{"id":"https://openalex.org/W7167024565","doi":"https://doi.org/10.1016/j.jphs.2026.07.001","title":"Chronic glucocorticoid exposure disrupts lactate homeostasis and hippocampal neurogenesis by reducing cerebrovascular monocarboxylate transporter 1, leading to behavioral abnormalities in mice","display_name":"Chronic glucocorticoid exposure disrupts lactate homeostasis and hippocampal neurogenesis by reducing cerebrovascular monocarboxylate transporter 1, leading to behavioral abnormalities in mice","publication_year":2026,"publication_date":"2026-07-02","ids":{"openalex":"https://openalex.org/W7167024565","doi":"https://doi.org/10.1016/j.jphs.2026.07.001","pmid":"https://pubmed.ncbi.nlm.nih.gov/42481133"},"language":"en","primary_location":{"id":"doi:10.1016/j.jphs.2026.07.001","doi":"https://doi.org/10.1016/j.jphs.2026.07.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jphs.2026.07.001","pdf_url":null,"source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jphs.2026.07.001","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008169301","display_name":"Ayami Kita","orcid":"https://orcid.org/0000-0003-2122-1876","observed_orcids":["https://orcid.org/0000-0003-2122-1876"]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ayami Kita-Shirakura","raw_affiliation_strings":["Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan. Electronic address: ayami.kita@setsunan.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan. Electronic address: ayami.kita@setsunan.ac.jp","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131311271","display_name":"Kaede Ishihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaede Ishihara","raw_affiliation_strings":["Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139923432","display_name":"Nagisa Kimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nagisa Kimura","raw_affiliation_strings":["Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139866166","display_name":"Momoka Tanida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Momoka Tanida","raw_affiliation_strings":["Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049089830","display_name":"Ryota Araki","orcid":"https://orcid.org/0000-0002-0881-9737","observed_orcids":["https://orcid.org/0000-0002-0881-9737"]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryota Araki","raw_affiliation_strings":["Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan","institution_ids":["https://openalex.org/I102826571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041622839","display_name":"Takeshi Yabe","orcid":"https://orcid.org/0000-0003-0732-0704","observed_orcids":["https://orcid.org/0000-0003-0732-0704"]},"institutions":[{"id":"https://openalex.org/I102826571","display_name":"Setsunan University","ror":"https://ror.org/0418a3v02","country_code":"JP","type":"education","lineage":["https://openalex.org/I102826571"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takeshi Yabe","raw_affiliation_strings":["Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan. Electronic address: yabe@pharm.setsunan.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan. Electronic address: yabe@pharm.setsunan.ac.jp","institution_ids":["https://openalex.org/I102826571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008169301","https://openalex.org/A5041622839"],"corresponding_institution_ids":["https://openalex.org/I102826571"],"apc_list":{"value":2070,"currency":"USD","value_usd":2070},"apc_paid":{"value":2070,"currency":"USD","value_usd":2070},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51189563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"162","issue":"1","first_page":"80","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.8192999958992004,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.8192999958992004,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.13490000367164612,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-glucocorticoid-exposure","display_name":"chronic glucocorticoid exposure","score":0.9860000014305115},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hippocampal-neurogenesis","display_name":"hippocampal neurogenesis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mct1","display_name":"MCT1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/brain-endothelial-cells","display_name":"brain endothelial cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/lactate-transport","display_name":"lactate transport","score":0.8980000019073486},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.9710000157356262}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7980999946594238},{"id":"https://openalex.org/C2781217356","wikidata":"https://www.wikidata.org/wiki/Q83426191","display_name":"Monocarboxylate transporter","level":4,"score":0.7874000072479248},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.7315999865531921},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.7276999950408936},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7269999980926514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7167999744415283},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5349000096321106},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5299999713897705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48330000042915344},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4106000065803528},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.3544999957084656},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3327000141143799},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.28060001134872437},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.2676999866962433}],"mesh":[{"descriptor_ui":"D000099233","descriptor_name":"Monocarboxylate Transport Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027501","descriptor_name":"Monocarboxylic Acid Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D027501","descriptor_name":"Monocarboxylic Acid Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jphs.2026.07.001","doi":"https://doi.org/10.1016/j.jphs.2026.07.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jphs.2026.07.001","pdf_url":null,"source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},{"id":"pmid:42481133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42481133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacological sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jphs.2026.07.001","doi":"https://doi.org/10.1016/j.jphs.2026.07.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jphs.2026.07.001","pdf_url":null,"source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1599336280","https://openalex.org/W1879552006","https://openalex.org/W1969636454","https://openalex.org/W1976745237","https://openalex.org/W1986895579","https://openalex.org/W1989240138","https://openalex.org/W1990559406","https://openalex.org/W1995322135","https://openalex.org/W2001725826","https://openalex.org/W2002301998","https://openalex.org/W2011624071","https://openalex.org/W2016927879","https://openalex.org/W2025129891","https://openalex.org/W2031598294","https://openalex.org/W2038811384","https://openalex.org/W2048654101","https://openalex.org/W2051021067","https://openalex.org/W2054275187","https://openalex.org/W2075650547","https://openalex.org/W2099540110","https://openalex.org/W2117217305","https://openalex.org/W2138089625","https://openalex.org/W2142789104","https://openalex.org/W2161767734","https://openalex.org/W2261440635","https://openalex.org/W2276029261","https://openalex.org/W2300528976","https://openalex.org/W2336464512","https://openalex.org/W2404569300","https://openalex.org/W2532463227","https://openalex.org/W2558272519","https://openalex.org/W2559312368","https://openalex.org/W2604209550","https://openalex.org/W2759050422","https://openalex.org/W2789730644","https://openalex.org/W2803309798","https://openalex.org/W2922751687","https://openalex.org/W2937273526","https://openalex.org/W2974315397","https://openalex.org/W2974527101","https://openalex.org/W2982216374","https://openalex.org/W2990139677","https://openalex.org/W3006231990","https://openalex.org/W3093253455","https://openalex.org/W3129219651","https://openalex.org/W3135292359","https://openalex.org/W4280523474","https://openalex.org/W4386874120","https://openalex.org/W4391449946","https://openalex.org/W4393183183","https://openalex.org/W4402667603","https://openalex.org/W4403613624","https://openalex.org/W4404130735","https://openalex.org/W4406087510","https://openalex.org/W4409212124","https://openalex.org/W4413744134","https://openalex.org/W4414253544"],"related_works":[],"abstract_inverted_index":{"Prolonged":[0,42],"glucocorticoid":[1,43,139],"elevation":[2,44,140],"is":[3],"strongly":[4],"associated":[5],"with":[6,30],"brain":[7,47,163],"dysfunction":[8,164],"and":[9,33,39,57,80,100,107,126,131,153,165],"the":[10,26,51,58,62,78,124,166],"pathogenesis":[11,167],"of":[12,28,36,61,94,116,146,168],"stress-related":[13,162],"disorders,":[14],"including":[15],"several":[16],"psychiatric":[17,31,40,169],"disorders.":[18,41,170],"Elevated":[19],"lactate":[20,48,76,98,121,142,148],"levels":[21],"have":[22],"been":[23],"reported":[24],"in":[25,77,87,110,123],"brains":[27],"patients":[29],"disorders":[32],"animal":[34],"models":[35],"chronic":[37,71,138],"stress":[38],"may":[45,159],"disrupt":[46],"homeostasis,":[49],"but":[50],"mechanisms":[52],"through":[53],"which":[54],"this":[55],"occurs":[56],"pathological":[59],"significance":[60],"disruption":[63],"are":[64],"incompletely":[65],"understood.":[66],"Here,":[67],"we":[68],"show":[69],"that":[70,137],"corticosterone":[72],"(CORT)":[73],"treatment":[74],"increases":[75],"hippocampus":[79,125],"reduces":[81],"monocarboxylate":[82],"transporter":[83],"1":[84],"(MCT1)":[85],"expression":[86,119],"hippocampal":[88,97,103,129],"cerebrovascular":[89,117,147],"endothelial":[90],"cells.":[91],"Cerebrovascular-specific":[92],"overexpression":[93],"MCT1":[95,118],"reduced":[96],"accumulation":[99,122,143],"ameliorated":[101],"impaired":[102,128],"neurogenesis,":[104],"depression-like":[105],"behavior,":[106],"cognitive":[108,132],"impairment":[109],"chronically":[111],"CORT-treated":[112],"mice.":[113],"Conversely,":[114],"knockdown":[115],"increased":[120],"caused":[127],"neurogenesis":[130,152],"impairment.":[133],"These":[134],"findings":[135],"suggest":[136],"induces":[141],"via":[144],"dysregulation":[145],"transport,":[149],"thereby":[150],"impairing":[151],"inducing":[154],"behavioral":[155],"abnormalities.":[156],"This":[157],"mechanism":[158],"contribute":[160],"to":[161]},"counts_by_year":[],"updated_date":"2026-07-23T05:56:39.545243","created_date":"2026-07-03T00:00:00"}