{"id":"https://openalex.org/W7166402310","doi":null,"title":"Noninvasive Prediction of Significant Hepatic Injury in Treatment-Na\u00efve Children with Chronic HBV Infection","display_name":"Noninvasive Prediction of Significant Hepatic Injury in Treatment-Na\u00efve Children with Chronic HBV Infection","publication_year":2026,"publication_date":"2026-06-01","ids":{"openalex":"https://openalex.org/W7166402310"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:ad85fb35985044f29dca16bc1d33d396","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ad85fb35985044f29dca16bc1d33d396","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Infection and Drug Resistance, Vol Volume 19, Iss Issue 1, Pp 1-16 (2026)","raw_type":"article"},"volume":null,"type":"article","indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.dovepress.com/noninvasive-prediction-of-significant-hepatic-injury-in-treatment-nave-peer-reviewed-fulltext-article-IDR","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wu J","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wu J","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139499467","display_name":"Xiaorong Peng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng X","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032980221","display_name":"Yunan Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chang Y","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5139482727","display_name":"Hongmei Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xu H","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49732997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.8339999914169312},{"id":"https://openalex.org/keywords/non-invasive-prediction","display_name":"non-invasive prediction","score":0.7689999938011169},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.49000000953674316},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.6330000162124634},{"id":"https://openalex.org/keywords/liver-stiffness","display_name":"liver stiffness","score":0.3779999911785126},{"id":"https://openalex.org/keywords/liver-elastography","display_name":"liver elastography","score":0.37599998712539673},{"id":"https://openalex.org/keywords/nomogram","display_name":"nomogram","score":0.7799999713897705},{"id":"https://openalex.org/keywords/machine-learning-prediction-models","display_name":"machine learning prediction models","score":0.6060000061988831},{"id":"https://openalex.org/keywords/lasso-feature-selection","display_name":"LASSO feature selection","score":0.7710000276565552},{"id":"https://openalex.org/keywords/treatment-naive-patients","display_name":"treatment-naive patients","score":0.6600000262260437},{"id":"https://openalex.org/keywords/prognostic-model-validation","display_name":"prognostic model validation","score":0.531000018119812},{"id":"https://openalex.org/keywords/noninvasive-fibrosis-assessment","display_name":"noninvasive fibrosis assessment","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C521751864","wikidata":"https://www.wikidata.org/wiki/Q1729207","display_name":"Christian ministry","level":2,"score":0.7924000024795532},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7419999837875366},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.42080000042915344},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.36079999804496765},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.3476000130176544},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.3361999988555908},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3203999996185303},{"id":"https://openalex.org/C2992125907","wikidata":"https://www.wikidata.org/wiki/Q1741837","display_name":"Child health","level":2,"score":0.3158000111579895},{"id":"https://openalex.org/C2777072776","wikidata":"https://www.wikidata.org/wiki/Q1983841","display_name":"Viral hepatitis","level":2,"score":0.30559998750686646},{"id":"https://openalex.org/C166888038","wikidata":"https://www.wikidata.org/wiki/Q4118322","display_name":"Infection control","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C44519122","wikidata":"https://www.wikidata.org/wiki/Q2296168","display_name":"Medical laboratory","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C191935318","wikidata":"https://www.wikidata.org/wiki/Q148","display_name":"China","level":2,"score":0.2529999911785126},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.25279998779296875}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:doaj.org/article:ad85fb35985044f29dca16bc1d33d396","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ad85fb35985044f29dca16bc1d33d396","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Infection and Drug Resistance, Vol Volume 19, Iss Issue 1, Pp 1-16 (2026)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/116778","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/noninvasive-prediction-of-significant-hepatic-injury-in-treatment-nave-peer-reviewed-fulltext-article-IDR","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:dovepress.com/116778","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/noninvasive-prediction-of-significant-hepatic-injury-in-treatment-nave-peer-reviewed-fulltext-article-IDR","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.4831213653087616}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Jiaying":[0],"Wu,":[1],"Xiaorong":[2],"Peng,":[3],"Yunan":[4,111],"Chang,":[5,112],"Hongmei":[6,53],"Xu":[7],"Department":[8,55,113],"of":[9,14,30,34,42,51,56,61,77,81,89,105,114,119,135,139,147,163,279,285,318,367,489],"Infectious":[10,57,115],"Diseases,":[11,28,58,75,116,133],"Children\u2019s":[12,59,117],"Hospital":[13,60,118],"Chongqing":[15,39,62,86,120,144],"Medical":[16,63,121],"University,":[17,64,122],"National":[18,65,123],"Clinical":[19,66,124,410,418,421],"Research":[20,67,125],"Center":[21,68,126],"for":[22,69,127,203,296,493],"Children":[23,70,128],"and":[24,27,37,45,71,74,84,92,129,132,142,150,190,225,236,240,248,256,272,337,353,396,417,426,432,439,446,455,463,470,484],"Adolescents\u2019":[25,72,130],"Health":[26,73,131],"Ministry":[29,76,134],"Education":[31,78,136],"Key":[32,40,79,87,137,145],"Laboratory":[33,41,80,88,138,146],"Child":[35,43,82,90,140,148],"Development":[36,83,141],"Disorders,":[38,85,143],"Infection":[44,91,149],"Immunity,":[46,93,151],"Chongqing,":[47,101,159],"401122,":[48,102,160],"People\u2019s":[49,103,161],"Republic":[50,104,162],"ChinaCorrespondence:":[52],"Xu,":[54],"No.":[94,152],"20,":[95,153],"Jinyu":[96,154],"Avenue,":[97,155],"Liangjiang":[98,156],"New":[99,157],"District,":[100,158],"China,":[106,164],"Tel":[107,165],"+86-13883589586,":[108],"Email":[109,167],"xuhongm0095@hospital.cqmu.edu.cn":[110],"+86-13308320406,":[166],"928705653@qq.comBackground:":[168],"Significant":[169],"hepatic":[170,507],"injury":[171],"(SHI)":[172],"in":[173,324,333,343,384,495],"children":[174,210,282,386,467,496],"with":[175,211,358,387,441,468,497],"chronic":[176,212,388,498,501],"hepatitis":[177,502],"B":[178,503],"virus":[179,504],"(HBV)":[180],"infection":[181,214],"requires":[182],"timely":[183],"identification,":[184],"yet":[185],"liver":[186,216],"biopsy":[187],"is":[188,404],"invasive":[189],"not":[191],"routinely":[192],"feasible.":[193],"This":[194,205],"study":[195],"aimed":[196],"to":[197,231,270,381],"develop":[198],"a":[199,274,364,372],"non-invasive":[200,373],"predictive":[201,275,374,394],"model":[202,267,297,375,461,482],"SHI.Methods:":[204],"retrospective":[206],"analysis":[207],"included":[208],"treatment-na\u00efve":[209,385],"HBV":[213,389,499],"undergoing":[215],"biopsy.":[217],"Participants":[218],"were":[219,246,254,283],"randomly":[220],"split":[221],"into":[222,406],"70%":[223],"training":[224,326],"30%":[226],"independent":[227,345],"testing":[228,346],"cohorts":[229],"prior":[230],"preprocessing.":[232],"Missing":[233],"data":[234,380,422],"imputation":[235],"least":[237],"absolute":[238],"shrinkage":[239],"selection":[241,245,436,449],"operator":[242],"(LASSO)-based":[243],"feature":[244],"performed,":[247],"nine":[249],"machine":[250],"learning":[251],"(ML)":[252],"models":[253],"developed":[255,371],"optimized":[257],"using":[258,437],"nested":[259],"cross-validation":[260],"(CV).":[261],"The":[262,348],"optimal":[263],"logistic":[264],"regression":[265,292],"(LR)":[266],"was":[268],"used":[269],"construct":[271],"validate":[273],"nomogram.Results:":[276],"A":[277],"total":[278],"246":[280],"eligible":[281],"included,":[284],"whom":[286],"147":[287,466],"(59.8%)":[288],"had":[289],"SHI.":[290],"LASSO":[291,438],"identified":[293],"five":[294],"predictors":[295],"development.":[298],"Among":[299],"the":[300,312,325,334,344],"evaluated":[301],"ML":[302],"models,":[303],"LR":[304,454,460],"showed":[305,350],"stable":[306],"performance,":[307],"achieving":[308],"an":[309],"area":[310],"under":[311],"receiver":[313],"operating":[314],"characteristic":[315],"curve":[316],"(AUC)":[317],"0.799":[319],"(95%":[320,329,339],"CI:":[321,330,340],"0.740\u2013":[322],"0.858)":[323],"folds,":[327,336],"0.781":[328],"0.585\u2013":[331],"0.972)":[332],"validation":[335,433],"0.707":[338],"0.562\u2013":[341],"0.851)":[342],"cohort.":[347],"nomogram":[349,476],"moderate":[351,393],"calibration":[352],"better":[354],"clinical":[355,379,485,490],"utility":[356],"compared":[357],"alanine":[359],"aminotransferase":[360],"(ALT)":[361],"alone":[362],"across":[363],"broad":[365],"range":[366],"threshold":[368],"probabilities.Conclusion:":[369],"We":[370],"based":[376],"on":[377],"routine":[378],"detect":[382],"SHI":[383,469,494],"infection,":[390,505],"which":[391],"exhibited":[392],"power":[395],"marginal":[397],"improvement":[398],"over":[399],"ALT":[400,445],"alone.":[401],"An":[402],"infographic":[403,487],"divided":[405],"four":[407],"parts":[408],"(A\u2013D):":[409],"Data":[411],"Collection,":[412],"Model":[413,415,430,448,479],"Selection,":[414],"Presentation,":[416],"Application.":[419],"A:":[420],"collection":[423],"includes":[424,434,465,481],"demographic":[425],"laboratory":[427],"data.":[428],"B:":[429],"construction":[431,462],"variable":[435],"VIF,":[440],"variables":[442],"such":[443,452],"as":[444,453],"HBeAb.":[447],"features":[450],"classifiers":[451],"RF,":[456],"highlighting":[457],"LR.":[458],"C:":[459],"evaluation":[464,483],"99":[471],"without":[472],"SHI,":[473],"followed":[474],"by":[475],"construction.":[477],"D:":[478],"application":[480],"decision-making.An":[486],"workflow":[488],"prediction":[491,510],"modeling":[492],"infection.Keywords:":[500],"significant":[506],"injury,":[508],"children,":[509]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-06-28T00:00:00"}