{"id":"https://openalex.org/W7167076321","doi":"https://doi.org/10.63626/21zenk44","title":"Ataxia-Telangiectasia Mutated (ATM) inhibitor induces antineoplastic effects in brain cancer cells: Evidence from in vitro investigations","display_name":"Ataxia-Telangiectasia Mutated (ATM) inhibitor induces antineoplastic effects in brain cancer cells: Evidence from in vitro investigations","publication_year":2026,"publication_date":"2026-06-30","ids":{"openalex":"https://openalex.org/W7167076321","doi":"https://doi.org/10.63626/21zenk44"},"language":"en","primary_location":{"id":"doi:10.63626/21zenk44","doi":"https://doi.org/10.63626/21zenk44","is_oa":true,"landing_page_url":"https://doi.org/10.63626/21zenk44","pdf_url":"https://biologycircle.com/index.php/crm/article/download/85/61","source":{"id":"https://openalex.org/S5407050332","display_name":"Cancer Research and Medicine","issn_l":"3104-4131","issn":["3104-4131","3135-2715"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://biologycircle.com/index.php/crm/article/download/85/61","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082275126","display_name":"Kinzah Kanwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195024194","display_name":"Riphah International University","ror":"https://ror.org/02kdm5630","country_code":"PK","type":"education","lineage":["https://openalex.org/I195024194"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Kinzah Kanwal","raw_affiliation_strings":["Medical Laboratory Technology , Riphah College of Rehabilitation & Allied Health Sciences , Riphah International University , Islamabad , Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Laboratory Technology , Riphah College of Rehabilitation & Allied Health Sciences , Riphah International University , Islamabad , Pakistan","institution_ids":["https://openalex.org/I195024194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139892957","display_name":"Tooba Khalid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195024194","display_name":"Riphah International University","ror":"https://ror.org/02kdm5630","country_code":"PK","type":"education","lineage":["https://openalex.org/I195024194"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Tooba Khalid","raw_affiliation_strings":["Medical Laboratory Technology , Riphah College of Rehabilitation & Allied Health Sciences , Riphah International University , Islamabad , Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Laboratory Technology , Riphah College of Rehabilitation & Allied Health Sciences , Riphah International University , Islamabad , Pakistan","institution_ids":["https://openalex.org/I195024194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040906956","display_name":"Maisra Azhar Butt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195024194","display_name":"Riphah International University","ror":"https://ror.org/02kdm5630","country_code":"PK","type":"education","lineage":["https://openalex.org/I195024194"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Maisra Azhar Butt","raw_affiliation_strings":["Medical Laboratory Technology , Riphah College of Rehabilitation & Allied Health Sciences , Riphah International University , Islamabad , Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Laboratory Technology , Riphah College of Rehabilitation & Allied Health Sciences , Riphah International University , Islamabad , Pakistan","institution_ids":["https://openalex.org/I195024194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091762803","display_name":"Sehrish Abbas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195024194","display_name":"Riphah International University","ror":"https://ror.org/02kdm5630","country_code":"PK","type":"education","lineage":["https://openalex.org/I195024194"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sehrish Abbas","raw_affiliation_strings":["Medical Laboratory Technology , Riphah College of Rehabilitation & Allied Health Sciences , Riphah International University , Islamabad , Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Laboratory Technology , Riphah College of Rehabilitation & Allied Health Sciences , Riphah International University , Islamabad , Pakistan","institution_ids":["https://openalex.org/I195024194"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111066150","display_name":"Shafaq Ashraf","orcid":"https://orcid.org/0009-0004-0091-5478","observed_orcids":["https://orcid.org/0009-0004-0091-5478"]},"institutions":[{"id":"https://openalex.org/I195024194","display_name":"Riphah International University","ror":"https://ror.org/02kdm5630","country_code":"PK","type":"education","lineage":["https://openalex.org/I195024194"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Shafaq Ashraf","raw_affiliation_strings":["Medical Laboratory Technology , Riphah College of Rehabilitation & Allied Health Sciences , Riphah International University , Islamabad , Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Laboratory Technology , Riphah College of Rehabilitation & Allied Health Sciences , Riphah International University , Islamabad , Pakistan","institution_ids":["https://openalex.org/I195024194"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I195024194"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"1","first_page":"29","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atm-inhibitors","display_name":"ATM inhibitors","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ataxia-telangiectasia","display_name":"ataxia telangiectasia","score":0.8690000176429749},{"id":"https://openalex.org/keywords/brain-cancer","display_name":"brain cancer","score":0.8289999961853027},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/imr-32-cells","display_name":"IMR-32 cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6370000243186951},{"id":"https://openalex.org/keywords/gadd45a","display_name":"GADD45A","score":0.578000009059906},{"id":"https://openalex.org/keywords/e2f1","display_name":"E2F1","score":0.7509999871253967},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.5419999957084656},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.7099999785423279},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.7419999837875366},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2777527632","wikidata":"https://www.wikidata.org/wiki/Q238382","display_name":"DAPI","level":3,"score":0.8921999931335449},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.7458999752998352},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6705999970436096},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6218000054359436},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5094000101089478},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5037000179290771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49300000071525574},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.4869999885559082},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.48330000042915344},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46000000834465027},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.44859999418258667},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4323999881744385},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4203000068664551},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4147999882698059},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4088999927043915},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.3919999897480011},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.38109999895095825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3580999970436096},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3474000096321106},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.34389999508857727},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.337799996137619},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.31130000948905945},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.30329999327659607},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29750001430511475},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29750001430511475},{"id":"https://openalex.org/C2776020440","wikidata":"https://www.wikidata.org/wiki/Q420705","display_name":"Crystal violet","level":2,"score":0.2874999940395355},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.2831999957561493},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.28279998898506165},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.28049999475479126},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.27799999713897705},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.267300009727478},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.265500009059906},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.26109999418258667},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.25619998574256897},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.25519999861717224}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.63626/21zenk44","doi":"https://doi.org/10.63626/21zenk44","is_oa":true,"landing_page_url":"https://doi.org/10.63626/21zenk44","pdf_url":"https://biologycircle.com/index.php/crm/article/download/85/61","source":{"id":"https://openalex.org/S5407050332","display_name":"Cancer Research and Medicine","issn_l":"3104-4131","issn":["3104-4131","3135-2715"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research and Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.63626/21zenk44","doi":"https://doi.org/10.63626/21zenk44","is_oa":true,"landing_page_url":"https://doi.org/10.63626/21zenk44","pdf_url":"https://biologycircle.com/index.php/crm/article/download/85/61","source":{"id":"https://openalex.org/S5407050332","display_name":"Cancer Research and Medicine","issn_l":"3104-4131","issn":["3104-4131","3135-2715"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research and Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7167076321.pdf","grobid_xml":"https://content.openalex.org/works/W7167076321.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2503538439","https://openalex.org/W3156137002","https://openalex.org/W2802016612","https://openalex.org/W2348404910","https://openalex.org/W4414030790","https://openalex.org/W1552614585","https://openalex.org/W4386537588","https://openalex.org/W4406693369","https://openalex.org/W2337292079","https://openalex.org/W4401610709"],"abstract_inverted_index":{"Background:":[0],"Brain":[1],"cancer":[2,51,280],"is":[3,18,55],"a":[4,97],"life-threatening":[5],"disease":[6],"that":[7],"originates":[8],"from":[9],"abnormal":[10],"cells":[11,76,93],"growth":[12,281],"uncontrollably":[13],"in":[14,123,138,159,277],"brain":[15,25,65,279],"tissues.":[16],"Treatment":[17],"challenging":[19],"because":[20],"of":[21,24,92,104,141,177,191,202,208,259,274],"the":[22,35,50,105,124,139,173,178,209,249,260],"delicacy":[23],"and":[26,39,59,71,80,109,120,151,189,204,235,254,282],"blood\u2013brain":[27],"barrier":[28],"which":[29],"does":[30],"not":[31,47],"allow":[32],"to":[33,63,100,114,135],"enter":[34],"medicines":[36,62],"easily.":[37],"Surgery":[38],"existing":[40],"chemotherapeutic":[41],"measures":[42],"are":[43],"helpful":[44],"but":[45],"may":[46],"destroy":[48],"all":[49],"cells.":[52,125,210],"Thus,":[53],"there":[54],"need":[56],"for":[57,68],"new":[58],"more":[60],"effective":[61],"treat":[64],"tumors":[66],"safely":[67],"subsequent":[69],"improvement":[70],"survival.":[72],"Methods:":[73],"Human":[74],"neuroblastoma":[75],"IMR-32":[77],"were":[78,94,112,129,219,240,262],"cultured":[79],"exposed":[81],"with":[82,164,245],"commercially":[83],"available":[84],"Ataxia-Telangiectasia":[85],"Mutated":[86],"(ATM)":[87],"inhibitor.":[88,166],"Effects":[89],"on":[90],"viability":[91,161,180],"evaluated":[95],"using":[96,131],"colorimetric":[98],"assay":[99,156],"determine":[101],"cytotoxic":[102],"impact":[103],"treatment.":[106,267],"Crystal":[107,197],"violet":[108,198],"DAPI":[110,184],"staining":[111,185,199],"performed":[113],"monitor":[115],"cellular":[116],"growth,":[117],"nuclear":[118,187],"morphology":[119],"apoptotic":[121,195],"changes":[122,137],"Gene":[126],"expression":[127,140],"levels":[128,258],"determined":[130],"real-time":[132],"PCR":[133],"(RT-PCR)":[134],"quantify":[136],"target":[142],"genes":[143,213,261],"including":[144],"apoptosis,":[145,253],"cell":[146,160,179,223,250],"cycle,":[147],"stress":[148,231],"related":[149,212],"markers":[150],"transcription":[152,236],"factors.":[153],"Results:":[154],"Toxicity":[155],"showed":[157,170],"reduction":[158],"after":[162,181],"treatment":[163],"ATM":[165,246,265,275],"Inhibitory":[167],"concentration":[168,174],"data":[169],"~7.5\u00b5M":[171],"as":[172],"inhibited":[175],"50%":[176],"48h":[182],"exposure.":[183],"revealed":[186],"condensation":[188],"fragmentation":[190],"DNA":[192],"content":[193],"indicating":[194],"changes.":[196],"indicated":[200],"inhibition":[201],"proliferation":[203],"colony":[205],"forming":[206],"ability":[207],"Apoptosis":[211],"(CASP3,":[214],"CASP7,":[215],"CASP9,":[216],"BAX,":[217],"BCL2)":[218],"largely":[220,241],"induced,":[221],"while":[222],"cycle":[224],"(CCND1,":[225],"CCND2,":[226],"CDKN1A,":[227],"CDKN2A,":[228],"CDKN1B,":[229],"CDKN2B),":[230],"(GADD34,":[232],"GADD45A,":[233],"GADD153)":[234],"factors":[237],"(E2F1,":[238],"E2F6)":[239],"inhibited.":[242],"Conclusion:":[243],"Exposure":[244],"inhibitor":[247,266,276],"restrained":[248],"proliferation,":[251],"induced":[252],"suppressed":[255],"colonization.":[256],"Transcriptomic":[257],"altered":[263],"by":[264],"The":[268],"results":[269],"indicate":[270],"potential":[271],"therapeutic":[272],"value":[273],"controlling":[278],"progression.":[283]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-07-03T00:00:00"}
