{"id":"https://openalex.org/W7166350524","doi":"https://doi.org/10.1038/s41598-026-59203-5","title":"Computational analysis of thrombosis risk in a patient with left ventricular assist device","display_name":"Computational analysis of thrombosis risk in a patient with left ventricular assist device","publication_year":2026,"publication_date":"2026-06-28","ids":{"openalex":"https://openalex.org/W7166350524","doi":"https://doi.org/10.1038/s41598-026-59203-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/42365070"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-59203-5","doi":"https://doi.org/10.1038/s41598-026-59203-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-59203-5","pdf_url":"https://www.nature.com/articles/s41598-026-59203-5_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-59203-5_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064333139","display_name":"Zhe Gou","orcid":"https://orcid.org/0000-0003-2725-8696","observed_orcids":["https://orcid.org/0000-0003-2725-8696"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Gou","raw_affiliation_strings":["College of Mechanical and Electrical Engineering, Central South University, Changsha, China","Hunan Engineering Research Center of Digital Heart, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Mechanical and Electrical Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Hunan Engineering Research Center of Digital Heart, Changsha, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shijun Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijun Hu","raw_affiliation_strings":["Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China","Hunan Engineering Research Center of Digital Heart, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Engineering Research Center of Digital Heart, Changsha, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139487419","display_name":"Yagang Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yagang Wu","raw_affiliation_strings":["Hunan Engineering Research Center of Digital Heart, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Engineering Research Center of Digital Heart, Changsha, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139469573","display_name":"Li Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Xie","raw_affiliation_strings":["Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China","Hunan Engineering Research Center of Digital Heart, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Engineering Research Center of Digital Heart, Changsha, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101501062","display_name":"Yongyi Wang","orcid":"https://orcid.org/0009-0009-1330-4971","observed_orcids":["https://orcid.org/0009-0009-1330-4971","https://orcid.org/0000-0003-0297-8232"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongyi Wang","raw_affiliation_strings":["Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China","Hunan Engineering Research Center of Digital Heart, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Engineering Research Center of Digital Heart, Changsha, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153267309","display_name":"Yaqi Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaqi Peng","raw_affiliation_strings":["Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China","Hunan Engineering Research Center of Digital Heart, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Engineering Research Center of Digital Heart, Changsha, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035601780","display_name":"Tianli Zhao","orcid":"https://orcid.org/0000-0002-8708-6761","observed_orcids":["https://orcid.org/0000-0002-8708-6761"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tianli Zhao","raw_affiliation_strings":["Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China. zhaotianli@csu.edu.cn","Hunan Engineering Research Center of Digital Heart, Changsha, China. zhaotianli@csu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China. zhaotianli@csu.edu.cn","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856"]},{"raw_affiliation_string":"Hunan Engineering Research Center of Digital Heart, Changsha, China. zhaotianli@csu.edu.cn","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035601780"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38130275,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/left-ventricular-assist-device","display_name":"left ventricular assist device","score":1.0},{"id":"https://openalex.org/keywords/thrombotic-risk","display_name":"thrombosis risk","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.8199999928474426},{"id":"https://openalex.org/keywords/wall-shear-stress","display_name":"wall shear stress","score":0.9869999885559082},{"id":"https://openalex.org/keywords/patient-specific-modeling","display_name":"patient-specific modeling","score":0.4790000021457672},{"id":"https://openalex.org/keywords/aortic-root","display_name":"aortic root","score":0.5450000166893005},{"id":"https://openalex.org/keywords/outflow-graft","display_name":"outflow graft","score":0.9409999847412109},{"id":"https://openalex.org/keywords/inflow-cannula","display_name":"inflow cannula","score":0.9729999899864197},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8029999732971191},{"id":"https://openalex.org/keywords/surgical-planning","display_name":"surgical planning","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7738999724388123},{"id":"https://openalex.org/C2778774980","wikidata":"https://www.wikidata.org/wiki/Q2897721","display_name":"Ventricular assist device","level":3,"score":0.7605999708175659},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.671500027179718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6158999800682068},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.5182999968528748},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.37950000166893005},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.34279999136924744},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.321399986743927},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.32019999623298645},{"id":"https://openalex.org/C71472368","wikidata":"https://www.wikidata.org/wiki/Q676880","display_name":"Text mining","level":2,"score":0.2757999897003174}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1038/s41598-026-59203-5","doi":"https://doi.org/10.1038/s41598-026-59203-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-59203-5","pdf_url":"https://www.nature.com/articles/s41598-026-59203-5_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:42365070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42365070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:dd938f3157784953b254acc10e2d780a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/dd938f3157784953b254acc10e2d780a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-59203-5","doi":"https://doi.org/10.1038/s41598-026-59203-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-59203-5","pdf_url":"https://www.nature.com/articles/s41598-026-59203-5_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6488007991","display_name":null,"funder_award_id":"52175263","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321514","display_name":"Central South University","ror":"https://ror.org/00f1zfq44"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7166350524.pdf","grobid_xml":"https://content.openalex.org/works/W7166350524.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Left":[0],"ventricular":[1],"assist":[2],"device":[3],"(LVAD)":[4],"implantation":[5,70],"has":[6],"become":[7],"an":[8],"important":[9],"treatment":[10],"for":[11,184],"heart":[12],"failure":[13],"patients.":[14],"However,":[15,155],"adverse":[16],"events":[17],"related":[18,61],"to":[19,36,62,74,152],"thrombosis":[20,45,54,104,136,157],"remain":[21],"severe":[22],"problems":[23],"after":[24],"LVAD":[25,41,72,133],"implantation.":[26],"In":[27],"this":[28],"study,":[29],"we":[30],"propose":[31],"a":[32,48,102],"novel":[33],"numerical":[34],"framework":[35],"evaluate":[37],"the":[38,78,84,90,98,113,116,121,124,128,135,139,142,146,156,160,164],"impact":[39],"of":[40,53,71,123,141],"on":[42,47],"hemodynamics":[43],"and":[44,66,93,120,127,145,163,187],"risk":[46,105,137,158],"patient-specific":[49],"level.":[50],"Potential":[51],"locations":[52,109],"are":[55],"identified":[56],"using":[57],"several":[58],"hemodynamic":[59],"indicators":[60],"wall":[63,177],"shear":[64,178],"stress":[65],"flow":[67],"velocity.":[68],"The":[69],"leads":[73],"reduced":[75,150],"washout":[76],"in":[77,83,89,97,106,190],"left":[79,129,147],"ventricle,":[80],"enhanced":[81,153,173],"recirculation":[82,174],"aorta,":[85],"large":[86],"velocity":[87,95],"gradients":[88],"inflow":[91,125,143],"cannula,":[92],"irregular":[94],"profiles":[96],"outflow":[99,118,166],"graft.":[100],"As":[101],"consequence,":[103],"three":[107],"typical":[108],"is":[110,149,168],"increased,":[111,169],"including":[112],"aortic":[114,161],"root,":[115],"curved":[117,165],"graft,":[119],"junction":[122,140],"cannula":[126,144],"ventricle.":[130],"By":[131],"increasing":[132],"workload,":[134],"at":[138,159],"ventricle":[148],"due":[151],"washout.":[154],"root":[162],"graft":[167],"resulting":[170],"from":[171],"either":[172],"or":[175],"increased":[176],"stress.":[179],"These":[180],"findings":[181],"provide":[182],"guidelines":[183],"surgical":[185],"planning":[186],"postoperative":[188],"management":[189],"clinical":[191],"practice.":[192]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-06-28T00:00:00"}