{"id":"https://openalex.org/W7166700624","doi":"https://doi.org/10.21873/invivo.14350","title":"Synergy of a Low-methionine Diet and Reduced-dose Cisplatinum Eradicates Experimental Lung-cancer Bone Metastases in a Nude-mouse Model","display_name":"Synergy of a Low-methionine Diet and Reduced-dose Cisplatinum Eradicates Experimental Lung-cancer Bone Metastases in a Nude-mouse Model","publication_year":2026,"publication_date":"2026-06-30","ids":{"openalex":"https://openalex.org/W7166700624","doi":"https://doi.org/10.21873/invivo.14350","pmid":"https://pubmed.ncbi.nlm.nih.gov/42379791"},"language":"en","primary_location":{"id":"doi:10.21873/invivo.14350","doi":"https://doi.org/10.21873/invivo.14350","is_oa":true,"landing_page_url":"https://doi.org/10.21873/invivo.14350","pdf_url":null,"source":{"id":"https://openalex.org/S115443242","display_name":"In Vivo","issn_l":"0258-851X","issn":["0258-851X","1791-7549"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322764940","host_organization_name":"Stanford University Highwire Press","host_organization_lineage":["https://openalex.org/P4322764940"],"host_organization_lineage_names":["Stanford University Highwire Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21873/invivo.14350","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025471735","display_name":"Yohei Asano","orcid":"https://orcid.org/0000-0002-8777-6076","observed_orcids":["https://orcid.org/0000-0002-8777-6076"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"YOHEI ASANO","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A","Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan","Department of Surgery, University of California, San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063794477","display_name":"KOHEI MIZUTA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KOHEI MIZUTA","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A","Department of Surgery, University of California, San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115725542","display_name":"YUTA MIYASHI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YUTA MIYASHI","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A","Department of Surgery, University of California, San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109489759","display_name":"Qinghong Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"QINGHONG HAN","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127201844","display_name":"SHUKUAN LI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SHUKUAN LI","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135066597","display_name":"BYUNG MO KANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BYUNG MO KANG","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A","Department of Surgery, University of California, San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121532644","display_name":"JIN SOO KIM","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JIN SOO KIM","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A","Department of Surgery, University of California, San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032191719","display_name":"Norio Yamamoto","orcid":"https://orcid.org/0000-0002-7250-625X","observed_orcids":["https://orcid.org/0000-0002-7250-625X"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NORIO YAMAMOTO","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132965798","display_name":"KATSUHIRO HAYASHI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KATSUHIRO HAYASHI","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072265818","display_name":"HIROAKI KIMURA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROAKI KIMURA","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127077184","display_name":"SHINJI MIWA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHINJI MIWA","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081080411","display_name":"Kentaro Igarashi","orcid":"https://orcid.org/0000-0003-2278-1736","observed_orcids":["https://orcid.org/0000-0003-2278-1736"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KENTARO IGARASHI","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113235396","display_name":"TAKASHI HIGUCHI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKASHI HIGUCHI","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089158442","display_name":"Sei Morinaga","orcid":"https://orcid.org/0000-0003-2961-9432","observed_orcids":["https://orcid.org/0000-0003-2961-9432"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SEI MORINAGA","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056910143","display_name":"HIROYUKI TSUCHIYA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROYUKI TSUCHIYA","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132938931","display_name":"SATORU DEMURA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SATORU DEMURA","raw_affiliation_strings":["Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERT M. HOFFMAN","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A.; all@anticancer.com","Department of Surgery, University of California, San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A.; all@anticancer.com","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.48244409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"4","first_page":"1979","last_page":"1986"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.37279999256134033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.37279999256134033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.17090000212192535,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer-bone-metastasis","display_name":"lung cancer bone metastasis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/methionine-restriction","display_name":"methionine restriction","score":0.972000002861023},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7139999866485596},{"id":"https://openalex.org/keywords/chemotherapy-dose-reduction","display_name":"chemotherapy dose reduction","score":0.8989999890327454},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8100000023841858},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7419999837875366},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7350000143051147},{"id":"https://openalex.org/keywords/metabolic-targeting","display_name":"metabolic targeting","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8075000047683716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5271000266075134},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4142000079154968},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.4124999940395355},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3418999910354614},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3334999978542328},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2727000117301941},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2644999921321869},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.25369998812675476}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.21873/invivo.14350","doi":"https://doi.org/10.21873/invivo.14350","is_oa":true,"landing_page_url":"https://doi.org/10.21873/invivo.14350","pdf_url":null,"source":{"id":"https://openalex.org/S115443242","display_name":"In Vivo","issn_l":"0258-851X","issn":["0258-851X","1791-7549"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322764940","host_organization_name":"Stanford University Highwire Press","host_organization_lineage":["https://openalex.org/P4322764940"],"host_organization_lineage_names":["Stanford University Highwire Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"journal-article"},{"id":"pmid:42379791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42379791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21873/invivo.14350","doi":"https://doi.org/10.21873/invivo.14350","is_oa":true,"landing_page_url":"https://doi.org/10.21873/invivo.14350","pdf_url":null,"source":{"id":"https://openalex.org/S115443242","display_name":"In Vivo","issn_l":"0258-851X","issn":["0258-851X","1791-7549"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322764940","host_organization_name":"Stanford University Highwire Press","host_organization_lineage":["https://openalex.org/P4322764940"],"host_organization_lineage_names":["Stanford University Highwire Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4264881908893585,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W1940550010","https://openalex.org/W2130422617"],"related_works":[],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"Bone":[1],"metastasis":[2,55],"of":[3,20,42,53,56,87,108,139,152,164,170,201,214,223,243],"lung":[4,57,258],"cancer":[5],"is":[6,12,16,28,246],"highly":[7],"recalcitrant,":[8],"and":[9,27,115,119,126,142,172,204],"current":[10],"treatment":[11,134,154,166],"palliative.":[13],"Methionine":[14],"addiction":[15,245],"a":[17,231,247],"fundamental":[18],"hallmark":[19],"cancer,":[21],"known":[22],"as":[23],"the":[24,40,71,85,132,147,162,165,189,199,215,221],"Hoffman":[25],"effect,":[26],"targeted":[29],"by":[30,80,161],"methionine":[31,244],"restriction":[32],"(MR).":[33],"The":[34,62,90,137,168,236],"present":[35,72,237],"study":[36],"aimed":[37],"to":[38,96,179,212],"evaluate":[39],"efficacy":[41,151,177,222],"MR":[43,117,121,144,171,206,219],"combined":[44],"with":[45,156,192,198],"low-dose":[46,109,140,173,202,224],"cisplatinum":[47,102,110,141,174,203],"on":[48],"an":[49,116,120,143,205],"experimental":[50,75,233],"nude-mouse":[51],"model":[52,77],"bone":[54],"cancer.":[58,259],"MATERIALS":[59],"AND":[60],"METHODS:":[61],"A549":[63,82],"human":[64],"lung-adenocarcinoma":[65],"cell":[66],"line":[67],"was":[68,78,185],"used":[69],"in":[70,188,230,256],"study.":[73],"An":[74],"bone-metastasis":[76,234],"established":[79],"implanting":[81],"cells":[83],"into":[84],"tibia":[86],"nude":[88],"mice.":[89],"mice":[91,190,196],"were":[92,129],"then":[93],"randomly":[94],"assigned":[95],"four":[97],"groups:":[98],"untreated":[99],"control;":[100],"standard-dose":[101,180,193],"(6":[103],"mg/kg,":[104,112],"intraperitoneally,":[105,113],"weekly);":[106],"combination":[107,138,169,200],"(3":[111],"weekly)":[114],"diet;":[118],"diet":[122,145,207],"only.":[123],"Tumor":[124],"growth":[125],"body":[127,209],"weight":[128,183,210],"monitored":[130],"during":[131],"3-week":[133],"period.":[135,167],"RESULTS:":[136],"had":[146],"most":[148],"tumor":[149],"inhibition":[150],"all":[153],"groups,":[155],"tumors":[157],"essentially":[158],"being":[159],"eradicated":[160],"end":[163],"showed":[175],"superior":[176],"compared":[178],"cisplatinum.":[181],"Furthermore,":[182],"loss":[184],"observed":[186],"only":[187],"treated":[191,197],"cisplatinum,":[194,225],"whereas":[195],"maintained":[208],"comparable":[211],"that":[213,240],"MR-alone":[216],"group.":[217],"CONCLUSION:":[218],"enhanced":[220],"while":[226],"mitigating":[227],"treatment-associated":[228],"toxicity":[229],"lung-cancer":[232],"model.":[235],"findings":[238],"suggest":[239],"metabolic":[241],"targeting":[242],"promising":[248],"therapeutic":[249],"strategy":[250],"enabling":[251],"effective":[252],"chemotherapy":[253],"dose":[254],"reduction":[255],"bone-metastatic":[257]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-07-01T00:00:00"}