{"id":"https://openalex.org/W7166646331","doi":"https://doi.org/10.1177/08828245261464827","title":"Reovirus Reassortants Reveal Context-Dependent Oncolytic Phenotypes Across Epithelial Cancer Cell Lines","display_name":"Reovirus Reassortants Reveal Context-Dependent Oncolytic Phenotypes Across Epithelial Cancer Cell Lines","publication_year":2026,"publication_date":"2026-06-30","ids":{"openalex":"https://openalex.org/W7166646331","doi":"https://doi.org/10.1177/08828245261464827","pmid":"https://pubmed.ncbi.nlm.nih.gov/42376862"},"language":"en","primary_location":{"id":"doi:10.1177/08828245261464827","doi":"https://doi.org/10.1177/08828245261464827","is_oa":false,"landing_page_url":"https://doi.org/10.1177/08828245261464827","pdf_url":null,"source":{"id":"https://openalex.org/S203476268","display_name":"Viral Immunology","issn_l":"0882-8245","issn":["0882-8245","1557-8976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5135784411","display_name":"J. Ryder Hutchinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170164250","display_name":"Elon University","ror":"https://ror.org/01szgyb91","country_code":"US","type":"education","lineage":["https://openalex.org/I170164250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Ryder Hutchinson","raw_affiliation_strings":["Department of Biology, Elon University, Elon, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Elon University, Elon, North Carolina, USA","institution_ids":["https://openalex.org/I170164250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139677515","display_name":"Owen M. Carter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170164250","display_name":"Elon University","ror":"https://ror.org/01szgyb91","country_code":"US","type":"education","lineage":["https://openalex.org/I170164250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Owen M. Carter","raw_affiliation_strings":["Department of Biology, Elon University, Elon, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Elon University, Elon, North Carolina, USA","institution_ids":["https://openalex.org/I170164250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120416840","display_name":"Charlotte V. Dagli","orcid":"https://orcid.org/0009-0005-1338-4626","observed_orcids":["https://orcid.org/0009-0005-1338-4626"]},"institutions":[{"id":"https://openalex.org/I170164250","display_name":"Elon University","ror":"https://ror.org/01szgyb91","country_code":"US","type":"education","lineage":["https://openalex.org/I170164250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlotte V. Dagli","raw_affiliation_strings":["Department of Biology, Elon University, Elon, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Elon University, Elon, North Carolina, USA","institution_ids":["https://openalex.org/I170164250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038483704","display_name":"Efra\u00edn E. Rivera-Serrano","orcid":"https://orcid.org/0000-0002-1039-7182","observed_orcids":["https://orcid.org/0000-0002-1039-7182"]},"institutions":[{"id":"https://openalex.org/I170164250","display_name":"Elon University","ror":"https://ror.org/01szgyb91","country_code":"US","type":"education","lineage":["https://openalex.org/I170164250"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Efra\u00edn E. Rivera-Serrano","raw_affiliation_strings":["Department of Biology, Elon University, Elon, North Carolina, USA"],"raw_orcid":"https://orcid.org/0000-0002-1039-7182","affiliations":[{"raw_affiliation_string":"Department of Biology, Elon University, Elon, North Carolina, USA","institution_ids":["https://openalex.org/I170164250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038483704"],"corresponding_institution_ids":["https://openalex.org/I170164250"],"apc_list":null,"apc_paid":null,"fwci":3.9713,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.94105406,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"39","issue":"7","first_page":"281","last_page":"287"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reovirus","display_name":"reovirus","score":0.8299999833106995},{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.9190000295639038},{"id":"https://openalex.org/keywords/reassortment","display_name":"reassortment","score":0.7540000081062317},{"id":"https://openalex.org/keywords/epithelial-tumors","display_name":"epithelial tumors","score":0.6679999828338623},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9359999895095825},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/virus-infectivity","display_name":"viral infectivity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/interferon-antagonism","display_name":"interferon antagonism","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.9391000270843506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8271999955177307},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6905999779701233},{"id":"https://openalex.org/C16154277","wikidata":"https://www.wikidata.org/wiki/Q2004399","display_name":"Reassortment","level":5,"score":0.650600016117096},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5985000133514404},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.5864999890327454},{"id":"https://openalex.org/C49744831","wikidata":"https://www.wikidata.org/wiki/Q600121","display_name":"Virotherapy","level":4,"score":0.5322999954223633},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4876999855041504},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.482699990272522},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4431999921798706},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4275999963283539},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39250001311302185},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.38260000944137573},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.367000013589859},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.36480000615119934},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.36079999804496765},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.3149000108242035},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.3018999993801117},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.29350000619888306},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.29170000553131104},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.28130000829696655},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2793000042438507},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2741999924182892},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2651999890804291},{"id":"https://openalex.org/C2779416561","wikidata":"https://www.wikidata.org/wiki/Q910576","display_name":"Reoviridae","level":4,"score":0.25119999051094055}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012087","descriptor_name":"Reoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012087","descriptor_name":"Reoviridae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016865","descriptor_name":"Reassortant Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016865","descriptor_name":"Reassortant Viruses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D030102","descriptor_name":"Orthoreovirus, Mammalian","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050130","descriptor_name":"Oncolytic Virotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050504","descriptor_name":"Oncolytic Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050504","descriptor_name":"Oncolytic Viruses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/08828245261464827","doi":"https://doi.org/10.1177/08828245261464827","is_oa":false,"landing_page_url":"https://doi.org/10.1177/08828245261464827","pdf_url":null,"source":{"id":"https://openalex.org/S203476268","display_name":"Viral Immunology","issn_l":"0882-8245","issn":["0882-8245","1557-8976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral Immunology","raw_type":"journal-article"},{"id":"pmid:42376862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42376862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7411612868309021}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309359","display_name":"Elon University","ror":"https://ror.org/01szgyb91"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1554417450","https://openalex.org/W1748462623","https://openalex.org/W1790034466","https://openalex.org/W1970731745","https://openalex.org/W1997019840","https://openalex.org/W2010490561","https://openalex.org/W2025697283","https://openalex.org/W2030523225","https://openalex.org/W2039185758","https://openalex.org/W2058427686","https://openalex.org/W2061727508","https://openalex.org/W2069087293","https://openalex.org/W2085450356","https://openalex.org/W2100702689","https://openalex.org/W2110811665","https://openalex.org/W2110839491","https://openalex.org/W2121865606","https://openalex.org/W2131710727","https://openalex.org/W2142894866","https://openalex.org/W2153214938","https://openalex.org/W2167279371","https://openalex.org/W2577695527","https://openalex.org/W2972770174","https://openalex.org/W3022327832","https://openalex.org/W3036107615","https://openalex.org/W3097960135","https://openalex.org/W3134501918","https://openalex.org/W3177833175","https://openalex.org/W4281701771","https://openalex.org/W4364381941","https://openalex.org/W4390793475","https://openalex.org/W4403668002","https://openalex.org/W4407351247","https://openalex.org/W4409499128"],"related_works":[],"abstract_inverted_index":{"Mammalian":[0],"reoviruses":[1,32,67,159],"are":[2],"promising":[3],"oncolytic":[4,149,185],"agents,":[5],"but":[6],"most":[7,127],"preclinical":[8],"and":[9,51,65,76,84,101,113,122,135,169,181],"clinical":[10],"work":[11],"has":[12],"focused":[13],"on":[14],"the":[15,23,77,90,110,126,132],"type":[16],"3":[17],"Dearing":[18],"(T3D)":[19],"prototype,":[20],"potentially":[21],"underestimating":[22],"therapeutic":[24],"relevance":[25],"of":[26,46,58],"broader":[27],"reovirus":[28],"genetic":[29],"diversity.":[30],"Because":[31],"possess":[33],"a":[34,56],"segmented":[35],"double-stranded":[36],"RNA":[37],"genome,":[38],"reassortment":[39,156],"can":[40,157],"generate":[41,158],"progeny":[42],"with":[43,160],"novel":[44],"combinations":[45],"traits":[47],"influencing":[48],"infectivity,":[49],"replication,":[50],"cytotoxicity.":[52],"Here,":[53],"we":[54],"evaluated":[55],"panel":[57],"previously":[59],"generated":[60],"T1L":[61,112],"\u00d7":[62],"T3D":[63,114],"reassortants":[64,104],"recombinant":[66],"across":[68,131,165],"three":[69,88],"epithelial":[70,166],"tumor":[71,167],"models:":[72],"A549":[73],"lung":[74],"adenocarcinoma":[75],"oral":[78],"squamous":[79],"carcinoma":[80],"cell":[81,95,120,182],"lines":[82],"OECM-1":[83],"CAL-27.":[85],"Across":[86],"all":[87],"models,":[89],"tested":[91],"viruses":[92],"displayed":[93],"marked":[94],"line-dependent":[96],"heterogeneity":[97],"in":[98,116,177],"both":[99],"cytotoxicity":[100,136],"infectivity.":[102],"Several":[103],"reduced":[105],"viability":[106],"more":[107,119],"effectively":[108],"than":[109],"parental":[111],"strains":[115],"one":[117],"or":[118,162],"lines,":[121],"DB62":[123],"emerged":[124],"as":[125],"broadly":[128],"active":[129],"candidate":[130],"panel.":[133],"Infectivity":[134],"overlapped":[137],"only":[138],"partially,":[139],"indicating":[140],"that":[141,155],"efficient":[142],"infection":[143],"alone":[144],"does":[145],"not":[146],"fully":[147],"predict":[148],"potency.":[150,186],"Together,":[151],"these":[152],"findings":[153],"show":[154],"enhanced":[161],"selective":[163],"activity":[164],"contexts":[168],"support":[170],"future":[171],"studies":[172],"examining":[173],"how":[174],"segment-dependent":[175],"differences":[176],"interferon":[178],"antagonism,":[179],"entry,":[180],"death":[183],"shape":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-07-01T00:00:00"}