{"id":"https://openalex.org/W7166515744","doi":"https://doi.org/10.1016/j.crmeth.2026.101508","title":"A computational method to design broad-spectrum T cell-inducing vaccines applied to Betacoronaviruses","display_name":"A computational method to design broad-spectrum T cell-inducing vaccines applied to Betacoronaviruses","publication_year":2026,"publication_date":"2026-06-29","ids":{"openalex":"https://openalex.org/W7166515744","doi":"https://doi.org/10.1016/j.crmeth.2026.101508","pmid":"https://pubmed.ncbi.nlm.nih.gov/42372721"},"language":"en","primary_location":{"id":"doi:10.1016/j.crmeth.2026.101508","doi":"https://doi.org/10.1016/j.crmeth.2026.101508","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crmeth.2026.101508","pdf_url":null,"source":{"id":"https://openalex.org/S4210214705","display_name":"Cell Reports Methods","issn_l":"2667-2375","issn":["2667-2375"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.crmeth.2026.101508","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015055542","display_name":"Phil Palmer","orcid":"https://orcid.org/0000-0002-9576-7540","observed_orcids":["https://orcid.org/0000-0002-9576-7540"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Phil Palmer","raw_affiliation_strings":["Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK"],"raw_orcid":"https://orcid.org/0000-0002-9576-7540","affiliations":[{"raw_affiliation_string":"Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080348865","display_name":"Sofiya Fedosyuk","orcid":"https://orcid.org/0000-0003-2437-5264","observed_orcids":["https://orcid.org/0000-0003-2437-5264"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sofiya Fedosyuk","raw_affiliation_strings":["DIOSynVax Ltd, University of Cambridge, Cambridge CB3 0ES, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DIOSynVax Ltd, University of Cambridge, Cambridge CB3 0ES, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104683905","display_name":"Srivatsan Parthasarathy","orcid":"https://orcid.org/0000-0001-7941-0827","observed_orcids":["https://orcid.org/0000-0001-7941-0827"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Srivatsan Parthasarathy","raw_affiliation_strings":["DIOSynVax Ltd, University of Cambridge, Cambridge CB3 0ES, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DIOSynVax Ltd, University of Cambridge, Cambridge CB3 0ES, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058100850","display_name":"Jonathan A. Holbrook","orcid":"https://orcid.org/0000-0001-8660-0282","observed_orcids":["https://orcid.org/0000-0001-8660-0282"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan Holbrook","raw_affiliation_strings":["DIOSynVax Ltd, University of Cambridge, Cambridge CB3 0ES, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DIOSynVax Ltd, University of Cambridge, Cambridge CB3 0ES, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058157236","display_name":"Charlotte L. George","orcid":"https://orcid.org/0000-0002-6585-3288","observed_orcids":["https://orcid.org/0000-0002-6585-3288"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charlotte George","raw_affiliation_strings":["Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Laura O\u2019Reilly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura O\u2019Reilly","raw_affiliation_strings":["Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068171209","display_name":"Lara Wiegand","orcid":"https://orcid.org/0009-0003-5108-9463","observed_orcids":["https://orcid.org/0009-0003-5108-9463"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]},{"id":"https://openalex.org/I4210140742","display_name":"Institute of Medical Microbiology and Hygiene","ror":"https://ror.org/04xqmb911","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210140742"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lara Wiegand","raw_affiliation_strings":["Institute of Medical Microbiology and Hygiene, University Hospital Regensburg, 93053 Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Hygiene, University Hospital Regensburg, 93053 Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431","https://openalex.org/I4210140742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006375541","display_name":"George Carnell","orcid":"https://orcid.org/0000-0001-8875-0989","observed_orcids":["https://orcid.org/0000-0001-8875-0989"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"George William Carnell","raw_affiliation_strings":["Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK; One Virology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK; One Virology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023133097","display_name":"Jonathan Luke Heeney","orcid":"https://orcid.org/0000-0003-2702-1621","observed_orcids":["https://orcid.org/0000-0003-2702-1621"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jonathan Luke Heeney","raw_affiliation_strings":["Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK; DIOSynVax Ltd, University of Cambridge, Cambridge CB3 0ES, UK. Electronic address: jlh66@cam.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK; DIOSynVax Ltd, University of Cambridge, Cambridge CB3 0ES, UK. Electronic address: jlh66@cam.ac.uk","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025504735","display_name":"Sneha Vishwanath","orcid":"https://orcid.org/0000-0001-9960-547X","observed_orcids":["https://orcid.org/0000-0001-9960-547X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sneha Vishwanath","raw_affiliation_strings":["Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK. Electronic address: sv446@cam.ac.uk"],"raw_orcid":"https://orcid.org/0000-0001-9960-547X","affiliations":[{"raw_affiliation_string":"Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK. Electronic address: sv446@cam.ac.uk","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5023133097","https://openalex.org/A5025504735"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":4824,"currency":"USD","value_usd":4824},"apc_paid":{"value":4824,"currency":"USD","value_usd":4824},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3970027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"8","first_page":"101508","last_page":"101508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/broad-spectrum-vaccine","display_name":"broad-spectrum vaccine","score":0.9160000085830688},{"id":"https://openalex.org/keywords/betacoronavirus","display_name":"Betacoronavirus","score":0.7910000085830688},{"id":"https://openalex.org/keywords/nucleocapsid-antigen","display_name":"nucleocapsid antigen","score":0.8389999866485596},{"id":"https://openalex.org/keywords/immunological-cross-reactivity","display_name":"immunological cross-reactivity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/antigen-design","display_name":"antigen design","score":0.4659999907016754},{"id":"https://openalex.org/keywords/sars-cov","display_name":"SARS-CoV","score":0.7300000190734863},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":1.0},{"id":"https://openalex.org/keywords/mers-cov","display_name":"MERS-CoV","score":1.0},{"id":"https://openalex.org/keywords/sarbecovirus","display_name":"Sarbecovirus","score":0.8169999718666077},{"id":"https://openalex.org/keywords/epitope-identification","display_name":"epitope identification","score":0.675000011920929},{"id":"https://openalex.org/keywords/pandemic-preparedness","display_name":"pandemic preparedness","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5867999792098999},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5809000134468079},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5370000004768372},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5042999982833862},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.4837000072002411},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.4781000018119812},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.4708000123500824},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.43220001459121704},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.4106999933719635},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40139999985694885},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3601999878883362},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.3553999960422516},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.34380000829696655},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3379000127315521},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.3273000121116638},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.32170000672340393},{"id":"https://openalex.org/C180915046","wikidata":"https://www.wikidata.org/wiki/Q575264","display_name":"Original antigenic sin","level":5,"score":0.31360000371932983},{"id":"https://openalex.org/C2781152039","wikidata":"https://www.wikidata.org/wiki/Q7318278","display_name":"Reverse vaccinology","level":4,"score":0.2775000035762787},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.27709999680519104},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.25529998540878296},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.25459998846054077},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.2538999915122986},{"id":"https://openalex.org/C139502532","wikidata":"https://www.wikidata.org/wiki/Q1122090","display_name":"Computational intelligence","level":2,"score":0.25130000710487366}],"mesh":[{"descriptor_ui":"D000073640","descriptor_name":"Betacoronavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000073640","descriptor_name":"Betacoronavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000095763","descriptor_name":"Immunoinformatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095763","descriptor_name":"Immunoinformatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065207","descriptor_name":"Middle East Respiratory Syndrome Coronavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D065207","descriptor_name":"Middle East Respiratory Syndrome Coronavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.crmeth.2026.101508","doi":"https://doi.org/10.1016/j.crmeth.2026.101508","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crmeth.2026.101508","pdf_url":null,"source":{"id":"https://openalex.org/S4210214705","display_name":"Cell Reports Methods","issn_l":"2667-2375","issn":["2667-2375"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Methods","raw_type":"journal-article"},{"id":"pmid:42372721","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42372721","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports methods","raw_type":"Journal Article"},{"id":"pmh:oai:https://nottingham-repository.worktribe.com/:66923214","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crmeth.2026.101508","pdf_url":null,"source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:nottingham-repository.worktribe.com:66923214","doi":null,"is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/66923214/1/PIIS2667237526002092","pdf_url":null,"source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13494552","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13494552/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Rep Methods","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.crmeth.2026.101508","doi":"https://doi.org/10.1016/j.crmeth.2026.101508","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crmeth.2026.101508","pdf_url":null,"source":{"id":"https://openalex.org/S4210214705","display_name":"Cell Reports Methods","issn_l":"2667-2375","issn":["2667-2375"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Methods","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7081301808357239}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335087","display_name":"Innovate UK","ror":"https://ror.org/05ar5fy68"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W2004583429","https://openalex.org/W2011301426","https://openalex.org/W2025080738","https://openalex.org/W2043098712","https://openalex.org/W2082317854","https://openalex.org/W2127322768","https://openalex.org/W2132022337","https://openalex.org/W2156125289","https://openalex.org/W2160378127","https://openalex.org/W2292472819","https://openalex.org/W2557802420","https://openalex.org/W2883783102","https://openalex.org/W2947128118","https://openalex.org/W3003257820","https://openalex.org/W3007643904","https://openalex.org/W3016073437","https://openalex.org/W3024570138","https://openalex.org/W3044770175","https://openalex.org/W3094514351","https://openalex.org/W3119858919","https://openalex.org/W3123967880","https://openalex.org/W3135351475","https://openalex.org/W3177828909","https://openalex.org/W3180541698","https://openalex.org/W3210401977","https://openalex.org/W4200059944","https://openalex.org/W4224274105","https://openalex.org/W4242729757","https://openalex.org/W4283395367","https://openalex.org/W4284689837","https://openalex.org/W4308773001","https://openalex.org/W4312019047","https://openalex.org/W4317542770","https://openalex.org/W4365447189","https://openalex.org/W4378172777","https://openalex.org/W4378348247","https://openalex.org/W4380882762","https://openalex.org/W4385322649","https://openalex.org/W4387025522","https://openalex.org/W4388966793","https://openalex.org/W4389992977","https://openalex.org/W4393153172","https://openalex.org/W4401912467","https://openalex.org/W4411095777","https://openalex.org/W4414533690","https://openalex.org/W7160230825"],"related_works":[],"abstract_inverted_index":{"Antigenically":[0],"diverse":[1],"pathogens":[2],"such":[3],"as":[4],"coronaviruses":[5,100],"pose":[6],"substantial":[7],"global":[8],"health":[9],"threats,":[10],"highlighting":[11],"the":[12,54,120,129],"need":[13],"for":[14,29,71,102,125,135],"broad-spectrum":[15,26,133],"vaccines.":[16],"Here,":[17],"we":[18,40,118],"introduce":[19],"Spectravax,":[20,39],"a":[21,42],"computational":[22,79,112],"method":[23],"that":[24],"designs":[25,113],"vaccines":[27,134],"accounting":[28],"genetic":[30],"diversity":[31],"in":[32,83,105],"both":[33],"host":[34,67],"and":[35,56,68,77,97,110],"pathogen":[36,69],"populations.":[37],"Using":[38],"designed":[41],"nucleocapsid":[43],"(N)":[44],"antigen":[45],"to":[46,51,74,94],"elicit":[47],"cross-reactive":[48],"immune":[49,92],"responses":[50,93],"viruses":[52],"from":[53],"Sarbecovirus":[55],"Merbecovirus":[57],"subgenera":[58],"of":[59,132],"Betacoronaviruses.":[60],"In":[61],"silico":[62],"analyses":[63],"demonstrated":[64],"superior":[65],"predicted":[66],"coverage":[70],"Spectravax":[72,88],"compared":[73],"wild-type":[75,109],"sequences":[76],"existing":[78,111],"designs.":[80],"Experimental":[81],"validation":[82],"mice":[84],"supported":[85],"these":[86],"predictions:":[87],"N":[89,122],"elicited":[90,114],"robust":[91],"SARS-CoV,":[95],"SARS-CoV-2,":[96],"MERS-CoV-the":[98],"three":[99],"responsible":[101,124],"major":[103],"outbreaks":[104],"humans":[106],"since":[107],"2002-while":[108],"limited":[115],"responses.":[116],"Furthermore,":[117],"identified":[119],"MERS-CoV":[121],"epitopes":[123],"Spectravax's":[126],"cross-reactivity,":[127],"advancing":[128],"rational":[130],"design":[131],"pandemic":[136],"preparedness.":[137]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2026-06-30T00:00:00"}
