{"id":"https://openalex.org/W7167333370","doi":"https://doi.org/10.1007/s44411-026-00746-4","title":"Effects of SGLT2 Inhibition on Cardiac Structure, Left Atrial Function, and Fibrotic Biomarkers in HFpEF with Type 2 Diabetes","display_name":"Effects of SGLT2 Inhibition on Cardiac Structure, Left Atrial Function, and Fibrotic Biomarkers in HFpEF with Type 2 Diabetes","publication_year":2026,"publication_date":"2026-07-04","ids":{"openalex":"https://openalex.org/W7167333370","doi":"https://doi.org/10.1007/s44411-026-00746-4"},"language":"en","primary_location":{"id":"doi:10.1007/s44411-026-00746-4","doi":"https://doi.org/10.1007/s44411-026-00746-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s44411-026-00746-4","pdf_url":null,"source":{"id":"https://openalex.org/S2756093218","display_name":"Bratislavsk\u00e9 lek\u00e1rske listy/Bratislava medical journal","issn_l":"0006-9248","issn":["0006-9248","1336-0345"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bratislava Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077456520","display_name":"Yi\u011fit Davuto\u011flu","orcid":"https://orcid.org/0000-0001-7485-156X","observed_orcids":["https://orcid.org/0000-0001-7485-156X"]},"institutions":[{"id":"https://openalex.org/I4210137267","display_name":"Denizli Devlet Hastanesi","ror":"https://ror.org/0364a8z71","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210137267"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Yigit Davutoglu","raw_affiliation_strings":["Department of Cardiology, Denizli State Hospital, Denizli, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-7485-156X","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Denizli State Hospital, Denizli, Turkey","institution_ids":["https://openalex.org/I4210137267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092198091","display_name":"Harun Akarsu","orcid":"https://orcid.org/0000-0001-9178-9972","observed_orcids":["https://orcid.org/0000-0001-9178-9972"]},"institutions":[{"id":"https://openalex.org/I4210164529","display_name":"\u0130stanbul Kanuni Sultan S\u00fcleyman E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/05jxvg504","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210164529"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Harun Akarsu","raw_affiliation_strings":["Kanuni Sultan S\u00fcleyman Training and Research Hospital, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanuni Sultan S\u00fcleyman Training and Research Hospital, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210164529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021925814","display_name":"Cihan \u0130lyas Sevgican","orcid":"https://orcid.org/0000-0002-8750-7335","observed_orcids":["https://orcid.org/0000-0002-8750-7335"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Cihan Ilyas Sevgican","raw_affiliation_strings":["Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107189797","display_name":"\u00d6zge \u00d6zden Kayhan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ozge Ozden Kayhan","raw_affiliation_strings":["Cardiology Department, Memorial Bahcelievler Hospital, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department, Memorial Bahcelievler Hospital, Istanbul, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005763870","display_name":"H\u00fclya Aybek","orcid":"https://orcid.org/0000-0002-0635-4251","observed_orcids":["https://orcid.org/0000-0002-0635-4251"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hulya Aybek","raw_affiliation_strings":["Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140026955","display_name":"Dogu Kilic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Dogu Kilic","raw_affiliation_strings":["Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070279339","display_name":"I\u015f\u0131k Tekin","orcid":"https://orcid.org/0000-0003-2151-920X","observed_orcids":["https://orcid.org/0000-0003-2151-920X"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Isik Tekin","raw_affiliation_strings":["Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018779103","display_name":"\u0130pek B\u00fcber","orcid":"https://orcid.org/0000-0003-2457-313X","observed_orcids":["https://orcid.org/0000-0003-2457-313X"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ipek Buber","raw_affiliation_strings":["Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Pamukkale University Faculty of Medicine, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5077456520"],"corresponding_institution_ids":["https://openalex.org/I4210137267"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"127","issue":"8","first_page":"3767","last_page":"3775"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.39399999380111694,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.39399999380111694,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.27730000019073486,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.24449999630451202,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9399999976158142},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9710000157356262},{"id":"https://openalex.org/keywords/empagliflozin","display_name":"empagliflozin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dapagliflozin","display_name":"dapagliflozin","score":1.0},{"id":"https://openalex.org/keywords/left-atrial-remodeling","display_name":"left atrial remodeling","score":0.8889999985694885},{"id":"https://openalex.org/keywords/left-atrial-reservoir-function","display_name":"left atrial reservoir function","score":0.8840000033378601},{"id":"https://openalex.org/keywords/left-ventricular-remodeling","display_name":"left ventricular remodeling","score":0.6729999780654907},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":0.9869999885559082},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.9760000109672546},{"id":"https://openalex.org/keywords/heart-type-fatty-acid-binding-protein","display_name":"heart-type fatty acid-binding protein","score":0.9869999885559082},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cardiac-magnetic-resonance","display_name":"cardiac magnetic resonance","score":0.7670000195503235},{"id":"https://openalex.org/keywords/transthoracic-echocardiography","display_name":"transthoracic echocardiography","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.925000011920929},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8205999732017517},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.8113999962806702},{"id":"https://openalex.org/C2775887513","wikidata":"https://www.wikidata.org/wiki/Q5373824","display_name":"Empagliflozin","level":4,"score":0.6699000000953674},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.5960999727249146},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5928000211715698},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.5249999761581421},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.48100000619888306},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.47920000553131104},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.4684999883174896},{"id":"https://openalex.org/C48277249","wikidata":"https://www.wikidata.org/wiki/Q1406926","display_name":"Preload","level":3,"score":0.40299999713897705},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3878999948501587},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.37700000405311584},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.3492000102996826},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.3447999954223633},{"id":"https://openalex.org/C2780346441","wikidata":"https://www.wikidata.org/wiki/Q55609890","display_name":"Doppler echocardiography","level":4,"score":0.34139999747276306},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.3357999920845032},{"id":"https://openalex.org/C2776008845","wikidata":"https://www.wikidata.org/wiki/Q5038325","display_name":"Cardiac magnetic resonance imaging","level":3,"score":0.33399999141693115},{"id":"https://openalex.org/C2776553924","wikidata":"https://www.wikidata.org/wiki/Q5270132","display_name":"Diabetic cardiomyopathy","level":4,"score":0.3089999854564667},{"id":"https://openalex.org/C31861589","wikidata":"https://www.wikidata.org/wiki/Q618068","display_name":"Cardiac index","level":4,"score":0.30660000443458557},{"id":"https://openalex.org/C21143770","wikidata":"https://www.wikidata.org/wiki/Q3366819","display_name":"End-diastolic volume","level":5,"score":0.30329999327659607},{"id":"https://openalex.org/C2779543058","wikidata":"https://www.wikidata.org/wiki/Q4200712","display_name":"Mass index","level":3,"score":0.30230000615119934},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.29750001430511475},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.2946000099182129},{"id":"https://openalex.org/C2779311642","wikidata":"https://www.wikidata.org/wiki/Q1131082","display_name":"Copeptin","level":3,"score":0.2687999904155731},{"id":"https://openalex.org/C2987145844","wikidata":"https://www.wikidata.org/wiki/Q5038325","display_name":"Cardiac magnetic resonance","level":3,"score":0.26809999346733093},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.2538999915122986},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.2533000111579895},{"id":"https://openalex.org/C35207712","wikidata":"https://www.wikidata.org/wiki/Q190402","display_name":"Central venous pressure","level":4,"score":0.2531000077724457},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.2526000142097473},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s44411-026-00746-4","doi":"https://doi.org/10.1007/s44411-026-00746-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s44411-026-00746-4","pdf_url":null,"source":{"id":"https://openalex.org/S2756093218","display_name":"Bratislavsk\u00e9 lek\u00e1rske listy/Bratislava medical journal","issn_l":"0006-9248","issn":["0006-9248","1336-0345"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bratislava Medical Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W59799898","https://openalex.org/W1983019374","https://openalex.org/W2042293234","https://openalex.org/W2048178709","https://openalex.org/W2053534478","https://openalex.org/W2057547167","https://openalex.org/W2070742162","https://openalex.org/W2089923812","https://openalex.org/W2123248199","https://openalex.org/W2124624517","https://openalex.org/W2125639808","https://openalex.org/W2158579769","https://openalex.org/W2343975335","https://openalex.org/W2546760584","https://openalex.org/W2563736117","https://openalex.org/W2585482805","https://openalex.org/W2763687967","https://openalex.org/W2768113698","https://openalex.org/W2884466498","https://openalex.org/W2915489961","https://openalex.org/W2921866736","https://openalex.org/W2948029031","https://openalex.org/W2948082779","https://openalex.org/W2954203217","https://openalex.org/W2998253528","https://openalex.org/W2999176505","https://openalex.org/W3037876601","https://openalex.org/W3045152892","https://openalex.org/W3157496867","https://openalex.org/W3164477560","https://openalex.org/W3187549347","https://openalex.org/W3193297191","https://openalex.org/W3193598686","https://openalex.org/W4220720726","https://openalex.org/W4293353625","https://openalex.org/W4327892896","https://openalex.org/W4365145997","https://openalex.org/W4366371744","https://openalex.org/W4386098321","https://openalex.org/W4389579015","https://openalex.org/W4392166458","https://openalex.org/W4396805435","https://openalex.org/W4400591502","https://openalex.org/W4401029840","https://openalex.org/W4407624732"],"related_works":["https://openalex.org/W7126207225","https://openalex.org/W4390204979","https://openalex.org/W7128248943","https://openalex.org/W4416060484","https://openalex.org/W4416046160","https://openalex.org/W3192928554","https://openalex.org/W4366815205","https://openalex.org/W4412078136","https://openalex.org/W7222329041","https://openalex.org/W4410233632"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-07-05T00:00:00"}