{"id":"https://openalex.org/W7166380450","doi":"https://doi.org/10.1002/ccs3.70090","title":"Plasma exosomal miR\u2010339\u20103p promotes myocardial remodeling in chronic heart failure by regulating USP25\u2010mediated DDX58 deubiquitination","display_name":"Plasma exosomal miR\u2010339\u20103p promotes myocardial remodeling in chronic heart failure by regulating USP25\u2010mediated DDX58 deubiquitination","publication_year":2026,"publication_date":"2026-06-26","ids":{"openalex":"https://openalex.org/W7166380450","doi":"https://doi.org/10.1002/ccs3.70090","pmid":"https://pubmed.ncbi.nlm.nih.gov/42367596"},"language":"en","primary_location":{"id":"doi:10.1002/ccs3.70090","doi":"https://doi.org/10.1002/ccs3.70090","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ccs3.70090","pdf_url":null,"source":{"id":"https://openalex.org/S40198776","display_name":"Journal of Cell Communication and Signaling","issn_l":"1873-9601","issn":["1873-9601","1873-961X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Communication and Signaling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1002/ccs3.70090","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057257683","display_name":"Guoqiang Jing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44673925","display_name":"Inner Mongolia Medical University","ror":"https://ror.org/01mtxmr84","country_code":"CN","type":"funder","lineage":["https://openalex.org/I44673925"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoqiang Jing","raw_affiliation_strings":["Department of Cardiology Affiliated Hospital of Inner Mongolia Medical University  Hohhot China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology Affiliated Hospital of Inner Mongolia Medical University  Hohhot China","institution_ids":["https://openalex.org/I44673925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081207491","display_name":"Ting Xu","orcid":"https://orcid.org/0000-0002-1381-1609","observed_orcids":["https://orcid.org/0000-0002-1381-1609","https://orcid.org/0009-0000-4134-9805"]},"institutions":[{"id":"https://openalex.org/I44673925","display_name":"Inner Mongolia Medical University","ror":"https://ror.org/01mtxmr84","country_code":"CN","type":"funder","lineage":["https://openalex.org/I44673925"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Xu","raw_affiliation_strings":["Inner Mongolia Medical University  Hohhot China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia Medical University  Hohhot China","institution_ids":["https://openalex.org/I44673925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103152289","display_name":"Yuhong Ma","orcid":"https://orcid.org/0009-0008-3883-9211","observed_orcids":["https://orcid.org/0009-0008-3883-9211","https://orcid.org/0000-0002-0134-3481"]},"institutions":[{"id":"https://openalex.org/I44673925","display_name":"Inner Mongolia Medical University","ror":"https://ror.org/01mtxmr84","country_code":"CN","type":"funder","lineage":["https://openalex.org/I44673925"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuhong Ma","raw_affiliation_strings":["Department of General Practice Affiliated Hospital of Inner Mongolia Medical University  Hohhot China"],"raw_orcid":"https://orcid.org/0009-0008-3883-9211","affiliations":[{"raw_affiliation_string":"Department of General Practice Affiliated Hospital of Inner Mongolia Medical University  Hohhot China","institution_ids":["https://openalex.org/I44673925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103152289"],"corresponding_institution_ids":["https://openalex.org/I44673925"],"apc_list":{"value":2860,"currency":"USD","value_usd":2860},"apc_paid":{"value":2860,"currency":"USD","value_usd":2860},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42205711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"3","first_page":"e70090","last_page":"e70090"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8457000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8457000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.10649999976158142,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-339-3p","display_name":"miR-339-3p","score":0.9850000143051147},{"id":"https://openalex.org/keywords/plasma-exosomes","display_name":"plasma exosomes","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.8190000057220459},{"id":"https://openalex.org/keywords/chronic-heart-failure","display_name":"chronic heart failure","score":1.0},{"id":"https://openalex.org/keywords/usp25","display_name":"USP25","score":0.996999979019165},{"id":"https://openalex.org/keywords/rig-i","display_name":"RIG-I","score":0.9940000176429749},{"id":"https://openalex.org/keywords/deubiquitination","display_name":"deubiquitination","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cardiomyocyte-injury","display_name":"cardiomyocyte injury","score":0.8460000157356262},{"id":"https://openalex.org/keywords/exosomal-mirna","display_name":"exosomal microRNAs","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cardiomyocyte-hypertrophy","display_name":"cardiomyocyte hypertrophy","score":0.7739999890327454},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.6460000276565552},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.7699999809265137},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.7390000224113464},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6177999973297119},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5928999781608582},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5834000110626221},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5767999887466431},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5698000192642212},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5034000277519226},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4699000120162964},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4659999907016754},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43459999561309814},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.42969998717308044},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.40220001339912415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39250001311302185},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.38260000944137573},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3165000081062317},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.2904999852180481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2842000126838684},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2797999978065491},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2766000032424927},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.27250000834465027},{"id":"https://openalex.org/C2778630268","wikidata":"https://www.wikidata.org/wiki/Q17113277","display_name":"Cell sorting","level":3,"score":0.2662999927997589},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2644999921321869},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.26269999146461487},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.2581999897956848},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.2556000053882599}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/ccs3.70090","doi":"https://doi.org/10.1002/ccs3.70090","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ccs3.70090","pdf_url":null,"source":{"id":"https://openalex.org/S40198776","display_name":"Journal of Cell Communication and Signaling","issn_l":"1873-9601","issn":["1873-9601","1873-961X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Communication and Signaling","raw_type":"journal-article"},{"id":"pmid:42367596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42367596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell communication and signaling","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13309614","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13309614/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Cell Commun Signal","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/ccs3.70090","doi":"https://doi.org/10.1002/ccs3.70090","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ccs3.70090","pdf_url":null,"source":{"id":"https://openalex.org/S40198776","display_name":"Journal of Cell Communication and Signaling","issn_l":"1873-9601","issn":["1873-9601","1873-961X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Communication and Signaling","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7850116491317749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W2047822292","https://openalex.org/W2955062002","https://openalex.org/W3082232720","https://openalex.org/W3159080725","https://openalex.org/W3159390200","https://openalex.org/W3167208319","https://openalex.org/W3210351483","https://openalex.org/W3215489203","https://openalex.org/W4206545192","https://openalex.org/W4220851749","https://openalex.org/W4283375385","https://openalex.org/W4315629210","https://openalex.org/W4318755017","https://openalex.org/W4318939628","https://openalex.org/W4375955530","https://openalex.org/W4385666855","https://openalex.org/W4385897412","https://openalex.org/W4387241723","https://openalex.org/W4410014075"],"related_works":[],"abstract_inverted_index":{"To":[0],"explore":[1],"the":[2,68,113,118,172,186,195],"mechanism":[3],"by":[4,33,99,142,165],"which":[5],"plasma":[6],"exosome":[7,178],"miR-339-3p":[8,136,144,179],"regulates":[9],"myocardial":[10,162,181],"remodeling":[11,182],"in":[12,183],"heart":[13],"failure":[14],"(HF).":[15],"Plasma":[16,177],"exosomes":[17],"were":[18,58,124],"isolated":[19],"from":[20],"5":[21,26],"patients":[22],"with":[23],"HF":[24,184],"and":[25,28,39,55,64,85,104,122,151,167,189,197],"controls,":[27],"cell":[29,49,62],"uptake":[30],"was":[31,74,88],"determined":[32],"transmission":[34],"electron":[35],"microscopy,":[36],"western":[37],"blot":[38],"PKH26":[40],"labeling.":[41],"Angiotensin":[42],"II":[43],"treated":[44],"AC16":[45],"cells":[46],"to":[47,60,66,79,90,126],"induce":[48],"hypertrophy.":[50],"Cell":[51],"counting":[52],"kit-8":[53],"assay":[54,103],"flow":[56],"cytometry":[57],"used":[59,89,125],"detect":[61],"viability":[63],"apoptosis":[65],"evaluate":[67],"effect":[69,174],"of":[70,115,135,158,175,199],"HF-exo.":[71,143],"High-throughput":[72],"sequencing":[73],"performed":[75],"on":[76],"exosomal":[77],"microRNAs":[78],"identify":[80],"key":[81],"differential":[82],"mirnas":[83],"(miR-339-3p),":[84],"database":[86],"screening":[87],"verify":[91],"downstream":[92],"target":[93,193],"proteins":[94,129],"ubiquitin-specific":[95],"protease":[96],"25":[97],"(USP25)":[98],"dual-luciferase":[100],"reporter":[101],"gene":[102],"reverse":[105,161],"transcription-quantitative":[106],"polymerase":[107],"chain":[108],"reaction/western":[109],"blot.":[110],"Searchtool":[111],"for":[112,194],"retrieval":[114],"interacting":[116],"genes,":[117],"Cancer":[119],"Genome":[120],"Atlas":[121],"co-immunoprecipitation":[123],"screen":[127],"USP25-interacting":[128],"(DDX58).":[130],"Analysis":[131],"revealed":[132],"that":[133],"inhibition":[134],"completely":[137],"reversed":[138],"cardiomyocyte":[139],"injury":[140,163],"induced":[141,164],"directly":[145],"targets":[146],"USP25,":[147],"down-regulates":[148],"its":[149,153],"expression,":[150],"impairs":[152],"K48-related":[154],"DDX58":[155,168],"deubiquitination.":[156],"Overexpression":[157],"USP25":[159],"can":[160,170],"mir-339-3p,":[166],"silencing":[169],"eliminate":[171],"protective":[173],"USP25.":[176],"promotes":[180],"through":[185],"miR-339-3p-USP25-DDX58":[187],"axis":[188],"is":[190],"a":[191],"potential":[192],"diagnosis":[196],"treatment":[198],"HF.":[200]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2026-06-28T00:00:00"}