{"id":"https://openalex.org/W7166564524","doi":"https://doi.org/10.2147/imcrj.s567374","title":"Malignant Transformation and Management of Cutaneous Squamous Cell Carcinoma in a 7-Year-Old Child with Xeroderma Pigmentosum: A Case Report from Somaliland","display_name":"Malignant Transformation and Management of Cutaneous Squamous Cell Carcinoma in a 7-Year-Old Child with Xeroderma Pigmentosum: A Case Report from Somaliland","publication_year":2026,"publication_date":"2026-06-01","ids":{"openalex":"https://openalex.org/W7166564524","doi":"https://doi.org/10.2147/imcrj.s567374","pmid":"https://pubmed.ncbi.nlm.nih.gov/42405187","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13332724"},"language":"en","primary_location":{"id":"doi:10.2147/imcrj.s567374","doi":"https://doi.org/10.2147/imcrj.s567374","is_oa":true,"landing_page_url":"https://doi.org/10.2147/imcrj.s567374","pdf_url":"https://www.dovepress.com/article/download/116848","source":{"id":"https://openalex.org/S2738884135","display_name":"International Medical Case Reports Journal","issn_l":"1179-142X","issn":["1179-142X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Medical Case Reports Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/116848","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5130933030","display_name":"Mohamed Aw Hashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I246527472","display_name":"University of Hargeisa","ror":"https://ror.org/023tegq12","country_code":"SO","type":"education","lineage":["https://openalex.org/I246527472"]}],"countries":["SO"],"is_corresponding":false,"raw_author_name":"Mohamed Osman Aw Hashi","raw_affiliation_strings":["Department of Dermatology and Venereology, Hargeisa Group Hospital, Hargeisa, Somaliland","Department of Medicine and Surgery, College of Medicine and Surgery, University of Hargeisa, Hargeisa, Somaliland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, Hargeisa Group Hospital, Hargeisa, Somaliland","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine and Surgery, College of Medicine and Surgery, University of Hargeisa, Hargeisa, Somaliland","institution_ids":["https://openalex.org/I246527472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139035445","display_name":"Sadam Ismail Ahmed","orcid":"https://orcid.org/0009-0005-6992-6682","observed_orcids":["https://orcid.org/0009-0005-6992-6682"]},"institutions":[{"id":"https://openalex.org/I4210087577","display_name":"Burao University","ror":"https://ror.org/005e2k071","country_code":"SO","type":"education","lineage":["https://openalex.org/I4210087577"]}],"countries":["SO"],"is_corresponding":true,"raw_author_name":"Sadam Ismail Ahmed","raw_affiliation_strings":["College of Medicine and Health Science, Department of Anesthesia, Burao Central University College, Burao, Somaliland"],"raw_orcid":"https://orcid.org/0009-0005-6992-6682","affiliations":[{"raw_affiliation_string":"College of Medicine and Health Science, Department of Anesthesia, Burao Central University College, Burao, Somaliland","institution_ids":["https://openalex.org/I4210087577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083711935","display_name":"Mohamed Ahmed Abdi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed Ahmed Abdi","raw_affiliation_strings":["Department of Pediatric Surgery, Hargeisa Group Hospital, Hargeisa, Somaliland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Hargeisa Group Hospital, Hargeisa, Somaliland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134445431","display_name":"Radia Abdirahman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Radia Mohamed Abdirahman","raw_affiliation_strings":["Department of Emergency, Hargeisa Group Hospital, Hargeisa, Somaliland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, Hargeisa Group Hospital, Hargeisa, Somaliland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086652501","display_name":"Riham Abdullahi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Riham Rashid Abdullahi","raw_affiliation_strings":["Department of Emergency, Hargeisa Group Hospital, Hargeisa, Somaliland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, Hargeisa Group Hospital, Hargeisa, Somaliland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5139035445"],"corresponding_institution_ids":["https://openalex.org/I4210087577"],"apc_list":{"value":2320,"currency":"USD","value_usd":2320},"apc_paid":{"value":2320,"currency":"USD","value_usd":2320},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 19","issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11868","display_name":"Cancer and Skin Lesions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xeroderma-pigmentosum","display_name":"xeroderma pigmentosum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cutaneous-squamous-cell-carcinoma","display_name":"cutaneous squamous cell carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/pediatric-skin-cancer","display_name":"pediatric skin cancer","score":0.7250000238418579},{"id":"https://openalex.org/keywords/wide-local-excision","display_name":"wide local excision","score":0.7910000085830688},{"id":"https://openalex.org/keywords/surgical-margins","display_name":"surgical margins","score":0.8970000147819519},{"id":"https://openalex.org/keywords/flap-reconstruction","display_name":"flap reconstruction","score":0.7120000123977661},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.578000009059906},{"id":"https://openalex.org/keywords/photosensitivity","display_name":"photosensitivity","score":0.6549999713897705},{"id":"https://openalex.org/keywords/genodermatoses","display_name":"genodermatosis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/resource-limited-settings","display_name":"resource-limited settings","score":0.8009999990463257},{"id":"https://openalex.org/keywords/somaliland","display_name":"Somaliland","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.919700026512146},{"id":"https://openalex.org/C2778378917","wikidata":"https://www.wikidata.org/wiki/Q612693","display_name":"Xeroderma pigmentosum","level":4,"score":0.8281999826431274},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.6248000264167786},{"id":"https://openalex.org/C2778156654","wikidata":"https://www.wikidata.org/wiki/Q666075","display_name":"Genodermatosis","level":3,"score":0.5996000170707703},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.4788999855518341},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.475600004196167},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.438400000333786},{"id":"https://openalex.org/C2778163040","wikidata":"https://www.wikidata.org/wiki/Q1307866","display_name":"Poikiloderma","level":2,"score":0.4287000000476837},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4115000069141388},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.3952000141143799},{"id":"https://openalex.org/C2778804307","wikidata":"https://www.wikidata.org/wiki/Q809758","display_name":"Basal cell carcinoma","level":3,"score":0.3952000141143799},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.350600004196167},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32179999351501465},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.27480000257492065},{"id":"https://openalex.org/C2778303017","wikidata":"https://www.wikidata.org/wiki/Q7998643","display_name":"Wide local excision","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C3020284061","wikidata":"https://www.wikidata.org/wiki/Q5194613","display_name":"Curative treatment","level":3,"score":0.26579999923706055},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.2596000134944916}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/imcrj.s567374","doi":"https://doi.org/10.2147/imcrj.s567374","is_oa":true,"landing_page_url":"https://doi.org/10.2147/imcrj.s567374","pdf_url":"https://www.dovepress.com/article/download/116848","source":{"id":"https://openalex.org/S2738884135","display_name":"International Medical Case Reports Journal","issn_l":"1179-142X","issn":["1179-142X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Medical Case Reports Journal","raw_type":"journal-article"},{"id":"pmid:42405187","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42405187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International medical case reports journal","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:13332724","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13332724/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int Med Case Rep J","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a400689eeff54171ae591803c218d4e8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a400689eeff54171ae591803c218d4e8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"International Medical Case Reports Journal, Vol Volume 19, Iss Issue 1, Pp 1-7 (2026)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/116848","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/malignant-transformation-and-management-of-cutaneous-squamous-cell-car-peer-reviewed-fulltext-article-IMCRJ","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/imcrj.s567374","doi":"https://doi.org/10.2147/imcrj.s567374","is_oa":true,"landing_page_url":"https://doi.org/10.2147/imcrj.s567374","pdf_url":"https://www.dovepress.com/article/download/116848","source":{"id":"https://openalex.org/S2738884135","display_name":"International Medical Case Reports Journal","issn_l":"1179-142X","issn":["1179-142X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Medical Case Reports Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7166564524.pdf","grobid_xml":"https://content.openalex.org/works/W7166564524.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1584564555","https://openalex.org/W2051521434","https://openalex.org/W2073237146","https://openalex.org/W2078518665","https://openalex.org/W2082139407","https://openalex.org/W2275939505","https://openalex.org/W2620536393","https://openalex.org/W2742893201","https://openalex.org/W2784360411"],"related_works":["https://openalex.org/W4210392061","https://openalex.org/W7152547580","https://openalex.org/W7131083072","https://openalex.org/W4409846824","https://openalex.org/W2332254944","https://openalex.org/W4411178878","https://openalex.org/W4407203531","https://openalex.org/W4414022407","https://openalex.org/W2013065810","https://openalex.org/W4207073474"],"abstract_inverted_index":{"Introduction:":[0],"Xeroderma":[1],"pigmentosum":[2],"(XP)":[3],"is":[4,57],"a":[5,22,75,88,114,154,172],"rare":[6],"autosomal":[7],"recessive":[8],"disorder":[9],"characterized":[10],"by":[11,254],"defective":[12],"DNA":[13],"repair,":[14],"leading":[15],"to":[16,27,82,217,238],"extreme":[17],"photosensitivity":[18],"Affected":[19],"individuals":[20],"have":[21],"profoundly":[23],"elevated":[24],"risk":[25],"estimated":[26],"be":[28],"more":[29,166],"than":[30,33],"10,000-fold":[31],"greater":[32],"the":[34,158,185,192,205,225,258,266],"general":[35],"population":[36],"of":[37,91,110,117,141,197,207,228,268],"developing":[38],"cutaneous":[39,198],"malignancies,":[40],"primarily":[41],"squamous":[42],"cell":[43],"carcinoma":[44],"(SCC).":[45],"Management":[46],"requires":[47],"rigorous":[48],"photoprotection":[49],"and":[50,67,121,131,175,194,245,264],"prompt,":[51],"often":[52],"repeated,":[53],"surgical":[54,210,251,271],"excisions.":[55],"This":[56,189],"critically":[58],"challenging":[59,215],"in":[60,200,213,221,233,273],"resource-limited":[61],"settings":[62,234],"with":[63,87,113,143,153,171,235],"high":[64],"ultraviolet":[65],"exposure":[66],"limited":[68,236],"surgical/oncological":[69],"infrastructure.":[70],"Case":[71],"Presentation:":[72],"We":[73],"report":[74],"7-year-old":[76],"female":[77],"from":[78],"rural":[79],"Somaliland,":[80],"born":[81],"consanguineous":[83],"parents,":[84],"She":[85],"presented":[86],"6-month":[89],"history":[90,116],"an":[92],"ulcerated,":[93],"bleeding":[94],"plaque":[95],"on":[96],"her":[97],"right":[98],"temple.":[99],"Two":[100],"younger":[101],"siblings":[102],"also":[103],"exhibited":[104],"milder":[105],"dermatological":[106],"symptoms,":[107],"raising":[108],"suspicion":[109],"familial":[111],"XP":[112,126,142,201],"2-year":[115],"progressive":[118],"photosensitivity,":[119],"xerosis,":[120],"freckling.":[122],"Examination":[123],"revealed":[124],"characteristic":[125],"findings":[127],"including":[128],"diffuse":[129],"poikiloderma":[130],"ocular":[132],"involvement":[133],"(conjunctival":[134],"growths,":[135],"dry":[136],"eyes).":[137],"A":[138,164],"clinical":[139],"diagnosis":[140],"suspected":[144],"SCC":[145,159,183,199],"was":[146,150,178],"made.":[147],"The":[148,249],"lesion":[149],"initially":[151],"excised":[152],"2mm":[155],"margin;":[156],"however,":[157],"recurred":[160],"within":[161],"three":[162],"months.":[163],"second,":[165],"extensive":[167],"wide":[168],"local":[169],"excision":[170,263],"4mm":[173,209],"margin":[174],"flap":[176],"reconstruction":[177],"successful.":[179],"Histopathology":[180],"confirmed":[181],"well-differentiated":[182],"invading":[184],"deep":[186],"dermis.":[187],"Conclusion:":[188],"case":[190],"highlights":[191,265],"aggressive":[193],"recurrent":[195],"nature":[196],"patients,":[202],"It":[203,223],"underscores":[204,224],"necessity":[206],"standard":[208],"margins":[211],"even":[212],"anatomically":[214],"areas":[216],"prevent":[218],"recurrence.":[219],"Even":[220],"childhood.":[222],"immense":[226],"challenges":[227],"managing":[229],"this":[230],"life-threatening":[231],"genodermatosis":[232],"access":[237],"specialized":[239],"multidisciplinary":[240],"care,":[241],"advanced":[242],"reconstructive":[243],"surgery,":[244],"lifelong":[246],"photoprotective":[247],"resources.":[248],"iterative":[250],"approach,":[252],"complicated":[253],"graft":[255],"failure,":[256],"illustrates":[257],"need":[259],"for":[260],"robust":[261],"primary":[262],"role":[267],"pragmatic,":[269],"adaptive":[270],"planning":[272],"low-resource":[274],"contexts.":[275]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-06-30T00:00:00"}