{"id":"https://openalex.org/W7167620003","doi":"https://doi.org/10.3390/biomedicines14071523","title":"High TRIM28 Expression Defines an Aggressive, Immune-Cold Phenotype with Worse Survival Outcomes in ER\u03b1-Positive Breast Cancer","display_name":"High TRIM28 Expression Defines an Aggressive, Immune-Cold Phenotype with Worse Survival Outcomes in ER\u03b1-Positive Breast Cancer","publication_year":2026,"publication_date":"2026-07-07","ids":{"openalex":"https://openalex.org/W7167620003","doi":"https://doi.org/10.3390/biomedicines14071523","pmid":"https://pubmed.ncbi.nlm.nih.gov/42511996","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13406493"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines14071523","doi":"https://doi.org/10.3390/biomedicines14071523","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14071523","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biomedicines14071523","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009194045","display_name":"Rashed Alhammad","orcid":"https://orcid.org/0000-0003-0313-4808","observed_orcids":["https://orcid.org/0000-0003-0313-4808"]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":true,"raw_author_name":"Rashed Alhammad","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Kuwait University, Kuwait City 13110, Kuwait"],"raw_orcid":"https://orcid.org/0000-0003-0313-4808","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Kuwait University, Kuwait City 13110, Kuwait","institution_ids":["https://openalex.org/I36721946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125221092","display_name":"Najla Salama","orcid":"https://orcid.org/0000-0002-7276-3926","observed_orcids":["https://orcid.org/0000-0002-7276-3926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Najla Salama","raw_affiliation_strings":["Department of Pharmaceutical Technology, College of Medical Science and Technologies, Tripoli P.O. Box 13628, Libya"],"raw_orcid":"https://orcid.org/0000-0002-7276-3926","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, College of Medical Science and Technologies, Tripoli P.O. Box 13628, Libya","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5140205820","display_name":"Lujain Alhammad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]},{"id":"https://openalex.org/I4210129520","display_name":"Ministry of Health","ror":"https://ror.org/036njfn21","country_code":"KW","type":"government","lineage":["https://openalex.org/I4210129520"]},{"id":"https://openalex.org/I4210150512","display_name":"Ibn Sina Hospital","ror":"https://ror.org/05359he25","country_code":"KW","type":"healthcare","lineage":["https://openalex.org/I4210150512"]}],"countries":["KW","SA"],"is_corresponding":false,"raw_author_name":"Lujain Alhammad","raw_affiliation_strings":["Neurology Department, Ibn Sina Hospital, Ministry of Health, Kuwait City 70035, Kuwait","Neuroscience Department, King Faisal Specialist Hospital and Research Centre, Riyadh 12713, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Ibn Sina Hospital, Ministry of Health, Kuwait City 70035, Kuwait","institution_ids":["https://openalex.org/I4210129520","https://openalex.org/I4210150512"]},{"raw_affiliation_string":"Neuroscience Department, King Faisal Specialist Hospital and Research Centre, Riyadh 12713, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5009194045"],"corresponding_institution_ids":["https://openalex.org/I36721946"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"7","first_page":"1523","last_page":"1523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trim28","display_name":"TRIM28","score":0.9890000224113464},{"id":"https://openalex.org/keywords/eralpha-positive-breast-cancer","display_name":"ER\u03b1-positive breast cancer","score":0.9549999833106995},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9789999723434448},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9240000247955322},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.7799999713897705},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.8379999995231628},{"id":"https://openalex.org/keywords/transcriptional-coregulators","display_name":"transcriptional coregulators","score":0.7379999756813049},{"id":"https://openalex.org/keywords/histologic-grade","display_name":"histologic grade","score":0.652999997138977},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.7739999890327454},{"id":"https://openalex.org/keywords/pam50-subtypes","display_name":"PAM50 molecular subtypes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/gene-set-enrichment-analysis","display_name":"gene set enrichment analysis","score":0.4959999918937683},{"id":"https://openalex.org/keywords/breast-cancer-molecular-subtypes","display_name":"breast cancer molecular subtypes","score":0.4860000014305115},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7634999752044678},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6926000118255615},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6922000050544739},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6657000184059143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6097000241279602},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.44909998774528503},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.4309000074863434},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4178999960422516},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.40709999203681946},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.3531000018119812},{"id":"https://openalex.org/C164465091","wikidata":"https://www.wikidata.org/wiki/Q7248371","display_name":"Prognostic variable","level":3,"score":0.3425000011920929},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3370000123977661},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.31700000166893005},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.30489999055862427},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.30320000648498535},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.30219998955726624},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.27799999713897705},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.27559998631477356},{"id":"https://openalex.org/C2777757722","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Mastectomy","level":4,"score":0.2711000144481659},{"id":"https://openalex.org/C118646709","wikidata":"https://www.wikidata.org/wiki/Q1657620","display_name":"CA15-3","level":4,"score":0.262800008058548},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2605000138282776},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2599000036716461},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.2538999915122986}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines14071523","doi":"https://doi.org/10.3390/biomedicines14071523","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14071523","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13406493","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13406493/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13406493/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:42511996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42511996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:08a5e59756a44571bd715774dfb7bb2a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/08a5e59756a44571bd715774dfb7bb2a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 14, Iss 7, p 1523 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines14071523","doi":"https://doi.org/10.3390/biomedicines14071523","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines14071523","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7167620003.pdf","grobid_xml":"https://content.openalex.org/works/W7167620003.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W2031203839","https://openalex.org/W2051377746","https://openalex.org/W2079201443","https://openalex.org/W2086277239","https://openalex.org/W2088895400","https://openalex.org/W2094746980","https://openalex.org/W2098589211","https://openalex.org/W2098683355","https://openalex.org/W2147789864","https://openalex.org/W2149441684","https://openalex.org/W2162371443","https://openalex.org/W2170431584","https://openalex.org/W2337195458","https://openalex.org/W2475032329","https://openalex.org/W2520064697","https://openalex.org/W2554252457","https://openalex.org/W2567668099","https://openalex.org/W2753351580","https://openalex.org/W2804658429","https://openalex.org/W2896734773","https://openalex.org/W2901276642","https://openalex.org/W3015634062","https://openalex.org/W3027286012","https://openalex.org/W3092458803","https://openalex.org/W3094531040","https://openalex.org/W3111317523","https://openalex.org/W3129510414","https://openalex.org/W3185354749","https://openalex.org/W4205339665","https://openalex.org/W4211005384","https://openalex.org/W4213147843","https://openalex.org/W4293419366","https://openalex.org/W4297348584","https://openalex.org/W4317722138","https://openalex.org/W4318819253","https://openalex.org/W4366817622","https://openalex.org/W4381987691","https://openalex.org/W4387098495","https://openalex.org/W4387848204","https://openalex.org/W4393935425","https://openalex.org/W4400280760","https://openalex.org/W4400838227","https://openalex.org/W4401393758","https://openalex.org/W4402128445","https://openalex.org/W4404289468"],"related_works":["https://openalex.org/W3144473838","https://openalex.org/W2591425673","https://openalex.org/W1993341673","https://openalex.org/W4225566722","https://openalex.org/W4285797490","https://openalex.org/W2098050195","https://openalex.org/W4415456663","https://openalex.org/W4417520658","https://openalex.org/W4281632424","https://openalex.org/W4416526656"],"abstract_inverted_index":{"Background:":[0],"Although":[1],"ER\u03b1-positive":[2,57,106,154,193,269,421,446],"breast":[3,10,58,107,194,199,422,447],"cancer":[4,11,59,195],"represents":[5],"approximately":[6],"70%":[7],"of":[8,23,40,211,314],"all":[9],"diagnoses":[12],"worldwide,":[13],"specific":[14],"prognostic":[15,54,81,126,352,418],"biomarkers":[16],"for":[17,223,290,437],"this":[18],"subtype":[19,60],"that":[20],"are":[21,395],"capable":[22],"stratifying":[24],"patients":[25,387],"remain":[26],"limited.":[27],"TRIM28":[28,77,100,133,187,202,212,280,316,358,361,394,414,432],"(KAP1/TIF1\u03b2),":[29],"which":[30,278],"is":[31,189,214,383,415],"a":[32,333,434],"multifunctional":[33],"E3":[34],"ubiquitin":[35],"ligase":[36],"and":[37,80,102,136,173,233,293,373,375,382,400,406,408,441],"transcriptional":[38],"coregulator":[39],"ER\u03b1,":[41],"has":[42,61],"been":[43,63],"shown":[44],"to":[45,75,96,123,166,181,197],"play":[46],"oncogenic":[47],"roles":[48],"in":[49,56,105,116,149,192,264,277,320,339,386,397,420,445],"multiple":[50,426],"malignancies.":[51],"However,":[52],"its":[53],"significance":[55,82],"not":[62],"explored":[64],"across":[65,83,356,425],"independent":[66,84,125,312,417,427],"patient":[67,85],"cohorts.":[68,428],"Methods:":[69],"Multiple":[70],"bioinformatics":[71],"tools":[72],"were":[73],"employed":[74],"assess":[76,182],"mRNA":[78],"expression":[79,101,134,188,203,281,359,362],"cohorts":[86],"totaling":[87],"over":[88],"4000":[89],"patients.":[90],"The":[91,351],"Kaplan\u2013Meier":[92],"plotter":[93],"was":[94,114,143,164,179,255,354],"used":[95,165,180],"examine":[97],"associations":[98],"between":[99],"survival":[103,220],"outcomes":[104],"cancer.":[108,448],"Multivariate":[109],"Cox":[110,147,260],"proportional":[111,261],"hazards":[112,262],"regression":[113,148,263],"performed":[115,144],"the":[117,150,206,265],"METABRIC":[118,308],"dataset":[119],"(n":[120,156,271],"=":[121,157,241,247,251,272,275,296,302,324,330,343,349],"1356)":[122],"confirm":[124],"value,":[127],"with":[128,170,217,235,285,317,332,365,378,393],"sensitivity":[129],"analyses":[130,306],"using":[131,145,258],"alternative":[132,357],"cutoffs":[135],"PAM50":[137,304],"subtype-specific":[138,305],"subgroup":[139],"analyses.":[140],"Independent":[141],"validation":[142,440],"multivariate":[146,259],"TCGA-BRCA":[151,266],"Firehose":[152,267],"Legacy":[153,268],"cohort":[155,270],"372).":[158],"Gene":[159],"Set":[160],"Cancer":[161,175],"Analysis":[162],"(GSCA)":[163],"investigate":[167],"pathways":[168],"associated":[169,216,284],"TRIM28-correlated":[171],"genes,":[172],"Breast":[174],"Gene-Expression":[176],"Miner":[177],"(Bc-GenExminer)":[178],"immune":[183,379],"cell":[184,380,398],"infiltration.":[185],"Results:":[186],"significantly":[190,384],"elevated":[191],"compared":[196],"normal":[198],"tissue.":[200],"High":[201],"(defined":[204],"as":[205,433],"upper":[207],"quartile,":[208],"\u226575th":[209],"percentile,":[210],"expression)":[213],"independently":[215,256,283],"worse":[218,286,318],"overall":[219],"after":[221,288],"adjustment":[222,289],"tumour":[224,226,366],"size,":[225,367],"mutational":[227],"burden":[228],"(TMB),":[229],"hormone":[230,389],"therapy":[231],"status,":[232],"age,":[234,291],"stratification":[236],"on":[237],"histologic":[238,368],"grade":[239],"(HR":[240,295,323,342],"1.21,":[242,344],"95%":[243,298,326,345],"CI:":[244,299,327,346],"1.03\u20131.41,":[245],"p":[246,301,329,348],"0.0194;":[248],"METABRIC,":[249],"n":[250],"1356).":[252],"This":[253],"finding":[254],"validated":[257,424],"372;":[273],"events":[274],"56),":[276],"high":[279,315],"remained":[282],"OS":[287,319],"T-stage,":[292],"TMB":[294],"2.02,":[297],"1.10\u20133.71,":[300],"0.024).":[303],"within":[307],"additionally":[309],"confirmed":[310],"an":[311,416],"association":[313],"Luminal":[321,340],"A":[322],"1.37,":[325],"1.08\u20131.74,":[328],"0.009),":[331],"directionally":[334],"consistent":[335],"but":[336],"non-significant":[337],"trend":[338],"B":[341],"0.93\u20131.58,":[347],"0.155).":[350],"effect":[353],"robust":[355],"cutoffs.":[360],"positively":[363],"correlates":[364,377],"grade,":[369],"Nottingham":[370],"Prognostic":[371],"Index,":[372],"TMB,":[374],"negatively":[376],"infiltration":[381],"lower":[385],"receiving":[388],"therapy.":[390],"Genes":[391],"co-expressed":[392],"enriched":[396],"cycle":[399],"DNA":[401],"damage":[402],"response":[403],"activation":[404],"signatures":[405],"RAS/MAPK":[407],"RTK":[409],"pathway":[410],"inhibition":[411],"signatures.":[412],"Conclusions:":[413],"biomarker":[419],"cancer,":[423],"These":[429],"findings":[430],"nominate":[431],"priority":[435],"candidate":[436],"prospective":[438],"clinical":[439],"targeted":[442],"experimental":[443],"investigation":[444]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-07-08T00:00:00"}