{"id":"https://openalex.org/W7166350965","doi":"https://doi.org/10.1186/s12967-026-08503-5","title":"Navigating AI and machine learning in cancer research: an end-to-end translational framework","display_name":"Navigating AI and machine learning in cancer research: an end-to-end translational framework","publication_year":2026,"publication_date":"2026-06-27","ids":{"openalex":"https://openalex.org/W7166350965","doi":"https://doi.org/10.1186/s12967-026-08503-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/42365374"},"language":"en","primary_location":{"id":"doi:10.1186/s12967-026-08503-5","doi":"https://doi.org/10.1186/s12967-026-08503-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-026-08503-5","pdf_url":null,"source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12967-026-08503-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5139469261","display_name":"Shalini Saha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]},{"id":"https://openalex.org/I4405270214","display_name":"JSS College of Pharmacy","ror":"https://ror.org/008jjc835","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405270214"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shalini Saha","raw_affiliation_strings":["Pharmaceutical Analysis, JSS College of Pharmacy, Mysore, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Analysis, JSS College of Pharmacy, Mysore, Karnataka, India","institution_ids":["https://openalex.org/I126824641","https://openalex.org/I4405270214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033686558","display_name":"Md Saif Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162827531","display_name":"Indian Institute of Technology Bombay","ror":"https://ror.org/02qyf5152","country_code":"IN","type":"education","lineage":["https://openalex.org/I162827531"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Md Saif Ali","raw_affiliation_strings":["Centre for Systems and Control, Indian Institute of Technology Bombay, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Systems and Control, Indian Institute of Technology Bombay, Mumbai, India","institution_ids":["https://openalex.org/I162827531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110742934","display_name":"Anand Kumar Tengli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]},{"id":"https://openalex.org/I4405270214","display_name":"JSS College of Pharmacy","ror":"https://ror.org/008jjc835","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405270214"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anand Kumar Tengli","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, JSS College of Pharmacy and JSS Academy of Higher Education and Research, Mysuru, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, JSS College of Pharmacy and JSS Academy of Higher Education and Research, Mysuru, India","institution_ids":["https://openalex.org/I126824641","https://openalex.org/I4405270214"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sankeerthana Renuka Prasad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sankeerthana Renuka Prasad","raw_affiliation_strings":["University Sophisticated Instrumentation Center (USIC), JSS Academy of Higher Education and Research (JSS AHER), Mysuru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Sophisticated Instrumentation Center (USIC), JSS Academy of Higher Education and Research (JSS AHER), Mysuru, Karnataka, India","institution_ids":["https://openalex.org/I126824641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139498186","display_name":"Pramod Mallikarjunaswamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pramod Mallikarjunaswamy","raw_affiliation_strings":["Division of Biochemistry, School of Life Sciences, JSS Academy of Higher Education and Research (JSS AHER), Mysuru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, School of Life Sciences, JSS Academy of Higher Education and Research (JSS AHER), Mysuru, Karnataka, India","institution_ids":["https://openalex.org/I126824641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039552597","display_name":"Ramkumar Pillappan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1333540553","display_name":"Nitte University","ror":"https://ror.org/029nydt37","country_code":"IN","type":"education","lineage":["https://openalex.org/I1333540553"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ramkumar Pillappan","raw_affiliation_strings":["NGSM Institute of Pharmaceutical Sciences (NGSMIPS), NITTE (Deemed to be University), Mangalore, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NGSM Institute of Pharmaceutical Sciences (NGSMIPS), NITTE (Deemed to be University), Mangalore, Karnataka, India","institution_ids":["https://openalex.org/I1333540553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026802182","display_name":"Komal Kumar Javarappa","orcid":"https://orcid.org/0000-0001-7750-167X","observed_orcids":["https://orcid.org/0000-0001-7750-167X"]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Komal Kumar Javarappa","raw_affiliation_strings":["University Sophisticated Instrumentation Center (USIC), JSS Academy of Higher Education and Research (JSS AHER), Mysuru, Karnataka, India. komalkumar@jssuni.edu.in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Sophisticated Instrumentation Center (USIC), JSS Academy of Higher Education and Research (JSS AHER), Mysuru, Karnataka, India. komalkumar@jssuni.edu.in","institution_ids":["https://openalex.org/I126824641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5026802182"],"corresponding_institution_ids":["https://openalex.org/I126824641"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":1.8469,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.88264204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"24","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.3334999978542328,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.8199999928474426},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.8429999947547913},{"id":"https://openalex.org/keywords/explainable-ai","display_name":"explainable AI","score":0.9210000038146973},{"id":"https://openalex.org/keywords/federated-learning","display_name":"federated learning","score":1.0},{"id":"https://openalex.org/keywords/algorithmic-bias","display_name":"algorithmic bias","score":0.9570000171661377},{"id":"https://openalex.org/keywords/clinical-decision-support","display_name":"clinical decision support","score":0.9449999928474426},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.9259999990463257},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.8889999985694885},{"id":"https://openalex.org/keywords/external-validation","display_name":"external validation","score":0.703000009059906},{"id":"https://openalex.org/keywords/decision-curve-analysis","display_name":"decision curve analysis","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.7638999819755554},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7293000221252441},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6826000213623047},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.6359999775886536},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4514999985694885},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.44119998812675476},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.4332999885082245},{"id":"https://openalex.org/C63527458","wikidata":"https://www.wikidata.org/wiki/Q5133829","display_name":"Clinical decision support system","level":3,"score":0.40790000557899475},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3833000063896179},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.36169999837875366},{"id":"https://openalex.org/C84525736","wikidata":"https://www.wikidata.org/wiki/Q831366","display_name":"Decision tree","level":2,"score":0.3431999981403351},{"id":"https://openalex.org/C157170001","wikidata":"https://www.wikidata.org/wiki/Q4781507","display_name":"Applications of artificial intelligence","level":2,"score":0.3102000057697296},{"id":"https://openalex.org/C75684735","wikidata":"https://www.wikidata.org/wiki/Q858810","display_name":"Big data","level":2,"score":0.30720001459121704},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.30379998683929443},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.30079999566078186},{"id":"https://openalex.org/C2989179672","wikidata":"https://www.wikidata.org/wiki/Q6806500","display_name":"Clinical decision making","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.2793999910354614},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.2702000141143799},{"id":"https://openalex.org/C107327155","wikidata":"https://www.wikidata.org/wiki/Q330268","display_name":"Decision support system","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C34585555","wikidata":"https://www.wikidata.org/wiki/Q1368723","display_name":"Learning curve","level":2,"score":0.2612000107765198},{"id":"https://openalex.org/C2779965156","wikidata":"https://www.wikidata.org/wiki/Q5227350","display_name":"Data sharing","level":3,"score":0.2612000107765198},{"id":"https://openalex.org/C57634137","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational science","level":2,"score":0.26100000739097595},{"id":"https://openalex.org/C2779019669","wikidata":"https://www.wikidata.org/wiki/Q25203946","display_name":"Asynchrony (computer programming)","level":3,"score":0.2551000118255615}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000098407","descriptor_name":"Federated Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098407","descriptor_name":"Federated Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098407","descriptor_name":"Federated Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098407","descriptor_name":"Federated Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098407","descriptor_name":"Federated Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098407","descriptor_name":"Federated Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098407","descriptor_name":"Federated Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098407","descriptor_name":"Federated Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098971","descriptor_name":"Data Analytics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098971","descriptor_name":"Data Analytics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098971","descriptor_name":"Data Analytics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098971","descriptor_name":"Data Analytics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098971","descriptor_name":"Data Analytics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098971","descriptor_name":"Data Analytics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098971","descriptor_name":"Data Analytics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098971","descriptor_name":"Data Analytics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12967-026-08503-5","doi":"https://doi.org/10.1186/s12967-026-08503-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-026-08503-5","pdf_url":null,"source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},{"id":"pmid:42365374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42365374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13312705","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42365374/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13312705/pdf/12967_2026_Article_8503.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Transl Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:60c1a5eacfac497bb6b354565dc93165","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/60c1a5eacfac497bb6b354565dc93165","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Translational Medicine, Vol 24, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12967-026-08503-5","doi":"https://doi.org/10.1186/s12967-026-08503-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-026-08503-5","pdf_url":null,"source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/16","display_name":"Peace, justice, and strong institutions","score":0.4254750907421112}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319237","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W1966716734","https://openalex.org/W1985046983","https://openalex.org/W1986187671","https://openalex.org/W1997212925","https://openalex.org/W2016559074","https://openalex.org/W2096192437","https://openalex.org/W2107665951","https://openalex.org/W2111547563","https://openalex.org/W2133169850","https://openalex.org/W2139132031","https://openalex.org/W2157076315","https://openalex.org/W2162755712","https://openalex.org/W2226880313","https://openalex.org/W2276530525","https://openalex.org/W2532031923","https://openalex.org/W2592929672","https://openalex.org/W2622068151","https://openalex.org/W2783063799","https://openalex.org/W2808845633","https://openalex.org/W2884561390","https://openalex.org/W2889905270","https://openalex.org/W2897620540","https://openalex.org/W2901139514","https://openalex.org/W2905810301","https://openalex.org/W2908201961","https://openalex.org/W2912213068","https://openalex.org/W2924551358","https://openalex.org/W2929028679","https://openalex.org/W2934399013","https://openalex.org/W2937307539","https://openalex.org/W2949358505","https://openalex.org/W2951209146","https://openalex.org/W2953532875","https://openalex.org/W2958089299","https://openalex.org/W2963232127","https://openalex.org/W2963981733","https://openalex.org/W2969628488","https://openalex.org/W2969881216","https://openalex.org/W2974817986","https://openalex.org/W2977262858","https://openalex.org/W2981869278","https://openalex.org/W2982580298","https://openalex.org/W2999309192","https://openalex.org/W3003189162","https://openalex.org/W3012501605","https://openalex.org/W3012875567","https://openalex.org/W3021654819","https://openalex.org/W3027051073","https://openalex.org/W3035339515","https://openalex.org/W3042276730","https://openalex.org/W3086667591","https://openalex.org/W3088521497","https://openalex.org/W3109650690","https://openalex.org/W3119527628","https://openalex.org/W3130794141","https://openalex.org/W3136907493","https://openalex.org/W3140760072","https://openalex.org/W3146345129","https://openalex.org/W3158064698","https://openalex.org/W3159175200","https://openalex.org/W3173875945","https://openalex.org/W3174786846","https://openalex.org/W3177617320","https://openalex.org/W3199772305","https://openalex.org/W3201352722","https://openalex.org/W3205594709","https://openalex.org/W4200191097","https://openalex.org/W4205164650","https://openalex.org/W4206042814","https://openalex.org/W4221106857","https://openalex.org/W4254096656","https://openalex.org/W4254278957","https://openalex.org/W4280488363","https://openalex.org/W4294636450","https://openalex.org/W4304014045","https://openalex.org/W4310852955","https://openalex.org/W4313585268","https://openalex.org/W4315436138","https://openalex.org/W4318425737","https://openalex.org/W4367836687","https://openalex.org/W4377967200","https://openalex.org/W4384071683","https://openalex.org/W4386387831","https://openalex.org/W4387457231","https://openalex.org/W4388719480","https://openalex.org/W4389816744","https://openalex.org/W4393935425","https://openalex.org/W4396780322","https://openalex.org/W4398781315","https://openalex.org/W4399781535","https://openalex.org/W4401083226","https://openalex.org/W4403107764","https://openalex.org/W4408135106","https://openalex.org/W4410768669","https://openalex.org/W4411116068","https://openalex.org/W4415411727","https://openalex.org/W7126205519","https://openalex.org/W7155104341"],"related_works":[],"abstract_inverted_index":{"Cancer":[0],"is":[1,8],"a":[2,29,67,137],"complex":[3],"and":[4,56,83,93,110,122,128,153,166],"heterogeneous":[5],"disease":[6],"that":[7,145],"characterized":[9],"by":[10,132],"multi-level":[11],"biological":[12],"variability.":[13],"Advances":[14],"in":[15,25,74,148],"high-throughput":[16],"technologies":[17],"have":[18],"led":[19],"to":[20],"large-scale,":[21],"high-dimensional":[22],"data":[23,38,62,91],"sets":[24],"cancer":[26,75],"research,":[27,76,79],"creating":[28],"pressing":[30],"need":[31],"for":[32,36,45,60,70],"powerful":[33],"computational":[34],"techniques":[35,41],"successful":[37,61],"analysis.":[39,63],"Current":[40],"may":[42],"be":[43],"inadequate":[44],"this":[46,141],"purpose,":[47],"thus":[48],"underscoring":[49],"the":[50],"potential":[51],"of":[52,171],"artificial":[53,71],"intelligence":[54],"(AI)":[55],"machine":[57,104],"learning":[58,73],"(ML)":[59],"This":[64],"review":[65,97],"provides":[66],"comprehensive":[68],"pipeline":[69],"intelligence/machine":[72],"including":[77,117],"preclinical":[78],"clinical":[80,138],"decision":[81],"support,":[82],"real-world":[84,173],"implementation.":[85],"It":[86],"emphasizes":[87],"several":[88],"important":[89],"technologies,":[90],"integration,":[92],"implementation":[94],"challenges.":[95],"The":[96],"critically":[98],"examines":[99],"multi-omics":[100],"fusion":[101],"architectures,":[102],"regularization-based":[103],"learning,":[105,112],"batch-effect":[106],"harmonization,":[107],"explainable":[108],"AI,":[109],"federated":[111],"while":[113],"addressing":[114],"translational":[115],"barriers":[116],"algorithmic":[118],"bias,":[119],"covariate":[120],"drift,":[121],"regulatory":[123],"asynchrony":[124],"across":[125],"Indian,":[126],"US,":[127],"EU":[129],"frameworks.":[130],"Anchored":[131],"Decision":[133],"Curve":[134],"Analysis":[135],"as":[136],"utility":[139],"benchmark,":[140],"narrative":[142],"framework":[143],"establishes":[144],"meaningful":[146],"progress":[147],"precision":[149],"oncology,":[150],"early":[151],"detection,":[152],"patient":[154],"outcomes":[155],"demands":[156],"not":[157],"only":[158],"predictive":[159],"accuracy":[160],"but":[161],"also":[162],"externally":[163],"validated,":[164],"population-representative,":[165],"governance-compliant":[167],"AI":[168],"systems":[169],"capable":[170],"sustained":[172],"oncology":[174],"impact.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-06-28T00:00:00"}