{"id":"https://openalex.org/W7166345847","doi":"https://doi.org/10.1186/s12885-026-16428-x","title":"Potential evaluation of SULT1A3 as an early diagnostic marker for nasopharyngeal carcinoma: a study based on serum proteomics screening and ELISA validation","display_name":"Potential evaluation of SULT1A3 as an early diagnostic marker for nasopharyngeal carcinoma: a study based on serum proteomics screening and ELISA validation","publication_year":2026,"publication_date":"2026-06-27","ids":{"openalex":"https://openalex.org/W7166345847","doi":"https://doi.org/10.1186/s12885-026-16428-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/42365246"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-026-16428-x","doi":"https://doi.org/10.1186/s12885-026-16428-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-026-16428-x","pdf_url":null,"source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12885-026-16428-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136491407","display_name":"Zhifang Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153371","display_name":"The First People's Hospital of Zhaoqing","ror":"https://ror.org/04gcfwh66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153371","https://openalex.org/I4405282241"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhifang Lin","raw_affiliation_strings":["Clinical Laboratory, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526060, China","institution_ids":["https://openalex.org/I4210153371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139503502","display_name":"Wei Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153371","display_name":"The First People's Hospital of Zhaoqing","ror":"https://ror.org/04gcfwh66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153371","https://openalex.org/I4405282241"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Song","raw_affiliation_strings":["Division of Spine Surgery, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Spine Surgery, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526060, China","institution_ids":["https://openalex.org/I4210153371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128733788","display_name":"Wenhai Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153371","display_name":"The First People's Hospital of Zhaoqing","ror":"https://ror.org/04gcfwh66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153371","https://openalex.org/I4405282241"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhai Liang","raw_affiliation_strings":["Clinical Laboratory, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526060, China","institution_ids":["https://openalex.org/I4210153371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119767598","display_name":"Jian Liu","orcid":"https://orcid.org/0000-0003-4362-5273","observed_orcids":["https://orcid.org/0000-0003-4362-5273"]},"institutions":[{"id":"https://openalex.org/I4210153371","display_name":"The First People's Hospital of Zhaoqing","ror":"https://ror.org/04gcfwh66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153371","https://openalex.org/I4405282241"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Liu","raw_affiliation_strings":["Clinical Laboratory, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526060, China","institution_ids":["https://openalex.org/I4210153371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112120511","display_name":"Ruiwei Gan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153371","display_name":"The First People's Hospital of Zhaoqing","ror":"https://ror.org/04gcfwh66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153371","https://openalex.org/I4405282241"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruiwei Gan","raw_affiliation_strings":["Clinical Laboratory, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526060, China","institution_ids":["https://openalex.org/I4210153371"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113416662","display_name":"Yueying Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153371","display_name":"The First People's Hospital of Zhaoqing","ror":"https://ror.org/04gcfwh66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153371","https://openalex.org/I4405282241"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yueying Wang","raw_affiliation_strings":["Clinical Laboratory, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526060, China. wangyueyinggd@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526060, China. wangyueyinggd@126.com","institution_ids":["https://openalex.org/I4210153371"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113416662"],"corresponding_institution_ids":["https://openalex.org/I4210153371"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50061897,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7360000014305115},{"id":"https://openalex.org/keywords/sult1a3","display_name":"SULT1A3","score":0.996999979019165},{"id":"https://openalex.org/keywords/leukotriene-a4-hydrolase","display_name":"leukotriene A4 hydrolase","score":0.8100000023841858},{"id":"https://openalex.org/keywords/fgl1","display_name":"FGL1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/serum-proteomics","display_name":"serum proteomics","score":0.890999972820282},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.7200000286102295},{"id":"https://openalex.org/keywords/m1-macrophage-infiltration","display_name":"M1 macrophage infiltration","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/random-forest","display_name":"random forest","score":0.37299999594688416},{"id":"https://openalex.org/keywords/recursive-feature-elimination","display_name":"recursive feature elimination","score":0.9070000052452087},{"id":"https://openalex.org/keywords/elisa-validation","display_name":"ELISA validation","score":0.5759999752044678},{"id":"https://openalex.org/keywords/vca-iga","display_name":"VCA-IgA","score":0.6460000276565552},{"id":"https://openalex.org/keywords/tumor-screening","display_name":"cancer screening","score":0.3619999885559082},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.6973999738693237},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6446999907493591},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5038999915122986},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4934000074863434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4846999943256378},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.46059998869895935},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4214000105857849},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4138999879360199},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.3944999873638153},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3273000121116638},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32260000705718994},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.314300000667572},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3034000098705292},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.3025999963283539},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C159744936","wikidata":"https://www.wikidata.org/wiki/Q1126730","display_name":"Spearman's rank correlation coefficient","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.2687999904155731},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.2667999863624573},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.26589998602867126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25929999351501465},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.25429999828338623},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.251800000667572},{"id":"https://openalex.org/C2779559962","wikidata":"https://www.wikidata.org/wiki/Q14905263","display_name":"Hsp27","level":5,"score":0.25130000710487366}],"mesh":[{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000077274","descriptor_name":"Nasopharyngeal Carcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015239","descriptor_name":"Arylsulfotransferase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015239","descriptor_name":"Arylsulfotransferase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015239","descriptor_name":"Arylsulfotransferase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12885-026-16428-x","doi":"https://doi.org/10.1186/s12885-026-16428-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-026-16428-x","pdf_url":null,"source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-8856378/v1","doi":"https://doi.org/10.21203/rs.3.rs-8856378/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8856378/v1","pdf_url":"https://www.researchsquare.com/article/rs-8856378/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:42365246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42365246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13573393","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13573393/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13573393/pdf/12885_2026_Article_16428.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:0264e76b0f9c48edb54c2365d6bad6fd","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0264e76b0f9c48edb54c2365d6bad6fd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 26, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12885-026-16428-x","doi":"https://doi.org/10.1186/s12885-026-16428-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-026-16428-x","pdf_url":null,"source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321160","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71"},{"id":"https://openalex.org/F4320336632","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1588125282","https://openalex.org/W2051965477","https://openalex.org/W2079572370","https://openalex.org/W2142205442","https://openalex.org/W2188730791","https://openalex.org/W2198441752","https://openalex.org/W2322318357","https://openalex.org/W2559861554","https://openalex.org/W2583706707","https://openalex.org/W2617423367","https://openalex.org/W2762615468","https://openalex.org/W2919811956","https://openalex.org/W2921763102","https://openalex.org/W2922441457","https://openalex.org/W2952907530","https://openalex.org/W3134631284","https://openalex.org/W3165613922","https://openalex.org/W3200810692","https://openalex.org/W3211562788","https://openalex.org/W4211017340","https://openalex.org/W4214595574","https://openalex.org/W4223447573","https://openalex.org/W4293384264","https://openalex.org/W4294216483","https://openalex.org/W4319748065","https://openalex.org/W4403299677","https://openalex.org/W4404046121","https://openalex.org/W4411238494"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Nasopharyngeal":[1],"carcinoma":[2],"(NPC)":[3],"represents":[4],"a":[5,33,199,300],"highly":[6],"prevalent":[7],"and":[8,16,59,120,152,171,190,229,264,292],"aggressive":[9],"malignancy":[10],"endemic":[11],"to":[12,21,36,68,85,128],"Southeast":[13],"Asia.":[14],"Early":[15],"accurate":[17],"diagnosis":[18],"is":[19,328],"critical":[20],"improving":[22],"survival":[23],"outcomes;":[24],"however,":[25],"the":[26],"absence":[27],"of":[28,39,210,247,307],"robust,":[29],"stage-specific":[30],"biomarkers":[31],"remains":[32],"key":[34],"obstacle":[35],"clinical":[37,319],"implementation":[38],"early":[40,305],"screening":[41],"strategies.":[42],"METHODS:":[43],"We":[44,116],"performed":[45],"untargeted":[46],"serum":[47,106,143],"proteomic":[48,287],"profiling":[49],"using":[50,93],"mass":[51],"spectrometry":[52],"in":[53,98,124,258,275,318,324],"15":[54,60],"treatment-na\u00efve":[55],"early-stage":[56],"NPC":[57,125],"patients":[58,126],"VCA-IgA-positive":[61],"healthy":[62],"controls.":[63,129],"Bioinformatics":[64],"analyses":[65],"were":[66,90,108,113,177],"conducted":[67],"identify":[69],"differentially":[70],"expressed":[71],"proteins":[72,107,123],"(DEPs).":[73],"Machine":[74],"learning":[75,290],"(random":[76],"forest":[77],"combined":[78],"with":[79,142,180],"recursive":[80],"feature":[81],"elimination)":[82],"was":[83],"employed":[84],"prioritize":[86],"candidate":[87,301],"biomarkers,":[88],"which":[89,111],"subsequently":[91],"verified":[92],"enzyme-linked":[94],"immunosorbent":[95],"assay":[96],"(ELISA)":[97],"independent":[99,241],"sample":[100],"cohorts.":[101],"RESULTS:":[102],"In":[103,198,239],"total,":[104],"1,428":[105],"identified,":[109],"among":[110],"1,410":[112],"reliably":[114],"quantified.":[115],"observed":[117],"31":[118],"upregulated":[119],"189":[121],"downregulated":[122],"relative":[127],"Spearman":[130],"correlation":[131],"analysis":[132],"revealed":[133],"significant":[134],"associations:":[135],"LTA4H":[136],"(leukotriene":[137],"A4":[138],"hydrolase)":[139],"levels":[140,176],"correlated":[141],"cell":[144],"infiltration":[145,183],"(r":[146,157,184],"=":[147,150,158,161,185,188,192,195,204,216,235,253,256,262,270,273,279],"0.383,":[148],"p":[149,160,187,194,215,224,234],"0.032)":[151],"CD8":[153],"+":[154],"T-cell":[155],"abundance":[156],"0.408,":[159],"0.021);":[162],"both":[163],"SULT1A3":[164,243,298,313],"(sulfotransferase":[165],"family":[166],"1":[167,260],"A":[168],"member":[169],"3)":[170],"FGL1":[172],"(fibrinogen-like":[173],"protein":[174],"1)":[175],"positively":[178],"associated":[179],"M1":[181],"macrophage":[182],"0.510,":[186],"0.003":[189],"r":[191],"0.430,":[193],"0.015,":[196],"respectively).":[197],"preliminary":[200],"validation":[201,323],"cohort":[202,259,276],"(n":[203,261,278],"80),":[205],"ELISA":[206,294],"yielded":[207],"AUC":[208,246],"values":[209],"0.631":[211],"(95%":[212,221,231,249,266],"CI:":[213,222,232,250,267],"0.515-0.736,":[214],"0.04)":[217],"for":[218,227,237,304],"LTA4H,":[219],"0.787":[220],"0.681-0.871,":[223],"<":[225],"0.001)":[226],"SULT1A3,":[228],"0.688":[230],"0.575-0.787,":[233],"0.002)":[236],"FGL1.":[238],"large-scale":[240],"validation,":[242,295],"achieved":[244],"an":[245,283],"0.826":[248],"0.766-0.876;":[251],"sensitivity":[252,269],"78.89%,":[254],"specificity":[255,272],"75.47%)":[257],"196)":[263],"0.796":[265],"0.723-0.857;":[268],"76.67%,":[271],"76.67%)":[274],"2":[277],"150).":[280],"CONCLUSIONS:":[281],"Through":[282],"integrated":[284],"workflow":[285],"combining":[286],"screening,":[288,320],"machine":[289],"prioritization,":[291],"multi-stage":[293],"we":[296],"identified":[297],"as":[299],"serum-based":[302],"biomarker":[303],"detection":[306],"NPC.":[308],"Preliminary":[309],"findings":[310],"suggest":[311],"that":[312],"may":[314],"have":[315],"potential":[316],"utility":[317],"though":[321],"further":[322],"independent,":[325],"multi\u2011center":[326],"cohorts":[327],"required.":[329]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2026-06-28T00:00:00"}