{"id":"https://openalex.org/W7167246169","doi":"https://doi.org/10.12659/ajcr.953192","title":"A 73-Year-Old Man With a Late Isolated Brain Metastasis of Clear Cell Renal Cell Carcinoma Following a Durable Complete Response to Lenvatinib\u2010Pembrolizumab, Resulting in Deferred Cytoreductive Nephrectomy","display_name":"A 73-Year-Old Man With a Late Isolated Brain Metastasis of Clear Cell Renal Cell Carcinoma Following a Durable Complete Response to Lenvatinib\u2010Pembrolizumab, Resulting in Deferred Cytoreductive Nephrectomy","publication_year":2026,"publication_date":"2026-07-03","ids":{"openalex":"https://openalex.org/W7167246169","doi":"https://doi.org/10.12659/ajcr.953192","pmid":"https://pubmed.ncbi.nlm.nih.gov/42452828","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13383680"},"language":"en","primary_location":{"id":"doi:10.12659/ajcr.953192","doi":"https://doi.org/10.12659/ajcr.953192","is_oa":true,"landing_page_url":"https://doi.org/10.12659/ajcr.953192","pdf_url":"https://amjcaserep.com/download/inPress/idArt/953192","source":{"id":"https://openalex.org/S2756455307","display_name":"American Journal of Case Reports","issn_l":"1941-5923","issn":["1941-5923"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320062","host_organization_name":"International Scientific Information Inc.","host_organization_lineage":["https://openalex.org/P4310320062"],"host_organization_lineage_names":["International Scientific Information Inc."],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://amjcaserep.com/download/inPress/idArt/953192","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112076486","display_name":"Fumihiro Ito","orcid":"https://orcid.org/0009-0007-7240-6113","observed_orcids":["https://orcid.org/0009-0007-7240-6113"]},"institutions":[{"id":"https://openalex.org/I4210091314","display_name":"Gifu Prefectural Tajimi Hospital","ror":"https://ror.org/00jy2zq62","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210091314"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Fumihiro Ito","raw_affiliation_strings":["Department of Urology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan","institution_ids":["https://openalex.org/I4210091314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122344061","display_name":"Koki Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091314","display_name":"Gifu Prefectural Tajimi Hospital","ror":"https://ror.org/00jy2zq62","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210091314"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koki Kobayashi","raw_affiliation_strings":["Department of Urology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan","institution_ids":["https://openalex.org/I4210091314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019960375","display_name":"Gaku Hayashi","orcid":"https://orcid.org/0009-0000-0978-3230","observed_orcids":["https://orcid.org/0009-0000-0978-3230"]},"institutions":[{"id":"https://openalex.org/I4210091314","display_name":"Gifu Prefectural Tajimi Hospital","ror":"https://ror.org/00jy2zq62","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210091314"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Gaku Hayashi","raw_affiliation_strings":["Department of Urology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan","institution_ids":["https://openalex.org/I4210091314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109244048","display_name":"Shunsuke Kamijo","orcid":"https://orcid.org/0009-0000-4832-7510","observed_orcids":["https://orcid.org/0009-0000-4832-7510"]},"institutions":[{"id":"https://openalex.org/I4210091314","display_name":"Gifu Prefectural Tajimi Hospital","ror":"https://ror.org/00jy2zq62","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210091314"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunsuke Kamijo","raw_affiliation_strings":["Department of Urology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan","institution_ids":["https://openalex.org/I4210091314"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5133171554","display_name":"Takashi Fujita","orcid":"https://orcid.org/0009-0004-0214-7265","observed_orcids":["https://orcid.org/0009-0004-0214-7265"]},"institutions":[{"id":"https://openalex.org/I4210091314","display_name":"Gifu Prefectural Tajimi Hospital","ror":"https://ror.org/00jy2zq62","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210091314"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Fujita","raw_affiliation_strings":["Department of Urology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan","institution_ids":["https://openalex.org/I4210091314"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112076486"],"corresponding_institution_ids":["https://openalex.org/I4210091314"],"apc_list":null,"apc_paid":null,"fwci":2.4016,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.82769208,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"27","issue":null,"first_page":"e953192","last_page":"e953192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9729999899864197},{"id":"https://openalex.org/keywords/lenvatinib","display_name":"lenvatinib","score":0.9580000042915344},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":1.0},{"id":"https://openalex.org/keywords/durable-complete-response","display_name":"durable complete response","score":0.7070000171661377},{"id":"https://openalex.org/keywords/cns-relapse","display_name":"central nervous system relapse","score":0.8410000205039978},{"id":"https://openalex.org/keywords/inferior-vena-cava-tumor-thrombus","display_name":"inferior vena cava tumor thrombus","score":0.8149999976158142},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/stereotactic-body-radiation-therapy","display_name":"stereotactic body radiotherapy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.753000020980835},{"id":"https://openalex.org/keywords/multikinase-inhibitor","display_name":"multikinase inhibitor","score":0.8980000019073486},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9772999882698059},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.7319999933242798},{"id":"https://openalex.org/C2780227381","wikidata":"https://www.wikidata.org/wiki/Q1357376","display_name":"Nephrectomy","level":3,"score":0.6937999725341797},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.6432999968528748},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.6237000226974487},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.48069998621940613},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.4269999861717224},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.41190001368522644},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39570000767707825},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3928999900817871},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36039999127388},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3391000032424927},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3366999924182892},{"id":"https://openalex.org/C3019926457","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Distant metastasis","level":4,"score":0.3163999915122986},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.31439998745918274},{"id":"https://openalex.org/C2779052582","wikidata":"https://www.wikidata.org/wiki/Q3473544","display_name":"Clear-cell sarcoma","level":3,"score":0.2946000099182129},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28929999470710754},{"id":"https://openalex.org/C2781199814","wikidata":"https://www.wikidata.org/wiki/Q18556242","display_name":"Clear cell carcinoma","level":3,"score":0.2856999933719635},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.28209999203681946},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27900001406669617},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.2709999978542328},{"id":"https://openalex.org/C2778601017","wikidata":"https://www.wikidata.org/wiki/Q6823242","display_name":"Metastasectomy","level":4,"score":0.2696000039577484}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000095384","descriptor_name":"Pathologic Complete Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009392","descriptor_name":"Nephrectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D065426","descriptor_name":"Cytoreduction Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.12659/ajcr.953192","doi":"https://doi.org/10.12659/ajcr.953192","is_oa":true,"landing_page_url":"https://doi.org/10.12659/ajcr.953192","pdf_url":"https://amjcaserep.com/download/inPress/idArt/953192","source":{"id":"https://openalex.org/S2756455307","display_name":"American Journal of Case Reports","issn_l":"1941-5923","issn":["1941-5923"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320062","host_organization_name":"International Scientific Information Inc.","host_organization_lineage":["https://openalex.org/P4310320062"],"host_organization_lineage_names":["International Scientific Information Inc."],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Case Reports","raw_type":"journal-article"},{"id":"pmid:42452828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42452828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of case reports","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:13383680","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13383680/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Case Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.12659/ajcr.953192","doi":"https://doi.org/10.12659/ajcr.953192","is_oa":true,"landing_page_url":"https://doi.org/10.12659/ajcr.953192","pdf_url":"https://amjcaserep.com/download/inPress/idArt/953192","source":{"id":"https://openalex.org/S2756455307","display_name":"American Journal of Case Reports","issn_l":"1941-5923","issn":["1941-5923"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320062","host_organization_name":"International Scientific Information Inc.","host_organization_lineage":["https://openalex.org/P4310320062"],"host_organization_lineage_names":["International Scientific Information Inc."],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7167246169.pdf","grobid_xml":"https://content.openalex.org/works/W7167246169.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W2805060661","https://openalex.org/W2904657085","https://openalex.org/W2912161657","https://openalex.org/W2913745075","https://openalex.org/W2939049629","https://openalex.org/W3014615279","https://openalex.org/W3088097675","https://openalex.org/W3090495129","https://openalex.org/W3091895724","https://openalex.org/W3131063362","https://openalex.org/W3157645496","https://openalex.org/W3171303543","https://openalex.org/W4327860654","https://openalex.org/W4409155739","https://openalex.org/W4409406802","https://openalex.org/W4414521801"],"related_works":["https://openalex.org/W7202174392","https://openalex.org/W4402718471","https://openalex.org/W4327860654","https://openalex.org/W2987505633","https://openalex.org/W4409445078","https://openalex.org/W7136079172","https://openalex.org/W7204490898","https://openalex.org/W2937799502","https://openalex.org/W4386089775","https://openalex.org/W4404247412"],"abstract_inverted_index":{"BACKGROUND":[0],"A":[1,102],"durable":[2,91,238],"complete":[3,68,92,191,240],"response,":[4],"or":[5],"sustained":[6],"disappearance":[7],"of":[8,84,145,180],"measurable":[9],"malignancy,":[10],"can":[11,57,235],"occur":[12,236,264],"in":[13,142,251],"selected":[14],"patients":[15],"with":[16,42,79,106,159,172],"metastatic":[17],"renal":[18,26,33,87,115,169,181],"cell":[19,25,27,34,86,88,168,170],"carcinoma":[20,28,35,89,171],"after":[21,66,90,242],"systemic":[22,216,267],"therapy.":[23],"Clear":[24],"is":[29,38,47],"the":[30,146],"most":[31],"common":[32],"subtype.":[36],"Lenvatinib":[37,176],"a":[39,76,113,210],"multikinase":[40],"inhibitor":[41],"antiangiogenic":[43],"activity,":[44],"and":[45,96,124,153,164,183,204,244],"pembrolizumab":[46,184],"an":[48],"anti-programmed":[49],"death-1":[50],"immune":[51],"checkpoint":[52],"inhibitor.":[53],"Although":[54],"this":[55],"combination":[56],"induce":[58],"deep":[59],"extracranial":[60,192,239],"responses,":[61],"central":[62,231],"nervous":[63,232],"system":[64,233],"relapse":[65,234],"prolonged":[67],"response":[69,93,241],"remains":[70,269],"incompletely":[71],"characterized.":[72],"This":[73,225],"report":[74],"describes":[75],"73-year-old":[77,103],"man":[78,104],"late":[80,229],"isolated":[81,230],"brain":[82,129,205,256],"metastasis":[83,214],"clear":[85,167],"to":[94],"lenvatinib-pembrolizumab":[95,243],"deferred":[97,245],"cytoreductive":[98,157,246],"nephrectomy.":[99,247],"CASE":[100],"REPORT":[101],"presented":[105],"right":[107,114],"flank":[108],"pain.":[109],"Computed":[110],"tomography":[111,131],"showed":[112,132],"tumor,":[116,148],"level":[117],"II":[118],"inferior":[119,149],"vena":[120,150],"cava":[121,151],"tumor":[122],"thrombus,":[123,152],"multiple":[125],"pulmonary":[126],"metastases.":[127,155],"Baseline":[128],"computed":[130],"no":[133],"intracranial":[134,261],"metastasis.":[135],"He":[136,200],"received":[137],"lenvatinib":[138],"plus":[139],"pembrolizumab,":[140],"resulting":[141],"marked":[143],"regression":[144],"primary":[147],"lung":[154],"Deferred":[156],"nephrectomy":[158],"thrombectomy":[160],"was":[161,177,186],"then":[162],"performed,":[163],"pathology":[165],"confirmed":[166],"extensive":[173],"treatment":[174],"effect.":[175],"discontinued":[178],"because":[179,260],"dysfunction,":[182],"monotherapy":[185],"continued.":[187],"The":[188],"patient":[189],"maintained":[190],"radiographic":[193],"remission":[194],"for":[195],"more":[196],"than":[197],"2":[198],"years.":[199],"later":[201],"developed":[202],"headache,":[203],"magnetic":[206,257],"resonance":[207,258],"imaging":[208,268],"revealed":[209],"solitary":[211],"left":[212],"occipital":[213],"without":[215],"recurrence.":[217],"Stereotactic":[218],"body":[219],"radiotherapy":[220],"achieved":[221],"local":[222],"control.":[223],"CONCLUSIONS":[224],"case":[226],"shows":[227],"that":[228],"despite":[237],"New":[248],"neurological":[249],"symptoms":[250],"long-term":[252],"responders":[253],"should":[254],"prompt":[255],"imaging,":[259],"progression":[262],"may":[263],"even":[265],"when":[266],"negative.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-07-04T00:00:00"}
