{"id":"https://openalex.org/W7166455817","doi":"https://doi.org/10.64898/2026.06.22.733821","title":"Prefrontal activation predicts response latency and is shaped by age and lifestyle","display_name":"Prefrontal activation predicts response latency and is shaped by age and lifestyle","publication_year":2026,"publication_date":"2026-06-28","ids":{"openalex":"https://openalex.org/W7166455817","doi":"https://doi.org/10.64898/2026.06.22.733821"},"language":"en","primary_location":{"id":"doi:10.64898/2026.06.22.733821","doi":"https://doi.org/10.64898/2026.06.22.733821","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.06.22.733821","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/06/28/2026.06.22.733821.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/06/28/2026.06.22.733821.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054287944","display_name":"Rufus Mitchell\u2010Heggs","orcid":"https://orcid.org/0000-0001-6303-0467","observed_orcids":["https://orcid.org/0000-0001-6303-0467"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Rufus Mitchell-Heggs","raw_affiliation_strings":["Centre for Neurotechnology and Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK","Connectome Health, Tobeleggweg 22, CH-8049 Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-6303-0467","affiliations":[{"raw_affiliation_string":"Centre for Neurotechnology and Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Connectome Health, Tobeleggweg 22, CH-8049 Zurich, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139536802","display_name":"Daniel Tamkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel Tamkin","raw_affiliation_strings":["Centre for Neurotechnology and Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK","Connectome Health, Tobeleggweg 22, CH-8049 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurotechnology and Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Connectome Health, Tobeleggweg 22, CH-8049 Zurich, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159385476","display_name":"Tauheed Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tauheed Ibrahim","raw_affiliation_strings":["Centre for Neurotechnology and Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurotechnology and Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049154370","display_name":"Lucas Scherdel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucas Scherdel","raw_affiliation_strings":["Connectome Health, Tobeleggweg 22, CH-8049 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connectome Health, Tobeleggweg 22, CH-8049 Zurich, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134512536","display_name":"Anita Snowdon","orcid":"https://orcid.org/0000-0002-1880-140X","observed_orcids":["https://orcid.org/0000-0002-1880-140X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anita Snowdon-Farrell","raw_affiliation_strings":["Centre for Neurotechnology and Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK","Connectome Health, Tobeleggweg 22, CH-8049 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurotechnology and Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Connectome Health, Tobeleggweg 22, CH-8049 Zurich, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089236137","display_name":"Alfred Curry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alfred Curry","raw_affiliation_strings":["Centre for Neurotechnology and Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurotechnology and Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027839817","display_name":"Onayomi Rosenior-Patten","orcid":"https://orcid.org/0000-0001-6632-1331","observed_orcids":["https://orcid.org/0000-0001-6632-1331"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Onayomi Rosenior-Patten","raw_affiliation_strings":["Centre for Neurotechnology and Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK","Connectome Health, Tobeleggweg 22, CH-8049 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurotechnology and Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Connectome Health, Tobeleggweg 22, CH-8049 Zurich, Switzerland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033931489","display_name":"Simon R. Schultz","orcid":"https://orcid.org/0000-0002-6794-5813","observed_orcids":["https://orcid.org/0000-0002-6794-5813"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon R Schultz","raw_affiliation_strings":["Centre for Neurotechnology and Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK","Connectome Health, Tobeleggweg 22, CH-8049 Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6794-5813","affiliations":[{"raw_affiliation_string":"Centre for Neurotechnology and Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Connectome Health, Tobeleggweg 22, CH-8049 Zurich, Switzerland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054287944"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.7538999915122986,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.7538999915122986,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.23690000176429749,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14434","display_name":"Historical and Modern Theater Studies","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dorsolateral-prefrontal-cortex","display_name":"dorsolateral prefrontal cortex","score":0.9869999885559082},{"id":"https://openalex.org/keywords/reaction-time","display_name":"reaction time","score":0.7689999938011169},{"id":"https://openalex.org/keywords/response-latency","display_name":"response latency","score":0.5680000185966492},{"id":"https://openalex.org/keywords/age-effects","display_name":"age effects","score":0.6169999837875366},{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.7609999775886536},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":1.0},{"id":"https://openalex.org/keywords/lifestyle","display_name":"lifestyle","score":0.375},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.7149999737739563},{"id":"https://openalex.org/keywords/individual-differences","display_name":"individual differences","score":0.6470000147819519},{"id":"https://openalex.org/keywords/test-retest-reliability","display_name":"test-retest reliability","score":0.8190000057220459},{"id":"https://openalex.org/keywords/neuropsychiatric-disorders","display_name":"neuropsychiatric disorders","score":0.7149999737739563},{"id":"https://openalex.org/keywords/modifiable-risk-factors","display_name":"modifiable risk factors","score":0.6679999828338623},{"id":"https://openalex.org/keywords/wearable-neuroimaging","display_name":"wearable neuroimaging","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C2780508717","wikidata":"https://www.wikidata.org/wiki/Q72788","display_name":"Dorsolateral prefrontal cortex","level":4,"score":0.6983000040054321},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.525600016117096},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4961000084877014},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4609000086784363},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.42080000042915344},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.4187000095844269},{"id":"https://openalex.org/C2984127161","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neural activity","level":2,"score":0.41679999232292175},{"id":"https://openalex.org/C162967406","wikidata":"https://www.wikidata.org/wiki/Q384176","display_name":"Stroop effect","level":3,"score":0.41449999809265137},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.4138999879360199},{"id":"https://openalex.org/C82876162","wikidata":"https://www.wikidata.org/wiki/Q17096504","display_name":"Latency (audio)","level":2,"score":0.3817000091075897},{"id":"https://openalex.org/C2776587650","wikidata":"https://www.wikidata.org/wiki/Q17146541","display_name":"Ventrolateral prefrontal cortex","level":4,"score":0.3659000098705292},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.35100001096725464},{"id":"https://openalex.org/C2775968953","wikidata":"https://www.wikidata.org/wiki/Q783092","display_name":"Executive functions","level":3,"score":0.3384000062942505},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31060001254081726},{"id":"https://openalex.org/C129564537","wikidata":"https://www.wikidata.org/wiki/Q1460873","display_name":"Neural correlates of consciousness","level":3,"score":0.30709999799728394},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.2964000105857849},{"id":"https://openalex.org/C120843803","wikidata":"https://www.wikidata.org/wiki/Q4955807","display_name":"Brain activity and meditation","level":3,"score":0.28369998931884766},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.26570001244544983},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.2596000134944916},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.2554999887943268},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.25110000371932983},{"id":"https://openalex.org/C26170363","wikidata":"https://www.wikidata.org/wiki/Q1981408","display_name":"Haemodynamic response","level":4,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.06.22.733821","doi":"https://doi.org/10.64898/2026.06.22.733821","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.06.22.733821","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/06/28/2026.06.22.733821.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.06.22.733821","doi":"https://doi.org/10.64898/2026.06.22.733821","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.06.22.733821","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/06/28/2026.06.22.733821.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7166455817.pdf","grobid_xml":"https://content.openalex.org/works/W7166455817.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W2018123056","https://openalex.org/W2151591509","https://openalex.org/W2731260452","https://openalex.org/W2901906577","https://openalex.org/W2958386327","https://openalex.org/W3139261093","https://openalex.org/W3165304737","https://openalex.org/W3175145615","https://openalex.org/W3210220090","https://openalex.org/W3216708225","https://openalex.org/W4205541584","https://openalex.org/W4221000532","https://openalex.org/W4238809637","https://openalex.org/W4392192160","https://openalex.org/W4392791500","https://openalex.org/W4394689176","https://openalex.org/W4400384210","https://openalex.org/W4401109062","https://openalex.org/W4401164724","https://openalex.org/W4403204821","https://openalex.org/W4408591610","https://openalex.org/W7163069443"],"related_works":["https://openalex.org/W2073688368","https://openalex.org/W2074710473","https://openalex.org/W4383218885","https://openalex.org/W2139104446","https://openalex.org/W4387053998","https://openalex.org/W2122289943","https://openalex.org/W1979201843","https://openalex.org/W2782187250","https://openalex.org/W4300457300","https://openalex.org/W2059184748"],"abstract_inverted_index":{"Abstract":[0],"Neurological":[1],"and":[2,44,47,73,157,179,203],"neuropsychiatric":[3,43],"conditions":[4],"affect":[5],"43%":[6],"of":[7,55,65,167,230],"the":[8,50,99,115,206],"global":[9],"population,":[10],"many":[11],"shaped":[12],"by":[13,82],"modifiable":[14],"lifestyle":[15,178],"exposures,":[16],"yet":[17],"their":[18],"relationship":[19],"to":[20,109,122],"cortical":[21,51],"haemodynamics":[22,216],"is":[23,31,40],"poorly":[24],"characterised.":[25],"The":[26],"dorsolateral":[27],"prefrontal":[28],"cortex":[29],"(dlPFC)":[30],"a":[32,62,165,218],"particularly":[33],"tractable":[34],"target:":[35],"it":[36],"underpins":[37],"executive":[38],"function,":[39],"disrupted":[41],"across":[42,161],"age-related":[45],"conditions,":[46],"lies":[48],"on":[49],"surface,":[52],"within":[53],"reach":[54],"scalable":[56],"optical":[57],"neuroimaging.":[58],"We":[59],"present":[60],"LUCID,":[61],"longitudinal":[63,228],"study":[64],"98":[66],"healthy":[67],"adults":[68],"combining":[69,176],"consumer":[70],"wearable":[71,172],"sleep":[72,202],"physical":[74],"activity":[75],"metrics":[76],"with":[77,95,111,144,170,196,225],"task-evoked":[78,214],"dlPFC":[79,90,215],"haemodynamics,":[80],"measured":[81],"time-domain":[83],"functional":[84,223],"near-infrared":[85],"spectroscopy":[86],"(TD-fNIRS).":[87],"Log-transformed":[88],"peak":[89],"activation":[91,133,184],"was":[92,151],"negatively":[93],"associated":[94],"response":[96,117],"latency":[97],"during":[98],"Switching":[100],"Stroop":[101],"task":[102,194],"in":[103,153,159,200,233],"both":[104,162],"hemispheres":[105],"(r":[106,119],"=":[107,120,142,189],"\u22120.32":[108],"\u22120.38),":[110],"stronger":[112],"associations":[113],"for":[114,227],"maximum":[116],"gradient":[118],"\u22120.46":[121],"\u22120.48),":[123],"such":[124],"that":[125],"greater":[126],"haemodynamic":[127],"responses":[128],"accompanied":[129],"faster":[130],"responses.":[131],"Peak":[132],"showed":[134],"moderate":[135],"test\u2013retest":[136],"reliability":[137],"(intraclass":[138],"correlation":[139],"coefficient,":[140],"ICC":[141],"0.57\u20130.69),":[143],"between-person":[145],"variance":[146],"exceeding":[147],"within-person":[148],"fluctuation.":[149],"Activation":[150],"lower":[152],"older":[154],"age":[155,204],"groups":[156],"higher":[158],"females":[160],"tasks.":[163],"In":[164],"subset":[166],"36":[168],"participants":[169],"complete":[171],"data,":[173],"exploratory":[174],"models":[175],"demographic,":[177],"scan-quality":[180],"features":[181],"predicted":[182],"bilateral":[183],"under":[185],"participant-grouped":[186],"cross-validation":[187],"(R\u00b2":[188],"0.29\u20130.37),":[190],"more":[191],"consistently":[192],"than":[193],"performance,":[195],"sex,":[197],"recent":[198],"change":[199],"REM":[201],"among":[205],"strongest":[207],"participant-level":[208],"contributors.":[209],"Together,":[210],"these":[211],"findings":[212],"identify":[213],"as":[217],"repeatable,":[219],"behaviourally":[220],"relevant":[221],"candidate":[222],"marker,":[224],"potential":[226],"investigation":[229],"lifestyle-associated":[231],"variation":[232],"brain":[234],"function.":[235]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-06-29T00:00:00"}
