{"id":"https://openalex.org/W7167259795","doi":"https://doi.org/10.2169/internalmedicine.7587-26","title":"Marked Hyperbilirubinemia in a Patient with Intrahepatic Cholestasis of Pregnancy and a UGT1A1 Polymorphism: A Case Report","display_name":"Marked Hyperbilirubinemia in a Patient with Intrahepatic Cholestasis of Pregnancy and a UGT1A1 Polymorphism: A Case Report","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7167259795","doi":"https://doi.org/10.2169/internalmedicine.7587-26","pmid":"https://pubmed.ncbi.nlm.nih.gov/42402405"},"language":"en","primary_location":{"id":"doi:10.2169/internalmedicine.7587-26","doi":"https://doi.org/10.2169/internalmedicine.7587-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7587-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7587-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7587-26/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090153459","display_name":"Natsuki Ishizaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Natsuki Ishizaki","raw_affiliation_strings":["Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, Japan","Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, Japan","institution_ids":["https://openalex.org/I130830085"]},{"raw_affiliation_string":"Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001452267","display_name":"Manabu Hayashi","orcid":"https://orcid.org/0000-0002-2213-3918","observed_orcids":["https://orcid.org/0000-0002-2213-3918"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Manabu Hayashi","raw_affiliation_strings":["Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013431676","display_name":"Tatsuro Sugaya","orcid":"https://orcid.org/0000-0002-8703-6078","observed_orcids":["https://orcid.org/0000-0002-8703-6078"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuro Sugaya","raw_affiliation_strings":["Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010191559","display_name":"Yosuke Takahata","orcid":"https://orcid.org/0000-0002-0354-7779","observed_orcids":["https://orcid.org/0000-0002-0354-7779"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yosuke Takahata","raw_affiliation_strings":["Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102743259","display_name":"Masashi Fujita","orcid":"https://orcid.org/0000-0001-5661-1415","observed_orcids":["https://orcid.org/0000-0001-5661-1415"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Fujita","raw_affiliation_strings":["Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017186029","display_name":"Kazumichi Abe","orcid":"https://orcid.org/0000-0001-5359-9465","observed_orcids":["https://orcid.org/0000-0001-5359-9465"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazumichi Abe","raw_affiliation_strings":["Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031116034","display_name":"Yasuyuki Kobayashi","orcid":"https://orcid.org/0000-0002-1134-0188","observed_orcids":["https://orcid.org/0000-0002-1134-0188"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuyuki Kobayashi","raw_affiliation_strings":["Department of Basic Pathology, Fukushima Medical University School of Medicine, Japan","Department of Diagnostic Pathology, Fukushima Medical University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Pathology, Fukushima Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I130830085"]},{"raw_affiliation_string":"Department of Diagnostic Pathology, Fukushima Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Erina Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Erina Suzuki","raw_affiliation_strings":["Department of Diagnostic Pathology, Fukushima Medical University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Pathology, Fukushima Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101717228","display_name":"Yuki Sato","orcid":"https://orcid.org/0000-0001-8000-0972","observed_orcids":["https://orcid.org/0000-0001-8000-0972"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Sato","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035539484","display_name":"Toma Fukuda","orcid":"https://orcid.org/0000-0002-5735-389X","observed_orcids":["https://orcid.org/0000-0002-5735-389X"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toma Fukuda","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010890117","display_name":"Shun Yasuda","orcid":"https://orcid.org/0000-0002-6520-902X","observed_orcids":["https://orcid.org/0000-0002-6520-902X","https://orcid.org/0000-0002-1573-6913"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shun Yasuda","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuko Hashimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Hashimoto","raw_affiliation_strings":["Department of Diagnostic Pathology, Fukushima Medical University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Pathology, Fukushima Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036475624","display_name":"Hiromasa Ohira","orcid":"https://orcid.org/0000-0003-4331-0634","observed_orcids":["https://orcid.org/0000-0003-4331-0634"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromasa Ohira","raw_affiliation_strings":["Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan","institution_ids":["https://openalex.org/I130830085"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130830085"],"apc_list":null,"apc_paid":null,"fwci":6.2244,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.95501567,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.6323000192642212,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.6323000192642212,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.14399999380111694,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0617000013589859,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrahepatic-cholestasis-of-pregnancy","display_name":"intrahepatic cholestasis of pregnancy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hyperbilirubinemia","display_name":"hyperbilirubinemia","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ugt1a1-polymorphism","display_name":"UGT1A1 polymorphism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":0.8830000162124634},{"id":"https://openalex.org/keywords/canalicular-cholestasis","display_name":"canalicular cholestasis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/pruritus","display_name":"pruritus","score":0.8740000128746033},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.531000018119812},{"id":"https://openalex.org/keywords/takayasu-arteritis","display_name":"Takayasu arteritis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.6980000138282776},{"id":"https://openalex.org/keywords/genetic-testing","display_name":"genetic testing","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9754999876022339},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6237000226974487},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5676000118255615},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5479000210762024},{"id":"https://openalex.org/C2779224579","wikidata":"https://www.wikidata.org/wiki/Q60195073","display_name":"Cholestasis of pregnancy","level":4,"score":0.43860000371932983},{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.42579999566078186},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.35510000586509705},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.29330000281333923},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.29100000858306885},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.25999999046325684}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2169/internalmedicine.7587-26","doi":"https://doi.org/10.2169/internalmedicine.7587-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7587-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7587-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},{"id":"pmid:42402405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42402405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal medicine (Tokyo, Japan)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2169/internalmedicine.7587-26","doi":"https://doi.org/10.2169/internalmedicine.7587-26","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.7587-26","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7587-26/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7167259795.pdf","grobid_xml":"https://content.openalex.org/works/W7167259795.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1969874914","https://openalex.org/W1975908064","https://openalex.org/W1982017203","https://openalex.org/W2016202086","https://openalex.org/W2016623506","https://openalex.org/W2123810061","https://openalex.org/W2161201067","https://openalex.org/W2181964530","https://openalex.org/W2326944091","https://openalex.org/W2898169117","https://openalex.org/W2918398078","https://openalex.org/W4220995692","https://openalex.org/W4290744721","https://openalex.org/W4382364882","https://openalex.org/W4391974719","https://openalex.org/W4407203474"],"related_works":["https://openalex.org/W3127710256","https://openalex.org/W2980182852","https://openalex.org/W2980211907","https://openalex.org/W2979033167","https://openalex.org/W3209452935","https://openalex.org/W2967943436","https://openalex.org/W4409015967","https://openalex.org/W2980282971","https://openalex.org/W4410347370","https://openalex.org/W4408416650"],"abstract_inverted_index":{"A":[0],"36-year-old":[1],"pregnant":[2],"woman":[3],"at":[4],"34":[5],"weeks":[6],"of":[7,65,90],"gestation,":[8],"who":[9],"had":[10],"been":[11],"receiving":[12],"tocilizumab":[13,72],"for":[14,43,87],"Takayasu":[15],"arteritis,":[16],"presented":[17],"with":[18,62,68],"pruritus":[19],"and":[20,51,71,80],"hyperbilirubinemia.":[21,82],"She":[22],"delivered":[23],"a":[24,44,52],"healthy":[25],"infant":[26],"the":[27,78,88],"day":[28],"after":[29],"admission.":[30],"However,":[31],"her":[32],"bilirubin":[33],"level":[34],"increased":[35],"to":[36,77],"32.2":[37],"mg/dL.":[38],"Genetic":[39],"testing":[40],"revealed":[41,55],"heterozygosity":[42],"uridine":[45],"diphosphate":[46],"glucuronosyltransferase":[47],"1A1":[48],"(UGT1A1)":[49],"polymorphism,":[50,70],"liver":[53],"biopsy":[54],"canalicular":[56],"cholestasis.":[57],"The":[58],"patient":[59],"was":[60,85],"diagnosed":[61],"intrahepatic":[63],"cholestasis":[64],"pregnancy":[66],"(ICP)":[67],"UGT1A1":[69],"therapy":[73],"might":[74],"have":[75],"contributed":[76],"marked":[79],"prolonged":[81],"Liver":[83],"histology":[84],"useful":[86],"diagnosis":[89],"ICP":[91],"in":[92],"this":[93],"case.":[94]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-07-04T00:00:00"}