{"id":"https://openalex.org/W7166808461","doi":"https://doi.org/10.1158/2159-8290.c.8568789","title":"Data from Pancreatic Cancer: Translating Tumor Biology into Actionability","display_name":"Data from Pancreatic Cancer: Translating Tumor Biology into Actionability","publication_year":2026,"publication_date":"2026-07-01","ids":{"openalex":"https://openalex.org/W7166808461","doi":"https://doi.org/10.1158/2159-8290.c.8568789"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.c.8568789","doi":"https://doi.org/10.1158/2159-8290.c.8568789","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.8568789","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2159-8290.c.8568789","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075614628","display_name":"Fiyinfolu O. Balogun","orcid":"https://orcid.org/0000-0003-4703-1560","observed_orcids":["https://orcid.org/0000-0003-4703-1560"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fiyinfolu O. Balogun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4703-1560","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035829341","display_name":"Mara H. Sherman","orcid":"https://orcid.org/0000-0001-7826-3888","observed_orcids":["https://orcid.org/0000-0001-7826-3888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mara H. Sherman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7826-3888","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033315908","display_name":"Wungki Park","orcid":"https://orcid.org/0000-0002-8006-3102","observed_orcids":["https://orcid.org/0000-0002-8006-3102"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wungki Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8006-3102","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058857144","display_name":"Kevin C. Soares","orcid":"https://orcid.org/0000-0002-0406-017X","observed_orcids":["https://orcid.org/0000-0002-0406-017X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin C. Soares","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0406-017X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052448371","display_name":"Marsha Reyngold","orcid":"https://orcid.org/0000-0001-9475-146X","observed_orcids":["https://orcid.org/0000-0001-9475-146X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marsha Reyngold","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9475-146X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076769480","display_name":"Joshua David Schoenfeld","orcid":"https://orcid.org/0000-0002-3970-9784","observed_orcids":["https://orcid.org/0000-0002-3970-9784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joshua D. Schoenfeld","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3970-9784","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024898449","display_name":"Anupriya Singhal","orcid":"https://orcid.org/0000-0001-8816-0065","observed_orcids":["https://orcid.org/0000-0001-8816-0065"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anupriya Singhal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8816-0065","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043757838","display_name":"Christine A. Iacobuzio\u2013Donahue","orcid":"https://orcid.org/0000-0002-4672-3023","observed_orcids":["https://orcid.org/0000-0002-4672-3023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine A. Iacobuzio-Donahue","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4672-3023","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076438320","display_name":"Eileen Mary O'Reilly","orcid":"https://orcid.org/0000-0002-8076-9199","observed_orcids":["https://orcid.org/0000-0002-8076-9199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eileen M. O\u2019Reilly","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8076-9199","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7509999871253967},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.7400000095367432},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.984000027179718},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.9129999876022339},{"id":"https://openalex.org/keywords/actionable-genomic-alterations","display_name":"actionable genomic alterations","score":0.8360000252723694},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.871999979019165},{"id":"https://openalex.org/keywords/resectable-pancreatic-cancer","display_name":"resectable pancreatic cancer","score":0.7419999837875366},{"id":"https://openalex.org/keywords/downstaging","display_name":"downstaging","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6672000288963318},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.6144999861717224},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.548799991607666},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5113000273704529},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.48579999804496765},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.4422999918460846},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4077000021934509},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.39309999346733093},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.36390000581741333},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3562000095844269},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3425999879837036},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3319999873638153},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.32339999079704285},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3073999881744385},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3043000102043152},{"id":"https://openalex.org/C3020076753","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic carcinoma","level":4,"score":0.29989999532699585},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2797999978065491},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26429998874664307},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.25760000944137573}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2159-8290.c.8568789","doi":"https://doi.org/10.1158/2159-8290.c.8568789","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.8568789","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.c.8568789","doi":"https://doi.org/10.1158/2159-8290.c.8568789","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.8568789","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7166840884","https://openalex.org/W3136137650","https://openalex.org/W3100678095","https://openalex.org/W2964386099","https://openalex.org/W4281556216","https://openalex.org/W3209789866","https://openalex.org/W7160300692","https://openalex.org/W7135650409","https://openalex.org/W4405850601","https://openalex.org/W3168507598"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1],"ductal":[2],"adenocarcinoma":[3],"(PDAC)":[4],"accounts":[5],"for":[6,42,51,136],"90%":[7],"of":[8,45,77,84,115,118],"pancreatic":[9],"cancers":[10],"and":[11,26,95,108,125,133],"has":[12],"a":[13,40,64,87,101],"very":[14],"poor":[15],"prognosis.":[16],"Ten":[17],"to":[18,28,33,73],"15%":[19,29],"are":[20,49,121],"staged":[21],"as":[22],"resectable":[23],"at":[24],"diagnosis,":[25],"5%":[27],"downstaged":[30],"with":[31,53,67,86,104],"therapy":[32],"where":[34],"surgery":[35],"is":[36,39,100],"feasible.":[37],"Chemotherapy":[38],"mainstay":[41],"all":[43],"stages":[44],"PDAC.":[46,78],"Targeted":[47],"therapies":[48,127],"available":[50],"patients":[52],"select":[54],"but":[55],"expanding":[56],"actionable":[57],"genomic":[58],"alterations.":[59],"The":[60],"tumor":[61],"microenvironment":[62],"provides":[63],"dense":[65],"stroma":[66],"an":[68],"immunosuppressive":[69],"milieu":[70],"that":[71,128],"contributes":[72],"inherent":[74],"treatment":[75,91,131],"resistance":[76],"Herein,":[79],"we":[80],"review":[81],"current":[82],"management":[83],"PDAC":[85,99],"focus":[88],"on":[89],"emerging":[90],"paradigms,":[92],"including":[93],"targeted":[94,124],"immunomodulatory":[96,126],"agents.":[97],"Significance:":[98],"complex":[102],"disease":[103,120],"unique":[105],"genomic,":[106],"immunologic,":[107],"clinical":[109],"features.":[110],"Recent":[111],"developments":[112],"in":[113],"understanding":[114],"the":[116],"pathobiology":[117],"this":[119,137],"translating":[122],"into":[123],"will":[129],"alter":[130],"paradigms":[132],"improve":[134],"outcomes":[135],"recalcitrant":[138],"malignancy.":[139]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-07-02T00:00:00"}
