{"id":"https://openalex.org/W7166669736","doi":"https://doi.org/10.31989/bchd.v9i6.2018","title":"Food bioactives as modulators of autophagy and mitophagy ininflammaging and healthy aging","display_name":"Food bioactives as modulators of autophagy and mitophagy ininflammaging and healthy aging","publication_year":2026,"publication_date":"2026-06-30","ids":{"openalex":"https://openalex.org/W7166669736","doi":"https://doi.org/10.31989/bchd.v9i6.2018"},"language":"en","primary_location":{"id":"doi:10.31989/bchd.v9i6.2018","doi":"https://doi.org/10.31989/bchd.v9i6.2018","is_oa":true,"landing_page_url":"https://doi.org/10.31989/bchd.v9i6.2018","pdf_url":"https://www.ffhdj.com/index.php/BioactiveCompounds/article/download/2018/5252","source":{"id":"https://openalex.org/S4210176959","display_name":"Bioactive Compounds in Health and Disease","issn_l":"2574-0334","issn":["2574-0334","2769-2426"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ffhdj.com/index.php/BioactiveCompounds/article/download/2018/5252","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113814720","display_name":"Danik M. Martirosyan","orcid":"https://orcid.org/0000-0001-9869-4191","observed_orcids":["https://orcid.org/0000-0001-9869-4191"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danik Martirosyan","raw_affiliation_strings":["Functional Food Institute , San Diego , CA -92116 , USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Food Institute , San Diego , CA -92116 , USA;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5128899809","display_name":"Isabella Baghdasaryan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160986391","display_name":"Los Angeles Valley College","ror":"https://ror.org/022dft797","country_code":"US","type":"education","lineage":["https://openalex.org/I160986391"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isabella Baghdasaryan","raw_affiliation_strings":["Functional Food Institute , San Diego , CA -92116 , USA;","Los Angeles Valley College , Los Angeles , CA , USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Food Institute , San Diego , CA -92116 , USA;","institution_ids":[]},{"raw_affiliation_string":"Los Angeles Valley College , Los Angeles , CA , USA,","institution_ids":["https://openalex.org/I160986391"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45978187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"6","first_page":"294","last_page":"313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":1.0},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.996999979019165},{"id":"https://openalex.org/keywords/healthy-aging","display_name":"healthy aging","score":0.996999979019165},{"id":"https://openalex.org/keywords/dietary-bioactive-compounds","display_name":"dietary bioactive compounds","score":0.7950000166893005},{"id":"https://openalex.org/keywords/mitochondrial-quality-control","display_name":"mitochondrial quality control","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ampk-signaling","display_name":"AMPK signaling","score":0.7319999933242798},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9850000143051147},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pink1-parkin-pathway","display_name":"PINK1/Parkin pathway","score":0.9919999837875366},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.968999981880188},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/spermidine","display_name":"spermidine","score":0.9739999771118164},{"id":"https://openalex.org/keywords/urolithin-a","display_name":"urolithin A","score":0.9980000257492065},{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":0.8859999775886536},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":1.0},{"id":"https://openalex.org/keywords/sulforaphane","display_name":"sulforaphane","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gut-microbiota-metabolites","display_name":"gut microbiota metabolites","score":0.8619999885559082},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8220999836921692},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.7892000079154968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.541700005531311},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.41679999232292175},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.41200000047683716},{"id":"https://openalex.org/C2776804853","wikidata":"https://www.wikidata.org/wiki/Q18045837","display_name":"PINK1","level":5,"score":0.4083000123500824},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39590001106262207},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.38659998774528503},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.38589999079704285},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.3727000057697296},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.3677000105381012},{"id":"https://openalex.org/C2777668072","wikidata":"https://www.wikidata.org/wiki/Q2472777","display_name":"Parkin","level":4,"score":0.3402999937534332},{"id":"https://openalex.org/C2777949483","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"Mechanistic target of rapamycin","level":4,"score":0.33649998903274536},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.33559998869895935},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31779998540878296},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3111000061035156},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.302700012922287},{"id":"https://openalex.org/C2780096491","wikidata":"https://www.wikidata.org/wiki/Q60574533","display_name":"Cellular stress response","level":4,"score":0.2815000116825104},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2806999981403351},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.2791999876499176},{"id":"https://openalex.org/C2776536020","wikidata":"https://www.wikidata.org/wiki/Q21113719","display_name":"Sirtuin 1","level":4,"score":0.2777000069618225},{"id":"https://openalex.org/C2778738651","wikidata":"https://www.wikidata.org/wiki/Q16546687","display_name":"Novelty","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C2779638656","wikidata":"https://www.wikidata.org/wiki/Q6043166","display_name":"Integrated stress response","level":5,"score":0.26910001039505005}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.31989/bchd.v9i6.2018","doi":"https://doi.org/10.31989/bchd.v9i6.2018","is_oa":true,"landing_page_url":"https://doi.org/10.31989/bchd.v9i6.2018","pdf_url":"https://www.ffhdj.com/index.php/BioactiveCompounds/article/download/2018/5252","source":{"id":"https://openalex.org/S4210176959","display_name":"Bioactive Compounds in Health and Disease","issn_l":"2574-0334","issn":["2574-0334","2769-2426"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.31989/bchd.v9i6.2018","doi":"https://doi.org/10.31989/bchd.v9i6.2018","is_oa":true,"landing_page_url":"https://doi.org/10.31989/bchd.v9i6.2018","pdf_url":"https://www.ffhdj.com/index.php/BioactiveCompounds/article/download/2018/5252","source":{"id":"https://openalex.org/S4210176959","display_name":"Bioactive Compounds in Health and Disease","issn_l":"2574-0334","issn":["2574-0334","2769-2426"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7166669736.pdf","grobid_xml":"https://content.openalex.org/works/W7166669736.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7134115714","https://openalex.org/W7106700237","https://openalex.org/W7155707913","https://openalex.org/W4414478622","https://openalex.org/W4414188655","https://openalex.org/W2098565530","https://openalex.org/W4415836627","https://openalex.org/W7172294953","https://openalex.org/W7095645784","https://openalex.org/W1976391651"],"abstract_inverted_index":{"Aging":[0],"is":[1,131],"associated":[2,174],"with":[3,36,175,193,236],"progressive":[4],"cellular":[5,24,167,231],"dysfunction,":[6],"mitochondrial":[7,196],"damage,":[8],"impaired":[9],"proteostasis,":[10],"and":[11,21,33,38,77,91,108,120,126,139,170,199,223,225,251,259],"chronic":[12],"low-grade":[13],"inflammation,":[14],"commonly":[15],"referred":[16],"to":[17,40,115,133,148,229],"as":[18,205,265],"inflammaging.":[19,200],"Autophagy":[20],"mitophagy,":[22,121,195],"the":[23,78,180,244,260,269],"quality":[25,168,197],"control":[26,169],"mechanisms":[27,173],"responsible":[28],"for":[29,165,280],"degrading":[30],"dysfunctional":[31],"proteins":[32],"mitochondria,":[34],"decline":[35,235],"age":[37],"contribute":[39],"age-related":[41],"pathologiesFood-derived":[42],"bioactive":[43,191],"compounds":[44,192,242],"modulate":[45],"these":[46],"processes":[47],"through":[48],"key":[49],"signaling":[50],"pathways,":[51],"including":[52,118],"AMP-activated":[53],"protein":[54],"kinase":[55,80],"(AMPK),":[56],"mechanistic":[57,125,146,187],"target":[58],"of":[59,179,246,262],"rapamycin":[60],"(mTOR),":[61],"sirtuin":[62],"1":[63,81],"(SIRT1),":[64],"nuclear":[65,72],"factor":[66,69,73],"erythroid":[67],"2-related":[68],"2":[70],"(Nrf2),":[71],"kappa":[74],"B":[75],"(NF-\u03baB),":[76],"PTEN-induced":[79],"(PINK1)/Parkin":[82],"pathway.":[83],"This":[84,182],"mini":[85],"review":[86,183,239],"synthesizes":[87],"current":[88],"mechanistic,":[89,249],"preclinical,":[90,250],"clinical":[92,252],"evidence":[93,247],"on":[94,124,215],"how":[95],"specific":[96,216],"bioactives\u2014resveratrol,":[97],"curcumin,":[98],"quercetin,":[99],"spermidine,":[100],"urolithin":[101,300],"A,":[102],"carotenoids,":[103],"omega-3":[104],"fatty":[105],"acids,":[106],"sulforaphane,":[107],"microbiota-derived":[109,257],"metabolites\u2014":[110],"may":[111],"influence":[112,230],"pathways":[113,233],"relevant":[114],"healthy":[116,281,288],"aging,":[117],"autophagy":[119],"based":[122],"primarily":[123],"preclinical":[127],"evidence.":[128],"Particular":[129],"attention":[130],"given":[132],"bioavailability,":[134],"microbiome-dependent":[135],"metabolism,":[136],"biomarker":[137],"limitations,":[138],"functional":[140,263,302],"food":[141,290,303],"development,":[142],"where":[143],"translation":[144,261],"from":[145],"findings":[147],"clinically":[149,162],"validated":[150],"applications":[151],"remains":[152],"incomplete.":[153],"Overall,":[154],"dietary":[155,274],"bioactives":[156,204,275],"represent":[157],"a":[158],"scientifically":[159],"grounded":[160],"but":[161],"developing":[163],"approach":[164],"supporting":[166],"reducing":[171],"inflammatory":[172],"biological":[176],"aging.":[177],"Novelty":[178],"study:":[181],"provides":[184],"an":[185],"integrated":[186],"framework":[188],"linking":[189],"food-derived":[190],"autophagy,":[194],"control,":[198],"Rather":[201],"than":[202],"presenting":[203],"general":[206],"antioxidants":[207],"or":[208],"anti-inflammatory":[209],"agents,":[210],"it":[211],"emphasizes":[212],"their":[213,226],"effects":[214],"regulatory":[217],"pathways\u2014AMPK,":[218],"mTOR,":[219],"SIRT1,":[220],"Nrf2,":[221],"NF-\u03baB,":[222],"PINK1/Parkin\u2014":[224],"reported":[227],"capacity":[228],"quality-control":[232],"that":[234,268],"age.":[237],"The":[238],"further":[240],"distinguishes":[241],"by":[243],"strength":[245],"across":[248],"levels.":[253],"It":[254],"also":[255],"highlights":[256],"metabolites":[258],"foods":[264],"priority":[266],"areas":[267],"field":[270],"must":[271],"advance":[272],"before":[273],"can":[276],"be":[277],"responsibly":[278],"recommended":[279],"aging":[282],"applications.":[283],"Keywords:":[284],"autophagy;":[285],"mitophagy;":[286],"inflammaging;":[287],"aging;":[289],"bioactives;":[291],"AMPK;":[292],"mTOR;":[293],"SIRT1;":[294],"Nrf2;":[295],"PINK1/Parkin;":[296],"resveratrol;":[297],"curcumin;":[298],"spermidine;":[299],"A;":[301]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-07-01T00:00:00"}
