],"scintillating":[69,109,137],"fiber":[70,110,138,149],"real-time":[72],"temporal":[73,92,196,252,270],"monitoring,":[74],"was":[75,123,213,219,267],"used":[76],"evaluate":[78],"beam":[79],"characteristics.":[80],"Custom":[81],"3D-printed":[82],"spacers":[83],"were":[84,106],"designed":[85],"ensure":[87],"reproducible":[88],"experimental":[89,141],"configurations.":[90],"pulse":[93],"structure":[94],"two":[97,118,191,264],"tubes":[99,163,266],"their":[101],"synchronization":[102],"during":[103],"simultaneous":[104],"irradiation":[105,159,173],"investigated":[107],"measurements.":[111],"Based":[112],"on":[113],"findings":[115],"dosimeters,":[119],"implemented":[124],"validated,":[126],"which":[127],"uses":[128],"cross-calibration":[130],"between":[131,189,262],"film":[134],"in":[139,188,195],"setup,":[142],"followed":[143],"by":[144,278],"pre-irradiation":[145],"verification":[146],"with":[147],"compensate":[151],"day-to-day":[153],"output":[154],"variations.":[155],"Main":[156],"results":[157],"Simultaneous":[158],"both":[161],"achieved":[164],"dose-rates":[165],"approximately":[167,211],"80":[168],"Gy/s":[169],"inside":[170],"homogeneous":[172],"field":[174],"suitable":[175],"studies.":[178],"Temporal":[179],"measurements":[180,281],"revealed":[181],"an":[182],"average":[183],"delay":[184],"10":[186],"ms":[187],"tubes,":[193],"resulting":[194],"heterogeneity":[198,272],"throughout":[199],"delivery":[201],"dose.":[204],"Additionally,":[205],"substantial":[207],"inter-session":[208,232],"variability":[209,218,233,241],"11%":[212],"found,":[214],"whereas":[215],"intra-session":[217,240],"relatively":[220],"low":[221],"around":[222,235],"\u223c4%.":[223],"Implementation":[224],"proposed":[227,284],"reduced":[230],"5%,":[236],"approaching":[237],"intrinsic":[239],"machine.":[244],"Significance":[245],"work":[247],"highlights":[248],"importance":[250],"dosimetry":[253],"studies,":[257],"measurable":[260],"desynchronization":[261],"identified,":[268],"generating":[269],"would":[274],"not":[275],"be":[276],"detected":[277],"integrated":[279],"alone.":[282],"framework":[286],"provides":[290],"investigations.":[297]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-07-08T00:00:00"}
