{"id":"https://openalex.org/W7166375932","doi":"https://doi.org/10.1080/14786419.2026.2694735","title":"Phytochemical profiling and antimelanoma activity of Balinese mace oleoresin with computational insights into BRAF inhibition","display_name":"Phytochemical profiling and antimelanoma activity of Balinese mace oleoresin with computational insights into BRAF inhibition","publication_year":2026,"publication_date":"2026-06-27","ids":{"openalex":"https://openalex.org/W7166375932","doi":"https://doi.org/10.1080/14786419.2026.2694735","pmid":"https://pubmed.ncbi.nlm.nih.gov/42364238"},"language":"en","primary_location":{"id":"doi:10.1080/14786419.2026.2694735","doi":"https://doi.org/10.1080/14786419.2026.2694735","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14786419.2026.2694735","pdf_url":null,"source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068120150","display_name":"Rini Retnosari","orcid":"https://orcid.org/0000-0001-7815-768X","observed_orcids":["https://orcid.org/0000-0001-7815-768X"]},"institutions":[{"id":"https://openalex.org/I102893293","display_name":"State University of Malang","ror":"https://ror.org/00ypgyy34","country_code":"ID","type":"education","lineage":["https://openalex.org/I102893293"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Rini Retnosari","raw_affiliation_strings":["Department of Chemistry, Universitas Negeri Malang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Universitas Negeri Malang","institution_ids":["https://openalex.org/I102893293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021446203","display_name":"I Wayan Mudianta","orcid":"https://orcid.org/0000-0002-0388-3828","observed_orcids":["https://orcid.org/0000-0002-0388-3828","https://orcid.org/0000-0002-7219-9819","https://orcid.org/0000-0002-5850-6691"]},"institutions":[{"id":"https://openalex.org/I4210090826","display_name":"Universitas Pendidikan Ganesha","ror":"https://ror.org/00bmjd793","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210090826"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"I Wayan Mudianta","raw_affiliation_strings":["Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pendidikan Ganesha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pendidikan Ganesha","institution_ids":["https://openalex.org/I4210090826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058002313","display_name":"Galih Satrio Putra","orcid":"https://orcid.org/0000-0003-4192-3621","observed_orcids":["https://orcid.org/0000-0003-4192-3621"]},"institutions":[{"id":"https://openalex.org/I102893293","display_name":"State University of Malang","ror":"https://ror.org/00ypgyy34","country_code":"ID","type":"education","lineage":["https://openalex.org/I102893293"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["ID","JP"],"is_corresponding":false,"raw_author_name":"Galih Satrio Putra","raw_affiliation_strings":["Department of Chemistry, Universitas Negeri Malang","Graduate School of Engineering Science, The University of Osaka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Universitas Negeri Malang","institution_ids":["https://openalex.org/I102893293"]},{"raw_affiliation_string":"Graduate School of Engineering Science, The University of Osaka","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139501526","display_name":"Riri Jonuarti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I245308123","display_name":"State University of Padang","ror":"https://ror.org/04jrfgq66","country_code":"ID","type":"education","lineage":["https://openalex.org/I245308123"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Riri Jonuarti","raw_affiliation_strings":["Department of Physics, Universitas Negeri Padang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Universitas Negeri Padang","institution_ids":["https://openalex.org/I245308123"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004718073","display_name":"Jalifah Latip","orcid":"https://orcid.org/0000-0002-9214-1251","observed_orcids":["https://orcid.org/0000-0002-9214-1251"]},"institutions":[{"id":"https://openalex.org/I102893293","display_name":"State University of Malang","ror":"https://ror.org/00ypgyy34","country_code":"ID","type":"education","lineage":["https://openalex.org/I102893293"]},{"id":"https://openalex.org/I885383172","display_name":"National University of Malaysia","ror":"https://ror.org/00bw8d226","country_code":"MY","type":"education","lineage":["https://openalex.org/I885383172"]}],"countries":["ID","MY"],"is_corresponding":false,"raw_author_name":"Jalifah Latip","raw_affiliation_strings":["Department of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia","Department of Chemistry, Universitas Negeri Malang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia","institution_ids":["https://openalex.org/I885383172"]},{"raw_affiliation_string":"Department of Chemistry, Universitas Negeri Malang","institution_ids":["https://openalex.org/I102893293"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5068120150"],"corresponding_institution_ids":["https://openalex.org/I102893293"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39866074,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.2632000148296356,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.2632000148296356,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.210099995136261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.18870000541210175,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nutmeg","display_name":"nutmeg","score":0.8920000195503235},{"id":"https://openalex.org/keywords/phytochemical-profiling","display_name":"phytochemical profiling","score":0.8320000171661377},{"id":"https://openalex.org/keywords/anti-melanoma-activity","display_name":"anti-melanoma activity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6740000247955322},{"id":"https://openalex.org/keywords/phenylpropanoids","display_name":"phenylpropanoids","score":0.8970000147819519},{"id":"https://openalex.org/keywords/neolignans","display_name":"neolignans","score":0.9729999899864197},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6299999952316284},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.878000020980835}],"concepts":[{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.7768999934196472},{"id":"https://openalex.org/C2780739214","wikidata":"https://www.wikidata.org/wiki/Q6723023","display_name":"Mace","level":4,"score":0.5669999718666077},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5138999819755554},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.446399986743927},{"id":"https://openalex.org/C2780577018","wikidata":"https://www.wikidata.org/wiki/Q2019407","display_name":"Oleoresin","level":2,"score":0.4399999976158142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4189999997615814},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36160001158714294},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3513999879360199},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31949999928474426},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2838999927043915},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27489998936653137}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/14786419.2026.2694735","doi":"https://doi.org/10.1080/14786419.2026.2694735","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14786419.2026.2694735","pdf_url":null,"source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},{"id":"pmid:42364238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42364238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural product research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.7098260521888733,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4919169696","display_name":null,"funder_award_id":"8.4.16/UN32.14.1/LT/2025","funder_id":"https://openalex.org/F4320329008","funder_display_name":"Universitas Negeri Malang"}],"funders":[{"id":"https://openalex.org/F4320329008","display_name":"Universitas Negeri Malang","ror":"https://ror.org/00ypgyy34"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2128542677","https://openalex.org/W2503346074","https://openalex.org/W2535800021","https://openalex.org/W2762842128","https://openalex.org/W2897455122","https://openalex.org/W3000045466","https://openalex.org/W3081667723","https://openalex.org/W3105421847","https://openalex.org/W3133742788","https://openalex.org/W3135630801","https://openalex.org/W3188220581","https://openalex.org/W3204319669","https://openalex.org/W4388572813","https://openalex.org/W4391680678","https://openalex.org/W4406851420"],"related_works":[],"abstract_inverted_index":{"The":[0,56],"chemical":[1],"composition":[2],"and":[3,21,35,72,86,112],"antimelanoma":[4],"activity":[5,58],"of":[6,28,109],"Balinese":[7],"mace":[8,110],"(Myristica":[9],"fragrans)":[10],"oleoresin":[11,15,111],"were":[12],"investigated.":[13],"Ethanolic":[14],"(OL3)":[16],"was":[17],"analysed":[18],"by":[19,52],"GC-MS":[20],"LC-HRMS,":[22],"leading":[23],"to":[24],"the":[25,68,93],"tentative":[26],"identification":[27],"84":[29],"metabolites,":[30],"mainly":[31],"phenylpropanoids,":[32],"diphenylalkanes,":[33],"neolignans,":[34],"fatty":[36],"acid":[37],"esters.":[38],"OL3":[39],"exhibited":[40],"dose-dependent":[41],"cytotoxicity":[42],"against":[43,77],"B16-F0":[44],"melanoma":[45],"cells":[46],"(IC50":[47],"=":[48],"282.80":[49],"ppm),":[50],"characterised":[51],"apoptotic":[53],"morphological":[54],"features.":[55],"observed":[57],"may":[59,89],"result":[60],"from":[61],"synergistic":[62],"interactions":[63],"among":[64],"multiple":[65],"constituents":[66,108],"within":[67],"oleoresin.":[69],"Molecular":[70],"docking":[71],"100-ns":[73],"molecular":[74],"dynamics":[75],"simulations":[76],"BRAF":[78],"kinase":[79],"(PDB:":[80],"6V34)":[81],"suggested":[82],"that":[83],"Myfracone":[84,87],"A":[85],"G":[88],"interact":[90],"stably":[91],"with":[92],"target":[94],"protein":[95],"(RMSD":[96],"<":[97],"3":[98],"\u00c5).":[99],"These":[100],"findings":[101],"provide":[102],"preliminary":[103],"insight":[104],"into":[105],"potential":[106],"bioactive":[107],"support":[113],"further":[114],"bioactivity-guided":[115],"investigation.":[116]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-06-28T00:00:00"}
