{"id":"https://openalex.org/W7167226306","doi":"https://doi.org/10.17632/zmvvv96zzx","title":"Developmental restriction of the jaw skeletal muscle cardiogenic potential","display_name":"Developmental restriction of the jaw skeletal muscle cardiogenic potential","publication_year":2026,"publication_date":"2026-07-03","ids":{"openalex":"https://openalex.org/W7167226306","doi":"https://doi.org/10.17632/zmvvv96zzx"},"language":"en","primary_location":{"id":"doi:10.17632/zmvvv96zzx","doi":"https://doi.org/10.17632/zmvvv96zzx","is_oa":true,"landing_page_url":"https://doi.org/10.17632/zmvvv96zzx","pdf_url":null,"source":{"id":"https://openalex.org/S7407050775","display_name":"Mendeley Data","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"volume":null,"type":"dataset","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17632/zmvvv96zzx","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5139957825","display_name":"Covadonga D\u00edaz D\u00edaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210095014","display_name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares","ror":"https://ror.org/00s29fn93","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095014"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"D\u00edaz D\u00edaz, Covadonga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5139957825"],"corresponding_institution_ids":["https://openalex.org/I2809107791","https://openalex.org/I4210095014","https://openalex.org/I4210115082"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.5684000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.5684000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.413100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skeletal-muscle-stem-cells","display_name":"skeletal muscle stem cells","score":0.8230000138282776},{"id":"https://openalex.org/keywords/masticatory-muscles","display_name":"masticatory muscles","score":0.7900000214576721},{"id":"https://openalex.org/keywords/satellite-cells","display_name":"satellite cells","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mesenchymal-progenitor-cells","display_name":"mesenchymal progenitor cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/cardiomyocyte-differentiation","display_name":"cardiomyocyte differentiation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/epigenetic-barriers","display_name":"epigenetic barriers","score":0.6629999876022339},{"id":"https://openalex.org/keywords/lineage-plasticity","display_name":"lineage plasticity","score":0.8840000033378601},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.5600000023841858},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6550999879837036},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6486999988555908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6147000193595886},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5419999957084656},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5102999806404114},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49230000376701355},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.47450000047683716},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4706999957561493},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.4632999897003174},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.4115999937057495},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.3873000144958496},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.38530001044273376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3709999918937683},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.366100013256073},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.3375999927520752},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32100000977516174},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.31869998574256897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30959999561309814},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.30869999527931213},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.30169999599456787},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.3001999855041504},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2928999960422516},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.2912999987602234},{"id":"https://openalex.org/C2776850375","wikidata":"https://www.wikidata.org/wiki/Q2477062","display_name":"Cardiogenic shock","level":3,"score":0.290800005197525},{"id":"https://openalex.org/C2910776680","wikidata":"https://www.wikidata.org/wiki/Q862600","display_name":"Multipotent Stem Cell","level":4,"score":0.2863999903202057},{"id":"https://openalex.org/C174054327","wikidata":"https://www.wikidata.org/wiki/Q6947920","display_name":"Myofilament","level":3,"score":0.2806999981403351},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.266400009393692}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.17632/zmvvv96zzx","doi":"https://doi.org/10.17632/zmvvv96zzx","is_oa":true,"landing_page_url":"https://doi.org/10.17632/zmvvv96zzx","pdf_url":null,"source":{"id":"https://openalex.org/S7407050775","display_name":"Mendeley Data","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.17632/zmvvv96zzx.1","doi":"https://doi.org/10.17632/zmvvv96zzx.1","is_oa":true,"landing_page_url":"https://doi.org/10.17632/zmvvv96zzx.1","pdf_url":null,"source":{"id":"https://openalex.org/S7407050775","display_name":"Mendeley Data","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.17632/zmvvv96zzx","doi":"https://doi.org/10.17632/zmvvv96zzx","is_oa":true,"landing_page_url":"https://doi.org/10.17632/zmvvv96zzx","pdf_url":null,"source":{"id":"https://openalex.org/S7407050775","display_name":"Mendeley Data","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1329279190","display_name":"New-generation cardiac therapeutic strategies directed to the activation of endogenous regenerative mechanisms","funder_award_id":"874764","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1728342668","display_name":null,"funder_award_id":"CEX2020\u2010001041\u2010S","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G2152959462","display_name":null,"funder_award_id":"CEX2020-001041-S","funder_id":"https://openalex.org/F4320323479","funder_display_name":"Centro Nacional de Investigaciones Cardiovasculares"},{"id":"https://openalex.org/G288011245","display_name":null,"funder_award_id":"CEX2020\u2010001041\u2010S","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G3012247180","display_name":null,"funder_award_id":"SC1-BHC","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G3154849253","display_name":null,"funder_award_id":"PID2022-140058NB-C31","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G4738309242","display_name":null,"funder_award_id":"P2022/BMD-7245","funder_id":"https://openalex.org/F4320313831","funder_display_name":"Comunidad de Madrid"},{"id":"https://openalex.org/G489313807","display_name":null,"funder_award_id":"CEX2020-001041-S","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5941068327","display_name":null,"funder_award_id":"SC1-BHC-07-2019","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G7396372118","display_name":null,"funder_award_id":"874764","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G7572322741","display_name":null,"funder_award_id":"CEX2020-001041-S","funder_id":"https://openalex.org/F4320313831","funder_display_name":"Comunidad de Madrid"},{"id":"https://openalex.org/G8389898267","display_name":null,"funder_award_id":"PID2022-140058NB-C31","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G8849668858","display_name":null,"funder_award_id":"101142005","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8920660035","display_name":null,"funder_award_id":"PID2022","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320313831","display_name":"Comunidad de Madrid","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320323479","display_name":"Centro Nacional de Investigaciones Cardiovasculares","ror":"https://ror.org/02qs1a797"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2559064005","https://openalex.org/W2102108981","https://openalex.org/W2804220648","https://openalex.org/W1536692549","https://openalex.org/W2038828204","https://openalex.org/W1967772789","https://openalex.org/W4389022813","https://openalex.org/W2128995496","https://openalex.org/W1973807810","https://openalex.org/W1997987443"],"abstract_inverted_index":{"Cardiovascular":[0],"diseases":[1],"are":[2,170,206],"a":[3,67,91],"leading":[4],"cause":[5],"of":[6,50,69,94,104,142,185],"mortality":[7],"worldwide":[8],"and":[9,76,85,145,156,208],"heart":[10,27],"failure":[11,28],"remains":[12],"an":[13],"end-stage":[14],"disease":[15],"with":[16],"no":[17],"other":[18,119],"treatment":[19],"than":[20],"transplantation.":[21],"A":[22],"promising":[23,46],"field":[24],"to":[25,73,172,210,216],"tackle":[26],"is":[29,56],"regenerative":[30],"medicine.":[31],"Whereas":[32],"cardiomyocyte":[33],"generation":[34],"in":[35],"large":[36],"numbers":[37],"from":[38,52,90,108,118,149,167],"pluripotent":[39],"or":[40],"reprogrammed":[41],"stem":[42,54,113,165],"cells":[43,55,106,130,144,148,166,176],"has":[44],"shown":[45],"results,":[47],"direct":[48],"derivation":[49,103],"cardiomyocytes":[51],"somatic":[53],"still":[57],"challenging.":[58],"Skeletal":[59],"muscle":[60,112,129,152],"progenitors":[61],"have":[62,100],"been":[63],"extensively":[64],"studied":[65],"as":[66],"source":[68],"cardiac":[70,175],"cells,":[71],"due":[72],"their":[74,124],"cellular":[75],"functional":[77],"similarities.":[78],"During":[79],"development,":[80],"the":[81,102,134,139,150,183,196],"right":[82],"ventricular":[83],"myocardium":[84],"jaw":[86,111,128],"skeletal":[87,120],"muscles":[88,169],"derive":[89],"common":[92],"pool":[93],"myogenic":[95],"mesodermal":[96],"progenitors.":[97],"Previous":[98],"studies":[99],"reported":[101],"cardiomyocyte-like":[105],"specifically":[107],"adult":[109],"mouse":[110],"cell":[114],"populations,":[115],"but":[116],"not":[117],"muscles,":[121],"suggesting":[122,199],"that":[123,164,190,200],"developmental":[125],"origin":[126],"endows":[127],"cardiogenic":[131,140,180,217],"potential.":[132],"In":[133],"present":[135],"study,":[136],"we":[137],"evaluated":[138],"potential":[141],"satellite":[143],"mesenchymal":[146],"progenitor":[147],"masticatory":[151,168],"by":[153,213],"reproducing,":[154],"optimizing":[155],"diversifying":[157],"previously":[158],"described":[159],"protocols.":[160],"We":[161],"consistently":[162],"found":[163],"unable":[171],"differentiate":[173],"into":[174],"under":[177],"any":[178],"tested":[179],"environment.":[181],"Furthermore,":[182],"addition":[184],"various":[186],"small":[187],"molecule":[188],"inhibitors":[189],"reprogram":[191],"repressive":[192],"epigenetic":[193,201],"marks":[194],"reaped":[195],"same":[197],"success,":[198],"barriers":[202],"restraining":[203],"lineage":[204],"plasticity":[205],"profound":[207],"unlikely":[209],"be":[211],"reversed":[212],"simple":[214],"exposure":[215],"environments.":[218]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-07-04T00:00:00"}
