{"id":"https://openalex.org/W7166555905","doi":"https://doi.org/10.1016/j.ijpx.2026.100594","title":"Cyano-modulated Zn(II)-Schiff base complexes for lysosome-targeted fluorescence imaging and pH-responsive camptothecin delivery","display_name":"Cyano-modulated Zn(II)-Schiff base complexes for lysosome-targeted fluorescence imaging and pH-responsive camptothecin delivery","publication_year":2026,"publication_date":"2026-06-29","ids":{"openalex":"https://openalex.org/W7166555905","doi":"https://doi.org/10.1016/j.ijpx.2026.100594","pmid":"https://pubmed.ncbi.nlm.nih.gov/42434439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13351152"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijpx.2026.100594","doi":"https://doi.org/10.1016/j.ijpx.2026.100594","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijpx.2026.100594","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590156726001143/pdf","source":{"id":"https://openalex.org/S4210204060","display_name":"International Journal of Pharmaceutics X","issn_l":"2590-1567","issn":["2590-1567"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics: X","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2590156726001143/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138051938","display_name":"Xi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Zhang","raw_affiliation_strings":["Department of Radiation Oncology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210099512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138056384","display_name":"Wenjie Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjie Sun","raw_affiliation_strings":["Department of Radiation Oncology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China","Zhejiang Engineering Research Center for Innovation and Application of Intelligent Radiotherapy Technology, Zhejiang-Hong Kong Precision Theranostics of Thoracic Tumors Joint Laboratory, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Zhejiang Engineering Research Center for Innovation and Application of Intelligent Radiotherapy Technology, Zhejiang-Hong Kong Precision Theranostics of Thoracic Tumors Joint Laboratory, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139614282","display_name":"Xin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN","HK"],"is_corresponding":true,"raw_author_name":"Xin Li","raw_affiliation_strings":["Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China","Joint Research Centre, HIM, The First Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]},{"raw_affiliation_string":"Joint Research Centre, HIM, The First Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139553507","display_name":"Yuanzhe Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuanzhe Li","raw_affiliation_strings":["College of Medicine, Etugen University, Ulaanbaatar, Mongolia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, Etugen University, Ulaanbaatar, Mongolia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004693707","display_name":"Shuo Xiang","orcid":"https://orcid.org/0000-0001-9937-7470","observed_orcids":["https://orcid.org/0000-0001-9937-7470"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuo Xiang","raw_affiliation_strings":["College of Materials Science and Engineering, Hunan University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Materials Science and Engineering, Hunan University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139571819","display_name":"Lifang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lifang Zhang","raw_affiliation_strings":["Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071675435","display_name":"Yiping Yang","orcid":"https://orcid.org/0000-0002-1291-7460","observed_orcids":["https://orcid.org/0000-0002-1291-7460"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yiping Yang","raw_affiliation_strings":["Joint Research Centre, HIM, The First Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Research Centre, HIM, The First Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I2801769982"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5004693707","https://openalex.org/A5071675435","https://openalex.org/A5139571819","https://openalex.org/A5139614282"],"corresponding_institution_ids":["https://openalex.org/I16609230","https://openalex.org/I168719708","https://openalex.org/I27781120","https://openalex.org/I2801769982"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":7.783,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.98097634,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"12","issue":null,"first_page":"100594","last_page":"100594"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.35030001401901245,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.031099999323487282,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysosomal-targeting","display_name":"lysosomal targeting","score":0.8849999904632568},{"id":"https://openalex.org/keywords/fluorescence-imaging","display_name":"fluorescence imaging","score":0.7300000190734863},{"id":"https://openalex.org/keywords/ph-responsive-drug-delivery","display_name":"pH-responsive drug delivery","score":0.7850000262260437},{"id":"https://openalex.org/keywords/camptothecin","display_name":"camptothecin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/theranostic-nanoplatform","display_name":"theranostic nanoplatform","score":0.8330000042915344},{"id":"https://openalex.org/keywords/intramolecular-charge-transfer","display_name":"intramolecular charge transfer","score":0.8379999995231628},{"id":"https://openalex.org/keywords/homo-lumo-gap","display_name":"HOMO-LUMO gap","score":0.8140000104904175},{"id":"https://openalex.org/keywords/4t1-cells","display_name":"4T1 cells","score":0.7919999957084656},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/luminescent-nanoparticles","display_name":"luminescent nanoparticles","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6811000108718872},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5594000220298767},{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.45590001344680786},{"id":"https://openalex.org/C42058472","wikidata":"https://www.wikidata.org/wiki/Q810214","display_name":"Base (topology)","level":2,"score":0.4253999888896942},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.3952000141143799},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3197999894618988},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.31360000371932983},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2736999988555908},{"id":"https://openalex.org/C185581394","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Base pair","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.24009999632835388}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ijpx.2026.100594","doi":"https://doi.org/10.1016/j.ijpx.2026.100594","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijpx.2026.100594","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590156726001143/pdf","source":{"id":"https://openalex.org/S4210204060","display_name":"International Journal of Pharmaceutics X","issn_l":"2590-1567","issn":["2590-1567"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics: X","raw_type":"journal-article"},{"id":"pmid:42434439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42434439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pharmaceutics: X","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13351152","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13351152/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Pharm X","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/76a88ad7-eb62-4151-8cb7-d7c9e34aa639","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2031/76a88ad7-eb62-4151-8cb7-d7c9e34aa639","pdf_url":null,"source":{"id":"https://openalex.org/S7407055387","display_name":"CityU Scholars","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zhang, X, Sun, W, Li, X, Li, Y, Xiang, S, Zhang, L & Yang, Y 2026, 'Cyano-modulated Zn(II)-Schiff base complexes for lysosome-targeted fluorescence imaging and pH-responsive camptothecin delivery', International Journal of Pharmaceutics: X, vol. 12, 100594. https://doi.org/10.1016/j.ijpx.2026.100594","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.ijpx.2026.100594","doi":"https://doi.org/10.1016/j.ijpx.2026.100594","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijpx.2026.100594","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590156726001143/pdf","source":{"id":"https://openalex.org/S4210204060","display_name":"International Journal of Pharmaceutics X","issn_l":"2590-1567","issn":["2590-1567"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics: X","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8038695038","display_name":null,"funder_award_id":"Y20240932","funder_id":"https://openalex.org/F4320324224","funder_display_name":"Wenzhou Municipal Science and Technology Bureau"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324224","display_name":"Wenzhou Municipal Science and Technology Bureau","ror":"https://ror.org/02fr0s482"},{"id":"https://openalex.org/F4320335581","display_name":"Young Scientists Fund","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7166555905.pdf","grobid_xml":"https://content.openalex.org/works/W7166555905.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1615964733","https://openalex.org/W1833654872","https://openalex.org/W1914501114","https://openalex.org/W1972333276","https://openalex.org/W1976041621","https://openalex.org/W1978298108","https://openalex.org/W1980945033","https://openalex.org/W1984883623","https://openalex.org/W1987604182","https://openalex.org/W1997787046","https://openalex.org/W2006118631","https://openalex.org/W2008028087","https://openalex.org/W2014014132","https://openalex.org/W2034046101","https://openalex.org/W2034947652","https://openalex.org/W2065076242","https://openalex.org/W2070986221","https://openalex.org/W2074154665","https://openalex.org/W2079507386","https://openalex.org/W2088628346","https://openalex.org/W2097951289","https://openalex.org/W2106542878","https://openalex.org/W2107502817","https://openalex.org/W2150829534","https://openalex.org/W2155239981","https://openalex.org/W2209802854","https://openalex.org/W2569511184","https://openalex.org/W2603076496","https://openalex.org/W2740618823","https://openalex.org/W2770166811","https://openalex.org/W2793703146","https://openalex.org/W2943301397","https://openalex.org/W2967002629","https://openalex.org/W2969538494","https://openalex.org/W2971120492","https://openalex.org/W2986301853","https://openalex.org/W2991456852","https://openalex.org/W3016024115","https://openalex.org/W3028589787","https://openalex.org/W3040905145","https://openalex.org/W3045619116","https://openalex.org/W3083432038","https://openalex.org/W3088843006","https://openalex.org/W3101974256","https://openalex.org/W3136571014","https://openalex.org/W3137206449","https://openalex.org/W3151259900","https://openalex.org/W3183361561","https://openalex.org/W3184822970","https://openalex.org/W3213834237","https://openalex.org/W4205337523","https://openalex.org/W4281865876","https://openalex.org/W4285388405","https://openalex.org/W4296369450","https://openalex.org/W4386002426","https://openalex.org/W4388290259","https://openalex.org/W4390465628","https://openalex.org/W4393986410","https://openalex.org/W4394015498","https://openalex.org/W4399777491","https://openalex.org/W4399861933","https://openalex.org/W4402620477","https://openalex.org/W4405284229","https://openalex.org/W4405529477","https://openalex.org/W4406540615","https://openalex.org/W4407165412","https://openalex.org/W4412600058","https://openalex.org/W4414656763"],"related_works":["https://openalex.org/W4412600058","https://openalex.org/W4410960821","https://openalex.org/W2021784952","https://openalex.org/W4388869097","https://openalex.org/W3083432038","https://openalex.org/W2791025710","https://openalex.org/W4403986952","https://openalex.org/W2052970457","https://openalex.org/W7220702985","https://openalex.org/W3011476574"],"abstract_inverted_index":{"Integrating":[0],"real-time":[1],"diagnostic":[2],"imaging":[3],"with":[4,155,228,298],"stimuli-responsive":[5],"therapy":[6],"into":[7],"a":[8,12,23,58,77,156,170,253,265,302],"single":[9],"nanoplatform":[10],"represents":[11],"core":[13],"research":[14],"direction":[15],"in":[16,81,139],"precision":[17,306],"oncology.":[18,307],"Nevertheless,":[19],"the":[20,47,55,82,97,114,124,132,140,165,246,275,280],"construction":[21],"of":[22,49,60,101,142,174,233,271,279],"lysosome-targeted":[24],"theranostic":[25],"system":[26],"that":[27,110,291],"simultaneously":[28],"combines":[29],"high-contrast":[30],"luminescence,":[31],"biosafety,":[32],"and":[33,66,70,118,152,235,274],"spatially":[34],"controlled":[35],"drug":[36,172,193,242,286],"release":[37,173,194,243],"characteristics":[38],"continues":[39],"to":[40,103,241],"pose":[41],"formidable":[42],"challenges.":[43],"Herein,":[44],"by":[45,245],"modulating":[46],"number":[48],"electron-withdrawing":[50],"cyano":[51],"(\u2013CN)":[52],"substituents":[53],"on":[54,260],"ligand":[56],"backbone,":[57],"series":[59],"Zn(II)-Schiff":[61,261],"base":[62,262],"complexes\u2014designated":[63],"Zn-0CN,":[64],"Zn-1CN,":[65],"Zn-2CN\u2014were":[67],"rationally":[68],"designed":[69],"synthesized.":[71],"The":[72,196],"cyano-governed":[73],"donor\u2013acceptor":[74],"topology":[75],"induced":[76],"pronounced":[78],"bathochromic":[79],"shift":[80],"emission":[83],"spectra":[84],"(497":[85],"nm":[86,91],"for":[87,92,284,305],"Zn-0CN":[88],"versus":[89],"543":[90],"Zn-2CN)":[93],"while":[94],"concurrently":[95],"elevating":[96],"fluorescence":[98,151],"quantum":[99],"yield":[100],"Zn-2CN":[102,126,135,198],"9.2%.":[104],"Density":[105],"functional":[106],"theory":[107],"calculations":[108],"revealed":[109],"Zn(II)":[111],"coordination":[112],"narrows":[113],"HOMO\u2013LUMO":[115],"energy":[116],"gap":[117],"enhances":[119],"intramolecular":[120],"charge":[121,129],"transfer;":[122],"notably,":[123],"bis-cyano-substituted":[125],"exhibited":[127,200],"strong":[128],"polarization":[130],"within":[131,176],"metal-binding":[133],"region.":[134],"nanoparticles":[136,168],"selectively":[137],"accumulated":[138],"lysosomes":[141],"4":[143],"T1":[144],"breast":[145],"cancer":[146],"cells,":[147],"displaying":[148],"bright":[149],"yellow-green":[150],"outstanding":[153],"colocalization":[154],"commercial":[157],"lysosomal":[158,248],"red":[159],"probe.":[160],"Following":[161],"camptothecin":[162],"(CPT)":[163],"encapsulation,":[164],"resulting":[166],"CPT@Zn-2CN":[167,221],"achieved":[169],"cumulative":[171],"92%":[175],"36":[177],"h":[178],"at":[179,186,207],"pH":[180,188,277],"5.6,":[181],"whereas":[182],"only":[183],"41%":[184],"leaked":[185],"physiological":[187],"7.4,":[189],"confirming":[190],"their":[191],"pH-triggered":[192],"capability.":[195],"bare":[197],"material":[199],"negligible":[201],"cytotoxicity":[202],"(cell":[203,231],"viability":[204],"exceeding":[205],"90%":[206],"100":[208],"\u03bcg\u00b7mL":[209,218],"\u22121":[210,219],").":[211],"At":[212],"an":[213,238],"equivalent":[214],"CPT":[215,230],"dosage":[216],"(20":[217],"),":[220],"elicited":[222],"markedly":[223],"superior":[224],"apoptosis":[225],"induction":[226],"compared":[227],"free":[229],"viabilities":[232],"20.5%":[234],"37.5%,":[236],"respectively),":[237],"enhancement":[239],"attributable":[240],"activated":[244],"acidic":[247],"milieu.":[249],"This":[250,288],"work":[251],"establishes":[252],"versatile":[254],"\u201cimaging\u2013drug":[255],"delivery":[256],"integration\u201d":[257],"platform":[258],"based":[259],"chemistry,":[263],"wherein":[264],"cyano-functionalization":[266],"strategy":[267,304],"enables":[268],"precise":[269],"tuning":[270],"photophysical":[272],"properties,":[273],"intrinsic":[276],"sensitivity":[278],"imine":[281],"bond":[282],"allows":[283],"lysosome-responsive":[285],"release.":[287],"study":[289],"demonstrates":[290],"such":[292],"complexes":[293],"can":[294],"seamlessly":[295],"combine":[296],"bioimaging":[297],"microenvironment-responsive":[299],"chemotherapy,":[300],"offering":[301],"promising":[303]},"counts_by_year":[{"year":2026,"cited_by_count":7}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-06-30T00:00:00"}